TABLE OF CONTENTS

Volume 13, Issue S1 (May 2006)

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Abstracts

1. Species Choice for Animal Modeling Cystic Fibrosis and Gene Therapy to the Airway

Xiaoming Liu, Ziying Yan, Meihui Luo, Liang N. Zhang, Cyndi Trygg, Carolina Smith, Keith Munson, William Guggino, Bruce Bunnell and John F. Engelhardt

Mol Ther 13: S1-S1; doi:10.1016/j.ymthe.2006.08.011

2. Identification of Different Modes of Viral Transport in the Non-Human Primate Brain after Convection-Enhanced Delivery of AAV Serotype Vectors

Marco A. Passini, Jie Bu, James C. Dodge, Lamya S. Shihabuddin, Tatyana V. Taksir, Denise A. Griffiths, John Bringas, Piotr Hadaczek, Mihaela Avramut, Seng H. Cheng and Krystof Bankiewicz

Mol Ther 13: S1-S1; doi:10.1016/j.ymthe.2006.08.012

3. Adeno-Associated Virus 2-Mediated Gene Transfer: Identification of a Cellular Protein Serine/Threonine Phosphatase Involved in Augmenting Vector Transduction Efficiency

Weihong Zhao, Jianqing Wu,, Li Zhong and Arun Srivastava

Mol Ther 13: S1-S2; doi:10.1016/j.ymthe.2006.08.013

4. Role of Notch1 in Augmenting Intracellular Trafficking and Transgene Expression of Recombinant Adeno-Associated Virus-2

Changchun Ren, April F. White and Selvarangan Ponnazhagan

Mol Ther 13: S2-S2; doi:10.1016/j.ymthe.2006.08.014

5. Mechanisms for Hairpin Loop Opening of |[ldquo]|Closed|[rdquo]| AAV-ITRs by Specific Cellular Endonuclease Activities, a Prerequisite for rAAV Vector Genome Recombinations In Vivo

Katsuya Inagaki, Theresa A. Storm, Mark A. Kay and Hiroyuki Nakai

Mol Ther 13: S2-S3; doi:10.1016/j.ymthe.2006.08.015

6. AAV8-Mediated Transgene Expression in Mice and Non-Human Primates

Hiroaki Mizukami, Jun Mimuro, Akira Ishiwata, Fumiko Ono, Takashi Matsushita, Takashi Okada, Masashi Urabe, Akihiro Kume, Keiji Terao, Yoichi Sakata and Keiya Ozawa

Mol Ther 13: S3-S3; doi:10.1016/j.ymthe.2006.08.016

7. Adeno-Associated Virus Type 2 (AAV2) Contains an Integrin alpha5beta1 Recognition Sequence Essential for Viral Cell Entry

Aravind Asokan, Julie B. Hamra, Mavis Agbandje-McKenna and Richard J. Samulski

Mol Ther 13: S3-S3; doi:10.1016/j.ymthe.2006.08.017

8. Adeno-Associated Virus 2-Mediated Gene Transfer: A Complex Interaction between Epidermal Growth Factor Receptor Protein Tyrosine Kinase Signaling and Ubiquitin/Proteasome Pathway in Transgene Expression

Li Zhong, Weihong Zhao, Jianqing Wu, Baozheng Li and Arun Srivastava

Mol Ther 13: S3-S4; doi:10.1016/j.ymthe.2006.08.018

9. Biology of rAAV8 in Mouse Liver Following Vector Administration at Birth

Katsuya Inagaki, Sally Fuess, Theresa A. Storm, Mark A. Kay and Hiroyuki Nakai

Mol Ther 13: S4-S4; doi:10.1016/j.ymthe.2006.08.019

10. Adeno-Associated Virus Type-1 Vectors Transduce Human Polarized Airway Epithelia without Polarity Preference

Ziying Yan, Diana C.M. Lei-Butters, Xiaoming Liu, Yulong Zhang, Meihui Luo, Liang Zhang, Roman Zak and John F. Engelhardt

Mol Ther 13: S4-S5; doi:10.1016/j.ymthe.2006.08.020

11. Transposition from a Gene-Deleted Adenoviral Vector Results in Phenotypic Correction in a Canine Model for Hemophilia B

Anja Ehrhardt, Hui Xu, Aaron M. Dillow, Stephen R. Yant, Timothy C. Nichols and Mark A. Kay

Mol Ther 13: S5-S5; doi:10.1016/j.ymthe.2006.08.022

12. Therapeutic Potential of the Chimeric Adenovirus 5/40 as Vector for Intestine-Directed Gene Therapy

Ester Rodriguez, Carolina Romero, Mireia Ferrer, Joan F. Burgue|[ntilde]|o, Ester Fernandez, Estel Gil, Hirofumi Hamada, Assumpcio Bosch and Miguel Chillon

Mol Ther 13: S5-S5; doi:10.1016/j.ymthe.2006.08.023

13. In Vivo Stable Transduction of Humanized Liver Tissue in Chimeric Mice Via High-Capacity Adenovirus-Lentivirus Hybrid Vector

Shuji Kubo, Miho Kataoka, Chise Tateno, Donna J. Palmer, Philip Ng, Katsutoshi Yoshizato and Noriyuki Kasahara

Mol Ther 13: S6-S6; doi:10.1016/j.ymthe.2006.08.024

14. High Efficiency and Long-Term Persistence In Vivo from a Helper Dependent Adenovirus/Epstein-Barr Virus Hybrid Vector

Sean D. Gallaher, Jose S. Gil and Arnold J. Berk

Mol Ther 13: S6-S6; doi:10.1016/j.ymthe.2006.08.025

15. Genetically Targeted Adenovirus Vector Carrying Reovirus |[sigma]|1-Based Attachment Protein for Improved Systemic Gene Delivery

Frederik H.E. Schagen, Harm C.A. Graat, Jan E. Carette, Terence S. Dermody, Michael A. vanGeer and Victor W. van Beusechem

Mol Ther 13: S6-S7; doi:10.1016/j.ymthe.2006.08.026

16. Direct Selection of Targeted Vector from a Random Peptide Library Displayed on Adenoviral Fiber Knob

Kazunori Aoki, Yoshiaki Miura, Kimiko Yoshida, Kazuteru Hatanaka, Takeshi Nishimoto, Shumpei Ohnami, Joanne T. Douglas, David T. Curiel and Teruhiko Yoshida

Mol Ther 13: S7-S7; doi:10.1016/j.ymthe.2006.08.027

17. Biodistribution, Innate Immune Response and Toxicity Following Intravenous Inoculation of Mice with Nonhuman Adenoviral Vectors

Dinesh S. Bangari, Anurag Sharma, Aseem Pandey, Harm HogenEsch and Suresh K. Mittal

Mol Ther 13: S7-S7; doi:10.1016/j.ymthe.2006.08.028

18. Comparison of Antitumor Activity of Cytosine Deaminase::Uracil Phosphoribosyl Transferase (CD::UPRT) and Purine Nucleoside Phosphorylase (PNP) Suicide Genes Using Replicative but Non-Disseminative Adenovirus Vectors

Jairo Jaime, Nadine Jabbour, William Parker, Eric Sorscher, Josephine Nalbantoglu and Bernard Massie

Mol Ther 13: S8-S8; doi:10.1016/j.ymthe.2006.08.029

19. A New, Plasmid-Based Adenoviral Vectoring System Derived from the Highly Immunogenic, Human Ad4 Strain

Zachary C. Hartman, Todd Mendelson and Andrea Amalfitano

Mol Ther 13: S8-S8; doi:10.1016/j.ymthe.2006.08.030

20. Construction and Characterization of Adenovirus Vectors Expressing Optimized Blood Stage Antigens of Plasmodium falciparum

Ping Chen, Svetlana Konovalova, Keith Limbach, Maureen E. Stefaniak, Noelle B. Patterson, Joseph J. Campo, Sheng Li, Richter King, Denise L. Doolan and Joseph T. Bruder

Mol Ther 13: S8-S9; doi:10.1016/j.ymthe.2006.08.031

21. Peptide-Targeted Ad19p-Based Adenoviral Vectors for Renal Gene Delivery

Laura Denby, Lorraine M. Work, Dan J. Von Seggern, Eugene Wu, Ela Hunt, Stuart A. Nicklin and Andrew H. Baker

Mol Ther 13: S9-S9; doi:10.1016/j.ymthe.2006.08.034

22. Creation of a Biological Pacemaker by Cell Fusion

Hee Cheol Cho, Yuji Kashiwakura and Eduardo Marb|[aacute]|n

Mol Ther 13: S9-S10; doi:10.1016/j.ymthe.2006.08.033

23. Catheter-Mediated Local Intramural Delivery of AdEC-SOD Inhibits Oxidative Stress and Reduces In-Stent Neointima by Accelerating Endothelial Cell Recovery in WHHL Rabbits Displaying Complex Human-Like Atherosclerotic Lesions

Olli Leppanen, Jan Hinrich Brasen, Tommi Heikura, Matias Inkala, Fabian Ahrens, Juha Rutanen, Anna-Liisa Levonen, Samar Basu, Mikko O. Laukkanen and Seppo Yla-Herttuala

Mol Ther 13: S10-S10; doi:10.1016/j.ymthe.2006.08.035

24. Widespread and Efficient Gene Delivery to the Heart and Liver Using AAV Serotype 9: Implications for Cardiovascular Disease and Hemophilia

Thierry VandenDriessche, Lieven Thorrez, Abel Acosta-Sanchez, Lilly Wang, Veerle Gillijns, Ma Ling, Herman Vandenburgh, Nico Mertens, Nico Callewaert, James Wilson, Desire Collen and Marinee Chuah

Mol Ther 13: S10-S11; doi:10.1016/j.ymthe.2006.08.036

25. Development and Characterization of Viral Vectors with High Specificity for Atherosclerotic Plaques

Katie M. White, Hildergard Buening, Lorraine M. Work, Michael Hallek, Stuart A. Nicklin and Andrew H. Baker

Mol Ther 13: S11-S11; doi:10.1016/j.ymthe.2006.08.037

26. Lentiviral Vector Delivery of vMIP-II Using Both Transplanted Endothelial and Progenitor Cells Enhances a Robust and Functional Angiogenesis In Vivo

Stephanie Cherqui, Camille Thorpe, Sunil M. Kurian and Daniel R. Salomon

Mol Ther 13: S11-S11; doi:10.1016/j.ymthe.2006.08.038

27. Prevention of Cardiac Remodeling and Heart Failure in Dahl-Salt Sensitive Rats by AAV Vector-Mediated Interleukin-10 Expression

Mutsuko Sarukawa, Takashi Okada, Toru Yoshioka, Takayuki Ito, Tatsuya Nomoto, Hiroaki Mizukami, Akihiro Kume, Keiji Yamamoto, Uichi Ikeda, Kazuyuki Shimada and Keiya Ozawa

Mol Ther 13: S12-S12; doi:10.1016/j.ymthe.2006.08.039

28. rAAV2/9 Mediated Gene Delivery of Acid |[alpha]|-Glucosidase Corrects the Cardiac Phenotype in a Mouse Model of Pompe Disease

Christina A. Pacak, Cathryn Mah, Kerry O. Cresawn, Melissa A. Lewis, Sean Germain and Barry J. Byrne

Mol Ther 13: S12-S12; doi:10.1016/j.ymthe.2006.08.040

29. Effect of AAV6-Mediated TIMP-2 Overexpression in a Murine Model of Heart Failure

Satsuki Mori, Xiaodong Zhu, Gregory Gibson, Benjamin Burkhead and Charles F. McTiernan

Mol Ther 13: S13-S13; doi:10.1016/j.ymthe.2006.08.041

30. Cardiac-Specific Gene Expression Using Pseudotyped AAV Vectors and the Cardiac Troponin-T Promoter

Konkal-Matt R. Prasad, Zequan Yang, Yaqin Xu, Stuart S. Berr and Brent A. French

Mol Ther 13: S13-S13; doi:10.1016/j.ymthe.2006.08.042

31. Dystrophin Expression in Muscles of Duchenne Muscular Dystrophy Patients Following High-Density Injections of Normal Myogenic Cells

Jacques P. Tremblay, Daniel Skuk, Marlyne Goulet, Brigitte Roy, Pierre Chapdelaine, Raynald Roy, Francine Dugr|[eacute]|, Jean-Pierre Bouchard, Jean-Guy Lachance, Michel Sylvain, Louise Desch|[ecirc]|nes and H|[eacute]|l|[egrave]|ne Senay

Mol Ther 13: S13-S14; doi:10.1016/j.ymthe.2006.08.044

32. Improvement of Muscle Mass Using shRNA Targeting Myostatin or Activin Receptor IIb

Julie Dumonceaux, Solenne Marie and Luis Garcia

Mol Ther 13: S14-S14; doi:10.1016/j.ymthe.2006.08.045

33. Systemic Delivery of AAV8/DC190-GAA to Pompe Mice Normalizes Muscle Pathology and Corrects Motor Function Deficits

R.J. Ziegler, M.A. Zhao, S.D. Bercury, J.A. Fidler, J.W. Foley, D. Armentano, S. Ryan, T. Taksir, D. Griffiths, L.S. Shihabuddin, R.K. Scheule and S.H. Cheng

Mol Ther 13: S14-S14; doi:10.1016/j.ymthe.2006.08.046

34. Phi C31 Integrase System Enhances Dystrophin Gene Expression in Skeletal Muscle of Mouse Models for Duchenne Muscular Dystrophy

Carmen Bertoni, Sohail Jarrahian, Thurman M. Wheeler, Yining Li, Eric C. Olivares, Michele P. Calos and Thomas A. Rando

Mol Ther 13: S14-S15; doi:10.1016/j.ymthe.2006.08.047

35. Systemic Administration of rAAV6-Microdystrophin Preserves Muscle Function and Extends Lifespan in the Dystrophin-/Utrophin- Mouse Model of Severe Muscular Dystrophy

Paul Gregorevic, Michael J. Blankinship, Elina Minami, James M. Allen, Charles E. Murry and Jeffrey S. Chamberlain

Mol Ther 13: S15-S15; doi:10.1016/j.ymthe.2006.08.048

36. Transplantation of SM/C-2.6+ Satellite Cells Transduced with Micro-Dystrophin CS1 cDNA by Lentiviral Vector into mdx Mice

Madoka Ikemoto, So-ichiro Fukada, Akiyoshi Uezumi, Satoru Masuda, Ampong Beryl Nyamekye, Hiroyuki Miyoshi, Hiroshi Yamamoto, Yuko Miyagoe-Suzuki and Shin'ichi Takeda

Mol Ther 13: S15-S15; doi:10.1016/j.ymthe.2006.08.049

37. Long-Term Expression of Mini-Human Dystrophin in Transgenic mdx Mice Improves Dystrophic Muscle Functions

Bing Wang, Juan Li, Chunlian Chen, Xiancheng Jiang, Terry O'Day, Jon Watchko and Xiao Xiao

Mol Ther 13: S16-S16; doi:10.1016/j.ymthe.2006.08.050

38. Morpholino Antisense Oligonucleotide Induced Exon Skipping Efficiently Restores Dystrophin Expression in the mdx Mouse

Dominic J. Wells, Caroline McCulley, Anna Graham, Ke Liu and Kim E. Wells

Mol Ther 13: S16-S16; doi:10.1016/j.ymthe.2006.08.051

39. Evaluation of rAAV-1 vs rAAV-8 Vectors and Their Mode of Delivery in Nonhuman Primate Skeletal Muscle

Alice Toromanoff, Yan Cherel, Jack-Yves Deschamps, Valder R. Arruda, Katherine A. High, Hansell H. Stedman, Mark E. Haskins, Fabienne Rolling, Ignacio Anegon, Philippe Moullier and Caroline Le Guiner

Mol Ther 13: S16-S17; doi:10.1016/j.ymthe.2006.08.052

40. Increased Transgene Expression of Dystrophin in mdx Muscle by RNAi-Mediated Silencing of Calpain Expression

Makiya Nishikawa, Kazuhiro Hirata, Kazuya Machida, Yuki Takahashi, Katsutoshi Yuasa, Shin'ichi Takeda and Yoshinobu Takakura

Mol Ther 13: S17-S17; doi:10.1016/j.ymthe.2006.08.053

41. Evaluation of Lung Cancer Virotherapy with Oncolytic Semliki Forest Virus Using Immunodeficient Rodent Tumor Model

Ann-Marie M|[auml]||[auml]|tt|[auml]|, Tiina Wahlfors, Katja H|[auml]|kkinen, Linda Jansson, Markus V|[auml]|h|[auml]|-Koskela, Ari Hinkkanen, Kimmo M|[auml]|kinen and Jarmo Wahlfors

Mol Ther 13: S17-S17; doi:10.1016/j.ymthe.2006.08.055

42. Resistance of Primary Ovarian Cancer Cells to Viral Oncolysis

Robert Strauss, Pavel Sova, Ying Liu, Zong Yi Li, Nicole Urban, Charles Drescher, Nancy Kiviat and Andre Lieber

Mol Ther 13: S18-S18; doi:10.1016/j.ymthe.2006.08.056

43. Long-Term T Cell Activation Following Combined In Situ Gene Therapy and Intensity-Modulated Radiotherapy Compared to Gene Therapy as Mono-Therapy in Prostate Cancer Patients

Tetsuo Fujita, Bin S. Teh, Terry L. Timme, Wei-Yuan Mai, Takefumi Satoh, Nobuyuki Kusaka, Koji Naruishi, Elmoataz Abdelfattah, Estuardo Aguilar-Cordova, Brian J. Miles, E. Brian Butler and Timothy C. Thompson

Mol Ther 13: S18-S18; doi:10.1016/j.ymthe.2006.08.057

44. Combination of Oncolytic Measles Virus Strains and Radiation Therapy Has Synergistic Activity in the Treatment of Glioblastoma Multiforme

Chunsheng Liu, Jann N. Sarkaria, Cory Allen, Paula J. Zollman, C. David James, Stephen J. Russell and Evanthia Galanis

Mol Ther 13: S19-S19; doi:10.1016/j.ymthe.2006.08.058

45. Paclitaxel-TRAIL Enhances the Distribution of Oncolytic Herpes Simplex Virus-1 in a Human Mammary Carcinoma Xenograft

Satoshi Nagano, Jean Y. Perentes, Rakesh K. Jain and Yves Boucher

Mol Ther 13: S19-S19; doi:10.1016/j.ymthe.2006.08.059

46. Phase I/II Study of Adenoviral Vector Delivery of HSV-tk Gene and the Intravenous Administration of Ganciclovir in Men with Local Recurrence of Prostate Cancer after Hormonal Therapy

Yasutomo Nasu, Haruki Kaku, Shin Ebara, Takashi Saika, Hiromi Kumon and Timothy C. Thompson

Mol Ther 13: S19-S20; doi:10.1016/j.ymthe.2006.08.060

47. A Combination Therapy of Selective Intraarterial Gendicine Infusion with Chemotherapy for Locally Advanced Head and Neck Carcinoma

Longjiang Li, Yuanding Huang, Lijuan Wang, Yi Li, Yuming Wen and Bo Han

Mol Ther 13: S20-S20; doi:10.1016/j.ymthe.2006.08.061

48. Adeno-Associated Viral (AAV) Vector- Mediated Systemic Delivery of mda-7/IL24 Inhibits Tumor Growth by Antitumor Bystander Effect

Ichiro Tahara, Koichi Miyake, Toshiyuki Kurai, Yukihiko Hirai, Eiji Uchida, Takashi Tajiri and Takashi Shimada

Mol Ther 13: S20-S20; doi:10.1016/j.ymthe.2006.08.062

49. Inhibition of Acid Ceramidase Expression by Small Interfering RNA Sensitize Human Prostae Cancer Cells to Apoptin Induced Cell Death

Xiang Liu, Guiwen Guo, Saeed N. Elojeimy, David H. Holman, Ayman Mahdy, Alicja Bielawska, Jacek Bielawski, Seymon Rubinchik, Jian-yun Dong, Thomas Keane, Mahvash Tavassoli, Yusuf A. Hannun and James N. Norris

Mol Ther 13: S21-S21; doi:10.1016/j.ymthe.2006.08.063

50. Adenoviral-Mediated Gene Transfer of Single Chain Fv 425:sTRAIL Fusion Protein Induces Target Cell Restricted Apoptosis in EGFR- Positive Tumor Cells and a Potent Bystander Effect

Hidde J. Haisma, Marike Dijkstra, Edwin Bremer and Wijnand Helfrich

Mol Ther 13: S21-S21; doi:10.1016/j.ymthe.2006.08.064

51. Clinical Study of Personalized Therapeutics Based on Genomic/Proteomic Profiling

John Nemunaitis, Neil Senzer, Jerry Shen, Phillip Maples, Donald Rao, Alex Tong, Padmasini Kumar, Joe Kuhn, Yu-An Zhang, Jian Liao, Iya Khalil, Colin Hill and Adi Gazdar

Mol Ther 13: S21-S22; doi:10.1016/j.ymthe.2006.08.066

52. A Phase 1 Dose-Escalation Trial of Intravesical CG0070 for Superficial Transitional Cell Carcinoma (TCC) of the Bladder after Bacillus Calmette-Guerin (BCG) Failure

Neil Senzer, John Nemunaitis, Michael Goldstein, James Arseneau, Don Lamm, Joe Stephenson, Harry Tsai, Kristina Neal, Junko Aimi, D.C. Yu, Daniel Maslyar, John Corman, James Mckiernan and James Burke

Mol Ther 13: S22-S22; doi:10.1016/j.ymthe.2006.08.067

53. Preliminary Results of a Pilot Phase I Clinical Trial of Adoptive Immunotherapy for B Cell Lymphoma Using CD8+ T Cells Genetically Modified To Express a Chimeric T Cell Receptor Recognizing CD20

