TABLE OF CONTENTS
Volume 15, Issue 4 (April 2007)
Editorial
Of Mouse Models and Men FREE
David A Williams Editor-in-Chief
Mol Ther 15: 643; doi:10.1038/sj.mt.6300133
In This Issue
In This Issue FREE
Mol Ther 15: 646; doi:10.1038/sj.mt.6300140
See also: Original Article by Paraskevakou et al. See also: Original Article by Heyes et al. See also: Original Article by Brunetti-Pierri et al. See also: Original Article by Ramunas et al. See also: Original Article by Prasad et al. See also: Original Article by Zamir et al.Research Highlights
Top of pageCommentaries
Gene Therapy and Biosecurity FREE
Michael J Imperiale
Mol Ther 15: 648-649; doi:10.1038/sj.mt.6300136
Immune Responses to AAV Capsid: Are Mice Not Humans After All? FREE
Roland W Herzog
Mol Ther 15: 649-650; doi:10.1038/sj.mt.6300123
See also: Original Article by Li et al.Reviews
Acquired and Multigenic Disease
History of Oncolytic Viruses: Genesis to Genetic Engineering FREE
Elizabeth Kelly and Stephen J Russell
Mol Ther 15: 651-659; advance online publication, February 13, 2007; doi:10.1038/sj.mt.6300108
Vector Engineering and Delivery
Cell-based Delivery of Oncolytic Viruses: A New Strategic Alliance for a Biological Strike Against Cancer FREE
Anthony T Power and John C Bell
Mol Ther 15: 660-665; advance online publication, January 30, 2007; doi:10.1038/sj.mt.6300098
Clinical Trials
The Continuing Contribution of Gene Marking to Cell and Gene Therapy FREE
Siok-Keen Tey and Malcolm K Brenner
Mol Ther 15: 666-676; advance online publication, February 13, 2007; doi:10.1038/sj.mt.6300109
Original Articles
Acquired and Multigenic Disease
Epidermal Growth Factor Receptor (EGFR)–Retargeted Measles Virus Strains Effectively Target EGFR- or EGFRvIII Expressing Gliomas FREE
Georgia Paraskevakou, Cory Allen, Takafumi Nakamura, Paula Zollman, C David James, Kah Whye Peng, Mark Schroeder, Stephen J Russell and Evanthia Galanis
Mol Ther 15: 677-686; advance online publication, February 13, 2007; doi:10.1038/sj.mt.6300105
Lentiviral-mediated Targeted NF-
B Blockade in Dorsal Spinal Cord Glia Attenuates Sciatic Nerve Injury–induced Neuropathic Pain in the Rat FREE
Alice Meunier, Alban Latrémolière, Elisa Dominguez, Annie Mauborgne, Stéphanie Philippe, Michel Hamon, Jacques Mallet, Jean-Jacques Benoliel and Michel Pohl
Mol Ther 15: 687-697; advance online publication, February 13, 2007; doi:10.1038/sj.mt.6300107
DJ-1 and Parkin Modulate Dopamine-dependent Behavior and Inhibit MPTP-induced Nigral Dopamine Neuron Loss in Mice FREE
Jean-Charles Paterna, Andreas Leng, Elisabeth Weber, Joram Feldon and Hansruedi Büeler
Mol Ther 15: 698-704; advance online publication, February 13, 2007; doi:10.1038/sj.mt.6300067
Vector Engineering and Delivery
Spatially Patterned Gene Delivery for Localized Neuron Survival and Neurite Extension FREE
Tiffany Houchin-Ray, Kevin J Whittlesey and Lonnie D Shea
Mol Ther 15: 705-712; advance online publication, February 13, 2007; doi:10.1038/sj.mt.6300106
Lipid Encapsulation Enables the Effective Systemic Delivery of Polyplex Plasmid DNA FREE
James Heyes, Lorne Palmer, Kitty Chan, Cory Giesbrecht, Lloyd Jeffs and Ian MacLachlan
Mol Ther 15: 713-720; advance online publication, February 13, 2007; doi:10.1038/sj.mt.6300101
Histone-mediated Transduction as an Efficient Means for Gene Delivery FREE
Kylie M Wagstaff, Dominic J Glover, David J Tremethick and David A Jans
Mol Ther 15: 721-731; advance online publication, February 27, 2007; doi:10.1038/sj.mt.6300093
Pseudo-hydrodynamic Delivery of Helper-dependent Adenoviral Vectors into Non-human Primates for Liver-directed Gene Therapy FREE
Nicola Brunetti-Pierri, Gary E Stapleton, Donna J Palmer, Yu Zuo, Viraj P Mane, Milton J Finegold, Arthur L Beaudet, Michelle M Leland, Charles E Mullins and Philip Ng
Mol Ther 15: 732-740; advance online publication, February 6, 2007; doi:10.1038/sj.mt.6300102
Adenovirus 5 Fibers Mutated at the Putative HSPG-binding Site Show Restricted Retargeting with Targeting Peptides in the HI Loop FREE
Angelika B Kritz, Campbell G Nicol, Kate L Dishart, Ruth Nelson, Susan Holbeck, Dan J Von Seggern, Lorraine M Work, John H McVey, Stuart A Nicklin and Andrew H Baker
