TABLE OF CONTENTS
Volume 14, Issue 4 (October 2006)
Editorial
Vector Insertion, Mutagenesis and Transgene Toxicity
David A. Williams
Mol Ther 14: 457; doi:10.1016/j.ymthe.2006.08.002
Inside This Month
Top of pageCommentary
Assays to Evaluate the Genotoxicity of Retroviral Vectors
Arthur W. Nienhuis
Mol Ther 14: 459-460; doi:10.1016/j.ymthe.2006.08.003
Partnering Aptamer and RNAi Technologies
John J. Rossi
Mol Ther 14: 461-462; doi:10.1016/j.ymthe.2006.08.004
Review Article
siRNA and isRNA: Two Edges of One Sword
Martin Schlee, Veit Hornung and Gunther Hartmann
Mol Ther 14: 463-470; doi:10.1016/j.ymthe.2006.06.001
Original Articles
Efficient and Persistent Splice Switching by Systemically Delivered LNA Oligonucleotides in Mice
Jennifer Roberts, Enzo Palma, Peter Sazani, Henrik Ørum, Moo Cho and Ryszard Kole
Mol Ther 14: 471-475; doi:10.1016/j.ymthe.2006.05.017
RNA Interference in Vitro and in Vivo Using a Chitosan/siRNA Nanoparticle System
Kenneth A. Howard, Ulrik L. Rahbek, Xiudong Liu, Christian K. Damgaard, Sys Zoffmann Glud, Morten Ø. Andersen, Mads B. Hovgaard, Alexander Schmitz, Jens R. Nyengaard, Flemming Besenbacher and Jørgen Kjems
Mol Ther 14: 476-484; doi:10.1016/j.ymthe.2006.04.010
Simultaneous Targeting of HCV Replication and Viral Binding with a Single Lentiviral Vector Containing Multiple RNA Interference Expression Cassettes
Scot D. Henry, Pascal van der Wegen, Herold J. Metselaar, Hugo W. Tilanus, Bob J. Scholte and Luc J. W. van der Laan
Mol Ther 14: 485-493; doi:10.1016/j.ymthe.2006.04.012
Optimization and Functional Effects of Stable Short Hairpin RNA Expression in Primary Human Lymphocytes via Lentiviral Vectors
Dong Sung An, F. Xiao-Feng Qin, Vincent C. Auyeung, Si Hua Mao, Sam K. P. Kung, David Baltimore and Irvin S. Y. Chen
Mol Ther 14: 494-504; doi:10.1016/j.ymthe.2006.05.015
Successful Reconstitution of Immunity in ADA-SCID by Stem Cell Gene Therapy Following Cessation of PEG-ADA and Use of Mild Preconditioning
H. Bobby Gaspar, Emma Bjorkegren, Kate Parsley, Kimberly C. Gilmour, Doug King, Joanna Sinclair, Fang Zhang, Aris Giannakopoulos, Stuart Adams, Lynette D. Fairbanks, Jane Gaspar, Lesley Henderson, Jin Hua Xu-Bayford, E. Graham Davies, Paul A. Veys, Christine Kinnon and Adrian J. Thrasher
Mol Ther 14: 505-513; doi:10.1016/j.ymthe.2006.06.007
In Vivo Gene Transfer into Adult Stem Cells in Unconditioned Mice by in Situ Delivery of a Lentiviral Vector
D. Nicole Worsham, Todd Schuesler, Christof von Kalle and Dao Pan
Mol Ther 14: 514-524; doi:10.1016/j.ymthe.2006.05.014
Hematopoietic Dysfunction in a Mouse Model for Fanconi Anemia Group D1
Susana Navarro, Nestor W. Meza, Oscar Quintana-Bustamante, José A. Casado, Ariana Jacome, Kimberly McAllister, Silvia Puerto, Jordi Surrallés, José C. Segovia and Juan A. Bueren
Mol Ther 14: 525-535; doi:10.1016/j.ymthe.2006.05.018
The Integration Profile of EIAV-Based Vectors
Caroline V. Hacker, Conrad A. Vink, Theresa W. Wardell, Sheena Lee, Peter Treasure, Susan M. Kingsman, Kyriacos A. Mitrophanous and James E. Miskin
Mol Ther 14: 536-545; doi:10.1016/j.ymthe.2006.06.006
G2 Cell Cycle Arrest and Cyclophilin A in Lentiviral Gene Transfer
Shangming Zhang, Guiandre Joseph, Karen Pollok, Lionel Berthoux, Lakshmi Sastry, Jeremy Luban and Kenneth Cornetta
Mol Ther 14: 546-554; doi:10.1016/j.ymthe.2006.05.022
Construction and Use of Retroviral Vectors Encoding the Toxic Gene Barnase
Sumit Agarwal, Bryan Nikolai, Tomoyuki Yamaguchi, Patrycja Lech and Nikunj V. Somia
Mol Ther 14: 555-563; doi:10.1016/j.ymthe.2006.03.025
Long-Term Clinical Improvement in MPTP-Lesioned Primates after Gene Therapy with AAV-hAADC
Krystof S. Bankiewicz, John Forsayeth, Jamie L. Eberling, Rosario Sanchez-Pernaute, Philip Pivirotto, John Bringas, Peter Herscovitch, Richard E. Carson, William Eckelman, Bryan Reutter and Janet Cunningham
Mol Ther 14: 564-570; doi:10.1016/j.ymthe.2006.05.005
A Dose-Ranging Study of AAV-hAADC Therapy in Parkinsonian Monkeys
John R. Forsayeth, Jamie L. Eberling, Laura M. Sanftner, Zhu Zhen, Philip Pivirotto, John Bringas, Janet Cunningham and Krystof S. Bankiewicz
Mol Ther 14: 571-577; doi:10.1016/j.ymthe.2006.04.008
Protective Regulatory T Cell Generation in Autoimmune Diabetes by DNA Covaccination with Islet Antigens and a Selective CTLA-4 Ligand
Yelena Glinka, Yigang Chang and Gérald J. Prud'homme
Mol Ther 14: 578-587; doi:10.1016/j.ymthe.2006.03.021
Multiple Innate Inflammatory Responses Induced after Systemic Adenovirus Vector Delivery Depend on a Functional Complement System
Anne Kiang, Zachary C. Hartman, Ruth S. Everett, Delila Serra, Haixiang Jiang, Michael M. Frank and Andrea Amalfitano
Mol Ther 14: 588-598; doi:10.1016/j.ymthe.2006.03.024
Serial Analysis of Gene Expression in Progressing and Regressing Mouse Tumors Implicates the Involvement of RANTES and TARC in Antitumor Immune Responses
Yukoh Nakazaki, Hidenori Hase, Hiroyuki Inoue, Yoshihito Beppu, Meng K. Xin, Gaku Sakaguchi, Ryo Kurita, Shigetaka Asano, Yusuke Nakamura and Kenzaburo Tani
Mol Ther 14: 599-606; doi:10.1016/j.ymthe.2006.04.014