Oliver W. Press, Jinjuan Wang, Catherine G. Lindgren, Eric Y. Chen, Ajay K. Gopal, John M. Pagel, Xiaojun Qian, Stanley R. Riddell, Philip D. Greenberg, Andrew Raubitschek and Michael C. Jensen

Mol Ther 13: S22-S23; doi:10.1016/j.ymthe.2006.08.068

54. TNFerade|[trade]| in Pancreas Cancer: Local Activation with Systemic Potential

Neil Senzer, John Nemunaitis, J. Macko and Thomas Davis

Mol Ther 13: S23-S23; doi:10.1016/j.ymthe.2006.08.069

55. Translating Preclinical Results into the Clinical Development of PV701, an Oncolytic Virus

Robert M. Lorence, M. Scot Roberts, James D. O'Neil, Pete T. Buasen, Li Zhang, William S. Groene and Michael K. Bamat

Mol Ther 13: S23-S23; doi:10.1016/j.ymthe.2006.08.070

56. The Efficacy of Replicating Virotherapy for Tumors Involves a Complex Equilibrium between Virus, Tumor and the Immune System

Rosa Maria Diaz, Feorilo Galivo, Jian Qiao, Jill Thompson, Timothy Kottke, John Bell, Glen Barber and Richard Vile

Mol Ther 13: S24-S24; doi:10.1016/j.ymthe.2006.08.071

57. Targeted Gene Delivery of Alpha-Interferon by Genetically Modified Hematopoietic Cells Inhibits Glioma Vascularization and Growth without Systemic Toxicity

Michele DePalma, Rossella Galli, Mary Anna Venneri, Letterio S. Politi, Ferdinando Pucci, Lucia Sergi Sergi, Elena Binda, Ehud Hauben and Luigi Naldini

Mol Ther 13: S24-S24; doi:10.1016/j.ymthe.2006.08.072

58. Oncolytic Measles Virus Delivery by Infected Cell Carriers |[ndash]| A Strategy To |[ldquo]|By-Pass|[rdquo]| the Pre-Existing Humoral Immune Response

Ianko D. Iankov, Boris R.A. Blechacz, Guy E. Griesmann, Mark J. Federspiel and Stephen J. Russell

Mol Ther 13: S24-S25; doi:10.1016/j.ymthe.2006.08.073

59. Targeted Gene Therapy of Malignant Glioma with Adult Stem Cells

Hrvoje Miletic, Yvonne Fischer, Tsanan Giroglou, Sara Litwak, Sandra Winkeler, Uwe Himmelreich, Werner Stenzel, Martina Deckert, Andreas H. Jacobs, Harald Neumann and Dorothee von Laer

Mol Ther 13: S25-S25; doi:10.1016/j.ymthe.2006.08.074

60. Radiation Improves Local Delivery of a Virus-Mimicking Nanostructure Complex in Tumors

Rebecca A. Abela, Liang Xu, Theodore S. Lawrence and Ming Zhang

Mol Ther 13: S25-S25; doi:10.1016/j.ymthe.2006.08.075

61. Successful Gene Therapy of a Mouse Model of Congenital Erythropoietic Porphyria with an Erythroid-Specific Lentiviral Vector

Elodie Robert, Magalie Lalanne, Isabelle Lamrissi-Garcia, Muriel Cario-Andre, Cecile Ged, Hubert De Verneuil and Francois Moreau-Gaudry

Mol Ther 13: S25-S26; doi:10.1016/j.ymthe.2006.08.077

62. Proteasome Activity Restricts Lentiviral Gene Transfer into Hematopoietic Stem Cells and Is Down-Regulated by Cytokines That Enhance Transduction

Francesca R. Santoni de Sio, Paolo Cascio, Anna Zingale, Mauro Gasparini and Luigi Naldini

Mol Ther 13: S26-S26; doi:10.1016/j.ymthe.2006.08.078

63. Long-Term Constitutive Expression of the Therapeutic Gene, IL2RG, Causes T-Cell Lymphomas in a Gene Therapy Model for XSCID

Niels-Bjarne Woods, Virginie Bottero, Manfred Schmidt, Christof von Kalle and Inder M. Verma

Mol Ther 13: S26-S27; doi:10.1016/j.ymthe.2006.08.079

64. Rescue of B Cell Development in an Animal Model of X-Linked Agammaglobulinemia (XLA) Via B Lineage-Specific Lentiviral Gene Therapy

Wenying Zhang, Stephanie Humblet-Baron, Kevin Kipp, Socheath Khim, Jordan Jarjour, Karen Sommer, Brigid Stirling, Lia Pernell and David J. Rawlings

Mol Ther 13: S27-S27; doi:10.1016/j.ymthe.2006.08.080

65. Long-Term Effects of Hematopoietic Stem Cell Gene Therapy in the Murine Model of Wiskott-Aldrich Syndrome: Persistence of Functional Correction of T Cells and Lack of Malignant Trasformation

Francesco Marangoni, Lo|[iuml]|c Dupr|[eacute]|, Samantha Scaramuzza, Cristina Panaroni, Sara Trifari, Raisa Jofra Hern|[aacute]|ndez, Adrian J. Thrasher, Anne Galy, Alessandro Aiuti, Luigi Naldini and Maria Grazia Roncarolo

Mol Ther 13: S27-S28; doi:10.1016/j.ymthe.2006.08.081

66. Gene Transfer-Mediated Expression of Murine Factor VIIa Improves Clot Formation in a Mouse Model for Bernard-Soulier Syndrome

Majed N. Aljamali, Paris Margaritis, Valder R. Arruda, Alex Schlachterman, Danielle Dunn, Jerry Ware and Katherine A. High

Mol Ther 13: S28-S28; doi:10.1016/j.ymthe.2006.08.082

67. The Chicken Hypersensitive Site (cHS4) Insulator Element Reduces Position Effects Thereby Increasing Expression from Globin Lentiviral Vectors

Paritha I. Arumugam, Jessica Scholes, Ping Xia, Natalya Perelman, Alexander Zarzuela, Jiing-Kuan Yee and Punam Malik

Mol Ther 13: S28-S28; doi:10.1016/j.ymthe.2006.08.083

68. Evidence for Correction of Mutations in the c-Kit Gene by rAAV Mediated Gene Targeting in W/Wv Mice

Arthur W. Nienhuis, John T. Gray, Serena Vayda, Amanda Cline, Marguerite V. Evans-Galea and David M. Bodine

Mol Ther 13: S29-S29; doi:10.1016/j.ymthe.2006.08.084

69. Selection of Hematopoietic Progenitor and Stem Cells in Transplanted Rhesus Macaques Using MGMT and HOXB4 Lentiviral Vectors

Yan Shou, John Gray, Brian Agricola, Zhijun Ma, Geeta K. Nair, Clinton F. Stewart, Derek A. Persons and Brian P. Sorrentino

Mol Ther 13: S29-S29; doi:10.1016/j.ymthe.2006.08.085

70. Long Term Correction of beta-Thalassemia by Transplantation of Transduced Hematopoietic Stem Cells

Annarita Miccio, Rossano Cesari, Francesco Lotti, Claudia Rossi, Francesca Tiboni, Francesca Sanvito, Maurilio Ponzoni, Samantha Routledge, Michael Antoniou and Giuliana Ferrari

Mol Ther 13: S30-S30; doi:10.1016/j.ymthe.2006.08.086

71. Alpha 1 Antitrypsin (AAT) Gene Therapy for the Prevention of Type 1 Diabetes

Sihong Song, Yuanqing Lu, Mei Tang, Bin Zhang, Clive Wasserfall, Martha Campbell-Thompson and Mark Atkinson

Mol Ther 13: S30-S30; doi:10.1016/j.ymthe.2006.08.088

72. Intravascular Interaction between Adenovirus and Platelets Promotes Adenovirus Sequestration, Degradation and Toxicity

Daniel Stone, Shaoheng Ni, Zong-Yi Li, Dmitry Shayakhmetov and Andre Lieber

Mol Ther 13: S30-S31; doi:10.1016/j.ymthe.2006.08.089

73. Cats Produce a Potent CTL Response after Neonatal Gene Therapy That Can Be Blocked with CTLA4-Ig

Katherine P. Ponder, Baomei Wang, Ping Wang, Xiucui Ma, Ramin Herati, Bin Wang, Karyn Cullen, Patty O'Donnell, Tina M. Primeau and Mark E. Haskins

Mol Ther 13: S31-S31; doi:10.1016/j.ymthe.2006.08.090

74. Cellular Immunity to Adeno-Associated Virus Capsid Attenuates Transgene Expression in the Liver

Samuel L. Murphy, Denise Sabatino, Federico Mingozzi, Shyrie Edmonson and Katherine High

Mol Ther 13: S31-S32; doi:10.1016/j.ymthe.2006.08.091

75. Protease-Activated Receptor 2 as a Novel Target for Immune Modulation for AAV-Mediated Gene Transfer to Skeletal Muscle

Stefano Baila, Christian Furlan Freguia, Danielle Dunn, Federico Mingozzi, Joerg Schuettrumpf and Valder R. Arruda

Mol Ther 13: S32-S32; doi:10.1016/j.ymthe.2006.08.092

76. In Vivo Suppression of Cytotoxic T Cell Responses by CD4+ Regulatory T Cells Activated by Hepatic Gene Transfer

Lixin Wang, Eric Dobrzynski, Julie Fitzgerald, Ou Cao and Roland W. Herzog

Mol Ther 13: S32-S32; doi:10.1016/j.ymthe.2006.08.093

77. TLR and Myd88 Signaling Pathway Is Required for the Full Induction of Host Adaptive Immune Responses to Adenoviral Vectors and Transgenes

Zhe Zhang, Yan Zhi, Joanita M. Figueredo, Roberto Calcedo, James R. Miller, Guang-Ping Gao and James M. Wilson

Mol Ther 13: S33-S33; doi:10.1016/j.ymthe.2006.08.094

78. Regulation of Immune Responses Against Factor VIII Following Nonviral Gene Transfer in Hemophilia A and FOXP3 Transgenic Mouse Models

Benjamin R. Harmeling, Steven Ziegler, Troy Torgerson, Liping Chen, Hans D. Ochs, David J. Rawlings and Carol H. Miao

Mol Ther 13: S33-S33; doi:10.1016/j.ymthe.2006.08.095

79. Systemic Administration of Lentiviral Vectors Triggers Innate Host Responses

Brian D. Brown, Ehud Hauben, Giovanni Sitia, Anna Zingale, Lucia Sergi Sergi, Lucca Guidotti, Maria Grazia Roncarolo and Luigi Naldini

Mol Ther 13: S33-S34; doi:10.1016/j.ymthe.2006.08.096

80. Pre-Existing Cytotoxic T-Lymphocyte (CTL) Responses to the AAV CAP Protein Do Not Interfere with AAV Transgene Expression in Mice

William M. Siders, Johanne Kaplan, Michael Lukason, Jacqueline Shields, Lisa Woodworth, Sam Wadsworth and Abraham Scaria

Mol Ther 13: S34-S34; doi:10.1016/j.ymthe.2006.08.097

81. Hippocampal Gene Knockdown of BACE1 by Lentiviral Gene Transfer of siRNA Reduces Amyloid Pathology and Improves Memory Performance in APP Transgenic Mice

Oded Singer, Robert A. Marr, Edward Rockenstein, Leslie Crow, Fred H. Gage, Inder M. Verma and Eliezer Masliah

Mol Ther 13: S34-S34; doi:10.1016/j.ymthe.2006.08.099

82. Cftr Gene Targeting in Murine ES Cells Mediated by the SFHR Technique

Federica Sangiuolo, Maria Favia, Lorenzo Guerra, Antonio Filareto, Maria Lucia Scaldaferri, Rosa Caroppo, Paola Spitalieri, Ruggiero Mango, Emanuela Bruscia, Dieter Gruenert, Valeria Casavola, Massimo De Felici and Giuseppe Novelli

Mol Ther 13: S34-S35; doi:10.1016/j.ymthe.2006.08.100

83. Cell-Type Specific Delivery of siRNAs with Aptamer-siRNA Chimeras

Paloma H. Giangrande, James O. McNamara, Eran Andrecheck, Eli Gilboa and Bruce A. Sullenger

Mol Ther 13: S35-S35; doi:10.1016/j.ymthe.2006.08.101

83. RNA Silencing: Role of Interferon System Components in Non-Specific Effects Induced by Chemically Synthesized Small Interfering RNAs, Enzymatically Synthesized Small Interfering RNAs and Short Hairpin RNAs

Christopher S. McAllister and Charles E. Samuel

Mol Ther 13: S35-S35; doi:10.1016/j.ymthe.2006.08.102

85. Von Willebrand Factor (VWF) Gene Targeting by Double-Strand Break Enhanced Homologous Recombination

Nicole L. Prokopishyn, Brian R. Davis, Jonathan B. Rosenberg, Michael DiCola, Jennifer Brosius, R. Michael Blaese and Richard A. Metz

Mol Ther 13: S35-S36; doi:10.1016/j.ymthe.2006.08.103

86. Inhibition of Choroidal Neovascularization In Vivo by Adenovirus Mediated Delivery of Short Hairpin RNAs Targeting Vascular Endothelial Growth Factor as a Potential Therapy for Age Related Macular Degeneration

Siobhan Cashman and Rajendra Kumar-Singh

Mol Ther 13: S36-S36; doi:10.1016/j.ymthe.2006.08.104

87. Efficient Delivery of Small Interfering RNA Targeting Pro-Inflammatory Cytokines in Experimental Arthritis

Maroun Khoury, Virginie Escriou, Pascale Louis-Plence, Dani|[egrave]|le Noel, Daniel Scherman, Christian Jorgensen, and Florence Apparailly

Mol Ther 13: S36-S36; doi:10.1016/j.ymthe.2006.08.105

88. Synthetic siRNAs for Huntington's Disease Therapy

Patrick D. Staber, Chandra Vargeese, Ines H. Martins, Barry Polisky, Alex Mas-Monteys, Scott Q. Harper and Beverly L. Davidson

Mol Ther 13: S36-S37; doi:10.1016/j.ymthe.2006.08.106

89. Gene Targeting of |[beta]|-Globin IVS2 Using Sequence-Specific Peptide Nucleic Acids

Jean Y. Kuan, Ryszard Kole, Peter E. Nielsen and Peter M. Glazer

Mol Ther 13: S37-S37; doi:10.1016/j.ymthe.2006.08.107

90. miRNA Shuttles Improve Therapeutic RNAi

Ryan L. Boudreau and Beverly L. Davidson

Mol Ther 13: S37-S37; doi:10.1016/j.ymthe.2006.08.108

91. Retroviral Vector Integrations Relate to Hematopoietic Stem Cell Gene Expression Patterns

Martijn H. Brugman, Karin Pike-Overzet, Carla Oerlemans-Bergs, Sigrid Swagemakers, Dick de Ridder, Frank J.T. Staal, Monique M.A. Verstegen and Gerard Wagemaker

Mol Ther 13: S37-S38; doi:10.1016/j.ymthe.2006.08.110

92. Gene Transfer to Ocular Stem Cells by Early Gestational Intra-Amniotic Injection of Lentiviral Vector

Masayuki Endo, Phil W. Zoltick, Daniel C. Chung, Jean Bennett and Alan W. Flake

Mol Ther 13: S38-S38; doi:10.1016/j.ymthe.2006.08.111

93. Increased Number of Lung CD34+ Sca-1+ Putative Stem Cells Mediated by Adenovirus Overexpression by Sonic Hedgehog in the Respiratory Tract of Adult Mice

Anja Krause, Ju Joh, Austen Gess, Howard Lou, Ronald G. Crystal and Stefan Worgall

Mol Ther 13: S38-S38; doi:10.1016/j.ymthe.2006.08.112

94. Modulation of Postnatal Muscle-Derived Stem Cell Fate Using siRNA

Jonathan B. Pollett, Karin A. Corsi, Jessica Tebbets, Bridget M. Deasy and Johnny Huard

Mol Ther 13: S39-S39; doi:10.1016/j.ymthe.2006.08.113

95. Effective Genetic Engineering of Human Embryonic Stem Cells Using the Sleeping Beauty Transposon System

Andrew Wilber, Jonathan L. Linehan, Xinghui Tian, R. Scott McIvor and Dan S. Kaufman

Mol Ther 13: S39-S39; doi:10.1016/j.ymthe.2006.08.114

96. Enforced HoxB4 Expressed Hematopoietic Stem Cells Transdifferentiate into Oligodendrocytes in Adult Mouse Brain

Noriko Miyake, Koichi Miyake, Sanae Hisayasu, Stefan Karlsson and Takashi Shimada

Mol Ther 13: S39-S40; doi:10.1016/j.ymthe.2006.08.115

97. Translational Studies toward Optimizing In Vivo Bone Marrow Stem Cell Gene Transfer Using Lentiviral Vector

D. Nicole Worsham, Daren Wang, Christof von Kalle, David A. Williams and Dao Pan

Mol Ther 13: S40-S40; doi:10.1016/j.ymthe.2006.08.116

98. Enrichment and Characterization of Ovarian Cancer Stem Cells

Zong Yi Li, Robert Strauss, Pavel Sova, Shaoheng Ni, Mujun Yu, Dmitry Shayakhmetov, Charles Drescher, Nicole Urban and Andre Lieber

Mol Ther 13: S40-S41; doi:10.1016/j.ymthe.2006.08.117

99. Dedifferentiation of Myotubes and Redifferentiation into an Osteogenic Lineage: A Cre-Lox System Study

Anne Olshanski, Hairong Peng, Xiao Xiao and Johnny Huard

Mol Ther 13: S41-S41; doi:10.1016/j.ymthe.2006.08.118

100. Inducible and Reversible Transgene Expression in Human Stem Cells Stably Transduced by Novel Lentiviral Vectors

Betty Y. Zhou, Zhaohui Ye, Peter Gao and Linzhao Cheng

Mol Ther 13: S41-S41; doi:10.1016/j.ymthe.2006.08.119

101. Molecular Mechanism Responsible for High Level Transgene Expression in Murine and Nonhuman Primate Liver with the Second Generation of Novel AAV Serotype Vectors

You Lu, Xun Sun, Larry T. Bish, Julie C. Johnston, Roberto Calcedo, Rebecca L. Grant, Gaung-Ping Gao and James M. Wilson

Mol Ther 13: S42-S42; doi:10.1016/j.ymthe.2006.08.121

102. Activation of the LMO2 Gene in Human Lymphoid Cells by rAAV-Mediated Targeted Insertion of a Single LTR Expression Cassette into the First Intron

Byoung Y. Ryu, John T. Gray, David M. Bodine and Arthur W. Nienhuis

Mol Ther 13: S42-S42; doi:10.1016/j.ymthe.2006.08.122

103. A Screen for Host Cellular Proteins That Interact with Adeno-Associated Virus Capsid Proteins Reveals Proteins Involved in AAV8 Transduction

Bassel Akache, Sally Fuess, Dirk Grimm and Mark A. Kay

Mol Ther 13: S42-S43; doi:10.1016/j.ymthe.2006.08.123

104. Role of the HI Loop in the Adeno-Associated Virus (AAV) Life Cycle

Nina DiPrimio, Aravind Asokan and Richard J. Samulski

Mol Ther 13: S43-S43; doi:10.1016/j.ymthe.2006.08.124

105. Interactions between Modified AAV Vectors and Alternative Cell Surface Receptors Define Intercellular Trafficking Pathways and Tranduction in Human Vascular Endothelial Cells

Matthew D. Stachler and Jeffrey S. Bartlett

Mol Ther 13: S43-S43; doi:10.1016/j.ymthe.2006.08.125

106. rAAV2 Traffics through Both the Late and Recycling Endosomes in a Dose-Dependent Fashion

Wei Ding, Liang N. Zhang, Charles Yeaman and John F. Engelhardt

Mol Ther 13: S44-S44; doi:10.1016/j.ymthe.2006.08.126

107. |[alpha]|2, 3 and |[alpha]|2,6 N-Linked Sialic Acid Facilitate Efficient Binding and Transduction by Adeno-Associated Virus Type 1 and 6

Zhijian Wu and R. Jude Samulski

Mol Ther 13: S44-S44; doi:10.1016/j.ymthe.2006.08.127

108. Study of an AAV-8 Capsid Mutant with Direct Heparin Binding Capability but Reduced Efficiency in Liver-Targeted Transduction

Xuan Shen, Hui Xu, Theresa Storm and Mark A. Kay

Mol Ther 13: S44-S45; doi:10.1016/j.ymthe.2006.08.128

109. Episomal AAV Vector Genome in the Histone-Associated Chromatin Form Is Capable of Superior Transcription with HDAC Inhibitor

Takashi Okada, Ryosuke Uchibori, Mayumi Iwata-Okada, Mutsuko Nonaka-Sarukawa, Takayuki Ito, Hiroaki Mizukami, Akihiro Kume and Keiya Ozawa

Mol Ther 13: S45-S45; doi:10.1016/j.ymthe.2006.08.129

110. Investigation of Biochemical Factors That May Influence Immunogencity of AAV2 Vectors

Bernd Hauck, Federico Mingozzi, Valder Arruda, Katherine A. High and J. Fraser Wright

Mol Ther 13: S45-S45; doi:10.1016/j.ymthe.2006.08.130

111. Post-Transcriptional Gene Silencing of Alpha-1 Antitrypsin by Small Interfering RNAs (siRNA)

Pedro E. Cruz, Alexandra Golant and Terence R. Flotte

Mol Ther 13: S45-S46; doi:10.1016/j.ymthe.2006.08.131

112. Overexpression of the Coxsackie Adenovirus Receptor (CAR) Gene Influences AAV2 Transduction in Human Trabecular Meshwork Cells

