TABLE OF CONTENTS
Volume 15, Issue 2 (February 2007)
Editorial
RNAi Gets Vote of Confidence from Big Pharma FREE
Robert M Frederickson Editor
Mol Ther 15: 221-222; doi:10.1038/sj.mt.6300099
In This Issue
In This Issue FREE
Mol Ther 15: 224; doi:10.1038/sj.mt.6300097
See also: Research Highlights by See also: Original Article by Wang et al. See also: Original Article by Hensley et al. See also: Original Article by Yan et al. See also: Original Article by Neal et al. See also: Original Article by Salva et al.Research Highlights
Top of pageCommentaries
A Peptide Fusion a Day Keeps the Aggregates Away FREE
Alain Prochiantz
Mol Ther 15: 226-227; doi:10.1038/sj.mt.6300088
See also: Original Article by Popiel et al.Armed Interference: Oncolytic Viruses Engineered to Carry Antitumor shRNAs FREE
David Kirn
Mol Ther 15: 227-228; doi:10.1038/sj.mt.6300089
See also: Original Article by Yoo et al.Reviews
Monogenic Disease
Viral Vector–mediated and Cell-based Therapies for Treatment of Cystic Fibrosis FREE
Terence R Flotte, Philip Ng, Doug E Dylla, Paul B McCray Jr, Guoshun Wang, Jay K Kolls and Jim Hu
Mol Ther 15: 229-241; doi:10.1038/sj.mt.6300002
Original Articles
Monogenic Disease
Adeno-associated Virus Type 5 Reduces Learning Deficits and Restores Glutamate Receptor Subunit Levels in MPS VII Mice CNS FREE
Gumei Liu, Yong Hong Chen, Xiaohua He, Inês Martins, Jason A Heth, John A Chiorini and Beverly L Davidson
Mol Ther 15: 242-247; doi:10.1038/sj.mt.6300016
Infectious Delivery and Expression of a 135 kb Human FRDA Genomic DNA Locus Complements Friedreich's Ataxia Deficiency in Human Cells FREE
Silvia Gomez-Sebastian, Alfredo Gimenez-Cassina, Javier Diaz-Nido, Filip Lim and Richard Wade-Martins
Mol Ther 15: 248-254; doi:10.1038/sj.mt.6300021
Acquired and Multigenic Disease
Adenovirus Transduction is Required for the Correction of Diabetes Using Pdx-1 or Neurogenin-3 in the Liver FREE
Alfred Y Wang, Anja Ehrhardt, Hui Xu and Mark A Kay
Mol Ther 15: 255-263; doi:10.1038/sj.mt.6300032
Long-term Suppression of Experimental Arthritis Following Intramuscular Administration of a Pseudotyped AAV2/1-TNFR:Fc Vector FREE
Ziv Sandalon, Elizabeth M Bruckheimer, Kurt H Lustig and Haim Burstein
Mol Ther 15: 264-269; doi:10.1038/sj.mt.6300043
Comparison of D-G3139 and Its Enantiomer L-G3139 in Melanoma Cells Demonstrates Minimal In Vitro but Dramatic In Vivo Chiral Dependency FREE
Johnathan C Lai, Bob D Brown, Anatoliy M Voskresenskiy, Stefan Vonhoff, Sven Klussman, Wenzhi Tan, Marco Colombini, Risini Weeratna, Paul Miller, Luba Benimetskaya and Cy A Stein
Mol Ther 15: 270-278; doi:10.1038/sj.mt.6300037
Oncolytic HSV and Erlotinib Inhibit Tumor Growth and Angiogenesis in a Novel Malignant Peripheral Nerve Sheath Tumor Xenograft Model FREE
