TABLE OF CONTENTS
Volume 13, Issue 2 (Febuary 2006)
Editorial
The End of the Beginning: OncolyticVirotherapy Achieves Clinical Proof-of-Concept
David H. Kirn
Mol Ther 13: 237-238; doi:10.1016/j.ymthe.2005.12.005
Inside This Month
Top of pageResearch Update
Top of pageReview
Gene Therapy Strategies for Duchenne Muscular Dystrophy Utilizing Recombinant Adeno-associated Virus Vectors
Michael J. Blankinship, Paul Gregorevic and Jeffrey S. Chamberlain
Mol Ther 13: 241-249; doi:10.1016/j.ymthe.2005.11.001
Original Articles
Safety and Efficacy of AAV-Mediated Calpain 3 Gene Transfer in a Mouse Model of Limb-Girdle Muscular Dystrophy Type 2A
Marc Bartoli, Carinne Roudaut, Samia Martin, Françoise Fougerousse, Laurence Suel, Jérôme Poupiot, Evelyne Gicquel, Fanny Noulet, Olivier Danos and Isabelle Richard
Mol Ther 13: 250-259; doi:10.1016/j.ymthe.2005.09.017
Determination of Specific CD4 and CD8 T Cell Epitopes after AAV2- and AAV8-hF.IX Gene Therapy
Jian Chen, Qi Wu, PingAr Yang, Hui-Chen Hsu and John D. Mountz
Mol Ther 13: 260-269; doi:10.1016/j.ymthe.2005.10.006
Recombinant Adenovirus Vaccines Can Successfully Elicit CD8+ T Cell Immunity under Conditions of Extreme Leukopenia
Natalie Grinshtein, Teng-Chih Yang, Robin Parsons, James Millar, Galina Denisova, Dilan Dissanayake, Jaina Leitch, Yonghong Wan and Jonathan Bramson
Mol Ther 13: 270-279; doi:10.1016/j.ymthe.2005.09.018
Transfection of Dendritic Cells with in Vitro-Transcribed CMV RNA Induces Polyclonal CD8+- and CD4+-Mediated CMV-Specific T Cell Responses
Annkristin Heine, Frank Grünebach, Tobias Holderried, Silke Appel, Markus M. Weck, Daniela Dörfel, Christian Sinzger and Peter Brossart
Mol Ther 13: 280-288; doi:10.1016/j.ymthe.2005.08.019
Exosomes Derived from Genetically Modified DC Expressing FasL Are Anti-inflammatory and Immunosuppressive
Seon Hee Kim, Nicole Bianco, Rajasree Menon, Eric R. Lechman, William J. Shufesky, Adrian E. Morelli and Paul D. Robbins
Mol Ther 13: 289-300; doi:10.1016/j.ymthe.2005.09.015
Potent Vaccine Therapy with Dendritic Cells Genetically Modified by the Gene-Silencing-Resistant Retroviral Vector GCDNsap
Tsukasa Nabekura, Makoto Otsu, Toshiro Nagasawa, Hiromitsu Nakauchi and Masafumi Onodera
Mol Ther 13: 301-309; doi:10.1016/j.ymthe.2005.09.021
Immunization with a Lentiviral Vector Stimulates both CD4 and CD8 T Cell Responses to an Ovalbumin Transgene
Helen M. Rowe, Luciene Lopes, Yasuhiro Ikeda, Ranbir Bailey, Isabelle Barde, Martin Zenke, Benjamin M. Chain and Mary K. Collins
Mol Ther 13: 310-319; doi:10.1016/j.ymthe.2005.08.025
Enhancement of Cellular Immune Response to a Prostate Cancer DNA Vaccine by Intradermal Electroporation
Anna-Karin Roos, Sonia Moreno, Christoph Leder, Maxim Pavlenko, Alan King and Pavel Pisa
Mol Ther 13: 320-327; doi:10.1016/j.ymthe.2005.08.005
Hypersensitivity and Loss of Disease Site Targeting Caused by Antibody Responses to PEGylated Liposomes
Adam Judge, Kevin McClintock, Janet R. Phelps and Ian MacLachlan
Mol Ther 13: 328-337; doi:10.1016/j.ymthe.2005.09.014
Activation of Refractory T Cell Responses against Hepatitis C Virus Core Protein by Ablation of Interfering Hydrophobic Domains
