TABLE OF CONTENTS

Volume 14, Issue 5 (November 2006)

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Editorial

NIH Funding of Gene Therapy Trials

David A. Williams

Mol Ther 14: 607; doi:10.1016/j.ymthe.2006.09.004

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Inside this Month

Inside this Month

Mol Ther 14: 608; doi:10.1016/j.ymthe.2006.09.002

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Research Updates

Research Update

Mol Ther 14: 609; doi:10.1016/j.ymthe.2006.09.003

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Conference

The Ninth Annual Meeting of the American Society of Gene Therapy

Robert M. Frederickson

Mol Ther 14: 610-612; doi:10.1016/j.ymthe.2006.09.005

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Review Article

Designing Nonviral Vectors for Efficient Gene Transfer and Long-Term Gene Expression

Dean A. Jackson, Stefan Juranek and Hans J. Lipps

Mol Ther 14: 613-626; doi:10.1016/j.ymthe.2006.03.026

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Original Articles

Involvement of Sphingolipids in Apoptin-Induced Cell Killing

Xiang Liu, Youssef H. Zeidan, Saeed Elojeimy, David H. Holman, Ahmed M. El-Zawahry, Gui-wen Guo, Alicja Bielawska, Jacek Bielawski, Zdzislaw Szulc, Semyon Rubinchik, Jian-Yun Dong, Thomas E. Keane, Mahvash Tavassoli, Yusuf A. Hannun and James S. Norris

Mol Ther 14: 627-636; doi:10.1016/j.ymthe.2006.07.001

Modulation of Ceramide Metabolism Enhances Viral Protein Apoptin's Cytotoxicity in Prostate Cancer

Xiang Liu, S. Elojeimy, A. M. El-Zawahry, D. H. Holman, A. Bielawska, J. Bielawski, S. Rubinchik, G.-W. Guo, J.-Y. Dong, T. Keane, Y. A. Hannun, M. Tavassoli and James S. Norris

Mol Ther 14: 637-646; doi:10.1016/j.ymthe.2006.06.005

Complete Regression of Established Subcutaneous B16 Murine Melanoma Tumors after Delivery of an HIV-1 Vpr-Expressing Plasmid by in Vivo Electroporation

Andrea N. McCray, Kenneth E. Ugen, Karuppiah Muthumani, J. J. Kim, David B. Weiner and Richard Heller

Mol Ther 14: 647-655; doi:10.1016/j.ymthe.2006.06.010

Anti-tumor Immunotherapy via Antigen Delivery from a Live Attenuated Genetically Engineered Pseudomonas aeruginosa Type III Secretion System-Based Vector

Olivier Epaulard, Bertrand Toussaint, Lauriane Quenee, Madiha Derouazi, Nabil Bosco, Christian Villiers, Rozenn Le Berre, Benoit Guery, Didier Filopon, Laurence Crombez, Patrice N. Marche and Benoit Polack

Mol Ther 14: 656-661; doi:10.1016/j.ymthe.2006.06.011

A Chimpanzee-Origin Adenovirus Vector Expressing the Rabies Virus Glycoprotein as an Oral Vaccine against Inhalation Infection with Rabies Virus

Dongming Zhou, Ann Cun, Yan Li, Zhiquan Xiang and Hildegund C.J. Ertl

Mol Ther 14: 662-672; doi:10.1016/j.ymthe.2006.03.027

Identification and Isolation of Embryonic Stem Cell-Derived Target Cells by Adenoviral Conditional Targeting

Tomoyuki Takahashi, Takao Kawai, Hiroaki Ushikoshi, Satoshi Nagano, Hatsue Oshika, Makoto Inoue, Takahiro Kunisada, Genzou Takemura, Hisayoshi Fujiwara and Ken-ichiro Kosai

Mol Ther 14: 673-683; doi:10.1016/j.ymthe.2006.05.010

Use of a Stringent Dimerizer-Regulated Gene Expression System for Controlled BMP2 Delivery

Jeong-Tae Koh, Chunxi Ge, Ming Zhao, Zhuo Wang, Paul H. Krebsbach, Zhuoran Zhao and Renny T. Franceschi

Mol Ther 14: 684-691; doi:10.1016/j.ymthe.2006.05.021

Preferential Silencing of a Common Dominant Rhodopsin Mutation Does Not Inhibit Retinal Degeneration in a Transgenic Model

Alessandra Tessitore, Fabiana Parisi, Michela Alessandra Denti, Mariacarmela Allocca, Umberto Di Vicino, Luciano Domenici, Irene Bozzoni and Alberto Auricchio

Mol Ther 14: 692-699; doi:10.1016/j.ymthe.2006.07.008

In Contrast to AAV-Mediated Cntf Expression, AAV-Mediated Gdnf Expression Enhances Gene Replacement Therapy in Rodent Models of Retinal Degeneration

Prateek K. Buch, Robert E. MacLaren, Yanaí Durán, Kamaljit S. Balaggan, Angus MacNeil, Frank C. Schlichtenbrede, Alexander J. Smith and Robin R. Ali

Mol Ther 14: 700-709; doi:10.1016/j.ymthe.2006.05.019

HSV-Mediated Delivery of Erythropoietin Restores Dopaminergic Function in MPTP-Treated Mice

Veljko Puskovic, Darren Wolfe, James Wechuck, David Krisky, Jeff Collins, Joseph C. Glorioso, David J. Fink and Marina Mata

Mol Ther 14: 710-715; doi:10.1016/j.ymthe.2006.07.004

Parkin Protects against Neurotoxicity in the 6-Hydroxydopamine Rat Model for Parkinson's Disease

Linda Vercammen, Anke Van der Perren, Elisabetta Vaudano, Rik Gijsbers, Zeger Debyser, Chris Van den Haute and Veerle Baekelandt

Mol Ther 14: 716-723; doi:10.1016/j.ymthe.2006.06.009

The Mouse Dystrophin Muscle Promoter/Enhancer Drives Expression of Mini-dystrophin in Transgenic mdx Mice and Rescues the Dystrophy in These Mice

Carrie L. Anderson, Yves De Repentigny, Carlo Cifelli, Philip Marshall, Jean-Marc Renaud, Ronald G. Worton and Rashmi Kothary

Mol Ther 14: 724-734; doi:10.1016/j.ymthe.2006.04.013

Targeted Retroviral Vectors Displaying a Cleavage Site-engineered Hemagglutinin (HA) through HA–protease Interactions

Judit Szécsi, Rosybel Drury, Véronique Josserand, Marie-Pierre Grange, Bertrand Boson, Irene Hartl, Richard Schneider, Christian J. Buchholz, Jean-Luc Coll, Stephen J. Russell, François-Loïc Cosset and Els Verhoeyen

Mol Ther 14: 735-744; doi:10.1016/j.ymthe.2006.04.007

The Internalization Route Resulting in Successful Gene Expression Depends on both Cell Line and Polyethylenimine Polyplex Type

Katharina von Gersdorff, Niek N. Sanders, Roosmarijn Vandenbroucke, Stefaan C. De Smedt, Ernst Wagner and Manfred Ogris

Mol Ther 14: 745-753; doi:10.1016/j.ymthe.2006.07.006

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