Yonatan Y Mahller, Sachin S Vaikunth, Mark A Currier, Shyra J Miller, Maria C Ripberger, Ya-Hsuan Hsu, Ruty Mehrian-Shai, Margaret H Collins, Timothy M Crombleholme, Nancy Ratner and Timothy P Cripe
Mol Ther 15: 279-286; doi:10.1038/sj.mt.6300038
Monogenic Disease
mda-7 in Combination with Bevacizumab Treatment Produces a Synergistic and Complete Inhibitory Effect on Lung Tumor Xenograft FREE
Satoshi Inoue, Amanda Hartman, Cynthia D Branch, Corazan D Bucana, Benjamin N Bekele, L Clifton Stephens, Sunil Chada and Rajagopal Ramesh
Mol Ther 15: 287-294; doi:10.1038/sj.mt.6300035
Vector Engineering and Delivery
VEGF-specific Short Hairpin RNA–expressing Oncolytic Adenovirus Elicits Potent Inhibition of Angiogenesis and Tumor Growth FREE
Ji Young Yoo, Joo-Hang Kim, Young-Guen Kwon, Eok-Cheon Kim, Nam Kyu Kim, Hye Jin Choi and Chae-Ok Yun
Mol Ther 15: 295-302; doi:10.1038/sj.mt.6300023
See also: Commentary by KirnProtein Transduction Domain-mediated Delivery of QBP1 Suppresses Polyglutamine-induced Neurodegeneration In Vivo FREE
H Akiko Popiel, Yoshitaka Nagai, Nobuhiro Fujikake and Tatsushi Toda
Mol Ther 15: 303-309; doi:10.1038/sj.mt.6300045
See also: Commentary by ProchiantzEvidence for Intercellular Trafficking of VP22 in Living Cells FREE
Marie-Luise Lemken, Claudia Wolf, Wolfgang A Wybranietz, Ulrike Schmidt, Irina Smirnow, Hans-Joerg Bühring, Andreas F Mack, Ulrich M Lauer and Michael Bitzer
Mol Ther 15: 310-319; doi:10.1038/sj.mt.6300013
Design of Tissue-specific Regulatory Cassettes for High-level rAAV-mediated Expression in Skeletal and Cardiac Muscle FREE
Maja Z Salva, Charis L Himeda, Phillip WL Tai, Eiko Nishiuchi, Paul Gregorevic, James M Allen, Eric E Finn, Quynh G Nguyen, Michael J Blankinship, Leonard Meuse, Jeffrey S Chamberlain and Stephen D Hauschka
Mol Ther 15: 320-329; doi:10.1038/sj.mt.6300027
A Two-hybrid Screen Identifies Cathepsins B and L as Uncoating Factors for Adeno-associated Virus 2 and 8 FREE
Bassel Akache, Dirk Grimm, Xuan Shen, Sally Fuess, Stephen R Yant, Dariya S Glazer, Julie Park and Mark A Kay
Mol Ther 15: 330-339; doi:10.1038/sj.mt.6300053
Targeted Gene Transfer to Fetal Rat Lung Interstitium by Ultrasound-guided Intrapulmonary Injection FREE
Tiago Henriques-Coelho, Sílvia Gonzaga, Masayuki Endo, Philip W Zoltick, Marcus Davey, Adelino F Leite-Moreira, Jorge Correia-Pinto and Alan W Flake
Mol Ther 15: 340-347; doi:10.1038/sj.mt.6300057
Optimizing Aerosol Gene Delivery and Expression in the Ovine Lung FREE
Gerry McLachlan, Alison Baker, Peter Tennant, Catherine Gordon, Christina Vrettou, Louise Renwick, Richard Blundell, Seng H Cheng, Ron K Scheule, Lee Davies, Hazel Painter, Rebecca L Coles, Anna E Lawton, Chris Marriott, Deborah R Gill, Stephen C Hyde, Uta Griesenbach, Eric W F W Alton, A Christopher Boyd, David J Porteous and D David S Collie
Mol Ther 15: 348-354; doi:10.1038/sj.mt.6300058