Guorong Li and Teresa Borras

Mol Ther 13: S46-S46; doi:10.1016/j.ymthe.2006.08.132

113. Transduction of Neural Cells in Primate Brain Using Adeno-Associated Virus (AAV) Serotypes 2 and 5

Eleni A. Markakis, Csaba Leranth, Jeremy Bober, R. Jude Samulski, J.E. Rabinowitz, X. Zhou, Kenneth Vives and D. Eugene Redmond Jr

Mol Ther 13: S46-S47; doi:10.1016/j.ymthe.2006.08.133

114. Revisiting rAAV Vector Integration in scid Mice: DNA-PKcs Deficiency Does Not Substantially Increase Integration Frequency in Hepatic and Non-Hepatic Tissues In Vivo

Katsuya Inagaki, Theresa A. Storm, Mark A. Kay and Hiroyuki Nakai

Mol Ther 13: S47-S47; doi:10.1016/j.ymthe.2006.08.134

115. Whole Genome Analysis Shows That AAV Integrates at Chromosome 19 AAV-S1 Sites and Other Chromosomal Sites That Frequently Share GGTC Micro-Homology with the AAV P5 Promoter

Horace R. Drew III, Linda J. Lockett and Gerald W. Both

Mol Ther 13: S47-S47; doi:10.1016/j.ymthe.2006.08.135

116. The Proposed AAV Serotypes 10 and 11 Serologically Cross-React with AAV8 and AAV4

Luk H. Vandenberghe, James R. Miller, Gaung-Ping Gao, Roberto Calcedo and James M. Wilson

Mol Ther 13: S47-S48; doi:10.1016/j.ymthe.2006.08.136

117. HSPG Binding Properties of Adeno-Associated Virus Retargeting Mutants and Consequences for Their In Vivo Tropism

Daniela Goldnau, Luca Perabo, Kathryn White, Jan Endell, Sibille Humme, Lorraine Work, Hanna Jannicki, Michael Hallek, Andrew H. Baker and Hildegard Buening

Mol Ther 13: S48-S48; doi:10.1016/j.ymthe.2006.08.137

118. In Vivo Tracking of Long Term Gene Expression of AAV1 Using Fluorescence Imaging System

Ryuichi Yoneyama, Julieta Palomeque, Kozo Hoshino, Alec M. De Grand, John V. Frangioni and Roger Joseph Hajjar

Mol Ther 13: S48-S49; doi:10.1016/j.ymthe.2006.08.138

119. Intrahepatic Injection of rAAV Serotype 2 Overcomes Gender-Related Differences on Liver Transduction

Kepa Berraondo, Julien S. Crettaz, Laura Ochoa, Astrid Paneda, Jesus Prieto, Inaki F. Troconiz and Gloria Gonz|[aacute]|lez-Aseguinolaza

Mol Ther 13: S49-S49; doi:10.1016/j.ymthe.2006.08.139

120. Tropism and Toxicity of Adeno-Associated Viral Vector Serotypes on Neurons and Glia In Vitro

Doug B. Howard, Kathleen Powers, Barry J. Hoffer, Yun Wang and Brandon K. Harvey

Mol Ther 13: S49-S49; doi:10.1016/j.ymthe.2006.08.140

121. Adenovirus Titers Determined by Quantitative Real-Time PCR Correlate with Infectious Titers

Maria A. Thomas, Peter Krajcsi, Drew L. Lichtenstein, Ann E. Tollefson and William S.M. Wold

Mol Ther 13: S49-S50; doi:10.1016/j.ymthe.2006.08.142

122. Generation of a Family of Ad5 Mutants with Slowed Packaging Kinetics but Non-Affected Packaging Efficiency

Raul Alba, Patrick Hearing, Assumpcio Bosch and Miguel Chillon

Mol Ther 13: S50-S50; doi:10.1016/j.ymthe.2006.08.143

123. Cysteine Protease Inactivation of Adenovirus Is Responsible for Thermal Stress-Induced Adenovirus Infectivity Loss

De-Min Zhu, Donna Williams and Shilu Wu

Mol Ther 13: S50-S50; doi:10.1016/j.ymthe.2006.08.144

124. Optimizing Adenoviral-Based Vaccination by Combining an RGD-Modified Capsid with a Helper-Dependent Adenovirus

Airi Harui, Michael D. Roth and Saroj K. Basak

Mol Ther 13: S50-S51; doi:10.1016/j.ymthe.2006.08.145

125. Enhancement of Virus Mediated Gene Transfer by Polycationic Compounds

Saara Lehmusvaara, Eveliina Pasanen, Outi Rautsi, Tanja Hakkarainen, Marika Ruponen and Jarmo Wahlfors

Mol Ther 13: S51-S51; doi:10.1016/j.ymthe.2006.08.146

126. Evaluation of Replication Competent and Replication Incompetent Adenovirus-Mediated Toxicity in Human Adrenocortical Cells

Urska Matkovic, Monia Pacenti, Marta Trevisan, Giulia Masi, Luisa Barzon and Giorgio Palu

Mol Ther 13: S51-S52; doi:10.1016/j.ymthe.2006.08.147

127. Modulation of Adenoviral Vector Transduction by Hyaluronan and CD44 In Vivo

Joshua N. Mallam, Saumya Chaudhuri, Patricia Chevez-Barrios, Lalita Wadhwa, Mary Y. Hurwitz and Richard L. Hurwitz

Mol Ther 13: S52-S52; doi:10.1016/j.ymthe.2006.08.148

128. Evaluation of a CD46-Transgenic Mouse as a Model for Adenovirus Distribution and Expression

Emma Andersson, Ida Grundberg, Karin Edlund and G|[ouml]|ran Wadell

Mol Ther 13: S52-S52; doi:10.1016/j.ymthe.2006.08.149

129. Adenovirus Serotype 35 Vector-Mediated Transduction in Mouse Hematopoietic Stem Cells Isolated from Human CD46-Transgenic Mice

Fuminori Sakurai, Kenji Kawabata, Takao Hayakawa and Hiroyuki Mizuguchi

Mol Ther 13: S52-S53; doi:10.1016/j.ymthe.2006.08.150

130. Insertion of Transgenes into the E3 or L3 Region To Allow Tumor Selective Expression from Armed Oncolytic Adenoviruses

Michael Robinson, Satya Yendluri, Derek Ko, Lynda Hawkins and Karin Jooss

Mol Ther 13: S53-S53; doi:10.1016/j.ymthe.2006.08.151

131. Design and Construction of an Adenovirus Vector Containing Fiber Fibritin/Canine CD40L Fibers Directed to Canine CD40-Expressing Cells

Masaharu Nakayama, Joel N. Glasgow, Bruce F. Smith, Jing Li, Nikolay Korokhov, Natalya Belousova, Kenzaburo Tani and David T. Curiel

Mol Ther 13: S53-S53; doi:10.1016/j.ymthe.2006.08.152

132. Increased GFP Gene Delivery to Human Prostate Cancer Cells Using Trancomplementing Adenoviral Vectors

Elena E. Mitrofanova, Robert C. Unfer, Martha Carvour, Molly Thrall, Jim Higginbotham, Prem Seth and Charles Link

Mol Ther 13: S53-S54; doi:10.1016/j.ymthe.2006.08.153

133. Adenovirus-Light Chain Inhibition of Growth Hormone Release from Pituitary Adenoma Cells

Thais Federici, Qingshan Teng, Mary Garrity-Moses, Christina Krudy, Jun Yang and Nicholas M. Boulis

Mol Ther 13: S54-S54; doi:10.1016/j.ymthe.2006.08.154

134. A Mechanistic and Kinetic Model for the Inactivation of Liquid-Formulated Adenoviral Vectors by the Delayed Onset of a Rapid Period of Penton Disassociation

David Frey and Cassandra Shu

Mol Ther 13: S54-S54; doi:10.1016/j.ymthe.2006.08.155

135. Replication Competent Ad11 Vectors Possess a High Potential for Human Cells Targeted Cancer Therapy

Ya-Fang Mei and Goran Wadell

Mol Ther 13: S54-S54; doi:10.1016/j.ymthe.2006.08.156

136. The Oncolytic Adenovirus Targeting to TERT and Rb Pathway Induced Specific Cytotoxicity to Tumor Cells

Rong Cai, Wei Zhang, Aiwen Dong, Kai Chen, Songbo Qiu, Xinyuan Liu and Cheng Qian

Mol Ther 13: S55-S55; doi:10.1016/j.ymthe.2006.08.157

137. Streamlined Method for the Simultaneous Construction and Purification of Multiple Recombinant Adenoviral Vectors

Thomas P. Quinn, Marylou G. Gibson, Michael Haugwitz, Michael Phelan and Andrew A. Farmer

Mol Ther 13: S55-S55; doi:10.1016/j.ymthe.2006.08.158

138. Targeted Adenoviral Vectors Expressing Soluble TGF|[beta]|RIIFc for Breast Cancer Metastasis

Zhen-Guo Wang Wang, Amanda Pister, M.B. Zafar, Sung Kim and Prem Seth

Mol Ther 13: S55-S55; doi:10.1016/j.ymthe.2006.08.159

139. Manufacture of a Replication-Selective and Enhanced-Lytic Adenovirus Vector

Moria Artlip, Sawako Ishikawa, Scott Jendrek and Dexter T.K. Poon

Mol Ther 13: S55-S55; doi:10.1016/j.ymthe.2006.08.160

140. Enhanced Cell Killing Effect of E1 Modified Adenoviruses Expressing HSV-TK Suicide Gene

Oh-Joon Kwon, Dong Hyun Ko, Jing Hwa Huang, Il-Kyu Choi, Sung-Mi Jung, Joo-Hang Kim, Byoung Chul Cho and Chae-Ok Yun

Mol Ther 13: S56-S56; doi:10.1016/j.ymthe.2006.08.161

141. Ovarian Cancer-Specific Gene Therapy by Oncolytic Adenovirus

Katsuyuki Hamada

Mol Ther 13: S56-S56; doi:10.1016/j.ymthe.2006.08.162

142. pFex: A Highly Efficient Adenoviral Vector System for Fiber Gene Modification

Shawn E. Lupold, Tarana A. Kudrolli, Wasim H. Chowdhurry and Ronald Rodriguez

Mol Ther 13: S56-S56; doi:10.1016/j.ymthe.2006.08.163

143. Development of Telomerase Specific Antineoplastic Adenovirus Telomelysin (OBP-301): Establishment of Useful Assay and Assessment for Antitumor Activity

Yuuri Hashimoto, Fuminori Teraishi, Yuichi Watanabe, Shunsuke Kagawa, Hitoshi Kawamura, Katsuyuki Nagai, Noriaki Tanaka, Yasuo Urata and Toshiyoshi Fujiwara

Mol Ther 13: S56-S56; doi:10.1016/j.ymthe.2006.08.164

144. Magnetically Responsive Nanoparticles Enhance Adenoviral Gene Delivery in Cultured Smooth Muscle Cells

Michael Chorny, Ilia Fishbein, Ivan Alferiev, Origene Nyanguile and Robert J. Levy

Mol Ther 13: S57-S57; doi:10.1016/j.ymthe.2006.08.165

145. Detection of the Primary Destabilizing Modification of Liquid-Formulated Adenoviral Vectors by Anion-Exchange High Performance Liquid Chromatography

Cassandra Shu and David Frey

Mol Ther 13: S57-S57; doi:10.1016/j.ymthe.2006.08.166

146. Development of Modified Adenovirus Vectors with Reduced Innate Immune Response

Hiroyuki Mizuguchi, Naoya Koizumi, Kenji Kawabata, Fuminori Sakurai and Takao Hayakawa

Mol Ther 13: S57-S58; doi:10.1016/j.ymthe.2006.08.167

147. Effective Gene Transfer to Human Glioma Cells Using High Capacity Adenoviral Vectors: Human Glioma Cells Express Substantial Levels of CAR and Integrin Adenoviral Co-Receptors

Marianela Candolfi, James F. Curtin, Weidong Xiong, Kurt M. Kroeger, Chunyan Liu, Altan Rentsendorj, Hasmik Agadjanian, Lali Medina-Kauwe, Philip Ng, Donna Palmer, Pedro R. Lowenstein and Maria G. Castro

Mol Ther 13: S58-S58; doi:10.1016/j.ymthe.2006.08.168

148. Characterisation of a Chimpanzee Adenovirus That Is Highly Infectious to Human Low-Passage Glioma Cells

Johan Skog, Emma Andersson, Karin Edlund, Ya-Fang Mei and G|[ouml]|ran Wadell

Mol Ther 13: S58-S58; doi:10.1016/j.ymthe.2006.08.169

149. Coxsackie and Adenovirus Receptor Binding Ablation Reduces Adenovirus Liver Tropism and Toxicity

Minjung Kim, A-Rum Yoon, Ji Young Yoo, Min-Ju Kim, Yoon-A Kang, Joo-Hang Kim and Chae-Ok Yun

Mol Ther 13: S58-S59; doi:10.1016/j.ymthe.2006.08.170

150. Metabolically Biotinylated Helper Dependent Adenovirus: A New and Rapid Approach for Targeting of High-Capacity Adenoviral Vector

Vincenzo Cerullo, Michael P. Seiler, Christopher Clarke, Aylet Erez, Michael A. Barry and Brendan Lee

Mol Ther 13: S59-S59; doi:10.1016/j.ymthe.2006.08.171

151. Treatment of Experimental Schwannomas with HSV Recombinant and Amplicon Vectors

Shilpa Prabhakar, Shanta Messerli, Samuel Rabkin, Robert Martuza and Xandra O. Breakefield

Mol Ther 13: S59-S59; doi:10.1016/j.ymthe.2006.08.174

152. Comparable Protection of Human T-Cells from High Dose Challenges of HIV-1 Using Gutless and Non-Gutless rSV40 Vectors Carrying Anti-Integrase scFv: Implications for Gene Therapy

Elena I. Marusich and David S. Strayer

Mol Ther 13: S59-S60; doi:10.1016/j.ymthe.2006.08.175

153. A Novel Gene Expression System Using Human Artificial Chromosome-HSV-1 Vectors

Daniela Moralli, Kirsty Simpson, Richard Wade-Martins and Zoia Larin Monaco

Mol Ther 13: S60-S60; doi:10.1016/j.ymthe.2006.08.176

154. Tetracycline-Inducible HSV Amplicon Vectors with Expanded Range of Gene Expression Regulation

Laryssa A. Comer, Juliet L. Fernandez, Sara M. Camp, Jessica C. Tebbets, Xandra O. Breakefield and Miguel Sena-Esteves

Mol Ther 13: S60-S60; doi:10.1016/j.ymthe.2006.08.177

155. Soluble HVEM Mediates Herpes Simplex Virus 1 (HSV-1) Infection of gD Receptor-Negative Cells

Hyunjung Baek, June-young Kyoung, Juhee Park, Kee-ho Lee, William F. Goins, Justus B. Cohen, Joseph C. Glorioso and Heechung Kwon

Mol Ther 13: S61-S61; doi:10.1016/j.ymthe.2006.08.178

156. Rapid Methods of Engineering HSV Amplicon Vectors

Kazue Kasai and Yoshinaga Saeki

Mol Ther 13: S61-S61; doi:10.1016/j.ymthe.2006.08.179

157. A Mutant Type 2 Herpes Simplex Virus Deleted for the Protein Kinase Domain of the ICP10 Gene Is a Potent Oncolytic Virus

Xinping Fu, Lihua Tao and Xiaoliu Zhang

Mol Ther 13: S61-S62; doi:10.1016/j.ymthe.2006.08.180

158. Real-Time Visualization of Neuronal Differentiation and Neurite Projection Using an Indicator HSV Amplicon Vector

Shigeru Tanaka, Kazue Kasai, E. Antonio Chiocca and Yoshinaga Saeki

Mol Ther 13: S61-S62; doi:10.1016/j.ymthe.2006.08.181

159. Novel Oncolytic HSV Armed with Platelet Factor 4, an Antiangiogenic Agent, Shows Enhanced Efficacy

Ta-Chiang Liu, Tingguo Zhang, Hiroshi Fukuhara, Toshi Kuroda, Tomoki Todo, Robert L. Martuza, Samuel D. Rabkin and Andreas Kurtz

Mol Ther 13: S62-S62; doi:10.1016/j.ymthe.2006.08.182

160. Innate Immune Responses to Viral Vectors Are Modulated by Complement Inhibitors in an Ex Vivo Model Using Whole Human Blood

Lindsay J. Stanbridge, Graciela Elgue, Javier Sanchez, Vincent Dussupt, Lucy C. Hudson, John D. Lambris, Thomas Totterman, Norman J. Maitland and Bo Nilsson

Mol Ther 13: S62-S63; doi:10.1016/j.ymthe.2006.08.183

161. Truncated Vesicular Stomatitis Virus G-Protein Improves Baculovirus Transduction Efficiency In Vitro and In Vitro

Minna U. Kaikkonen, Jani K. Raty, Kari J. Airenne, Thomas Wirth, Tommi Heikura and Seppo Yla-Herttuala

Mol Ther 13: S63-S63; doi:10.1016/j.ymthe.2006.08.184

162. Bioluminescence Imaging of a Tetanus Toxin C-Terminal Fusion Protein after Vector Delivery

Lisa Pike and Sam Wang

Mol Ther 13: S63-S63; doi:10.1016/j.ymthe.2006.08.185

163. Baculovirus-Mediated Gene Transfer in New Zealand White Rabbit Skeletal Muscle

Tommi T. Heikura, Miia M. Roschier, Anssi J. Mahonen, Hanna P. Lesch, Tuomas T. Rissanen, Olli H. Laitinen, Kari J. Airenne and Seppo Yla-Herttuala

Mol Ther 13: S63-S63; doi:10.1016/j.ymthe.2006.08.186

164. HSV-1 Vector-Based Assay To Identify Inhibitors of the Vanilloid Receptor

Rahul Srinivasan, Darren Wolfe, Shaohua Huang, David Krisky, Adrian Sculptoreanu, Peter A. Friedman, William C. de Groat and Joseph C. Glorioso

Mol Ther 13: S63-S64; doi:10.1016/j.ymthe.2006.08.187

165. Enhanced Baculovirus-Mediated Transduction of Human Cancer Cells by Tumor-Homing Peptides

Anna R. Makela, Heli Matilainen, Daniel White and Christian Oker-Blom

Mol Ther 13: S64-S64; doi:10.1016/j.ymthe.2006.08.188

166. OncoVEX: A Family of Oncolytic Herpes Simplex Viruses Optimised for Therapeutic Use

Robert S. Coffin, Binlei Liu, Han Ziqun, Magdalena Assenberg, Suzanne Thomas, Jennifer Hu and Guy Simpson

Mol Ther 13: S64-S64; doi:10.1016/j.ymthe.2006.08.189

167. Polyethyleneimines as Vehicles for Oral Gene Delivery

Eytan A. Klausner and Kam W. Leong

Mol Ther 13: S64-S65; doi:10.1016/j.ymthe.2006.08.191

168. Peptide Aldehyde Inhibitors of the Proteasome as Improved Gene Transfer Agents

Molly E. Martin, Ji-Seon Kim and Kevin G. Rice

Mol Ther 13: S65-S65; doi:10.1016/j.ymthe.2006.08.192

169. Patterned Substrate-Mediated DNA Delivery Using Soft Lithography for Neural Tissue Engineering

Tiffany L. Houchin and Lonnie D. Shea

Mol Ther 13: S65-S66; doi:10.1016/j.ymthe.2006.08.193

170. Transfected Cell Arrays for Assessment of Estrogen Receptor Activation in Breast Cancer Cells

Angela K. Pannier, Zain Bengali, Eric A. Ariazi, V. Craig Jordan and Lonnie D. Shea

Mol Ther 13: S66-S66; doi:10.1016/j.ymthe.2006.08.194

171. PEG-b-PPA/DNA Micelles for Liver Targeted-Gene Delivery

Xuan Jiang, Hui Dai, Kam W. Leong and Hai-Quan Mao

Mol Ther 13: S66-S66; doi:10.1016/j.ymthe.2006.08.195

172. Spatially-Controlled Delivery of Cyclodextrin-Based Polyplexes from Solid Surfaces

In-Kyu Park, Horst A. von Recum, Shaoyi Jiang and Suzie H. Pun

Mol Ther 13: S67-S67; doi:10.1016/j.ymthe.2006.08.196

173. Novel Cell-Specific Gene Delivery for Tumors Using a Drug or Gene Delivery System Based on Responses to Intracellular Signals (D-RECS) Concept

Yoshiki Katayama, Jeong Hun Kang, Daisuke Asai, Takeshi Mori and Takuro Niidome

Mol Ther 13: S67-S67; doi:10.1016/j.ymthe.2006.08.197

174. Chloroquine and Chloroquine Analogues in Non-Viral Delivery

Jianjun Cheng, Ryan Zeidan, Swaroop Mishra, Aijie Liu, Suzie Pun, Greg Jensen, Nathalie Bellocq, Rajan Kulkarni and Mark E. Davis

Mol Ther 13: S67-S68; doi:10.1016/j.ymthe.2006.08.198

175. Delivery Via Non-Viral Options to the Auditory Structures

Mark J. Praetorius, Christoph Klingmann, Douglas E. Brough, Peter K. Plinkert and Hinrich Staecker

Mol Ther 13: S68-S68; doi:10.1016/j.ymthe.2006.08.199

176. An Inhibitor of Fumarylacetoacetate Hydrolase (Fah) for Selection of Transplanted Hepatocytes and Gene Correction In Vivo

Karsten Wursthorn, John F. Witte, R.L. Bateman, Milton Finegold, Ronald W. McClard and Markus Grompe

Mol Ther 13: S68-S68; doi:10.1016/j.ymthe.2006.08.200

177. A Novel Class of Cationic Amphiphiles for Airway Gene Delivery

Keun-Sik Kim, Qun Li, Takeshi Suda and Dexi Liu

Mol Ther 13: S68-S69; doi:10.1016/j.ymthe.2006.08.201

178. Structure-Activity Relationships in a Library of Pyridinium Non-Viral Vectors for Gene Delivery

Marc A. Ilies, Betty H. Johnson, Aaron Miller, William A. Seitz, E. Brad Thompson and Alexandru T. Balaban

