Molecular Therapy - Figure 1 for article: Central Nervous System-directed AAV2//5-Mediated Gene Therapy Synergizes with Bone Marrow Transplantation in the Murine Model of Globoid-cell Leukodystrophy

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Central Nervous System-directed AAV2/5-Mediated Gene Therapy Synergizes with Bone Marrow Transplantation in the Murine Model of Globoid-cell Leukodystrophy

Darshong Lin, Anthony Donsante, Shannon Macauley, Beth Levy, Carole Vogler and Mark S Sands

Figure 1.

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Donor hematopoietic chimerism. Partial donor chimerism (25–35% GFP⁺ cells) was observed in the bone marrow of normal (WT), BMT-treated (BMT), or combination-treated (CmTx) Twitcher mice 40 days following myeloreductive conditioning (400 rad) and injection of 106 unfractionated GFP⁺ bone marrow cells. The means and 1 SD are shown.

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FIGURE 1

Central Nervous System-directed AAV2/5-Mediated Gene Therapy Synergizes with Bone Marrow Transplantation in the Murine Model of Globoid-cell Leukodystrophy

Figure 1.