Molecular Therapy

FIGURE 8

FROM:

Central Nervous System-directed AAV2/5-Mediated Gene Therapy Synergizes with Bone Marrow Transplantation in the Murine Model of Globoid-cell Leukodystrophy

Darshong Lin, Anthony Donsante, Shannon Macauley, Beth Levy, Carole Vogler and Mark S Sands

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Figure 8.

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Behavioral analysis. The combination-treated Twitcher mice (filled diamonds, n=17) performed significantly better than untreated (filled triangles, n=14), BMT-treated (open circles, n=15), or AAV2/5-treated (open triangles, n=15) Twitcher mice in the constant speed and accelerating rotarod paradigms. Both the BMT-treated and AAV2/5-treated Twitcher groups performed significantly better than the untreated Twitcher mice in both rotarod assays. There was no significant improvement in any of the treated Twitcher mice in the wire hang test when compared to untreated Twitcher mice. All the treated Twitcher mice had significant deficits compared to untreated normal mice (filled circles, n=12) in both rotarod paradigms and in the wire hang assay.

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