Molecular Therapy

FIGURE 7

FROM:

Central Nervous System-directed AAV2/5-Mediated Gene Therapy Synergizes with Bone Marrow Transplantation in the Murine Model of Globoid-cell Leukodystrophy

Darshong Lin, Anthony Donsante, Shannon Macauley, Beth Levy, Carole Vogler and Mark S Sands

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Figure 7.

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Body weight. The body weights of all the groups of animals were indistinguishable up to 21 days of age. Beyond 28 days of age the body weights of untreated (filled triangles) and BMT-treated (open circles) Twitcher mice were identical and decreased precipitously. Beyond 35 days of age the mean body weight of the AAV2/5-treated group (open triangles) decreased rapidly. The mean body weight of the combination-treated Twitcher mice (filled diamonds) remained relatively constant for the duration of the study, albeit less than either the untreated (filled circles) or BMT-treated (open squares) normal mice.

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