TABLE OF CONTENTS
Volume 13, Issue 3 (March 2006)
Research Update |
Inside This Month |
Commentary |
Review Article |
Original Articles |
Short Communications
Editorial
Stable CNS Gene Delivery with Sleeping Beauty Armed with a High-capacity HSV Virion
David A. Williams
Mol Ther 13: 457-458; doi:10.1016/j.ymthe.2006.01.005
Research Update
Top of pageInside This Month
Top of pageCommentary
The Message is Sufficient: Towards Nontoxic Delivery of Endonucleases
Christopher Baum
Mol Ther 13: 461-462; doi:10.1016/j.ymthe.2006.02.001
Review Article
Recombinant Adeno-associated Viral Vectors as Therapeutic Agents to Treat Neurological Disorders
Ronald J. Mandel, Fredric P. Manfredsson, Kevin D. Foust, Aaron Rising, Sharon Reimsnider, Kevin Nash and Corinna Burger
Mol Ther 13: 463-483; doi:10.1016/j.ymthe.2005.11.009
Lentiviral Vectors for Use in the Central Nervous System
Johan Jakobsson and Cecilia Lundberg
Mol Ther 13: 484-493; doi:10.1016/j.ymthe.2005.11.012
Original Articles
Design of Noninflammatory Synthetic siRNA Mediating Potent Gene Silencing in Vivo
Adam D. Judge, Gurneet Bola, Amy C. H. Lee and Ian MacLachlan
Mol Ther 13: 494-505; doi:10.1016/j.ymthe.2005.11.002
AAV Transcytosis through Barrier Epithelia and Endothelium
Giovanni Di Pasquale and John A. Chiorini
Mol Ther 13: 506-516; doi:10.1016/j.ymthe.2005.11.007
Efficient Neuronal Gene Transfer with AAV8 Leads to Neurotoxic Levels of Tau or Green Fluorescent Proteins
Ronald L. Klein, Robert D. Dayton, Nancy J. Leidenheimer, Karen Jansen, Todd E. Golde and Richard M. Zweig
Mol Ther 13: 517-527; doi:10.1016/j.ymthe.2005.10.008
Transduction Characteristics of Adeno-associated Virus Vectors Expressing Cap Serotypes 7, 8, 9, and Rh10 in the Mouse Brain
Cassia N. Cearley and John H. Wolfe
Mol Ther 13: 528-537; doi:10.1016/j.ymthe.2005.11.015
CNS-Directed AAV2-Mediated Gene Therapy Ameliorates Functional Deficits in a Murine Model of Infantile Neuronal Ceroid Lipofuscinosis
Megan A. Griffey, David Wozniak, Michael Wong, Ellen Bible, Kendra Johnson, Steven M. Rothman, Annie E. Wentz, Jonathan D. Cooper and Mark S. Sands
Mol Ther 13: 538-547; doi:10.1016/j.ymthe.2005.11.008
Histopathological and Behavioral Improvement of Murine Mucopolysaccharidosis Type VII by Intracerebral Transplantation of Neural Stem Cells
Yasuyuki Fukuhara, Xiao-Kang Li, Yusuke Kitazawa, Masumi Inagaki, Kentaro Matsuoka, Motomichi Kosuga, Rika Kosaki, Takuya Shimazaki, Hitoshi Endo, Akihiro Umezawa, Hideyuki Okano, Takao Takahashi and Torayuki Okuyama
Mol Ther 13: 548-555; doi:10.1016/j.ymthe.2005.09.020
Identification of Novel Biomarkers for Niemann–Pick Disease Using Gene Expression Analysis of Acid Sphingomyelinase Knockout Mice
Rajwinder Dhami, Marco A. Passini and Edward H. Schuchman
Mol Ther 13: 556-564; doi:10.1016/j.ymthe.2005.08.020
Gene Therapy Restores Vision-Dependent Behavior as Well as Retinal Structure and Function in a Mouse Model of RPE65 Leber Congenital Amaurosis
Ji-jing Pang, Bo Chang, Ashok Kumar, Steven Nusinowitz, Syed M. Noorwez, Jie Li, Asha Rani, Thomas C. Foster, Vince A. Chiodo, Thomas Doyle, Huashi Li, Ritu Malhotra, Jacqueline T. Teusner, J. Hugh McDowell, Seok-Hong Min, Qiuhong Li, Shalesh Kaushal and William W. Hauswirth
Mol Ther 13: 565-572; doi:10.1016/j.ymthe.2005.09.001
Inhibition of Ocular Neovascularization by Hedgehog Blockade
Enrico M. Surace, Kamaljit S. Balaggan, Alessandra Tessitore, Claudio Mussolino, Gabriella Cotugno, Ciro Bonetti, Aniello Vitale, Robin R. Ali and Alberto Auricchio
Mol Ther 13: 573-579; doi:10.1016/j.ymthe.2005.10.010
Neuronal Precursor-Restricted Transduction via in Utero CNS Gene Delivery of a Novel Bipartite HSV Amplicon/Transposase Hybrid Vector
William J. Bowers, Michael A. Mastrangelo, Darlene F. Howard, Hilary A. Southerland, Kathleen A. Maguire-Zeiss and Howard J. Federoff
Mol Ther 13: 580-588; doi:10.1016/j.ymthe.2005.11.011
Recombinant Herpes Vector-mediated Analgesia in a Primate Model of Hyperalgesia
David C. Yeomans, Ying Lu, Charles E. Laurito, Michael C. Peters, Gina Vota-Vellis, Steven P. Wilson and George D. Pappas
Mol Ther 13: 589-597; doi:10.1016/j.ymthe.2005.08.023
A Clonal Cell Line from Immortalized Olfactory Ensheathing Glia Promotes Functional Recovery in the Injured Spinal Cord
M. Teresa Moreno–Flores, Elizabeth J. Bradbury, M. Jesús Martín-Bermejo, Marta Agudo, Filip Lim, Érika Pastrana, Jesús Ávila, Javier Díaz-Nido, Stephen B. McMahon and Francisco Wandosell
Mol Ther 13: 598-608; doi:10.1016/j.ymthe.2005.11.014
Choroidal Neovascularization in Transgenic Mice Expressing Prokineticin 1: An Animal Model for Age-related Macular Degeneration
Nobushige Tanaka, Masahito Ikawa, Nathan L. Mata and Inder M. Verma
Mol Ther 13: 609-616; doi:10.1016/j.ymthe.2005.08.024
Sleeping Beauty-Mediated Transposition and Long-term Expression in Vivo: Use of the LoxP/Cre Recombinase System to Distinguish Transposition-Specific Expression
Paul R. Score, Lalitha R. Belur, Joel L. Frandsen, Jennifer L. Guerts, Tomoyuki Yamaguchi, Nikunj V. Somia, Perry B. Hackett, David A. Largaespada and R. Scott McIvor
Mol Ther 13: 617-624; doi:10.1016/j.ymthe.2005.10.015
Short Communications
RNA as a Source of Transposase for Sleeping Beauty-Mediated Gene Insertion and Expression in Somatic Cells and Tissues
Andrew Wilber, Joel L. Frandsen, Jennifer L. Geurts, David A. Largaespada, Perry B. Hackett and R. Scott McIvor
Mol Ther 13: 625-630; doi:10.1016/j.ymthe.2005.10.014