Mol Ther 13: S69-S69; doi:10.1016/j.ymthe.2006.08.202

179. In Vivo Delivery of DNA or siRNA Formulated into Nanoparticles with Linear PEI

Anne-Laure Bolcato-Bellemin, Marie-Elise Bonnet and Patrick Erbacher

Mol Ther 13: S69-S69; doi:10.1016/j.ymthe.2006.08.203

180. Transfection Efficiency of Albumin-Containing DNA/Polyethylenimine Complexes in Primary Human Respiratory Epithelial Cells and In Vivo in the Murine Airways

Sante Di Gioia, Joanna Rejman, Salvatore Carrabino, Elena Copreni, Lucia Palmieri and Massimo Conese

Mol Ther 13: S70-S70; doi:10.1016/j.ymthe.2006.08.204

181. Quantitative Evaluation of Long Term Gene Expression In Vivo after Delivery of Polyethylenimine-Conjugated Sleeping Beauty Transposon DNA

Kelly M. Podetz-Pedersen, Jason B. Bell, Terry W. Steele, Joel L. Frandsen, Thomas W. Shier, R. Scott McIvor and Perry B. Hackett

Mol Ther 13: S70-S70; doi:10.1016/j.ymthe.2006.08.205

182. Branched Chitosan Oligomers Enhance Gene Delivery In Vitro and after Lung Administration In Vivo

Mohamed M. Issa, Magnus K|[ouml]|ping-H|[ouml]|gg|[aring]|rd, Kristoffer Tommeraas, Kjell M. V|[aring]|rum, Bj|[oslash]|rn E. Christensen, Olav Smids|[oslash]|rd and Per Artursson

Mol Ther 13: S70-S71; doi:10.1016/j.ymthe.2006.08.206

183. Targeting of Muscle Cells with Functionalised Lipid Particles

Harald Heider, Sandro Rusconi and Denis Bron

Mol Ther 13: S71-S71; doi:10.1016/j.ymthe.2006.08.207

184. Novel Cationic Multivalent Lipids Show Improved Delivery of siRNA and DNA

Nathan F. Bouxsein, Kai K. Ewert, Christopher S. McAllister, Heather M. Evans, Charles E. Samuel and Cyrus R. Safinya

Mol Ther 13: S71-S71; doi:10.1016/j.ymthe.2006.08.208

185. Structural Advantage of Dendritic poly(L- lysine) in Gene Delivery In Vitro and In Vivo

Takuro Niidome, Masato Yamagata, Takayuki Iida, Takahito Kawano, Kouhei Shiba and Yoshiki Katayama

Mol Ther 13: S72-S72; doi:10.1016/j.ymthe.2006.08.209

186. Efficient In Vivo Gene Expression by DNA/ Polycation/Polyanion Ternary Complexses

Tomoko Ito, Keiko Abe, Chieko Yoshihara, Naoko Iida Tanaka and Yoshiyuki Koyama

Mol Ther 13: S72-S73; doi:10.1016/j.ymthe.2006.08.210

187. Modular Cationic Peptides as Gene Delivery Agents

Rukkumani Rajagopalan, Jennifer Xavier, Nalam M. Rao and Vijaya Gopal

Mol Ther 13: S73-S73; doi:10.1016/j.ymthe.2006.08.211

188. Internalization of Novel Delivery Vector TAT-Streptavidin into Human Cells

Johanna Rinne, Brian Albarran, Juulia Jylh|[auml]|v|[auml]|, Teemu O. Ihalainen, Pasi Kankaanp|[auml]||[auml]|, Vesa P. Hyt|[ouml]|nen, Patrick S. Stayton, Markku S. Kulomaa and Maija Vihinen-Ranta

Mol Ther 13: S73-S73; doi:10.1016/j.ymthe.2006.08.212

189. Enhanced Nuclear Import and Transfection Efficiency by Disaccharide-Modified PEIs

Takeshi Nagasaki, Toshiki Shiga, Tomomi Jinta and Seiji Shinkai

Mol Ther 13: S73-S74; doi:10.1016/j.ymthe.2006.08.213

190. Gene Delivery without Nonspecific Biological Response: Comprehensive Analysis of Cell Bioactivity Using a Novel Cationic Polymer-Based System

Kayo Masago, Keiji Itaka, Nobuhiro Nishiyama, Shigeto Fukushima and Kazunori Kataoka

Mol Ther 13: S74-S74; doi:10.1016/j.ymthe.2006.08.214

191. Design, Synthesis, and Characterization of a New Class of Quaternary Ammonium Gemini Amphiphiles for Gene Delivery

Qun Li, Guisheng Zhang, Wei Xu and Dexi Liu

Mol Ther 13: S74-S74; doi:10.1016/j.ymthe.2006.08.215

192. RGD- Functionalised Liposome for Tumour Targeting

Jianmeizi (May) Chen, Ayesha Ahmad, Andrew D. Miller, Michael Keller, Eric Perouzel and Michael R. Jorgensen

Mol Ther 13: S74-S75; doi:10.1016/j.ymthe.2006.08.216

193. Gene Transfection Using Inorganic Particle/PVA/DNA Complexes Prepared by Ultra High Pressure Technology

Tsuyoshi Kimura, Kwangoo Nam, Sihngo Mutsuo, Hidekazu Yoshizawa, Masahiro Okada, Tsutomu Furuzono, Toshiya Fujisato and Akio Kishida

Mol Ther 13: S75-S75; doi:10.1016/j.ymthe.2006.08.217

194. Development of Novel DNA Formulations Based on Polymers and Cyclodextrin for Gene Delivery to the Muscle

Caroline Roques, Andr|[eacute]| Salmon, Marc Y. Fiszman, Elias Fattal and Yves Fromes

Mol Ther 13: S75-S76; doi:10.1016/j.ymthe.2006.08.218

195. Tat Peptide Conjugates of Low Molecular Weight Polyethylenimine as Effective Non-Viral Gene Delivery Vectors

Shu Wang

Mol Ther 13: S76-S76; doi:10.1016/j.ymthe.2006.08.219

196. Genetic Manipulation of Dendritic Cells through the Use of Immunolipoplexes To Induce T Cell-Specific Tolerance In Vivo

Peng H. Tan, Robert I. Lechler, Giovanna Lombardi and Andrew J.T. George

Mol Ther 13: S76-S76; doi:10.1016/j.ymthe.2006.08.220

197. Development of Chitosan Nanoparticles for Gene Delivery System

Zhi-Hong Yang, Toshinori Sato and Yoshiyuki Koyama

Mol Ther 13: S76-S77; doi:10.1016/j.ymthe.2006.08.221

198. In Vitro and In Vivo Gene-Transferring Characteristics of Novel Cationic Lipids, DMKD(O,O|[prime]|-dimyristyl-N-lysyl aspartate) and DMKE(O,O|[prime]|-dimyristyl-N-lysyl Glutamate)

Hong Sung Kim, In Ho Song, Jong Chul Kim, Eun Jung Kim, Yeon Kyung Lee, Jung Seok Kim, Kyung Hye Koo, Doo Ok Jang and Yong Serk Park

Mol Ther 13: S77-S77; doi:10.1016/j.ymthe.2006.08.222

199. Plasmid DNA Delivery by Nanoparticule Loaded Coronary Stent

Cunxian Song, Xu Jin, Dunwan Zhu, Chao Zhang, Hongfan Sun, Linhua Zhang and Kangde Yao

Mol Ther 13: S77-S78; doi:10.1016/j.ymthe.2006.08.223

200. A Novel Non-Viral Polymer for Plasmid Delivery to Bone Marrow Stromal Cells (BMSC)

Basak A. Clements, Vanessa Incani, Cezary Kucharski, Afsaneh Lavasanifar and Hasan Uludag

Mol Ther 13: S78-S78; doi:10.1016/j.ymthe.2006.08.224

201. Selective Targeting of Nucleic Acid Nanoparticles to Hepatocytes In Vivo

Darren H. Wakefield, So Wong, David B. Rozema, Jason J. Klein and Jon A. Wolff

Mol Ther 13: S78-S78; doi:10.1016/j.ymthe.2006.08.225

202. Effect of Modification with Lipophilic Fragments and Inclusion of Endosomolytic Peptide on Transfection Efficiency Mediated by Lysine Dendrimers

Anna A. Egorova, Polina L. Il'ina, Anton V. Kiselev, Aleksandre N. Baranov, Irina I. Tarasenko, Gennadii P. Vlasov and Vladislav S. Baranov

Mol Ther 13: S78-S78; doi:10.1016/j.ymthe.2006.08.226

203. Salt Conditions during Polyplex Formation Significantly Alters Transfection

Qixin Leng, Jason Kahn, Jingsong Zhu, Puthapparampil Scaria and Archibald J. Mixson

Mol Ther 13: S79-S79; doi:10.1016/j.ymthe.2006.08.227

204. Novel Gene Transduction Technology by Credia TF

Motoyoshi Tanaka, Madoka Tonosaki, Masafumi Umekage, Tomio Konaka, Ikeda Hisafumi and Hirotsugu Uemura

Mol Ther 13: S79-S79; doi:10.1016/j.ymthe.2006.08.228

205. AAV-Mediated Gene Transfer to Muscle and Liver of MPS VI Animal Models

Alessandra Tessitore, Armida Faella, Fabiana Parisi, Mark Haskins and Alberto Auricchio

Mol Ther 13: S79-S79; doi:10.1016/j.ymthe.2006.08.230

206. Frequency and Analysis of Liver Tumors in AAV-Treated B6C3F1 Hybrid Mice

Peter L. Bell, A. David Moscioni, Robert J. McCarter, Di Wu, Guang-Ping Gao, Albert Hoang, Julio San Miguel, Xun Sun, Nelson Wivel, Steven E. Raper, Emma E. Furth, Mark L. Batshaw and James M. Wilson

Mol Ther 13: S80-S80; doi:10.1016/j.ymthe.2006.08.231

207. Long-Term Therapy for PKU in Mice by rAAV Pseudotype 8 Gene Transfer to Liver

Alexandre Rebuffat, Zhaobing Ding, Panco Georgiev and Beat Thony

Mol Ther 13: S80-S80; doi:10.1016/j.ymthe.2006.08.232

208. Sleeping Beauty Transposon-Mediated Long-Term |[alpha]|-L-iduronidase Expression and Correction of Lysosomal Pathology in the Murine Model of Mucopolysaccharidosis (MPS) Type I

Elena L. Aronovich, Jason B. Bell, Lalitha R. Belur, Roland Gunther, Brenda Koniar, David C.C. Erickson, Patricia A. Schachern, R. Scott McIvor, Chester B. Whitley and Perry B. Hackett

Mol Ther 13: S80-S81; doi:10.1016/j.ymthe.2006.08.233

209. Correction of Hunter Syndrome in the MPSII Mouse Model by AAV2/8-Mediated Gene Delivery

Monica Cardone, Vinicia Assunta Polito, Stefano Pepe, Linda Mann, Alessandra D'Azzo, Alberto Auricchio, Andrea Ballabio and Maria Pia Cosma

Mol Ther 13: S81-S81; doi:10.1016/j.ymthe.2006.08.234

210. Permanent Correction of Leptin Deficiency through Cutaneous Gene Therapy. Lentivirus but Not Retrovirus-Transduced Human Keratinocyte Orthotopic Grafts Achieve Therapeutic Systemic Leptin Levels

Laura Rico, Isabel Mirones, Blanca Duarte, Almudena Holguin, Antonio Bernad, Marcela Del Rio and Fernando Larcher

Mol Ther 13: S81-S81; doi:10.1016/j.ymthe.2006.08.235

211. Development of Helper-Dependent Adenovirus (HDAd) Vectors for Gene Therapy in the Mouse Model for Glycogen Storage Disease Type Ia (GSD-Ia)

Dwight D. Koeberl, Lopamudra Banerjee, Baodong Sun, Andrew Bird, Y.T. Chen, Kazuhiro Hiro and Lawrence Chan

Mol Ther 13: S81-S82; doi:10.1016/j.ymthe.2006.08.236

212. Delivery of Galactocerebrosidase Activity to the Peripheral Nervous System of Mice with Globoid Cell Leukodystrophy (Krabbe Disease) by Intramuscular Injection

Mohammad A. Rafi, Han Zhi Rao, Paola Luzi, Mark T. Curtis and David A. Wenger

Mol Ther 13: S82-S82; doi:10.1016/j.ymthe.2006.08.237

213. Improving the Therapeutic Index of Helper-Dependent Adenoviral Vector for Crigler-Najjar Gene Therapy

David Dimmock, Nicola Brunetti-Pierri, Viraj Mane, Donna Palmer, Arthur Beaudet and Philip Ng

Mol Ther 13: S82-S82; doi:10.1016/j.ymthe.2006.08.238

214. Dominant-Negative Interference in the Pahenu2 Mouse: Modified Forms of PAH

Andreas Zori, Dawn D. Yang, Jon-Michael Knapp, Catherine E. Charron, Jennifer E. Embury, Stacy L. Porvasnik and Philip J. Laipis

Mol Ther 13: S82-S83; doi:10.1016/j.ymthe.2006.08.239

215. Treating Hypoparathyroidism through Regulated Expression of Parathyroid Hormone in Skeletal Muscle

Maja Z. Salva and Stephen D. Hauschka

Mol Ther 13: S83-S83; doi:10.1016/j.ymthe.2006.08.240

216. Long Term Portal Vein Administration of AAV-WPRE Vector Results in Increased Incidence of Neoplastic Disease and Hepatic Pathology

Jennifer E. Embury, Catherine C. Charron, Amy E. Poirier, Andreas Zori, Russ Carmichael, Terry R. Flotte and Philip J. Laipis

Mol Ther 13: S83-S83; doi:10.1016/j.ymthe.2006.08.241

217. Comparison of Hepatic Vein and Peripheral Vein Delivery of an AAV2/8 Vector Encoding Human a-Galactosidase A to Rhesus Macaques

Bradley L. Hodges, Qiuming Chu, Jennifer B. Nietupski, Karen M. Ashe, Kristin M. Taylor, Robin J. Ziegler, Seng H. Cheng, John Marshall and Ronald K. Scheule

Mol Ther 13: S84-S84; doi:10.1016/j.ymthe.2006.08.242

218. Gene Therapy and Enzyme Replacement in a Mouse Model of Late Infantile Neuronal Ceroid Lipofuscinosis

Michael Chang, David Sleat, Seng Cheng, Marco Passini, Peter Lobel and Beverly L. Davidson

Mol Ther 13: S84-S84; doi:10.1016/j.ymthe.2006.08.243

219. Persistent Correction of Hyperphenylalaninemia Following Liver-Directed, rAAV2/8-Mediated Gene Therapy for Murine Phenylketonuria (PKU)

Cary O. Harding, Melanie B. Gillingham, Elizabeth Daghighi, Andrew Bird and Dwight D. Koeberl

Mol Ther 13: S84-S84; doi:10.1016/j.ymthe.2006.08.244

220. AAV Mediated Gene Transfer of Smad7 in Different Models of Cystic Kidney Diseases

Andrea Keppler, Barbara Leuchs, Carolin Stump, Steven Dooley, Juergen Kleinschmidt and Norbert Gretz

Mol Ther 13: S85-S85; doi:10.1016/j.ymthe.2006.08.245

221. A New Retroviral Gene Therapy Approach for Cystinuria Research

Sreedhar Sagi, Marcus Picard-Maureau, Rudiger Dorries, Peter Alken, Maurice S. Michel and Thomas Knoll

Mol Ther 13: S85-S85; doi:10.1016/j.ymthe.2006.08.246

222. Aberrant Striatal Gene Expression in the Striatum of HPRT-Knockout Mouse

Shaochun Song, C. Ramana Bhasker, Ling Guo and Theodore Friedmann

Mol Ther 13: S85-S85; doi:10.1016/j.ymthe.2006.08.247

223. Proteomic Analysis of the Striatum of Wild Type and HPRT-Deficient Mouse

Ling T. Guo, Charles C. King, Shaochun Song and Theodore Friedmann

Mol Ther 13: S85-S86; doi:10.1016/j.ymthe.2006.08.248

224. Pyruvate Dehydrogenase Complex Deficiency Caused by the Ubiquitin-Proteasome System-Mediated Degradation in E1|[beta]| Subunit

Zongchao Han, Arun Srivastava and Peter Stacpoole

Mol Ther 13: S86-S86; doi:10.1016/j.ymthe.2006.08.249

225. A Novel Mechanism between Diabetes Mellitus Complications and Procalcitonin Gene Expression

Mehmet A. Soylemez, Ceyhan Sayar, Bilge Turkover, Guven Toksoy and Tulay Yardimci

Mol Ther 13: S86-S86; doi:10.1016/j.ymthe.2006.08.250

226. Effective Gene Therapy in an Authentic Mouse Model of Tay-Sachs Related Diseases

Begona Cachon-Gonzlez, Susan Wang, Robin Ziegler, Seng H. Cheng and Timothy M. Cox

Mol Ther 13: S86-S87; doi:10.1016/j.ymthe.2006.08.251

227. Sustained Correction of Hyperphenylalaninemia in Female Pahenu2 Mouse by a Self-Complementary Adeno-Associated Virus Vector

Akihiro Kume, Tsuyoshi Ogura, Takashi Matsushita, Hiroaki Mizukami, Masashi Urabe, Takashi Okada and Keiya Ozawa

Mol Ther 13: S87-S87; doi:10.1016/j.ymthe.2006.08.252

228. AAV Mediated Hypoxia-Inducible VEGF Expression and Neovascular Formation in Ischemic Pig Myocardium

Hua Su, Yerem Yeghiazarians, Andrew Lee, Yu Huang, Janice Arakawa-Hoyt, Jianqin Ye, Gina Orcino, William Growssman and Yuet W. Kan

Mol Ther 13: S87-S87; doi:10.1016/j.ymthe.2006.08.254

229. Use of rAAV Transduced Endothelial Progenitor Cells for the Treatment of Myocardial Infarction in Rat Model

Sabyasachi Sen, Juan Merchan, Jarrod Dean, Marcia Silver, Mary Gavin, Elizabeth Eaton, Tengiz Tkebuchava, Maasaki Ii, Young-Sup Yoon, Douglas W. Losordo and Ryuichi Aikawa

Mol Ther 13: S88-S88; doi:10.1016/j.ymthe.2006.08.255

230. In Vivo Fluorescence Tracking System for Cardiac Stem Cell Therapy

Kozo Hoshino, Hung Q. Ly, Irina Pomerantseva, Yoshiaki Takewa, Ryuichi Yoneyama, Yoshiaki Kawase, Alec M. DeGrande, John V. Frangioni and Roger J. Hajjar

Mol Ther 13: S88-S88; doi:10.1016/j.ymthe.2006.08.256

231. Gene Transfer of a Synthetic Pacemaker Channel into the Heart: A Novel Strategy for Biological Pacing

Yuji Kashiwakura, Hee Choel Cho, Ezana Azene and Eduardo Marb|[aacute]|n

Mol Ther 13: S89-S89; doi:10.1016/j.ymthe.2006.08.257

232. Short-Term, In Vivo Correction of VLCAD Deficiency in Mice: Steps toward a Gene Therapy for Cardiomyopathy

Tien Nguyen, Jan Daniels, Lawrence Merritt, Dietrich Matern, Jerry Vockley, Philip A. Wood and David B. Schowalter

Mol Ther 13: S89-S89; doi:10.1016/j.ymthe.2006.08.258

233. Conjugating Polymer Vector to Magnetic Nanobeads Enhances Local Gene Expression in the Heart

Wenzhong Li, Nan Ma, Leelee Ong, Alexander Kaminski, Peter Lorenz, Brigitte M. Putzer, Ren-Ke Li, Christof Stamm and Gustav Steinhoff

Mol Ther 13: S89-S89; doi:10.1016/j.ymthe.2006.08.259

234. Long Term Effects of pcDNA3-VEGF165 Intramyocardial Transfer after Experimental Myocardial Infarction in the Rat Scar Tissue Extracellular Matrix

Fabio D. Mataveli, Sang W. Han, Aline Mendes, Rose Kanashiro, Paulo Tucci, Helena B. Nader and Maria Aparecida S. Pinhal

Mol Ther 13: S90-S90; doi:10.1016/j.ymthe.2006.08.260

235. Herpes Simplex Virus Vector Mediated Heme Oxygenase Gene Therapy of Heart Ischemia-Reperfusion

William F. Goins, Arthur R. Frampton, Atsunori Nakao, Koji Tomiyama, David S. Clawson, James Wechuck, Shao-hua Huang, David M. Krisky, Justus B. Cohen, Noriko Murase and Joseph C. Glorioso

Mol Ther 13: S90-S90; doi:10.1016/j.ymthe.2006.08.261

236. Ultrasound-Targeted Microbubble Destruction Augments Cardiac AAV-Mediated Gene Transfer after Systemic Administration in Adult Rats

Oliver J. M|[uuml]|ller, Stefanie Schinkel, Hugo A. Katus, J|[uuml]|rgen A. Kleinschmidt and Raffi Bekeredjian

Mol Ther 13: S91-S91; doi:10.1016/j.ymthe.2006.08.262

237. Gene Expression Profiles in Diabetic Cardiomyopathy Following SERCA2a Gene Transfer

Djamel Lebeche, Susumu Sakata, Yuri Sakata, Naoya Sakata, Elie R. Chemaly, Miyako Takaki and Roger J. Hajjar

