Molecular Therapy

FIGURE 5

FROM:

Adenovirus-based Prime-boost Immunization for Rapid Vaccination Against Anthrax

Michael J McConnell, Philip C Hanna and Michael J Imperiale

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Figure 5.

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Single-injection immunization. Mice were immunized with a single injection of 5 times 109 particles of Ad.D4 1, 2, or 3 weeks before challenge, or left unimmunized (Naïve). (a) Anti-PA total IgG in sera taken from mice 1 day before spore challenge. (b) LeTx-neutralizing titers of sera taken from mice 1 day before spore challenge. Bars represent the average value for each group with error bars representing the SEM (n=5/group). (c) One, two, or three weeks after immunization mice were challenged with 1.5 times 105 Sterne 34F2 spores (137 times LD50) by subcutaneous injection and monitored for survival over 14 days.

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