Helen A. Andersson, Rana A.K. Singh and Michael A. Barry
Mol Ther 13: 338-346; doi:10.1016/j.ymthe.2005.09.005
Second-Generation Replication-Competent Oncolytic Adenovirus Armed with Improved Suicide Genes and ADP Gene Demonstrates Greater Efficacy without Increased Toxicity
Kenneth N. Barton, Dell Paielli, Yingshu Zhang, Sweaty Koul, Stephen L. Brown, Mei Lu, John Seely, Jae Ho Kim and Svend O. Freytag
Mol Ther 13: 347-356; doi:10.1016/j.ymthe.2005.10.005
Bystander Effect Contributes to the Antitumor Efficacy of CaSm Antisense Gene Therapy in a Preclinical Model of Advanced Pancreatic Cancer
Yan Yan, Semyon Rubinchik, April L. Wood, William E. Gillanders, Jian-yun Dong, Dennis K. Watson and David J. Cole
Mol Ther 13: 357-365; doi:10.1016/j.ymthe.2005.06.485
Integration Site Selection by HIV-Based Vectors in Dividing and Growth-Arrested IMR-90 Lung Fibroblasts
Angela Ciuffi, Richard S. Mitchell, Christian Hoffmann, Jeremy Leipzig, Paul Shinn, Joseph R. Ecker and Frederic D. Bushman
Mol Ther 13: 366-373; doi:10.1016/j.ymthe.2005.10.009
Successful Treatment of UGT1A1 Deficiency in a Rat Model of Crigler–Najjar Disease by Intravenous Administration of a Liver-Specific Lentiviral Vector
Pascal van der Wegen, Rogier Louwen, Ali M. Imam, Ruvalic M. Buijs-Offerman, Maarten Sinaasappel, Frank Grosveld and Bob J. Scholte
Mol Ther 13: 374-381; doi:10.1016/j.ymthe.2005.09.022
Efficient control of gene expression in the hematopoietic system using a single Tet-on inducible lentiviral vector
Isabelle Barde, Maria Antonietta Zanta-Boussif, Sylvain Paisant, Marylene Leboeuf, Philippe Rameau, Christophe Delenda and Olivier Danos
Mol Ther 13: 382-390; doi:10.1016/j.ymthe.2005.09.012
Equal Potency of Gammaretroviral and Lentiviral SIN Vectors for Expression of O 6-Methylguanine–DNA Methyltransferase in Hematopoietic cells
Axel Schambach, Jens Bohne, Saurabh Chandra, Elke Will, Geoffrey P. Margison, David A. Williams and Christopher Baum
Mol Ther 13: 391-400; doi:10.1016/j.ymthe.2005.08.012
Overcoming Diabetes-Induced Hyperglycemia through Inhibition of Hepatic Phosphoenolpyruvate Carboxykinase (GTP) with RNAi
Alicia G. Gómez-Valadés, Anna Vidal-Alabró, Maria Molas, Jordi Boada, Jordi Bermúdez, Ramon Bartrons and José C. Perales
Mol Ther 13: 401-410; doi:10.1016/j.ymthe.2005.08.026
Effective Inhibition of HBV Replication in Vivo by Anti-HBx Short Hairpin RNAs
Sergio Carmona, Abdullah Ely, Carol Crowther, Naazneen Moolla, Felix H. Salazar, Patricia L. Marion, Nicolas Ferry, Marc S. Weinberg and Patrick Arbuthnot
Mol Ther 13: 411-421; doi:10.1016/j.ymthe.2005.10.013
Intracellular Trafficking of Plasmids during Transfection Is Mediated by Microtubules
Erin E. Vaughan and David A. Dean
Mol Ther 13: 422-428; doi:10.1016/j.ymthe.2005.10.004
Mechanistic Studies of Sequential Injection of Cationic Liposome and Plasmid DNA
Jing-Shi Zhang, Feng Liu, Christine C. Conwell, Yadi Tan and Leaf Huang
Mol Ther 13: 429-437; doi:10.1016/j.ymthe.2005.08.021
Mammalian Gene Targeting with Designed Zinc Finger Nucleases
Matthew H. Porteus
Mol Ther 13: 438-446; doi:10.1016/j.ymthe.2005.08.003
