Molecular Therapy

FIGURE 1

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Second-Generation Replication-Competent Oncolytic Adenovirus Armed with Improved Suicide Genes and ADP Gene Demonstrates Greater Efficacy without Increased Toxicity

Kenneth N. Barton, Dell Paielli, Yingshu Zhang, Sweaty Koul, Stephen L. Brown, Mei Lu, John Seely, Jae Ho Kim and Svend O. Freytag

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Figure 1.

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Western blotting demonstrating expression of yCD/mutTKSR39 and ADP proteins. (A) The blot was probed with a mixture of polyclonal antibodies to yCD and bCD. The positions of the 17-kDa yCD, 59-kDa yCD/mutTKSR39, and 88-kDa bCD/wtTK fusion proteins are indicated. The yCD/mutTKSR39 fusion protein is susceptible to proteolysis between the yCD and the mutTKSR39 moieties and the yCD moiety is detected. Ad5-yCD is a replication-competent adenovirus containing only the yCD gene in the E1 region. (B) The blot was probed with an antibody to ADP. The position of the 11.6-kDa ADP protein is indicated.

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