Lentiviral Vectors for T-cell Suicide Gene Therapy: Preservation of T-cell Effector Function After Cytokine-mediated Transduction FREE
Waseem Qasim, Taylor Mackey, Jo Sinclair, Ilenia Chatziandreou, Christine Kinnon, Adrian J Thrasher and H Bobby Gaspar
Mol Ther 15: 355-360; doi:10.1038/sj.mt.6300042
Modifying the Proliferative State of Target Cells to Control DNA Expression and Identifying Cell Types Transfected In Vivo FREE
Kathryn W Riddle, Hyun-Joon Kong, J Kent Leach, Claudia Fischbach, Charles Cheung, Kristi S Anseth and David J Mooney
Mol Ther 15: 361-368; doi:10.1038/sj.mt.6300017
EGF Receptor Activation Decreases Retroviral Gene Transfer through Protein Kinase C-
FREE
Raghvendra Singh and Stelios T Andreadis
Mol Ther 15: 369-377; doi:10.1038/sj.mt.6300050
Vector Toxicology, Immunogenicity and Safety
Toll-like Receptor 9 Triggers an Innate Immune Response to Helper-dependent Adenoviral Vectors FREE
Vincenzo Cerullo, Michael P Seiler, Viraj Mane, Nicola Brunetti-Pierri, Christian Clarke, Terry K Bertin, John R Rodgers and Brendan Lee
Mol Ther 15: 378-385; doi:10.1038/sj.mt.6300031
Vaccine Technology
Dendritic Cell Function After Gene Transfer with Adenovirus-calcium Phosphate Co-precipitates FREE
Michael P Seiler, Stephen Gottschalk, Vincenzo Cerullo, Maheshika Ratnayake, Viraj P Mane, Christian Clarke, Donna J Palmer, Philip Ng, Cliona M Rooney and Brendan Lee
Mol Ther 15: 386-392; doi:10.1038/sj.mt.6300029
Type I Interferon Inhibits Antibody Responses Induced by a Chimpanzee Adenovirus Vector FREE
Scott E Hensley, Ann S Cun, Wynetta Giles-Davis, Yan Li, Zhiquan Xiang, Marcio O Lasaro, Bryan R G Williams, Robert H Silverman and Hildegund C J Ertl
Mol Ther 15: 393-403; doi:10.1038/sj.mt.6300024
Inhibitor of Heat-shock Protein 90 Enhances the Antitumor Effect of DNA Vaccine Targeting Clients of Heat-shock Protein FREE
Chi-Chen Lin, Cheng-Fen Tu, Meng-Chi Yen, Ming-Chuan Chen, Wan-Jung Hsieh, Wen-Chang Chang, Wen-Tsang Chang and Ming-Derg Lai
Mol Ther 15: 404-410; doi:10.1038/sj.mt.6300014
Enhanced Cellular Immune Responses Elicited by an Engineered HIV-1 Subtype B Consensus-based Envelope DNA Vaccine FREE
Jian Yan, Hanna Yoon, Sanjeev Kumar, Mathura P Ramanathan, Natasha Corbitt, Michele Kutzler, Anlan Dai, Jean D Boyer and David B Weiner
Mol Ther 15: 411-421; doi:10.1038/sj.mt.6300036
Hydrodynamic Limb Vein Delivery of a Xenogeneic DNA Cancer Vaccine Effectively Induces Antitumor Immunity FREE
Zane C Neal, Mary K Bates, Mark R Albertini and Hans Herweijer
Mol Ther 15: 422-430; doi:10.1038/sj.mt.6300046
Cell Therapy
Autologous Transplantation of Muscle Precursor Cells Modified with a Lentivirus for Muscular Dystrophy: Human Cells and Primate Models FREE
Simon P Quenneville, Pierre Chapdelaine, Daniel Skuk, Matin Paradis, Marlyne Goulet, Joël Rousseau, Xiao Xiao, Luis Garcia and Jacques P Tremblay
Mol Ther 15: 431-438; doi:10.1038/sj.mt.6300047