Mol Ther 13: S91-S91; doi:10.1016/j.ymthe.2006.08.263

238. Knock down Phospholamban To Improve Heart Function by AAV-Mediated shRNA

Xiaochun Lu, Guang Yang, Xiaoying Li and Xiaobing Wu

Mol Ther 13: S91-S92; doi:10.1016/j.ymthe.2006.08.264

239. Histological Measurement of Myocardial Infarct Area Does Not Provide a Sensitive Assessment of Infarct Size in a Mouse Chronic Infarct Model

Junya Takagawa, Yan Zhang, Richard E. Sievers, Neel K. Kapasi, Maelene L. Wong, Yerem Yeghiazarians, Randall J. Lee, William Grossman and Matthew L. Springer

Mol Ther 13: S92-S92; doi:10.1016/j.ymthe.2006.08.265

240. Hemiparkisonism Induced through Unilateral Expression of Adenovirus-Mediated Clostridial Light Chain Gene in the Substantia Nigra

Jun Yang, Qingshan Teng, Mary E. Garrity-Moses, Thais Federici, John Butler, Shearwood McClelland III and Nicholas M. Boulis

Mol Ther 13: S92-S92; doi:10.1016/j.ymthe.2006.08.267

241. A Dose-Ranging Study of AAV-hAADC Therapy in Parkinsonian Monkeys

John R. Forsayeth, Jamie L. Eberling, Laura M. Sanftner, Zhu Zhen, Philip Pivirotto, John Bringas, Janet Cunningham and Krystof S. Bankiewicz

Mol Ther 13: S93-S93; doi:10.1016/j.ymthe.2006.08.268

242. Neuronal Specificity of |[alpha]|-Synuclein Toxicity and the Effect of Parkin Co-Expression in Primates

Toru Yasuda, Masahiko Takada, Hideki Mochizuki and Yoshikuni Mizuno

Mol Ther 13: S93-S93; doi:10.1016/j.ymthe.2006.08.269

243. Control of Undesirable Effects of GDNF Delivered in the Striatum of Healthy Rats Using a Tetracycline-Inducible AAV1 Vector

Abdelwahed Chtarto, Xin Yang, Mansoor Sharifi, Olivier Bockstael, Enni Lehtonen, David Blum, Laurence Abeloos, Jean-Marie Jaspar, Thierry Velu, Jacques Brotchi, Marc Levivier and Liliane Tenenbaum

Mol Ther 13: S93-S93; doi:10.1016/j.ymthe.2006.08.270

244. New Gene Therapy for Parkinson's Disease by Down Regulation of |[alpha]|-Synuclein

Hideki Mochizuki, Hiromi Hayashita-Kinoh, Masanori Yamada and Yoshikuni Mizuno

Mol Ther 13: S93-S94; doi:10.1016/j.ymthe.2006.08.271

245. Delivery of IGF-1 in the Spinal Cord of a Mouse Model of ALS after Intraparenchymal Injection of an Adeno-Associated Vector

Christine Haenggeli, Angelo C. Lepore, Natalie Perez, Brian K. Kaspar and Jeffrey D. Rothstein

Mol Ther 13: S94-S94; doi:10.1016/j.ymthe.2006.08.272

246. Efficient Gene Transfer to Peripheral Nervous System Via Systemic Delivery of AAV Vectors

Chunping Qiao, Jianbin Li, Tong Zhu, Bing Wang, Juan Li, and Xiao Xiao

Mol Ther 13: S94-S94; doi:10.1016/j.ymthe.2006.08.273

247. Devising A|[beta]|-Specific Passive Immunization Strategies for Alzheimer's Disease Using rAAV Vector-Mediated scFv Antibody Delivery

Kelly L. Fowlkes, Michael A. Mastrangelo, Wade C. Narrow, Yona Levites, Todd E. Golde, Howard J. Federoff and William J. Bowers

Mol Ther 13: S94-S95; doi:10.1016/j.ymthe.2006.08.274

248. Revealing the Role(s) of TNF-alpha in Early Alzheimer's Disease Via rAAV-Mediated Hippocampal Gene Transfer in a Triple Transgenic Mouse Model

Michelle C. Janelsins, Michael A. Mastrangelo, Keigan M. Park, Kelly L. Fowlkes, Maria Kinsky, Wade C. Narrow, Salvatore Oddo, Frank M. LaFerla, Howard J. Federoff and William J. Bowers

Mol Ther 13: S95-S95; doi:10.1016/j.ymthe.2006.08.275

249. Fusion Intrabodies as Anti-Huntington Gene Therapy

Julie McLear, Jack Webster, Nikolas Webster and Anne Messer

Mol Ther 13: S95-S95; doi:10.1016/j.ymthe.2006.08.276

250. Protection Against Huntington's Diease Progression: AAV-Mediated Delivery of Biotherapeutics

Adrian P. Kells, Rebecca A. Henry, Stephanie M. Hughes, Richard L.M. Faull and Bronwen Connor

Mol Ther 13: S95-S96; doi:10.1016/j.ymthe.2006.08.277

251. Gene-Based Interferon-Beta Therapy for Experimental Autoimmune Encephalomyelitis

Ritika Jaini, Drew Hannaman, Justin M. Johnson, Robert M. Bernard, Cengiz Z. Altuntas, Maida M. de las Alas, Pavani Kesaraju, Alain Luxembourg, Claire F. Evans and Vincent K. Tuohy

Mol Ther 13: S96-S96; doi:10.1016/j.ymthe.2006.08.278

252. Targeted Transgene Integration of the Human ATM cDNA Mediated by HSV/AAV Hybrid Amplicon Vector

Jocelyn D. Sanford, Angelika Oehmig, Katherine F. Perry, Xandra O. Breakefield and Maria L. Cortes

Mol Ther 13: S96-S96; doi:10.1016/j.ymthe.2006.08.279

253. AAV Delivery of a Trans-Splicing RNA Re-Directs SMN2 Splicing and Results in Increased Full-Length SMN

Tristan H. Coady, Monir Shababi and Christian L. Lorson

Mol Ther 13: S97-S97; doi:10.1016/j.ymthe.2006.08.280

254. Protecting the CNS Using AntiOxidant Gene Transfer: HIV-1 Glycoprotein gp120 Induces Blood-Brain Barrier Abnormalities That May Be Prevented by rSV40 Gene Transfer of AntiOxidant Enzymes

Jean-Pierre Louboutin, Beverly A.S. Reyes, Lokesh Agrawal, Elisabeth J. van Bockstaele and David S. Strayer

Mol Ther 13: S97-S97; doi:10.1016/j.ymthe.2006.08.281

255. Preventing In Vivo Neurotoxicity Caused by HIV-1 Gp120 Using SV40 Vector Delivery of the Anti-Oxidant Enzymes Superoxide Dismutase and Glutathione Peroxidase

Lokesh Agrawal, Jean-Pierre Louboutin, Beverly A.S. Reyes, Elisabeth Van Bockstaele and David S. Strayer

Mol Ther 13: S97-S98; doi:10.1016/j.ymthe.2006.08.282

256. Novel Therapeutic Strategy for Ischemic Stroke by Bone Marrow Stromal Cells and Ex Vivo HGF and FGF2 Genes Transfer with Replication-Incompetent HSV-1 Vector

Naosuke Nonoguchi, Ming-Zhu Zhao, Naokado Ikeda, Yoshihito Miki, Daisuke Furutama, Fumiharu Kimura, Mari Dezawa, Hiroshi Funakoshi, Robert S. Coffin, Shin-ichi Miyatake and Toshihiko Kuroiwa

Mol Ther 13: S98-S98; doi:10.1016/j.ymthe.2006.08.283

257. VEGF Gene Transfered Bone Marrow Stromal Cells by Replication-Deficiet Herpes Simplex Virus Type-1 (HSV-1) Vector Can Improve the Neurological Deficits and Reduce the Infaction in Rat Ischemic Brain

Yoshihito Miki, Naosuke Nonoguchi, Naokado Ikeda, Ming-Zhu Zhao, Daisuke Furutama, Robert S. Coffin, Naosuke Nonoguchi and Shin-ichi Miyatake

Mol Ther 13: S98-S99; doi:10.1016/j.ymthe.2006.08.284

258. CNS-Directed Antioxidant Enzyme Delivery: Protecting Neurons from Oxidative Stress and Apoptosis Induced by HIV-1

Lokesh Agrawal, Jean-pierre Louboutin and David S. Strayer

Mol Ther 13: S99-S99; doi:10.1016/j.ymthe.2006.08.285

259. Plasmid DNA Encoding the Anti-Inflammatory Cytokine Gene, Interleukin-10 (IL-10) for Chronic Pain Control: Taking Advantage of Nuclear Scaffold/Matrix Attachment Regions

Erin D. Milligan, Stephen J. Langer, Travis S. Hughes, Evan M. Sloane, John H. Mahoney, Brian M. Jekich, Steven F. Maier, Leslie A. Leinwand and Linda R. Watkins

Mol Ther 13: S99-S99; doi:10.1016/j.ymthe.2006.08.286

260. ITRs Necessary for IL-10 Encoding Naked Plasmid Induced Reversal of Chronic Pain State in Rat

T.S. Hughes, S.J. Langer, E.M. Sloane, J. Mahoney, B. Jekich, K.W. Johnson, R.E. Chavez, E.D. Milligan, L.R. Watkins and L.A. Leinwand

Mol Ther 13: S100-S100; doi:10.1016/j.ymthe.2006.08.287

261. In Vivo Over-Expression of Fractalkine, a Putative Neuron-to-Glia Signal, To Characterize Underlying Mechanisms of Neuropathic Pain

Stephen J. Langer, David Busha, Erin D. Milligan, Travis S. Hughes, Julie Wieseler-Frank, Linda R. Watkins and Leslie A. Leinwand

Mol Ther 13: S100-S100; doi:10.1016/j.ymthe.2006.08.288

262. Delivery of CCL21 to Metastatic Disease Improves the Efficacy of Adoptive T Cell Therapy

Uma Thanarajasingam, Laura Sanz Alcober, Rosa Maria Diaz, Jian Qiao, Luis Sanchez-Perez, Timothy Kottke, Jill Thompson and Richard Vile

Mol Ther 13: S100-S101; doi:10.1016/j.ymthe.2006.08.316

263. Antigen-Specific and MHC-Independent Tumor Cell Lysis by Redirected Human CD4+ T Cells Grafted with an Antibody-Type Immunoreceptor

Andreas Hombach, Heike Koehler, Gunter Rappl and Hinrich Abken

Mol Ther 13: S101-S101; doi:10.1016/j.ymthe.2006.08.317

264. Immune Gene-Therapy of Cancer Using Redirected Na|[iuml]|ve or Effector Lymphocytes

Dinorah Friedmann-Morvinski, Tova Waks and Zelig Eshhar

Mol Ther 13: S101-S101; doi:10.1016/j.ymthe.2006.08.318

265. Non-Viral Delivery of Interleukin-2 and Soluble Flk-1 Inhibits Metastatic and Primary Tumor Growth in Renal Cell Carcinoma

James W. Yockman, Won Jong Kim, Chien-Wen Chang and Sung Wan Kim

Mol Ther 13: S101-S101; doi:10.1016/j.ymthe.2006.08.319

266. Gene Modification of T Antigen Presenting Cells for the Induction of Antitumor Immunity

Aaron E. Foster, Ann M. Leen, Timothy Lee, Juan Vera, Gianpietro Dotti and Cliona M. Rooney

Mol Ther 13: S101-S102; doi:10.1016/j.ymthe.2006.08.320

267. Synergistic Antitumor Effect of neu DNA Vaccine and Low Dose of Geldanamycin

Chi-Chen Lin, Meng-Chi Yen and Ming-Derg Lai

Mol Ther 13: S102-S102; doi:10.1016/j.ymthe.2006.08.321

268. CD19-Targeted Normal and CLL Patient T Cells Expanded with Beads Can Eradicate Systemic Tumors In Vivo

J. Stefanski, R. Brentjens, D. Hollyman, M. Bonyhadi, M. Sadelain and I. Rivi|[egrave]|re

Mol Ther 13: S102-S102; doi:10.1016/j.ymthe.2006.08.322

269. Integrated CD28 and 4-1BB Signals Strongly Potentiate CD8+ T Cell Mediated radication of Metastatic Prostate Cancer

Xiao-Song Zhong, Maiko Matsushita, Aurore Saudemont, Elmer Santos and Michel Sadelain

Mol Ther 13: S103-S103; doi:10.1016/j.ymthe.2006.08.323

270. The RheoSwitch|[reg]| Therapeutic System Precisely Regulates IL-2 Expression in Melanoma Cells and Supports Survival of NK Cells at the Tumor Site

Anand K. Katakam, Qin Yang, Steve Goding, Prasanna Kumar and Per H. Basse

Mol Ther 13: S103-S103; doi:10.1016/j.ymthe.2006.08.324

271. Full-Length Antibody Therapy Mediated by Adenovirus in Rodent and Non-Primate Animal Models

Wenfang Shi, Jie Chen, Minghong Jiang, Changqing Su and Qijun Qian

Mol Ther 13: S104-S104; doi:10.1016/j.ymthe.2006.08.325

272. Conversion of a Tumor-Binding Peptide Identified by Phage Display to a Functional Chimeric T-Cell Antigen Receptor

Colette R.J. Pameijer, Araceli Hamlett, Bessie Meechovet, Jamie Buckmaster, Brenda Aguilar, Christine Wright, Wen- Chung Chang, Christine E. Brown and Michael C. Jensen

Mol Ther 13: S104-S104; doi:10.1016/j.ymthe.2006.08.326

273. Immuno Gene Therapy of Feline Fibrosarcoma Using Intratumoral Magnetofection or Gene-Activated Matrices for Gene Delivery |[ndash]| Preliminary Results of a Veterinary Clinical Study

Ulrike Schillinger, Bianca Schwarz, Tina Kempf, Anika Jahnke, Cornelia Fischer, Anne Loecher, Stefanie Schlemmer, Johannes Hirschberger, Thomas Brill, Roberto Koestlin, Bernd Gaensbacher and Christian Plank

Mol Ther 13: S105-S105; doi:10.1016/j.ymthe.2006.08.327

274. Antitumor Effect of Controlled Expression of Interleukin-12 in a Murine Model of Liver Metastases

Itsaso Mauleon, Julien Crettaz, Gloria Gonzalez-Aseguinolaza, Maider Zabala, Gabriela Kramer, Stephan Kochanek, Jesus Prieto and Ruben Hernandez-Alcoceba

Mol Ther 13: S105-S105; doi:10.1016/j.ymthe.2006.08.328

275. Immunostimulatory Antigen Loaded Microparticles as Cancer Vaccines

Aliasger K. Salem, Anthony D. Sandler, George J. Weiner, Xueqing Zhang, Nicki K. Baman, Xiaoyan Zhu and Christopher E. Dahle

Mol Ther 13: S105-S105; doi:10.1016/j.ymthe.2006.08.329

276. Phase I Trial of Sequential Administration of Recombinant DNA and Adenovirus Expressing L523S Protein in Early Stage Non Small Cell Lung Cancer (NSCLC)

John Nemunaitis, Thomas Meyers, Neil Senzer, Casey Cunningham, Howard West, Eric Vallieresma, Stephen Anthony, Svetislava Vukelja, Barry Berman, Heather Tully, Beena Pappen, Stephen Sarmiento, Rosemarie Arzaga, Steven Duniho, Susan Engardt, Madeleine Meagher and Martin Cheever

Mol Ther 13: S106-S106; doi:10.1016/j.ymthe.2006.08.330

277. Clinical Evaluation of Dendritic Cell Vaccination for Patients with Recurrent Glioma: Results of a Clinical Phase I/II Trial

Ryuya Yamanaka, Junpei Homma, Naoki Yajima, Masakazu Sano and Masuhiro Takahashi

Mol Ther 13: S106-S106; doi:10.1016/j.ymthe.2006.08.331

278. Therapeutic Activities of IL-12 Gene- Modified Macrophages Embedded in Gelatin Matrix Hemostatic Sealant (FloSeal|[reg]|) in a Mouse Model of Residual Prostate Cancer

Ken-ichi Tabata, Masami Watanabe, Takefumi Satoh, Wei-hau Tian, Hongyu Wang, ElMoataz Abdel Fattah, Guang Yang, Daniel Floryk, Dov Kadmon and Timothy C. Thompson

Mol Ther 13: S106-S106; doi:10.1016/j.ymthe.2006.08.332

279. Eradication of Renal Cell Carcinoma in Mice Mediated by NK Cell Activation Using Inactivated Sendai Virus Particle (HVJ-E)

Atsuko Fujihara, Masayuki Kurooka, Tsuneharu Miki and Yasufumi Kaneda

Mol Ther 13: S107-S107; doi:10.1016/j.ymthe.2006.08.333

280. RANTES and TARC Enhanced the Antitumor Immune Effects of GM-CSF

Hiroyuki Inoue, Takafumi Nakamura, Meng Xin, Yoshito Beppu, Gaku Sakaguchi, Ryo Kurita, Hidenori Hase, Yukoh Nakazaki, Yoshikazu Yonemitsu, Koichi Takayama, Yoichi Nakanishi, Yusuke Nakamura, Shigetaka Asano and Kenzaburo Tani

Mol Ther 13: S107-S107; doi:10.1016/j.ymthe.2006.08.334

281. Adenovirus-Mediated CD40 Ligand Therapy Induces Tumor Cell Apoptosis and Systemic Immunity in the TRAMP-C2 Mouse Prostate Cancer Model

Helena Dzojic, Angelica Loskog, Thomas Totterman and Magnus Essand

Mol Ther 13: S107-S107; doi:10.1016/j.ymthe.2006.08.335

282. Antitumor Efficacy of Intravenous Administration of Oncolytic Herpes Simplex Virus Expressing Interleukin 12

Yi Guan, Yasushi Ino, Hiroshi Fukuhara and Tomoki Todo

Mol Ther 13: S108-S108; doi:10.1016/j.ymthe.2006.08.336

283. DNA Vaccination with Genes Encoding an Antigenic Protein and Fas Ligand Increased Antigen-Specific Humoral Responses

Osamu Shimozato, Ayako Sato, Kiyoko Kawamura, Quanhai Li, Guangyu Ma and Masatoshi Tagawa

Mol Ther 13: S108-S108; doi:10.1016/j.ymthe.2006.08.337

284. Reduced Lung Metastasis of Secreted Type of Substance P Gene Modified Mouse Melanoma Cells

Xianghui He, Zhixiang Zhang, Liwei Zhu, Tom C. Tsang and David T. Harris

Mol Ther 13: S108-S108; doi:10.1016/j.ymthe.2006.08.338

285. Concanavalin A That Bears Direct Cytotoxicity and Immunomodulating Activity Via Mannose-Specific Cellular Binding Has Therapeutic Effect in a Murine In Situ Hepatoma Model

Chih-Peng Chang, Ying-Tai Jin and Huan-Yao Lei

Mol Ther 13: S109-S109; doi:10.1016/j.ymthe.2006.08.339

286. Biodistribution and Cearance Following Intraperitoneal Injection of Murine Interleukin-12 Plasmid Formulated with a Novel Polymeric Delivery System

Elaine Brunhoeber, Majed Matar, Khursheed Anwer and Jason G. Fewell

Mol Ther 13: S109-S109; doi:10.1016/j.ymthe.2006.08.340

287. Safety and Toxicity Following Intraperitoneal Injection of Murine Interleukin-12 Plasmid Formulated with a Novel Polymeric Delivery System

Jason G. Fewell, Jennifer Rice, Majed Matar and Khursheed Anwer

Mol Ther 13: S109-S109; doi:10.1016/j.ymthe.2006.08.341

288. Bi-Modality Induction of TNF|[alpha]|: Neoadjuvant Chemoradiotherapy and TNFerade|[trade]| in Patients with Locally Advanced, Resectable Esophageal Carcinoma

Neil Senzer, Kenneth Chang, Stephen Swisher, Tony Reid, Ann Mauer, Amitabh Chak, Harlan Pinto and John Nemunaitis

Mol Ther 13: S110-S110; doi:10.1016/j.ymthe.2006.08.343

289. Adenoviral-Mediated p53 Gene Therapy (Advexin) in a Patient with Li-Fraumeni Syndrome with a Mixed Germ Cell Tumor: Tolerability and Response

Neil Senzer, Jeffrey Lamont and John Nemunaitis

Mol Ther 13: S110-S110; doi:10.1016/j.ymthe.2006.08.344

290. Prolegomenon to a Phase II Study of an ICP34.5/ICP47 Deleted Herpes Simplex Virus Containing the Coding Sequence for GM-CSF in Patients with Melanoma

Neil Senzer and John Nemunaitis

Mol Ther 13: S110-S110; doi:10.1016/j.ymthe.2006.08.345

291. In Vivo Characterization of Seneca Valley Virus (SVV-001), a Novel Oncolytic Picornavirus for Systemic Treatment of Patients with Solid Tumors with Neuroendocrine Features

Kevin D. Burroughs, Kristine Skele, Christian Sherk, Brian Jones, Ann-Jeanette Vasko, Laura Hales, Seshidhar R. Police and Paul L. Hallenbeck

Mol Ther 13: S111-S111; doi:10.1016/j.ymthe.2006.08.346

292. Polyethylenimine Mediated Oral Cancer Targeted PUMA Gene Delivery Suppressed Tumor Growth and Prolonged Survival

Benson Chen, Ming-Shyan Huang, Steven Yeh, Mark Y.P. Kuo and Michael Hsiao

Mol Ther 13: S111-S111; doi:10.1016/j.ymthe.2006.08.347

293. Sustained Expression of Kringle 1 Domain of Human Hepatocyte Growth Factor (HGFK1) Effectively Inhibits Angiogenesis, Growth and Metastasis of Hepatocellular Carcinoma

Zan Shen, Zhen Fan Yang, Yi Gao, Ching Chiu Liu, Samuel S. Ng, Sheung Tat Fan, Ming-liang He, Tsai-ping Li, Ren-bao Gan, Hsiang-fu Kung and Marie Chia-mi Lin

