TABLE OF CONTENTS
Volume 15, Issue 1 (January 2007)
Editorial
ASGT Advises NIH on Funding of Gene Therapy Trials
David A Williams Editor-in-Chief
Mol Ther 15: 1-2; doi:10.1038/sj.mt.6300051
In This Issue
In This Issue
Mol Ther 15: 4; doi:10.1038/sj.mt.6300070
See also: Original Article by Iankov et al. See also: Original Article by Power et al. See also: Original Article by Wilson et al. See also: Commentary by HackettSee also: Original Article by Ehrhardt et al. See also: Original Article by Gasmi et al.Research Highlights
Top of pageCommentaries
Personalizing Oncolytic Virotherapy?
Balveen Kaur and E Antonio Chiocca
Mol Ther 15: 6-7; doi:10.1038/sj.mt.6300056
See also: Original Article by Yu et al.Apoptin Studies Illuminate Intersection Between Lipidomics and Tumor Suppressors
Sunil Chada and Rajagopal Ramesh
Mol Ther 15: 7-9; doi:10.1038/sj.mt.6300055
Integrating DNA Vectors for Gene Therapy
Perry B Hackett
Mol Ther 15: 10-12; doi:10.1038/sj.mt.6300065
Reviews
Vector Toxicology, Immunogenicity and Safety
Retroviral Insertion Mutagenesis in Mice as a Comparative Oncogenomics Tool to Identify Disease Genes in Human Leukemia
Ivo P Touw and Stefan J Erkeland
Mol Ther 15: 13-19; doi:10.1038/sj.mt.6300040
Vector Engineering and Delivery
Transduction of Brain by Herpes Simplex Virus Vectors
Bradford K Berges, John H Wolfe and Nigel W Fraser
Mol Ther 15: 20-29; doi:10.1038/sj.mt.6300018
Original Articles
Monogenic Disease
Complete Correction of Enzymatic Deficiency and Neurochemistry in the GM1-gangliosidosis Mouse Brain by Neonatal Adeno-associated Virus–mediated Gene Delivery
M L D Broekman, R C Baek, L A Comer, J L Fernandez, T N Seyfried and M Sena-Esteves
Mol Ther 15: 30-37; doi:10.1038/sj.mt.6300004
AAV1 Mediated Co-expression of Formylglycine-Generating Enzyme and Arylsulfatase A Efficiently Corrects Sulfatide Storage in a Mouse Model of Metachromatic Leukodystrophy
Toshiyuki Kurai, Sanae Hisayasu, Ryo Kitagawa, Makoto Migita, Hidenori Suzuki, Yukihiko Hirai and Takashi Shimada
Mol Ther 15: 38-43; doi:10.1038/sj.mt.6300012
Central Nervous System-directed AAV2/5-Mediated Gene Therapy Synergizes with Bone Marrow Transplantation in the Murine Model of Globoid-cell Leukodystrophy
Darshong Lin, Anthony Donsante, Shannon Macauley, Beth Levy, Carole Vogler and Mark S Sands
Mol Ther 15: 44-52; doi:10.1038/sj.mt.6300026
Phenotypic Correction of 
-Sarcoglycan Deficiency by Intra-arterial Injection of a Muscle-specific Serotype 1 rAAV Vector
Francoise Fougerousse, Marc Bartoli, Jérôme Poupiot, Ludovic Arandel, Muriel Durand, Nicolas Guerchet, Evelyne Gicquel, Olivier Danos and Isabelle Richard
Mol Ther 15: 53-61; doi:10.1038/sj.mt.6300022
Acquired and Multigenic Disease
Striatal Delivery of Neurturin by CERE-120, an AAV2 Vector for the Treatment of Dopaminergic Neuron Degeneration in Parkinson's Disease
Mehdi Gasmi, Christopher D Herzog, Eugene P Brandon, Justine J Cunningham, G Anthony Ramirez, Elias T Ketchum and Raymond T Bartus
Mol Ther 15: 62-68; doi:10.1038/sj.mt.6300010
Therapeutic Angiogenesis Inhibits or Rescues Chemotherapy-induced Peripheral Neuropathy: Taxol- and Thalidomide-induced Injury of Vasa Nervorum is Ameliorated by VEGF
Rudolf Kirchmair, Anne B Tietz, Eleftheria Panagiotou, Dirk H Walter, Marcy Silver, Young-Sup Yoon, Peter Schratzberger, Alberto Weber, Kengo Kusano, David H Weinberg, Allan H Ropper, Jeffrey M Isner and Douglas W Losordo
Mol Ther 15: 69-75; doi:10.1038/sj.mt.6300019
Lentiviral Vector Transduction of a Dominant-negative Rev Gene Into Human CD34+ Hematopoietic Progenitor Cells Potently Inhibits Human Immunodeficiency Virus-1 Replication
Ingrid Bahner, Teiko Sumiyoshi, Mercy Kagoda, Robin Swartout, Denise Peterson, Karen Pepper, Fred Dorey, Jacob Reiser and Donald B Kohn
Mol Ther 15: 76-85; doi:10.1038/sj.mt.6300025
Prolonged Remission of Diabetes by Regeneration of 
Cells in Diabetic Mice Treated with Recombinant Adenoviral Vector Expressing Glucagon-like Peptide-1
Meng-Ju Liu, Seungjin Shin, Na Li, Toshikatsu Shigihara, Young-Sun Lee, Ji-Won Yoon and Hee-Sook Jun
