TABLE 1
FROM:
The "Perivascular Pump" Driven by Arterial Pulsation is a Powerful Mechanism for the Distribution of Therapeutic Molecules within the Brain
Piotr Hadaczek, Yoji Yamashita, Hanna Mirek, Laszlo Tamas, Martha C. Bohn, Charles Noble, John W. Park and Krystof Bankiewicz
BACK TO ARTICLETable 1. Study groups and conditions for intrastriatal infusions in rats by CED
| Study groups and conditions | BSA | Liposomes | AAV2 |
|---|---|---|---|
| Group H, high blood pressure/heart rate | 3 rats (both hemispheres) | 6 rats (right hemisphere) | 6 rats (left hemisphere) |
| Group L, low blood pressure/heart rate | 3 rats (both hemispheres) | 6 rats (right hemisphere) | 6 rats (left hemisphere) |
| Group N, no heart action | 3 rats (both hemispheres) | 3 rats (both hemispheres) | 3 rats (both hemispheres) |
| CED infusate | BSA-FITC conjugate (0.5  g) | Dil-DS 65-nm liposomes (200 M) | AAV2-hGFP (5.6  1013 capsids/ml) |
All rats received 5-l infusions per hemisphere at the following rates: 0.2 l/min for 10 min and 0.5 l/min for 6 min. CED, convection-enhanced delivery; BSA, bovine serum albumin; FITC, fluorescein 5'-isothiocyanate; Dil-DS, 1,1'-dioctadecyl-3,3,3',3'-tetramethylindocarbocyanine-5,5'-disulfonic acid; AAV2, adeno-associated virus 2; hGFP, humanized green fluorescent protein.