Mol Ther 13: S111-S112; doi:10.1016/j.ymthe.2006.08.348

294. The Histone Deacetylase Inhibitor FK228 Increases Histone Acetylation, Coxsackie Adenovirus Receptor Levels and Adenovirus Transgene Expression in Human LOX IMVI Melanoma Xenografts

Merrill E. Goldsmith, Kenneth Steadman, Alian Aguila, Michael C. Alley, William R. Waud, Susan Bates and Tito Fojo

Mol Ther 13: S112-S112; doi:10.1016/j.ymthe.2006.08.349

295. Effects of Sustained Anti-Angiogenic Gene Therapy in Multi-Stage Prostate Cancer in TRAMP Mice

Tatyana Isayeva, Diptiman Chanda and Selvarangan Ponnazhagan

Mol Ther 13: S112-S112; doi:10.1016/j.ymthe.2006.08.350

296. Transgene Expression and Neutralizing Antibody Production after Submandibular Gland Administration of AdhAQP1

Corinne M. Goldsmith, Changyu Zheng, Molly Vallant, Richard D. Irwin and Bruce J. Baum

Mol Ther 13: S113-S113; doi:10.1016/j.ymthe.2006.08.351

297. Safety of Repeat Intracerebral Administration of MV-CEA in Rhesus Macaques in Support of a Phase I/II Clinical Trial for Patients with Recurrent Gliomas

Rae M. Myers, Mary E. Harvey, Suzanne M. Greiner, Diane C. Soeffker, James W. Krempski, Paula J. Zollman, Steven E. Shelton, Raffel Corey, Goerss J. Stephan, Kaufmann J. Timothy, Federspiel J. Mark, Peng Kah-Whye, Russell J. Stephen and Galanis Evanthia

Mol Ther 13: S113-S113; doi:10.1016/j.ymthe.2006.08.352

298. Combination Effect of Telomerase-Specific Replication-Competent Adenovirus (Telomelysin, OBP-301) and p53 Gene Therapy in Human Non- Small Cell Lung and Colon Cancer Cells

Ryo Sakai, Fuminori Teraishi, Toru Kojima, Yoshihiro Ikeda, Masayoshi Hioki, Toshiya Fujiwara, Futoshi Uno, Shunsuke Kagawa, Yuuri Hashimoto, Yuichi Watanabe, Yasuo Urata, Noriaki Tanaka and Toshiyoshi Fujiwara

Mol Ther 13: S114-S114; doi:10.1016/j.ymthe.2006.08.353

299. In Vivo Luciferase Imaging for Analysis of Oncolytic Adenoviruses for Renal Cell Cancer

Kilian Guse, Tuuli Ranki, Tanja Hakkarainen, Martti Ala- Opas, Tommi Pisto, Merja S|[auml]|rkioja, Maria Rajecki, Anna Kanerva and Akseli Hemminki

Mol Ther 13: S114-S114; doi:10.1016/j.ymthe.2006.08.354

300. Gene Therapy for Gastric Cancer Cells Via CEA-Targeted Adv-FZ33

Toshihiro Tanaka, Jianhua Huang, Sachie Hirai, Motomu Kuroki, Masahide Kuroki, Naoki Watanabe, Kazunori Kato and Hirofumi Hamada

Mol Ther 13: S114-S115; doi:10.1016/j.ymthe.2006.08.355

301. Safe and Effective Treatment of Ovarian Cancer Models Using Targeted Adenovirus Vector Delivery and Selective Expression of Tumor Necrosis Factor

Selva R. Murugesan, Masaki Akiyama, David A. Einfeld, Thomas J. Wickham and C. Richter King

Mol Ther 13: S115-S115; doi:10.1016/j.ymthe.2006.08.356

302. Anti-Angiogenic Treatment Enhances Anti- Tumor Effects of an Oncolytic Virus in an Experimental Rat Glioma Model

Kazuhiko Kurozumi, Jennifer Cutter, William Carson, Ming Yang, Gregory Christoforidis, Antonio E. Chiocca and Balveen Kaur

Mol Ther 13: S115-S116; doi:10.1016/j.ymthe.2006.08.357

303. Enhanced Antitumor Efficacy of Telomerase-Selective Oncolytic Adenoviral Agent OBP-401 with Docetaxel: Preclinical Evaluation of Chemovirotherapy

Yoshihiro Ikeda, Toshiya Fujiwara, Shunsuke Kagawa, Masayoshi Hioki, Ryo Sakai, Toru Kojima, Yasuo Urata, Noriaki Tanaka and Toshiyoshi Fujiwara

Mol Ther 13: S116-S116; doi:10.1016/j.ymthe.2006.08.358

304. Therapeutic Efficacy of a Mesothelin Promoter-Based Conditionally Replicative Adenovirus Monitored by In Vivo Imaging of an Ovarian Cancer Model

Yuko Tsuruta, Larisa Pereboeva, Martina Breidenbach, Daniel T. Rein, Masaharu Nakayama, Gene P. Siegal and David T. Curiel

Mol Ther 13: S116-S116; doi:10.1016/j.ymthe.2006.08.359

305. Targeting the Gene and the Derived Gene- Product into Tumors

Shulin Li, Ryan Craig and Marina Torrero

Mol Ther 13: S117-S117; doi:10.1016/j.ymthe.2006.08.360

306. Imaging HSV-1 Viral Oncolysis of Colon Cancer Cells by microPET

Darshini Kuruppu, Aijun Zhu, Meixiang Yu, Anna-Liisa Brownell and Kenneth K. Tanabe

Mol Ther 13: S117-S117; doi:10.1016/j.ymthe.2006.08.361

307. Prostate Targeted TSTA Oncolytic Adenovirus

Makoto Sato, Steve Huyn, Russell Powell, Michael Carey, Sanjiv S. Gambhir and Lily Wu

Mol Ther 13: S117-S118; doi:10.1016/j.ymthe.2006.08.362

308. Valproic Acid, a Histone Deacetylase Inhibitor, Is an Antagonist for Oncolytic Adenoviral Gene Therapy

Naser Uddin Hoti, Shawn E. Lupold, Wasim Chowdhury, Jer-Tsong Hsieh and Ronald Rodriguez

Mol Ther 13: S118-S118; doi:10.1016/j.ymthe.2006.08.363

309. Oncolytic Efficacy and Enhanced Safety of Measles Virus Activated by Tumor-Secreted Matrix-Metalloproteases

Christoph Springfeld, Veronika von Messling, Marie Frenzke, Guy Ungerechts, Christian Buchholz and Roberto Cattaneo

Mol Ther 13: S118-S118; doi:10.1016/j.ymthe.2006.08.364

310. Antitumor Effect of Telomerase-Specific Virotherapy in Pleural Dissemination of Human Malignant Mesothelioma

Yuichi Watanabe, Yuuri Hashimoto, Toru Kojima, Shunsuke Kagawa, Hitoshi Kawamura, Katsuyuki Nagai, Noriaki Tanaka, Yasuo Urata and Toshiyoshi Fujiwara

Mol Ther 13: S118-S118; doi:10.1016/j.ymthe.2006.08.365

311. Target-Specific Knockdown and Enhanced Anti-Tumor Outcome by an Oncolytic Virus- Delivered Small Interfering RNA (siRNA)

Alex W. Tong, Yu-An Zhang, Shirley Samuel, Patrick Chen, Yuqiao Shen and John Nemunaitis

Mol Ther 13: S118-S119; doi:10.1016/j.ymthe.2006.08.366

312. Clearance of Helper Adenovirus by an AAV1 Clinical Vector Manufacturing Process

Barb Thorne, Paulene Quigley, Gina Nichols, David Price, Christine Moore, Kristin Parker, Tsering Sangmo, Eric Pastor, Morgan Peterson, Ryan Takeya and Richard Peluso

Mol Ther 13: S119-S119; doi:10.1016/j.ymthe.2006.08.368

313. Cell Type Specific Media Optimization for Clinical Retroviral Transduction Protocols

J. Stefanski, O. Borquez-Ojeda, T. Budak-Alpdogan, R. Kendle, M. Przybylowski, D. Hollyman, M. Sadelain and I. Rivi|[egrave]|re

Mol Ther 13: S119-S120; doi:10.1016/j.ymthe.2006.08.369

314. Developing Gene Transfer Vectors for Cancer Therapy: Identifying and Overcoming Regulatory Challenges

Rosemarie Aurigemma

Mol Ther 13: S120-S120; doi:10.1016/j.ymthe.2006.08.370

315. Identification and Control of Bacterial Contamination in an Academic Good Manufacturing Practice Facility

Timothy P. O'Connor, Neil R. Hackett, Robert G. Pergolizzi, Dolan Sondhi, Julie L. Boyer, Stephen M. Kaminsky and Ronald G. Crystal

Mol Ther 13: S120-S120; doi:10.1016/j.ymthe.2006.08.371

316. Production of Adenoviral Vectors in an Academic cGMP Facility

M.F. Medina, J. Rudy, U. Sankar, D. Chong, R. Foley and J. Gauldie

Mol Ther 13: S121-S121; doi:10.1016/j.ymthe.2006.08.372

317. Simplified Concentration and Purification of Lentivirus Pseudotypes

Robert H. Kutner, Brian DaLeo and Jakob Reiser

Mol Ther 13: S121-S121; doi:10.1016/j.ymthe.2006.08.373

318. Collaborative Development of an Effective Method To Produce Clinical RNAi Products

Sriram Ramakrishnan, Jeffrey E. Darnell, Gary Gates, Hugo L. Gonzales, Justin Miller and Henry Hebel

Mol Ther 13: S121-S121; doi:10.1016/j.ymthe.2006.08.374

319. Comparison of Serum-Free Media for Optimal Ex Vivo Transduction of Human CD34+ Cells

Joanna L. Ireland, Greg M. Podsakoff, Donald B. Kohn and Barbara C. Engel

Mol Ther 13: S122-S122; doi:10.1016/j.ymthe.2006.08.375

320. Modeling Human Brain Cancer in Transgenic E2F1 Mice

Melissa V. Olson, Kenneth D. Aldape, Gregory N. Fuller, Marta M. Alonso, Candelaria Gomez-Manzano, Johnson G. David and Fueyo Juan

Mol Ther 13: S122-S122; doi:10.1016/j.ymthe.2006.08.377

321. Sea Urchin sns Chromatin Insulator Prevents Silencing and Positional Effect Variegation of Oncoretroviral Vectors Transgene Expression in Murine Erythroid Cell Line

Danilo D'Apolito, Santina Acuto, Rosalba Di Marzo, Mariella Bagliesi, Valentina Motta, Elena Baiamonte, Roberta Calzolari, Vito Franco, Giovanni Spinelli and Aurelio Maggio

Mol Ther 13: S122-S123; doi:10.1016/j.ymthe.2006.08.378

322. Syngeneic Cotton Rat Cancer Model for Replicating Adenoviral Vectors

Jason C. Steel, Brian J. Morrison, Poonam Mannan, Gregory A. Prince, Kevin C. Yim, Brian K. Miles, Oliver Wildner and John C. Morris

Mol Ther 13: S123-S123; doi:10.1016/j.ymthe.2006.08.379

323. In Vivo Regulation of rAAV-Mediated GDNF Expression in the Rat Striatum

Corinna Burger, Emily Piercefield, Layla Sullivan, Ronald Mandel and Nicholas Muyczka

Mol Ther 13: S123-S123; doi:10.1016/j.ymthe.2006.08.380

324. Development of Bioluminescence Tomography for Three-Dimensional Real Time Imaging of Gene Expression

Nathalie Y. Toussaint, Lu Yin, Aaron Hirko, Qiang Wang, Qizhi Zhang, Huabei Jiang and Sean Sullivan

Mol Ther 13: S123-S124; doi:10.1016/j.ymthe.2006.08.381

325. In Vitro Gene Knockdown of Rat Pyruvate Dehydrogenase E1 |[alpha]| mRNA by Self- Complementary Adeno-Associated Virus-Mediated Small Interfering RNA Delivery

Zongchao Han, Marina Gorbatyuk, Alfred Lewin, Arun Srivastava and Peter Stacpoole

Mol Ther 13: S124-S124; doi:10.1016/j.ymthe.2006.08.382

326. A Versatile Tool for Conditional Gene Expression and Knockdown

Jolanta Szulc, Maciej Wiznerowicz, Friedrich Beermann, Didier Trono and Patrick Aebischer

Mol Ther 13: S124-S124; doi:10.1016/j.ymthe.2006.08.383

327. Muscle Specific and Efficient Transgene Expression Using the Fast and Slow Troponin I Promoters in Cell Culture

Marilyne Blain, Angela Kumar, Kenneth E. Hastings, George Karpati, Bernard Massie and Renald Gilbert

Mol Ther 13: S125-S125; doi:10.1016/j.ymthe.2006.08.384

328. Transcriptionally Targeted Cancer Gene Therapy for Small Cell Lung Cancer

Nina Pedersen, Thomas T. Poulsen, Mikkel W. Pedersen, Michael S. Lan, Mary B. Breslin and Hans S. Poulsen

Mol Ther 13: S125-S125; doi:10.1016/j.ymthe.2006.08.385

329. Electroporation-Mediated Delivery of Cre- Expressing Plasmids to the Lung Results in Tissue-Specific DNA Excision in Transgenic Mice

Aaron M. Miller and David A. Dean

Mol Ther 13: S125-S126; doi:10.1016/j.ymthe.2006.08.386

330. Effect of Different Inducible Minimal Promoters in the RheoSwitch|[reg]| Therapeutic System That Give Robust and Long-Term In Vivo Gene Expression

Jessica L. Seitzer, Anand Katakam, Marti A. DiPietro, Prasanna Kumar and David W. Potter

Mol Ther 13: S126-S126; doi:10.1016/j.ymthe.2006.08.387

331. Small Fragment Homologous Replacement (SFHR) Modification of Genomic HPRT Occurs in the Presence of Wild-Type p53 in Lymphoblastoid Cells

Babak Bedayat, Alireza Abdolmohammadi, Rosalie Maurisse, Jennifer Shwarz, Judi Cheung, David De Semir, Patric K O'Neill, Janice A. Nicklas and Dieter C. Gruenert

Mol Ther 13: S126-S126; doi:10.1016/j.ymthe.2006.08.388

332. Routes of Ligand Administration That Give Efficient and Robust In Vivo Induction with the RheoSwitch|[reg]| Therapeutic System

Marti A. DiPietro, Jessica L. Seitzer and David W. Potter

Mol Ther 13: S126-S127; doi:10.1016/j.ymthe.2006.08.389

333. Focused Ultrasound-Induced Transgene Activation in Skeletal Muscles

Xiaochun Lu, Georgii Sankin, John Madden and Pei Zhong

Mol Ther 13: S127-S127; doi:10.1016/j.ymthe.2006.08.390

334. A Novel Sequence-Specific Anti-Gene LNA Molecule and Its Comparison to Tail-Clamp bisPNA

Rongbin Ge, Juhana E. Heinonen, Mathias G. Svahn, Abdalla J. Mohamed, Karin E. Lundin and C.I. Edvard Smith

Mol Ther 13: S127-S127; doi:10.1016/j.ymthe.2006.08.391

335. Global Transcriptional Profiles of Murine C2C12 Myoblasts Treated with IGF-1

C. Ramana Bhasker, Shaochun Song and Theodore Friedmann

Mol Ther 13: S127-S127; doi:10.1016/j.ymthe.2006.08.392

336. Impact of Convective Flow on the Cellular Uptake and Transfection Activity of Lipoplex and Adenovirus

Takahiro Fujiwara, Hidetaka Akita, Katsuko Furukawa, Takashi Ushida and Hideyoshi Harashima

Mol Ther 13: S128-S128; doi:10.1016/j.ymthe.2006.08.393

337. Adenoviral Delivery of the RheoSwitch|[reg]| Therapeutic System to Mouse Brain and Liver

David W. Potter, Marti A. DiPietro, Jessica L. Seitzer, Anand Katakam and Prasanna Kumar

Mol Ther 13: S128-S128; doi:10.1016/j.ymthe.2006.08.394

338. Microarray Analysis of Genes Regulated during Induction of Osteogenesis by Human Lim Mineralization Protein-3 (LMP-3) in Human Mesenchymal Stem Cells

Wanda Lattanzi, Camilla Bernardini, Enrico Pola, Andrea Gambotto, Fabrizio Michetti and Paul D. Robbins

Mol Ther 13: S128-S129; doi:10.1016/j.ymthe.2006.08.395

339. FIV Lentiviral Vector Gene Transfer for Hemophilia A

C.P. Chikkanna-Gowda, Litao Xie, Yubin Kang, Melissa A. Hickey, Patrick L. Sinn, Jessica D. Goreham-Voss, Steven W. Pipe and Paul B. McCray Jr.

Mol Ther 13: S129-S129; doi:10.1016/j.ymthe.2006.08.396

340. Cellular Uptake and Subsequent Intracellular of R8-Liposomes Introduced at Low Temperature

Akitada Iwasa, Hidetaka Akita, Ikramy Khalil, Kentaro Kogure, Shiroh Futaki and Hideyoshi Harashima

Mol Ther 13: S129-S129; doi:10.1016/j.ymthe.2006.08.397

341. Lentivirus Transduction of Murine Embryonic Stem Cells with Truncated Human Low-Affinity Nerve Growth Factor Permits Efficient Purification of Genetically Modified Cells without Loss of Stem Cell Characteristics

Ralf-Harto H|[uuml]|bner, Maija Kiuru, Anja Krause, Stefano Rivella, Robert G. Pergolizzi and Ronald G. Crystal

Mol Ther 13: S130-S130; doi:10.1016/j.ymthe.2006.08.399

342. RUNX1 Increases Proliferation of Embryoid Bodies Derived from Human Embryonic Stem Cells

Jenice D'Costa, Alan D. Friedman, Elias Zambidis and Curt I. Civin

Mol Ther 13: S130-S130; doi:10.1016/j.ymthe.2006.08.400

343. Vascular Endothelial Growth Factor Prevents Bone Marrow Derived-Mesenchymal Stem Cell Senescence In Vitro

Jennifer Pons, Hua Su, Yu Huang and Y.W. Kan

Mol Ther 13: S131-S131; doi:10.1016/j.ymthe.2006.08.401

344. AAV Vector-Mediated Msx1 Gene Transfer Induces Hematopoietic Stem/Progenitor Cells in Skeletal Muscle

Masaharu Nobuyoshi, Akihiro Kume, Takashi Matsushita, Hiroaki Mizukami, Takashi Okada, Masashi Urabe, Yuichi Ohgoshi, Takashi Endo and Keiya Ozawa

Mol Ther 13: S131-S131; doi:10.1016/j.ymthe.2006.08.402

345. Hematopoietic Stem-Progenitor Cells Express CD52 mRNA and Membrane Protein

Sebastien Morisot, Robert W. Georgantas III and Curt I. Civin

Mol Ther 13: S131-S132; doi:10.1016/j.ymthe.2006.08.403

346. The ACE System, a Mammalian Artificial Chromosome Engineering Technology: Delivery and Transgene Expression in Human Adult & Embryonic Stem Cells

Sandra L. Vanderbyl, Brent Sullenbarger, Neil MacDonald, Melanie Golembiewski, Carl F. Perez, Harry C. Ledebur Jr and Larry C. Lasky

Mol Ther 13: S132-S132; doi:10.1016/j.ymthe.2006.08.404

347. Expression of the N-Formyl Peptide Receptor in Bone Marrow-Derived Human Mesenchymal Stem Cells

Anand Viswanathan, Richard G. Painter, Nicholas A. Lanson Jr and Guoshun Wang

Mol Ther 13: S132-S132; doi:10.1016/j.ymthe.2006.08.405

348. Kruppel-Like Factor 4 Regulates Proliferation of Human and Mouse Hematopoietic Stem-Progenitor Cells, but Is Not Essential for Mouse Hematopoietic Repopulation

Jonathan K. Alder, Robert W. Georgantas, Richard L. Hildreth and Curt I. Civin

Mol Ther 13: S132-S133; doi:10.1016/j.ymthe.2006.08.406

349. Pretreatment of the Esophagus with Manganese Superoxide Dismutase-Plasmid Liposome (MnSOD-PL) Complex Increases Migration and Proliferation of Marrow Stem Cell Progenitors of Esophageal Squamous Epithelium

Yunyun Niu, Michael W. Epperly and Joel S. Greenberger

Mol Ther 13: S133-S133; doi:10.1016/j.ymthe.2006.08.407

350. Ectopic Retroviral Expression of LMO2, but Not IL2R|[gamma]|, Blocks Human T-Cell Development from CD34+ Progenitor Cells: Implications for Gene Therapy

Karin Pike-Overzet, Dick de Ridder, Floor Weerkamp, Miranda R.M. Baert, Monique M. Verstegen, Steven J. Howe, Adrian J. Thrasher, Gerard Wagemaker, Jacques J.M. van Dongen and Frank J.T. Staal

Mol Ther 13: S133-S133; doi:10.1016/j.ymthe.2006.08.408

351. Inhibition of Thyroid Hormone Receptors in the Neural Stem Cells of Newborn and Adult Mice In Vivo: Consequences on Target Gene Expression

Zahra Hassani, Gladys Alfama, Jean-Christophe Fran|[ccedil]|ois, Carinne Giovannangeli and Barbara A. Demeneix

Mol Ther 13: S134-S134; doi:10.1016/j.ymthe.2006.08.409

352. CD34+ Hematopoietic Stem-Progenitor Cell MicroRNA Expression and Function: The miR Circuit Diagram of Differentiation Control

Robert W. Georgantas, Richard L. Hildreth, John Alder, Carlo Croece, George A. Calin and Curt I. Civin