Mol Ther 15: 741-749; advance online publication, January 23, 2007; doi:10.1038/sj.mt.6300094
Efficient Whole-body Transduction with Trans-splicing Adeno-associated Viral Vectors FREE
Arkasubhra Ghosh, Yongping Yue, Chun Long, Brian Bostick and Dongsheng Duan
Mol Ther 15: 750-755; advance online publication, January 30, 2007; doi:10.1038/sj.mt.6300081
Expression of a Truncated Cystic Fibrosis Transmembrane Conductance Regulator with an AAV5-pseudotyped Vector in Primates FREE
Anne C Fischer, Carolina I Smith, Liudmila Cebotaru, Xuemei Zhang, Frederic B Askin, Jerry Wright, Sandra E Guggino, Robert J Adams, Terence Flotte and William B Guggino
Mol Ther 15: 756-763; advance online publication, February 13, 2007; doi:10.1038/sj.mt.6300059
Topoisomerase Inhibition Accelerates Gene Expression after Adeno-associated Virus-mediated Gene Transfer to the Mammalian Heart FREE
Konkal-Matt R Prasad, Yaqin Xu, Zequan Yang, Marie-Claire Toufektsian, Stuart S Berr and Brent A French
Mol Ther 15: 764-771; advance online publication, February 13, 2007; doi:10.1038/sj.mt.6300071
Vector Toxicology, Immunogenicity and Safety
Replication-deficient Adenovirus Induces Host Topoisomerase I Activity: Implications for Adenovirus-mediated Gene Expression FREE
Gideon Zamir, Evelyne Zeira, Andrew E Gelman, Abraham Shaked, Kim M Olthoff, Ahmed Eid and Eithan Galun
Mol Ther 15: 772-781; advance online publication, February 13, 2007; doi:10.1038/sj.mt.6300110
Importance of Murine Study Design for Testing Toxicity of Retroviral Vectors in Support of Phase I Trials FREE
Elke Will, Jeff Bailey, Todd Schuesler, Ute Modlich, Brenden Balcik, Ben Burzynski, David Witte, Gerlinde Layh-Schmitt, Cornelia Rudolph, Brigitte Schlegelberger, Christof von Kalle, Christopher Baum, Brian P Sorrentino, Lars M Wagner, Patrick Kelly, Lilith Reeves and David A Williams
Mol Ther 15: 782-791; advance online publication, February 13, 2007; doi:10.1038/sj.mt.6300083
Pre-existing AAV Capsid-specific CD8+ T Cells are Unable to Eliminate AAV-transduced Hepatocytes FREE
Hua Li, Samuel L Murphy, Wynetta Giles-Davis, Shyrie Edmonson, Zhiquan Xiang, Yan Li, Marcio O Lasaro, Katherine A High and Hildegund CJ Ertl
Mol Ther 15: 792-800; advance online publication, January 23, 2007; doi:10.1038/sj.mt.6300090
Suppression of Clonal Dominance in Cultured Human Lymphoid Cells by Addition of the cHS4 Insulator to a Lentiviral Vector FREE
Marguerite V Evans-Galea, Matthew M Wielgosz, Hideki Hanawa, Deo Kumar Srivastava and Arthur W Nienhuis
Mol Ther 15: 801-809; advance online publication, February 13, 2007; doi:10.1038/sj.mt.6300103
Cell Therapy
Real-time Fluorescence Tracking of Dynamic Transgene Variegation in Stem Cells FREE
John Ramunas, Heather J Montgomery, Liam Kelly, Tanya Sukonnik, James Ellis and Eric J Jervis
Mol Ther 15: 810-817; advance online publication, February 6, 2007; doi:10.1038/sj.mt.6300073
Lentivirally Transduced Recipient-derived Dendritic Cells Serve to Ex Vivo Expand Functional FcR
-sufficient Double-negative Regulatory T Cells FREE
Christopher W Thomson, Miriam E Mossoba, Christopher Siatskas, Wenhao Chen, April Sung, Jeffrey A Medin and Li Zhang
Mol Ther 15: 818-824; advance online publication, January 30, 2007; doi:10.1038/sj.mt.6300082
Clinical Trials
Adoptive Transfer of Chimeric Antigen Receptor Re-directed Cytolytic T Lymphocyte Clones in Patients with Neuroblastoma FREE
Julie R Park, David L DiGiusto, Marilyn Slovak, Christine Wright, Araceli Naranjo, Jamie Wagner, Hunsar B Meechoovet, Cherrilyn Bautista, Wen-Chung Chang, Julie R Ostberg and Michael C Jensen
Mol Ther 15: 825-833; advance online publication, February 13, 2007; doi:10.1038/sj.mt.6300104
Suicide Gene Therapy With Adenoviral Delivery of HSV-tK Gene for Patients With Local Recurrence of Prostate Cancer After Hormonal Therapy FREE
Yasutomo Nasu, Takashi Saika, Shin Ebara, Nobuyuki Kusaka, Haruki Kaku, Fernando Abarzua, Daisuke Manabe, Timothy C Thompson and Hiromi Kumon
Mol Ther 15: 834-840; advance online publication, February 27, 2007; doi:10.1038/sj.mt.6300096
