TABLE OF CONTENTS
Volume 15, Issue 3 (March 2007)
Editorial
Are Lentivirus Vectors Safer? FREE
David A Williams Editor-in-Chief
Mol Ther 15: 439; doi:10.1038/sj.mt.6300111
In This Issue
Top of pageResearch Highlights
Top of pageCommentaries
Gene Therapy Prolongs PSA Doubling Time in Prostate Cancer Patients FREE
Timothy C Thompson and Ron Rodriguez
Mol Ther 15: 442-443; doi:10.1038/sj.mt.6300085
See also: Original Article by Freytag et al.Genetic Manipulation of Skin Stem Cells: Success, Hope, and Challenges Ahead FREE
Yann Barrandon
Mol Ther 15: 443-444; doi:10.1038/sj.mt.6300113
Reviews
Vector Engineering and Delivery
The Genetic Engineering of Hematopoietic Stem Cells: the Rise of Lentiviral Vectors, the Conundrum of the LTR, and the Promise of Lineage-restricted Vectors FREE
Alex H Chang and Michel Sadelain
Mol Ther 15: 445-456; advance online publication, January 16, 2007; doi:10.1038/sj.mt.6300060
Replication-competent Vectors and Empty Virus-like Particles: New Retroviral Vector Designs for Cancer Gene Therapy or Vaccines FREE
Charlotte Dalba, Bertrand Bellier, Noriyuki Kasahara and David Klatzmann
Mol Ther 15: 457-466; advance online publication, January 23, 2007; doi:10.1038/sj.mt.6300054
Cell Therapy
Biomaterials Approach to Expand and Direct Differentiation of Stem Cells FREE
Chou Chai and Kam W Leong
Mol Ther 15: 467-480; advance online publication, January 30, 2007; doi:10.1038/sj.mt.6300084
Original Articles
Monogenic Disease
Enhanced Survival of the LINCL Mouse Following CLN2 Gene Transfer Using the rh.10 Rhesus Macaque-derived Adeno-associated Virus Vector FREE
Dolan Sondhi, Neil R Hackett, Daniel A Peterson, Jamie Stratton, Michael Baad, Kelly M Travis, James M Wilson and Ronald G Crystal
Mol Ther 15: 481-491; advance online publication, December 19, 2006; doi:10.1038/sj.mt.6300049
Correction of the Biochemical and Functional Deficits in Fabry Mice Following AAV8–mediated Hepatic Expression of 
-galactosidase A FREE
Robin J Ziegler, Maribeth Cherry, Christine M Barbon, Chester Li, Scott D Bercury, Donna Armentano, Robert J Desnick and Seng H Cheng
Mol Ther 15: 492-500; advance online publication, December 26, 2006; doi:10.1038/sj.mt.6300066
Physiological Correction of Pompe Disease by Systemic Delivery of Adeno-associated Virus Serotype 1 Vectors FREE
Cathryn Mah, Christina A Pacak, Kerry O Cresawn, Lara R DeRuisseau, Sean Germain, Melissa A Lewis, Denise A Cloutier, David D Fuller and Barry J Byrne
Mol Ther 15: 501-507; advance online publication, January 23, 2007; doi:10.1038/sj.mt.6300100
Pharmacological Enhancement of Mutated -Glucosidase Activity in Fibroblasts from Patients with Pompe Disease FREE
Giancarlo Parenti, Alfredo Zuppaldi, M Gabriela Pittis, M Rosaria Tuzzi, Ida Annunziata, Germana Meroni, Caterina Porto, Francesca Donaudy, Barbara Rossi, Massimiliano Rossi, Mirella Filocamo, Alice Donati, Bruno Bembi, Andrea Ballabio and Generoso Andria
Mol Ther 15: 508-514; advance online publication, January 9, 2007; doi:10.1038/sj.mt.6300074
Acquired and Multigenic Disease
Polyethylenimine-complexed Plasmid Particles Targeting Focal Adhesion Kinase Function as Melanoma Tumor Therapeutics FREE
Shufeng Li, Wei Dong, Yiwei Zong, Wu Yin, Guanghui Jin, Qingang Hu, Xiaofeng Huang, Wenhui Jiang and Zi-Chun Hua
Mol Ther 15: 515-523; advance online publication, February 6, 2007; doi:10.1038/sj.mt.6300072
Macrophage-mediated Bystander Effect Triggered by Tumor Cell Apoptosis FREE
Yinghui Huang, Casey Lee, Per Borgström and Ruth A Gjerset
Mol Ther 15: 524-533; advance online publication, January 16, 2007; doi:10.1038/sj.mt.6300080
Specific Inhibition of HBV Replication In Vitro and In Vivo With Expressed Long Hairpin RNA FREE
Marc S Weinberg, Abdullah Ely, Samantha Barichievy, Carol Crowther, Steven Mufamadi, Sergio Carmona and Patrick Arbuthnot
Mol Ther 15: 534-541; advance online publication, January 9, 2007; doi:10.1038/sj.mt.6300077
