Molecular Therapy

FIGURE 3

FROM:

Central Nervous System-directed AAV2/5-Mediated Gene Therapy Synergizes with Bone Marrow Transplantation in the Murine Model of Globoid-cell Leukodystrophy

Darshong Lin, Anthony Donsante, Shannon Macauley, Beth Levy, Carole Vogler and Mark S Sands

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Figure 3.

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GALC localization. GALC-positive (blue) cells were observed in the cerebral cortex, hippocampus, lateral ventricle, and thalamus of untreated normal mice. Numerous intensely staining GALC-positive cells were detected in the same structures from combination-treated (CmTx) and AAV2/5-treated (AAV) Twitcher mice. However, very few GALC-positive cells were observed in similar regions of either BMT-treated (BMT) or untreated (Twi) Twitcher brains.

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