Mol Ther 13: S134-S134; doi:10.1016/j.ymthe.2006.08.410

353. Biological Comparison of Mesenchymal Stem Cells Derived from Bone Marrow and Adipose Tissue

Reza Izadpanah, Cynthia Trygg, Christopher Kriedt and Bruce Bunnell

Mol Ther 13: S134-S135; doi:10.1016/j.ymthe.2006.08.411

354. Genetic Modification of Murine Stromal- Derived Cells (MSC) in Suspension Culture as a Model for the Rapid Generation of Transplantable Cytoreagents

Yung-Wei Pan, Tammy Tien Luoh and Peter Kurre

Mol Ther 13: S135-S135; doi:10.1016/j.ymthe.2006.08.412

355. A Platform for Gene Delivery to Embryonic Stem Cells Using HSV

April M. Sunyog, Darren Wolfe, James Wechuck, David Krisky, Ying Jiang and Joseph Glorioso

Mol Ther 13: S135-S135; doi:10.1016/j.ymthe.2006.08.413

356. Engineering of Cell Surface Sialic Acids for Polymeric Gene Delivery

Yihua Loo, S.-Gopalan Sampathkumar, Prabhani U. Atukorale, Kevin J. Yarema and Kam W. Leong

Mol Ther 13: S135-S136; doi:10.1016/j.ymthe.2006.08.414

357. Site-Specific Integration of Immortalization Genes in Human Adult Stem Cells Mediated by DirectIt|[trade]| Recombinases

Anna Tretiakova and Malla Padidam

Mol Ther 13: S136-S136; doi:10.1016/j.ymthe.2006.08.415

358. Lentiviral Vector Integration in Mouse Bone Marrow Stem Cells Undergoing Gene Therapy

Xiaolin Wu, Weijing He, Shawn M. Burgess, Robert A. Clark and Senlin Li

Mol Ther 13: S136-S136; doi:10.1016/j.ymthe.2006.08.416

359. Production of Megakaryocytes and Platelets from Common Marmoset (Callithrix jacchus) ES Cells by Constitutive Expression of tal1/scl Gene

Tomoko Yokoo, Ryo Kurita, Erika Sasaki, Kashiya Takasugi, Hideyuki Imoto, Yoshikuni Tanioka, Yasushi Soda and Kenzaburo Tani

Mol Ther 13: S137-S137; doi:10.1016/j.ymthe.2006.08.417

360. Transmitochondrial Stem Cells: Toward Autologous Cybrid Stem Cell Therapy and Synergistic Transient Regenerative Gene Therapy for Mitochondrial (mt)DNA Diseases

Roger Bertolotti

Mol Ther 13: S137-S137; doi:10.1016/j.ymthe.2006.08.418

361. Lentiviral Vector Transduction Efficiency and Biosafety Profile of Adult Mesenchymal Stem Cells

Barry M. McGrath, Ciara O'Shea, Linda Howard, Mary Murphy, Frank Barry, Timothy O'Brien and Padraig M. Strappe

Mol Ther 13: S137-S138; doi:10.1016/j.ymthe.2006.08.419

Top

Abstracts

362. Evaluation the Effects of MIP-1a on Ex Vivo Expansion of Cord Blood Hematopoietic Progenitor Cells in Different Culture Media

Kamran Alimoghaddam, Mitra Khalili, Massoud Soleimani, Moezi Lili, Panthea Ghodsi, Alireza Arjmand and Ardeshir Ghavamzadeh

Mol Ther 13: S138-S138; doi:10.1016/j.ymthe.2006.08.420

363. Homing of Bone Marrow Cells to the Respiratory Epithelium in a Murine Acute Infection Model

Joanna Rejman and Massimo Conese

Mol Ther 13: S138-S138; doi:10.1016/j.ymthe.2006.08.421

364. The Effect of Overexpression of Vascular Endothelial Growth Factor in Mouse Embryonic Stem Cells on Angiogenesis

Ying Ka Lau and Jennifer L. West

Mol Ther 13: S138-S139; doi:10.1016/j.ymthe.2006.08.422

365. Human Embryonic Stem Cells: Genetic Conversion to the Fanconi Anemia Phenotype

Beiqing Pan and Christopher E. Walsh

Mol Ther 13: S139-S139; doi:10.1016/j.ymthe.2006.08.423

366. Suicide Gene Therapy of Glioma Using Genetically Engineered Human Mesenchymal Stem Cells

Hiroki Namba, Shaoyi Li, Tsutomu Tokuyama, Junkoh Yamamoto and Naoki Yokota

Mol Ther 13: S139-S139; doi:10.1016/j.ymthe.2006.08.424

367. Lentivirus Pseudotyped with Envelope Proteins F and HN from Sendai Virus Transduce Airway Epithelium Efficiency and Persistently

Uta Griesenbach, Katsuyuki Mitomo, Makoto Inoue, Lucinda Somerton, Raymond Farley, Charanjit Singh, Toshiaki Tabata, Yasuji Ueda, Satoshi Fujikawa, Kentaro Washizawa, Mamoru Hasegawa and Eric W.F.W. Alton

Mol Ther 13: S139-S140; doi:10.1016/j.ymthe.2006.08.426

368. Lentiviral Vector Strain of Origin and Target Cell Species-Specific Restriction Factors Influence Transduction Efficiency

Christoph A. Kahl, Paula M. Cannon, Jill Oldenburg and Donald B. Kohn

Mol Ther 13: S140-S140; doi:10.1016/j.ymthe.2006.08.427

369. Development of an Amplifiable Gene Expression System in Lentivirus Vectors

Kit L. Shaw, Karen Pepper, Denise Petersen, Shundi Ge, Gay Crooks and Donald B. Kohn

Mol Ther 13: S140-S140; doi:10.1016/j.ymthe.2006.08.428

370. CRM1 Enhances the Lentiviral Vector Production

Hsin-Lung Lo, Tammy Chang, Paola M. Marcovecchio, Priscilla Yam, John A. Zaia and Jiing-Kuan Yee

Mol Ther 13: S141-S141; doi:10.1016/j.ymthe.2006.08.429

371. Optimization of Feline Immunodeficiency Viral Vectors for RNA Interference

Scott Q. Harper, Patrick D. Staber, Christine Rowley, Sarah Fineberg, Dalyz Ochoa, Colleen Stein and Beverly L. Davidson

Mol Ther 13: S141-S141; doi:10.1016/j.ymthe.2006.08.430

372. Optimizing Foamy Virus Vectors That Inhibit HIV Infection

Jason A. Taylor, Lucia Vojtech, Erik M. Olson, James M. Allen, Grant D. Trobridge, David W. Russell and Robert E. Richard

Mol Ther 13: S141-S142; doi:10.1016/j.ymthe.2006.08.431

373. Targeting the Central Nervous System by Intravenous Administration of a Targeting Lentiviral Vector

Koki Morizono, Yiming Xie, Gene-Errol Ringpis, Nonia Pariente and Irvin S.Y. Chen

Mol Ther 13: S142-S142; doi:10.1016/j.ymthe.2006.08.432

374. Hepatitis Delta Virus-Mediated Amplification of Therapeutic RNAi

Dirk Haussecker, Menashe Elazar, Jeff S. Glenn and Mark A. Kay

Mol Ther 13: S142-S142; doi:10.1016/j.ymthe.2006.08.433

375. A Glaucoma Gene Therapy Model: Eighteen Cat Study Revealing Long-Term Targeted Genetic Modification of the Anterior Chamber by Lentiviral Vectors

Pranay D. Khare, Nils Loewen, Roman Barraza, Michael Fautsch, Douglas Johnson and Eric Poeschla

Mol Ther 13: S142-S143; doi:10.1016/j.ymthe.2006.08.434

376. Hepatic Tropism of Adenoviral Type 5 Vectors Can Be Mediated by Multiple Coagulation Factors

Alan L. Parker, Campbell G. Nicol, Simon N. Waddington, Suzanne M. Buckley, Dmitry M. Shayakhmetov, Shaoheng H. Ni, Andre Lieber, John H. McVey, Laura Denby, Stuart A. Nicklin and Andrew H. Baker

Mol Ther 13: S143-S143; doi:10.1016/j.ymthe.2006.08.436

377. Intravascular Delivery of Adenovirus Vectors Rapidly Targets Platelets to the Reticuloendothelial System

Daniel Stone, Shaoheng Ni, Zong-Yi Li, Dmitry Shayakhmetov and Andre Lieber

Mol Ther 13: S143-S144; doi:10.1016/j.ymthe.2006.08.437

378. Phase I Trial of Intravenous Infusion of Onyx 015 and Enbrel in Solid Tumor Patients

Gerald Edelman, Neil Senzer, Michael Nemunaitis, Casey Cunningham, Paige Sovern, Alex Tong and John Nemunaitis

Mol Ther 13: S144-S144; doi:10.1016/j.ymthe.2006.08.438

379. Identification of Structural Aspects of Adenovirus Interactions with Host Factors In Vivo Using Tandem Mass Spectrometry

Oleksandr Kalyuzhniy, Catalin Doneanu, Martin Sadilek and Dmitry M. Shayakhmetov

Mol Ther 13: S144-S144; doi:10.1016/j.ymthe.2006.08.439

380. Alternative Cellular Receptor for B-Group Adenoviruses: Implications for Gene Therapy

Sebastian Tuve, Hongjie Wang, Anuj Gaggar, Ying Liu and Andre Lieber

Mol Ther 13: S145-S145; doi:10.1016/j.ymthe.2006.08.440

381. The Adenoviral Fiber Shaft Is a Major Determinant of Kupffer Cell Necrosis

Jeffrey S. Smith, Jie Tian, Susan C. Stevenson and Andrew P. Byrnes

Mol Ther 13: S145-S145; doi:10.1016/j.ymthe.2006.08.441

382. The Polysaccharide Mannan as a Novel Chemical Coupling Partner for Adenovirus Vectors with a Potential Use for Genetic Vaccination

Sigrid Espenlaub, Andreas Wortmann, Tatjana Dick, Stefan Kochanek and Florian Kreppel

Mol Ther 13: S145-S146; doi:10.1016/j.ymthe.2006.08.442

383. Polyethylene Glycol Modification of Adenovirus Vectors Reduces Thrombocytopenia through Decreased Platelet Clearance and Activation

Hoyin Mok, Francisca C. Gushkin, Sean Hofherr, Jose A. Lopez and Michael A. Barry

Mol Ther 13: S146-S146; doi:10.1016/j.ymthe.2006.08.443

384. Species B Adenovirus and Hematopoietic Cells Revisited

Goeran Wadell, Anna Segerman, William Burmeister, Steven Cusack, Emma Andersson, Karin Edlund, Praveen Papareddy, Dan Gustafsson, Kristina Lindman, Marko Marttila, Johan Skog, Niklas Arnberg and Ya-fang Mei

Mol Ther 13: S146-S146; doi:10.1016/j.ymthe.2006.08.444

385. Tol2 Transposon as a Gene Therapy Vector: Characterization, Optimization and Correction of Hereditary Tyrosinemia Type 1 in Mouse

Darius Balciunas, Andrew Wilber, Kirk Wangensteen, Jason Bell, Aron Geurts, Perry B. Hackett, David A. Largaespada, R. Scott McIvor and Stephen C. Ekker

Mol Ther 13: S147-S147; doi:10.1016/j.ymthe.2006.08.446

386. Chromosomal Integration Sites of Double-Stranded Linear DNA in Mouse ES Cells

Fumi Ohbayashi and Ko Mitani

Mol Ther 13: S147-S147; doi:10.1016/j.ymthe.2006.08.447

387. Advantageous Properties of the piggyBac Transposon System for Gene Transfer in Human Cells

Matthew H. Wilson, Craig J. Coates, Edward J. Rebar and Alfred L. George Jr.

Mol Ther 13: S147-S148; doi:10.1016/j.ymthe.2006.08.448

388. Chromosomal Rearrangements in Mammalian Cells Are Induced at High Frequency by the Bacteriophage Derived Integrase phiC31

Anja Ehrhardt, Jeffrey A. Engler, Hui Xu, Athena Cherry and Mark A. Kay

Mol Ther 13: S148-S148; doi:10.1016/j.ymthe.2006.08.449

389. Directed Transposon Integration in Human Cells

Stephen R. Yant, Yong Huang, Bassel Akache and Mark A. Kay

Mol Ther 13: S148-S149; doi:10.1016/j.ymthe.2006.08.450

390. Phage c31 Integrase Induces Chromosomal Aberrations in Primary Human Fibroblasts

Jian Liu, Iben Jeppesen, Kate Nielsen and Thomas G. Jensen

Mol Ther 13: S149-S149; doi:10.1016/j.ymthe.2006.08.451

391. De Novo Human Artificial Chromosome Formation Is Predetermined by Initial Chromatin Assembly and Transcriptional Patterns after Transfection

Hiroshi Nakashima, Megumi Nakano, Ryoko Ohnishi, Yasushi Hiraoka, Yasufumi Kaneda, Akio Sugino and Hiroshi Masumoto

Mol Ther 13: S149-S149; doi:10.1016/j.ymthe.2006.08.452

392. Duration of Expression of the Sleeping Beauty Transposase Gene in Mouse Liver Following Hydrodynamic Delivery

Jason B. Bell, Elena L. Aronovich, Brenda L. Koniar, Jeffrey M. Schreifels, Ann M. Clifford, Nathan D. Hoekstra and Perry B. Hackett

Mol Ther 13: S150-S150; doi:10.1016/j.ymthe.2006.08.453

393. Non-Viral Gene Transfer Using the Sleeping Beauty Transposon for Long-Term Gene Expression in the CNS of Neonatal Mice

Zachary L. Demorest, Walter C. Low, Andrew B. Freese and John R. Ohlfest

Mol Ther 13: S150-S150; doi:10.1016/j.ymthe.2006.08.454

394. Neuron-Specific, In Vivo Gene Delivery Mediated by Non-Viral Vectors

In-Kyu Park, Jurate Lasiene, Jennifer M. Knox, Shinn-Huey Chou, Philip J. Horner and Suzie H. Pun

Mol Ther 13: S151-S151; doi:10.1016/j.ymthe.2006.08.456

395. Role of Caveoli on Membrane Raft in the Internalization of Non-Viral Vectors

Peng H. Tan, Maria Manunta and Andrew J.T. George

Mol Ther 13: S151-S151; doi:10.1016/j.ymthe.2006.08.457

396. Quantitative Analysis of Non-Viral Gene Therapy in a Three-Dimensional Liver Bioreactor

Nathan Tedford, Jennifer Fang, Karel Domansky, Linda G. Griffith and Douglas A. Lauffenburger

Mol Ther 13: S151-S152; doi:10.1016/j.ymthe.2006.08.458

397. Compacted DNA Nanoparticles Transfect Cells by Binding to Cell Surface Nucleolin

Xuguang Chen and Pamela B. Davis

Mol Ther 13: S152-S152; doi:10.1016/j.ymthe.2006.08.459

398. Extracellular Matrix Identity and Surface Density Alter Transfection by Complexes Delivered from a Cell-Adhesive Substrate

Zain Bengali and Lonnie D. Shea

Mol Ther 13: S152-S153; doi:10.1016/j.ymthe.2006.08.460

399. Solid Nanobeads Prevents Polycations from Entering the Nuclei and Enhanced Transfection Efficiency

Wenzhong Li, Nan Ma, Leelee Ong, Alexander Kaminski, Peter Lorenz, Brigitte M. P|[uuml]|tzer, Ren-Ke Li, Christof Stamm and Gustav Steinhoff

Mol Ther 13: S153-S153; doi:10.1016/j.ymthe.2006.08.461

400. Peptide-Mediated Gene Transfer of Lipid/ DNA-Based Complexes to Cells Expressing CXC- Receptor 4

Wouter H. Driessen, Nobutaka Fujii, Hirokazu Tamamura and Sean M. Sullivan

Mol Ther 13: S153-S153; doi:10.1016/j.ymthe.2006.08.462

401. Quantitative Bioluminescence Imaging of Transgene Expression In Vivo

Garrett R. Rettig, Marie McAnuff, Dijie Liu, Ji-Seon Kim and Kevin G. Rice

Mol Ther 13: S154-S154; doi:10.1016/j.ymthe.2006.08.463

402. Intracellular Trafficking of QD-FRET Nanoparticles for Gene Delivery

Hunter H. Chen, Yi-Ping Ho, Tza-Huei Wang and Kam W. Leong

Mol Ther 13: S154-S154; doi:10.1016/j.ymthe.2006.08.464

403. Long-Term, High alpha-L-iduronidase Expression in MPS I Dogs Following Neonatal, Intravenous, Retroviral Vector Gene Therapy

Anne Traas, Ping Wang, Xiucui Ma, Patricia O'Donnell, Meg Sleeper, Gus Aguirre, Mark Haskins and Katherine P. Ponder

Mol Ther 13: S154-S155; doi:10.1016/j.ymthe.2006.08.466

404. Therapeutic Correction of PKU in a Mouse Model by Ectopic Expression of PAH and Its BH4- Cofactor Genes in Skeletal Muscle by a Recombinant Triple-Cistronic AAV2-Based Pseudotype 1 Vector

Zhaobing Ding, Cary O. Harding, Alexandre Rebuffat, Lina Elzaouk, Jon A. Wolff and Beat Thony

Mol Ther 13: S155-S155; doi:10.1016/j.ymthe.2006.08.467

405. Correction of the Murine Model of Hereditary Tyrosinemia Type I Using Messenger RNA as a Source of Transposase for Sleeping Beauty Mediated Integration of the FAH Gene

Andrew Wilber, Kirk J. Wangensteen, Yixin Chen, Lijuan Zhou, Joel L. Frandsen, Jason Bell, Zongyu Chen, Stephen C. Ekker, R. Scott McIvor and Xin Wang

Mol Ther 13: S155-S156; doi:10.1016/j.ymthe.2006.08.468

406. rAAV-Mediated Expression of Wnt10b cDNA Prevents the Development of Obesity in DIO Rats

George Aslanidi, Glenn Philipsberg, Vadim Kroutov, Kenneth Lamb, Erik Kohlbrenner, Martha Campbell-Thompson, Glenn Walter, Philip J. Scarpace and Sergei Zolotukhin

Mol Ther 13: S156-S156; doi:10.1016/j.ymthe.2006.08.469

407. A Single Unilateral Injection of AAV1-ASA and AAV1-FGE Vectors into the Hippocampus Results in Bilateral Expression and Widespread Distribution of ASA and Prevention of Sulfatide Storage in the Whole Brain of MLD Model Mice

Toshiyuki Kurai, Sanae Hisayasu, Yukihiko Hirai, Makoto Migita, Hidenori Suzuki and Takashi Shimada

Mol Ther 13: S156-S156; doi:10.1016/j.ymthe.2006.08.470

408. Safety of Lysosomal Enzymes Over-Expression in HSC for Gene Therapy of Storage Disorders

Alessandra Biffi, Ilaria Visigalli, Martina Cesani, Alessia Capotondo, Francesca R. Santoni de Sio, Isabella Pallavicini, Anna Zingale and Luigi Naldini

Mol Ther 13: S157-S157; doi:10.1016/j.ymthe.2006.08.471

409. Complete Correction of Enzymatic Deficiency and Lysosomal Storage throughout the Brain in a Mouse Model of GM1-gangliosidosis after Neonatal Intracerebroventricular Injection of an AAV1 Vector Encoding Lysosomal Acid Beta- galactosidase

Marike L. D. Broekman, Rena Baek, Laryssa A. Comer, Thomas N. Seyfried and Miguel Sena-Esteves

Mol Ther 13: S157-S157; doi:10.1016/j.ymthe.2006.08.472

410. Physiological Correction of Glycogen Storage Disease Type II Using Adeno-Associated Virus Serotype 1 Vectors

Cathryn Mah, Christina A. Pacak, Kerry O. Cresawn, Lara R. DeRuisseau, Sean Germain, Melissa A. Lewis, David D. Fuller and Barry J. Byrne

Mol Ther 13: S158-S158; doi:10.1016/j.ymthe.2006.08.473

411. The Metabolic Basis of Sexual Dimorphism in PKU Mice after PAH Gene Treatment

Li Chen and Savio L.C. Woo

Mol Ther 13: S158-S158; doi:10.1016/j.ymthe.2006.08.474

412. A Novel Friedreich's Ataxia Model and In Vivo Gene Rescue Using HSV-1 Amplicon Vectors in Transgenic Mice

Filip Lim, Gloria Palomo, Christina Mauritz, Alfredo Gimenez, Belen Illana, Francisco Wandosell and Javier Diaz-Nido

Mol Ther 13: S158-S158; doi:10.1016/j.ymthe.2006.08.476

413. Targeting the Low-Density Lipoprotein Receptor on the Blood-Brain Barrier for Transport of |[beta]|-Glucoronidase Can Treat the Neurological Degeneration of MPSVII

Brian J. Spencer and Inder M. Verma

Mol Ther 13: S159-S159; doi:10.1016/j.ymthe.2006.08.477

414. Non-Allele Specific RNA Interference in the CAG140 Knock-In Mouse Model of Huntington's Disease

Jodi L. McBride, Scott Q. Harper, Patrick D. Staber, Ines H. Martins, Haim Burstein, Richard W. Peluso, Barry Polisky, Barrie J. Carter and Beverly L. Davidson

Mol Ther 13: S159-S159; doi:10.1016/j.ymthe.2006.08.478

415. Stimulating Full-Length SMN2 Expression by Delivering Bi-Functional RNAs Via a Viral Vector

Travis D. Baughan, Monir Shababi, Gregory E. Tullis and Christian L. Lorson

Mol Ther 13: S159-S160; doi:10.1016/j.ymthe.2006.08.479

416. Gene Therapy for Parkinsons Disease by In Vivo Plasmid Transfer of Human Hepatocyte Growth Factor in Primate Model

Akihiko Ishida, Hiromi Koike and Ryuichi Morishita

Mol Ther 13: S160-S160; doi:10.1016/j.ymthe.2006.08.480

417. Combination Brain and Systemic Injections of AAV Results in Whole Body Therapy and Extension of Lifespan in the Niemann-Pick Mouse