Viral Clostridial Light Chain Gene-based Control of Penicillin-induced Neocortical Seizures FREE
Jun Yang, Qingshan Teng, Thais Federici, Imad Najm, Stephan Chabardes, Michael Moffitt, Andreas Alexopoulos, Jonathan Riley and Nicholas M Boulis
Mol Ther 15: 542-551; advance online publication, January 9, 2007; doi:10.1038/sj.mt.6300069
Vector Engineering and Delivery
Retroviral Vectors Encoding a Reverse Transcription-activated Transgene Efficiently Limit Expression of the Gene to Target Cells FREE
John Douglas Burke and John C Morris
Mol Ther 15: 552-559; advance online publication, December 26, 2006; doi:10.1038/sj.mt.6300062
Stable Transgene Expression in Mice Generated from Retrovirally Transduced Embryonic Stem Cells FREE
Sanae Hamanaka, Tsukasa Nabekura, Makoto Otsu, Hisahiro Yoshida, Michio Nagata, Joichi Usui, Satoru Takahashi, Toshiro Nagasawa, Hiromitsu Nakauchi and Masafumi Onodera
Mol Ther 15: 560-565; advance online publication, December 19, 2006; doi:10.1038/sj.mt.6300063
Modulation of Adenoviral Transduction In Vitro and In Vivo by Hyaluronan and its Receptor CD44 FREE
Saumya R Chaudhuri, Joshua N Mallam, Patricia Chévez-Barrios, Lalita Wadhwa, Philip Ng, Mary Y Hurwitz and Richard L Hurwitz
Mol Ther 15: 566-570; advance online publication, December 19, 2006; doi:10.1038/sj.mt.6300044
Enhancement of Gene Transfer to Human Myeloid Cells by Adenovirus–Fiber Complexes FREE
Ronald R Nepomuceno, Lars Pache and Glen R Nemerow
Mol Ther 15: 571-578; advance online publication, December 19, 2006; doi:10.1038/sj.mt.6300048
Gene Transfer to Ocular Stem Cells by Early Gestational Intraamniotic Injection of Lentiviral Vector FREE
Masayuki Endo, Philip W Zoltick, Daniel C Chung, Jean Bennett, Antoneta Radu, Nidal Muvarak and Alan W Flake
Mol Ther 15: 579-587; advance online publication, January 23, 2007; doi:10.1038/sj.mt.6300092
Vector Toxicology, Immunogenicity and Safety
Engineering Oncolytic Measles Virus to Circumvent the Intracellular Innate Immune Response FREE
Iana Haralambieva, Ianko Iankov, Kosei Hasegawa, Mary Harvey, Stephen J Russell and Kah-Whye Peng
Mol Ther 15: 588-597; advance online publication, January 16, 2007; doi:10.1038/sj.mt.6300076
Targeting Interferon- Increases Antitumor Efficacy and Reduces Hepatotoxicity of E1A-mutated Spread-enhanced Oncolytic Adenovirus FREE
Elena V Shashkova, Jacqueline F Spencer, William S M Wold and Konstantin Doronin
Mol Ther 15: 598-607; advance online publication, December 26, 2006; doi:10.1038/sj.mt.6300064
Vaccine Technology
A CD46-binding Chimpanzee Adenovirus Vector as a Vaccine Carrier FREE
Nia Tatsis, Ariella Blejer, Marcio O Lasaro, Scott E Hensley, Ann Cun, Lello Tesema, Yan Li, Guang-Ping Gao, Zhi Q Xiang, Dongming Zhou, James M Wilson and Hildegund C J Ertl
Mol Ther 15: 608-617; advance online publication, January 16, 2007; doi:10.1038/sj.mt.6300078
Cell Therapy
Multiple Reduced-intensity Conditioning Regimens Facilitate Correction of Fabry Mice After Transplantation of Transduced Cells FREE
Sheng-Ben Liang, Makoto Yoshimitsu, Armando Poeppl, Vanessa I Rasaiah, Jianhui Cai, Daniel H Fowler and Jeffrey A Medin
Mol Ther 15: 618-627; advance online publication, January 16, 2007; doi:10.1038/sj.mt.6300075
Intravenously Injected Human Fibroblasts Home to Skin Wounds, Deliver Type VII Collagen, and Promote Wound Healing FREE
David T Woodley, Jennifer Remington, Yi Huang, Yingping Hou, Wei Li, Douglas R Keene and Mei Chen
Mol Ther 15: 628-635; advance online publication, January 23, 2007; doi:10.1038/sj.mt.6300041
Clinical Trials
Five-year Follow-up of Trial of Replication-competent Adenovirus-mediated Suicide Gene Therapy for Treatment of Prostate Cancer FREE
Svend O Freytag, Hans Stricker, James Peabody, Jan Pegg, Dell Paielli, Benjamin Movsas, Kenneth N Barton, Stephen L Brown, Mei Lu and Jae Ho Kim
Mol Ther 15: 636-642; advance online publication, January 16, 2007; doi:10.1038/sj.mt.6300068
See also: Commentary by Thompson & Rodriguez