Mol Ther 15: 86-93; doi:10.1038/sj.mt.6300005
Identification of Differentially Expressed Genes Involved in the Formation of Multicellular Tumor Spheroids by HT-29 Colon Carcinoma Cells
Kleomenis Dardousis, Chris Voolstra, Monic Roengvoraphoj, Asieb Sekandarzad, Senait Mesghenna, Johannes Winkler, Yon Ko, Jürgen Hescheler and Agapios Sachinidis
Mol Ther 15: 94-102; doi:10.1038/sj.mt.6300003
Acquired and Multigenic Disease
Nectin-1 Expression by Squamous Cell Carcinoma is a Predictor of Herpes Oncolytic Sensitivity
Zhenkun Yu, Prasad S Adusumilli, David P Eisenberg, Elizabeth Darr, Ronald A Ghossein, Sen Li, Shiquan Liu, Bhuvanesh Singh, Jatin P Shah, Yuman Fong and Richard J Wong
Mol Ther 15: 103-113; doi:10.1038/sj.mt.6300009
See also: Commentary by Kaur & ChioccaVector Engineering and Delivery
Infected Cell Carriers: A New Strategy for Systemic Delivery of Oncolytic Measles Viruses in Cancer Virotherapy
Ianko D Iankov, Boris Blechacz, Chunsheng Liu, Jeffrey D Schmeckpeper, James E Tarara, Mark J Federspiel, Noel Caplice and Stephen J Russell
Mol Ther 15: 114-122; doi:10.1038/sj.mt.6300020
Carrier Cell-based Delivery of an Oncolytic Virus Circumvents Antiviral Immunity
Anthony T Power, Jiahu Wang, Theresa J Falls, Jennifer M Paterson, Kelley A Parato, Brian D Lichty, David F Stojdl, Peter A J Forsyth, Harry Atkins and John C Bell
Mol Ther 15: 123-130; doi:10.1038/sj.mt.6300039
Development of a Conditionally Replicating Pseudorabies Virus for HER-2/neu-overexpressing Bladder Cancer Therapy
Ai-Li Shiau, Yu-Ping Lin, Gia-Shing Shieh, Chih-Hau Su, Wen-Luan Wu, Yuh-Shyan Tsai, Chih-Wei Cheng, Ming-Derg Lai and Chao-Liang Wu
Mol Ther 15: 131-138; doi:10.1038/sj.mt.6300001
PiggyBac Transposon-mediated Gene Transfer in Human Cells
Matthew H Wilson, Craig J Coates and Alfred L George Jr
Mol Ther 15: 139-145; doi:10.1038/sj.mt.6300028
Somatic Integration From an Adenoviral Hybrid Vector into a Hot Spot in Mouse Liver Results in Persistent Transgene Expression Levels In Vivo
Anja Ehrhardt, Stephen R Yant, Jeffery C Giering, Hui Xu, Jeffrey A Engler and Mark A Kay
Mol Ther 15: 146-156; doi:10.1038/sj.mt.6300011
The Influence of Antisense Oligonucleotide Length on Dystrophin Exon Skipping
P L Harding, A M Fall, K Honeyman, S Fletcher and S D Wilton
Mol Ther 15: 157-166; doi:10.1038/sj.mt.6300006
Control of Splicing Efficiency by the Mouse Histone H2a Element in a Murine Leukemia Virus–based Retroviral Vector
Jun-Tae Lee, Seung Shin Yu, V Narry Kim and Sunyoung Kim
Mol Ther 15: 167-172; doi:10.1038/sj.mt.6300007
Murine Retroviral but not Human Cellular Promoters Induce In Vivo Erythroid-specific Deregulation that can be Partially Prevented by Insulators
Elodie Robert-Richard, Emmanuel Richard, Punam Malik, Cécile Ged, Hubert de Verneuil and François Moreau-Gaudry
Mol Ther 15: 173-182; doi:10.1038/sj.mt.6300030
Vector Toxicology, Immunogenicity and Safety
Effective Suicide Gene Therapy for Leukemia in a Model of Insertional Oncogenesis in Mice
Martina Blumenthal, Dianne Skelton, Karen A Pepper, Thomas Jahn, Emily Methangkool and Donald B Kohn
Mol Ther 15: 183-192; doi:10.1038/sj.mt.6300015
Vaccine Technology
Baculovirus-based Vaccination Vectors Allow for Efficient Induction of Immune Responses Against Plasmodium falciparum Circumsporozoite Protein
Robert Strauss, Andreas Hüser, Shaoheng Ni, Sebastian Tuve, Nancy Kiviat, Papa Salif Sow, Christian Hofmann and André Lieber
Mol Ther 15: 193-202; doi:10.1038/sj.mt.6300008
Adenovirus-based Prime-boost Immunization for Rapid Vaccination Against Anthrax
Michael J McConnell, Philip C Hanna and Michael J Imperiale
Mol Ther 15: 203-210; doi:10.1038/sj.mt.6300034
Clinical Trials
Stem Cell Collection and Gene Transfer in Fanconi Anemia
Patrick F Kelly, Susan Radtke, Christof von Kalle, Brenden Balcik, Kimberley Bohn, Robin Mueller, Todd Schuesler, Moira Haren, Lilith Reeves, Jose A Cancelas, Thomas Leemhuis, Richard Harris, Arleen D Auerbach, Franklin O Smith, Stella M Davies and David A Williams
Mol Ther 15: 211-219; doi:10.1038/sj.mt.6300033