Marco A. Passini, Jie Bu, Jonathan A. Fidler, Joseph W. Foley, James C. Dodge, Robin J. Ziegler, Wendy W. Yang, Jennifer Clarke, Tatyana V. Taksir, Denise A. Griffiths, Michael A. Zhao, Catherine R. O'Riordan, Lamya S. Shihabuddin, Edward H. Schuchman and Seng H. Cheng

Mol Ther 13: S160-S160; doi:10.1016/j.ymthe.2006.08.481

418. AAV-Mediated sFLT-1 Gene Therapy for Ocular Neovascularization: Longevity, Toxicity and Efficacy Results from Mice and Monkeys

E.P. Rakoczy, C.M. Lai, W.Y. Shen, M. Brankov, N. Barnett, S.Y. Lee, S.G. Leaver, I. Yeo, C.L. Ang and I.J. Constable

Mol Ther 13: S160-S161; doi:10.1016/j.ymthe.2006.08.482

419. Rescue of Cone Photoreceptors after Lentiviral Gene Transfer of Rpe65 cDNA in Knockout Mouse Models of Leber Congenital Amaurosis

Alexis-Pierre Bemelmans, Corinne Kostic, Dana Hornfeld, Meriem Tekaya, Sylvain V. Crippa, William W. Hauswirth, Janis Lem, Mathias Seeliger, Andreas Wenzel and Yvan Arsenijevic

Mol Ther 13: S161-S161; doi:10.1016/j.ymthe.2006.08.483

420. Hydrodynamic Limb Vein Delivery of Naked IGF-1 Plasmid DNA Provides Therapeutic Benefit in SOD1(G93A) Murine ALS Model

Gyula Acsadi, Roumen Anguelov, Xingli Li, Mary Kay Bates, Jon A. Wolff and Hans Herweijer

Mol Ther 13: S161-S161; doi:10.1016/j.ymthe.2006.08.484

421. Killing of Normal Cells Combined with TLR Engagement and CD40 Ligation Generates Autoimmune T Cell Reactivity Sufficient To Treat Large Established Tumors

Luis Sanchez-Perez, Gregory Daniels, Timothy Kottke, Rosa Maria Diaz, Jill Thompson, Heung Chong, Alan Melcher and Richard Vile

Mol Ther 13: S162-S162; doi:10.1016/j.ymthe.2006.08.486

422. Enhancement of Human Monocyte-Derived Dendritic Cell Functions by Adenovirus- Mediated RNA Interference of STAT-3

Tomoko Iwata, Hidetoshi Sumimoto, Hiroyuki Mizuguchi and Yutaka Kawakami

Mol Ther 13: S162-S162; doi:10.1016/j.ymthe.2006.08.487

423. Combination of Sleeping Beauty-Mediated INF-gamma Gene Transfer with CpG Oligodeoxynucleotides Provides Long-Term Survival of Intracranial Glioblastoma in Mice

Anhua Wu, Zachary L. Demorest, Isabelita Vengco, Wei Chen, Walter C. Low, Andrew B. Freese and John R. Ohlfest

Mol Ther 13: S162-S163; doi:10.1016/j.ymthe.2006.08.488

424. Myd88/TLR Signaling Is Required for Immunotherapy-Mediated Glioblastoma Regression

James F. Curtin, Gwendalyn D. King, Marianela Candolfi, Chunyan Liu, Kathrin S. Michelsen, Moshe Arditi, Tamer M. Fakhouri, Begonya Comin-Anduix, Antoni Ribas, Pedro R. Lowenstein and Maria G. Castro

Mol Ther 13: S163-S163; doi:10.1016/j.ymthe.2006.08.489

425. Translation of Enhanced Dendritic Cell Vaccines Using a CID-Inducible CD40 Receptor

Natalia Lapteva, Brent A. Hanks, Jianghong Jiang, Kevin M. Slawin and David M. Spencer

Mol Ther 13: S163-S164; doi:10.1016/j.ymthe.2006.08.490

426. dSLIM Immunomodulators Induce Anti- Tumor Responses Both In Vitro and In Vivo

Manuel Schmidt, Javier Cristobal, Astrid Sander, Bernadette Brzezicha, Sven A. Konig Merediz and Burghardt Wittig

Mol Ther 13: S164-S164; doi:10.1016/j.ymthe.2006.08.491

427. Adenovirus Mediated GRP94/gp96 Expression in Treatment of Neuroblastoma

Shanling Liu, Jiangao Zhu, He Wang, Takashi Kon and Chuan- Yuan Li

Mol Ther 13: S164-S164; doi:10.1016/j.ymthe.2006.08.492

428. Development of an Effective Safety Switch for Selective Elimination of Human T Cells In Vivo after Adoptive Transfer

Tom van Meerten, Henk Rozemuller, Wendy Mackus, Paul Parren, Jan van de Winkel, Marie-Jose Claessen, Rozemarijn van Rijn, Anton Hagenbeek, Anton Martens and Saskia Ebeling

Mol Ther 13: S164-S165; doi:10.1016/j.ymthe.2006.08.493

429. Adenoviral-Mediated Interleukin-15 Receptor-|[alpha]| Gene Therapy of Murine Breast Cancer

Brian J. Morrison, Yutaka Tagaya, Jason C. Steel, Poonam Mannan, Thomas A. Waldmann, John C. Morris and Yoshio Sakai

Mol Ther 13: S165-S165; doi:10.1016/j.ymthe.2006.08.494

430. EGFRvIII Retargeted Oncolytic Measles Virus Strains Have Significant Antitumor Activity Against Gliomas

Cory Allen, Sompong Vongpunsawad, Takafumi Nakamura, C. David James, Mark Schroeder, Roberto Cattaneo, Caterina Giannini, James Krempski, Stephen J. Russell and Evanthia Galanis

Mol Ther 13: S165-S166; doi:10.1016/j.ymthe.2006.08.496

431. Treatment of Multi-Focal CRC Liver Metastases with Repeated Infusion of Oncolytic Vesicular Stomatitis Virus Via the Hepatic Artery

Minoru Yamaki, Katsunori Shinozaki, Savio L.C. Woo and Toshimasa Asahara

Mol Ther 13: S166-S166; doi:10.1016/j.ymthe.2006.08.497

432. Characterization of a Novel Oncolytic Measles Virus Retargeted Against the Urokinase Receptor: In Vitro and In Vivo Studies

Jaime R. Merchan, Caili Tong, Takafumi Nakamura, Ianko Iankov and Stephen J. Russell

Mol Ther 13: S166-S167; doi:10.1016/j.ymthe.2006.08.498

433. Combination Therapy of Androgen-Independent Prostate Cancer Using a Prostate Restricted Replicative Adenovirus and a Replication-Defective Adenovirus Encoding Human Endostatin-Angiostatin Fusion Gene

Xiong Li, Sudhanshu P. Raikwar, You-Hong Liu, Sang-Jin Lee, Yan-Ping Zhang, Shaobo Zhang, Liang Cheng, Sang-Don Lee, Beth Elisa Juliar, Thomas A. Gardner, Meei-Huey Jeng and Chinghai Kao

Mol Ther 13: S167-S167; doi:10.1016/j.ymthe.2006.08.499

434. Oncolytic Virotherapy Using the HSV Mutant rQNestin34.5 towards CD133+ Brain Tumor Stem Cells

Akihiro Otsuki, Ankita Patel, Suzanne Camilli, Kazue Kasai, Sigeru Tanaka, E. Antonio Chiocca and Yoshinaga Saeki

Mol Ther 13: S167-S167; doi:10.1016/j.ymthe.2006.08.500

435. A Fiber-Modified, Relaxin-Expressing Oncolytic Adenovirus Prolongs Survival of Tumor Bearing Mice

Shanthi Ganesh, Melinda VanRoey, Neeraja Idamakanti and Karin Jooss

Mol Ther 13: S167-S168; doi:10.1016/j.ymthe.2006.08.501

436. Coxsackievirus A21 Has Potent Oncolytic Activity in Multiple Myeloma

Elizabeth M. Hadac and Stephen J. Russell

Mol Ther 13: S168-S168; doi:10.1016/j.ymthe.2006.08.502

437. An E1b-19kD-Deleted p53-Expressing Replicating Adenovirus Markedly Enhances the Induction of Apoptosis When Combined with Cisplatin in Head and Neck Cancer Cells

David I. Kutler, Harald Sauthoff, Jin Cheng, Yao Qi Huang, Sheila Heitner, William N. Rom and John G. Hay

Mol Ther 13: S168-S168; doi:10.1016/j.ymthe.2006.08.503

438. Targeting HSV-1 Virions for Specific Binding to Epidermal Growth Factor Receptor-VIII on Tumor Cells

Paola Grandi, Juliet Fernandez, Oscar Szentirmai, Robert Carter, Xandra O. Breakefield and Miguel Sena-Esteves

Mol Ther 13: S168-S168; doi:10.1016/j.ymthe.2006.08.504

439. Genetic Manipulation of Liver Sinusoidal Endothelial Cells (LSEC) and Repopulation of the Mouse Liver with Transplanted LSEC Has Therapeutic Implications

Antonia Follenzi, Daniel Benten, Marco Ulla, Michele De Palma, Phyllis Novikoff and Sanjeev Gupta

Mol Ther 13: S169-S169; doi:10.1016/j.ymthe.2006.08.506

440. Overexpression of Bcl-2 Prevented MSCs from Apoptosis and Improved Heart Function

Nan Ma, Wenzhong Li, Catharina Nesselmann, Leelee Ong, Alexander Kaminski, Brigitte M. P|[uuml]|tzer, Ren-Ke Li, Christof Stamm and Gustav Steinhoff

Mol Ther 13: S169-S169; doi:10.1016/j.ymthe.2006.08.507

441. Stable Oligo-to Polyclonal Hematopoiesis without Clonal Exhaustion Following Extended Reduced Intensity Selection of MGMT-P140K Expressing Murine Repopulating Stem Cells in Serially Transplanted Mice

C.R. Ball, I.H. Pilz, M. Schmidt, M. Schrempp, C. von Kalle and H. Glimm

Mol Ther 13: S169-S170; doi:10.1016/j.ymthe.2006.08.508

442. LV Expressing MR Reporter Genes Allows In Vivo Monitoring of Stem Cell Gene Therapy

Mario Amendola, Letterio S. Politi, Marcello Cadioli, Rossella Galli, Elena Binda, Andrea Falini, Sonia Levi, Giuseppe Scotti, Alessandra Biffi and Luigi Naldini

Mol Ther 13: S170-S170; doi:10.1016/j.ymthe.2006.08.509

443. Successful Long-Term Doxycycline-Regulated Transgene Expression in the Retina of Nonhuman Primates Following Subretinal Injection of Recombinant AAV Vectors

Knut Stieger, Guyl|[egrave]|ne Le Meur, Francoise Lasne, Michel Weber, Jack-Yves Deschamps, Delphine Nivard, Alexandra Mendes-Madeira, Nathalie Provost, Laurent Martin, Philippe Moullier and Fabienne Rolling

Mol Ther 13: S170-S170; doi:10.1016/j.ymthe.2006.08.510

444. Use of dsAAV8-Mediated Gene Transfer to Endogenous |[beta]|-Cells To Investigate the Therapeutic Efficacy of Immunoregulatory Gene Products in Preventing the Onset of Diabetes in NOD Mice

Khaja K. Rehman, Zhong Wang, Xiao Xiao and Paul D. Robbins

Mol Ther 13: S171-S171; doi:10.1016/j.ymthe.2006.08.511

445. Developmental Stage Determines Distribution of Organ Transduction after Intra-Amniotic Injection of Lentiviral Vector

Masayuki Endo, Tiago H. Coelho, Phil W. Zoltick and Alan W. Flake

Mol Ther 13: S171-S171; doi:10.1016/j.ymthe.2006.08.512

446. Inhibition of Hepatic Stellate Cell Activation and Liver Fibrosis by Expression of Cytoglobin In Vivo

Ruian Xu, Phillip Harrison, Xinyan Li, Miao Chen, Hua Li, Pik-to Cheung, Weidong Xiao and Farzin Farzaneh

Mol Ther 13: S171-S172; doi:10.1016/j.ymthe.2006.08.513

447. AP20187-Inducible Insulin-Like Effects in Diabetic Muscle and Liver Transduced with AAV

Gabriella Cotugno, Pietro Formisano, Ferdinando Giacco, Victor M. Rivera, Francesco Beguinot and Alberto Auricchio

Mol Ther 13: S172-S172; doi:10.1016/j.ymthe.2006.08.514

448. Suicide Gene-Mediated Conditional Ablation of Tumors Derived from Transplanted Embryonic Stem Cells

Juyeon Jung, Joanne Kim, Robert G. Pergolizzi and Ronald G. Crystal

Mol Ther 13: S172-S172; doi:10.1016/j.ymthe.2006.08.516

449. Sca-1+ Cell-Based Gene Therapy with a Modified Fibroblast Growth Factor 2 (FGF2) Increased Endosteal/Trabecular Bone Formation in Mice

Susan L. Hall, K.-H. William Lau, Shin-Tai Chen, Matilda H.-C. Sheng, Apurva K. Srivastava, Henry J. Klamut, Jon E. Wergedal, Daila S. Gridley, Subburaman Mohan and David J. Baylink

Mol Ther 13: S173-S173; doi:10.1016/j.ymthe.2006.08.517

450. Novel, Injectable, Genetically Engineered Stem Cell-Based System for Anterior Spinal Fusion

Rod J. Oskouian, Gadi Pelled, Yoram Zilberman, Yamit Tal, Zulma Gazit and Dan Gazit

Mol Ther 13: S173-S174; doi:10.1016/j.ymthe.2006.08.518

451. AAV-BDNF Augments Neurogenesis in Both the Normal Adult Rat Brain and the Quinolinic Acid Lesion Model of Huntington's Disease

Rebecca A. Henry, Stephanie M. Hughes, Richard L.M. Faull and Bronwen J. Connor

Mol Ther 13: S174-S174; doi:10.1016/j.ymthe.2006.08.519

452. Bone Marrow Stem Cells Are Potent Targets for Gene Therapy of Epidermolysis Bullosa, a Genetic Blistering Skin Disease

Katsuto Tamai, TaKehiko Yamazaki, Otsuru Satoru, Takenao Chino, Yasushi Kikuchi and Yasufumi Kaneda

Mol Ther 13: S174-S174; doi:10.1016/j.ymthe.2006.08.520

453. Injectionof Different Adult Cell Types into Mouse Myocardium Three Days after Myocardial Infarction Using a Novel Echo-Guided Technique Improves Cardiac Function

Yan Zhang, Junya Takagawa, Richard E. Sievers, Maelene L. Wong, Christian Heiss, Mohan N. Viswanathan, Neel K. Kapasi, Jianqin Ye, Elyse Foster, William Grossman, Matthew L. Springer and Yerem Yeghiazarians

Mol Ther 13: S175-S175; doi:10.1016/j.ymthe.2006.08.521

454. Recognition of Tumor Antigens by In Vitro Developed T Cells from Hematopoietic Stem Cells Retrovirally Transduced with TCR Genes

Yangbing Zhao, Zhili Zheng, Cyrille J. Cohen, Steven A. Rosenberg and Richard A. Morgan

Mol Ther 13: S175-S175; doi:10.1016/j.ymthe.2006.08.522

455. Genetically Engineered Adult Stem Cells and Hybrid Scaffolds as a Platform for Intervertebral Disc Regeneration

Nadav Kimelman, Rod J. Oskouian, Yoram Zilberman, Gadi Pelled, Zulma Gazit and Dan Gazit

Mol Ther 13: S175-S176; doi:10.1016/j.ymthe.2006.08.523

456. Gene Transfer to Skin Stem Cells by Early Gestational Intra-Amniotic Injection of Lentiviral Vector

Masayuki Endo, Phil W. Zoltick, William H. Peranteau, Mayumi Ito, George Cotsarelis and Alan W. Flake

Mol Ther 13: S176-S176; doi:10.1016/j.ymthe.2006.08.524

457. Reverse Transcriptase Deficient Retroviral Vectors for Transient Cell Modification

Melanie Galla, Axel Schambach, Elke Will and Christopher Baum

Mol Ther 13: S177-S177; doi:10.1016/j.ymthe.2006.08.526

458. Development of Non-Integrating and Site- Specifically Integrating Lentiviral Vectors

Luis Apolonia, Simon Waddington, Mary Collins, Adrian Thrasher and Nicola Philpott

Mol Ther 13: S177-S177; doi:10.1016/j.ymthe.2006.08.527

459. Murine Study To Evaluate Long-Term Transgene Expression of the MSCV-MGMTP140K wc Retroviral Vector in Support of a Phase I Gene Transfer Trial-Limitations of the Murine Model as a Pre-Clinical Tool

Elke Will, Jeff Bailey, Todd Schuesler, Brenden Balcik, Ben Burzynski, David Witte, Gerlinde Layh-Schmitt, Christof vonKalle, Christopher Baum, Brian P. Sorrentino, Lars M. Wagner, Lilith Reeves and David A. Williams

Mol Ther 13: S177-S178; doi:10.1016/j.ymthe.2006.08.528

Top

Abstracts

460. MGMTP140K Vector Constructs for Efficient In Vivo Enrichment of Genetically Corrected Cells Following Hematopoietic Cell Gene Transfer

U.R. Sorg, V. Kleff, G. Nagel, B. Opalka, J. Thomale, B. Kaina and T. Moritz

Mol Ther 13: S178-S178; doi:10.1016/j.ymthe.2006.08.529

461. Evaluation of In Vivo Model Systems for Safety Assessment of HIV-1 Based Lentiviral Vectors

Yuan Zhao, Selina Azam, Kenneth Keating and Robin Thorpe

Mol Ther 13: S178-S178; doi:10.1016/j.ymthe.2006.08.530

462. Comparison of EMCV IRES and FMDV 2A Cleavage Factor for Expression of Canine MGMT and a Second Transgene Using HIV-1 Vectors

Srinivas N. Kumar, Tatiana Zaboikina, Michail Zaboikin and Friedrich G. Schuening

Mol Ther 13: S179-S179; doi:10.1016/j.ymthe.2006.08.531

463. COX-2-Based Gene Therapy: Reduction of Intraocular Pressure in a Glaucoma Gene Therapy Animal Model with Lentiviral Vectors Expressing COX-2, a Prostaglandin Synthase, or a Prostaglandin Receptor

Roman A. Barraza and Eric M. Poeschla

Mol Ther 13: S179-S179; doi:10.1016/j.ymthe.2006.08.532

464. Use of Equine Infectious Anaemia Virus (EIAV) To Mediate Indoleamine 2,3-dioxygenase Gene Transfer to Murine Corneal Allograft Transplantation Model Results in Prolongation of Allograft Survival In Vivo with Little Immunogenicity

Peng H. Tan, Sven C. Beutelspacher and Andrew J.T. George

Mol Ther 13: S179-S180; doi:10.1016/j.ymthe.2006.08.533

465. Pseudotyping Lentiviral Vectors with a Modified GP64 Envelope Proteins Redirects Gene Transfer In Vitro and In Vitro

David Markusic, Niek van Til, Alexander Kanitz, Johan Hiralall, Ronald Oude-Elferink and Jurgen Seppen

Mol Ther 13: S180-S180; doi:10.1016/j.ymthe.2006.08.534

466. Comprehensive Analyses of Diverse Lentiviral and Retroviral Vectors for Post-Entry Restriction by TRIM5|[alpha]| and Implications for Gene Therapy

Dyana T. Saenz and Eric M. Poeschla

Mol Ther 13: S180-S180; doi:10.1016/j.ymthe.2006.08.535

467. Lentiviral Vector (LV) Non-Coding Elements That Impart High Titers and Expression to |[beta]|-Globin (h|[beta]|) Cassettes

F. Urbinati, P. Xia, A. Perumbeti, M. Xia, A. Corsinotti, A. Zarzuela, N. Perelman and P. Malik

Mol Ther 13: S181-S181; doi:10.1016/j.ymthe.2006.08.536

468. Evaluation of Factors Influencing the Production Titers of SIV-Derived Lentiviral Vectors

Nora Naumann, Suk See De Ravin, Morvarid Moayeri, Uimook Choi, Yasuhiro Ikeda and Harry L. Malech

Mol Ther 13: S181-S181; doi:10.1016/j.ymthe.2006.08.537

469. Optimization of the Lentivirus Vector Containing the MSCV-U3 and EF1|[alpha]| Double Internal Promoters

Naoya Uchida, Hideki Hanawa, Motoko Yamamoto and Takashi Shimada

Mol Ther 13: S182-S182; doi:10.1016/j.ymthe.2006.08.538

470. ABCB4 P-Glycoprotein Reduces Infectivity of Lentiviral Particles by Increasing Their Phosphatidylcholine Content

Niek P. van Til, Kirstin Heutinck, Ronald P.J. Oude Elferink and Jurgen Seppen

Mol Ther 13: S182-S182; doi:10.1016/j.ymthe.2006.08.539

471. Chimeric Lentiviral Vectors with Safety Insurance

Kritika Kachapati, Geetanjali Sachdeva and Suresh Arya

Mol Ther 13: S182-S183; doi:10.1016/j.ymthe.2006.08.540

472. Biodistribution of Semliki Forest Virus Vectors and Effect of Preimmunizations in Mice

Juan R. Rodriguez, Erkuden Casales, Jesus Prieto and Cristian Smerdou

Mol Ther 13: S183-S183; doi:10.1016/j.ymthe.2006.08.541

473. Semliki Based Systems for the Production of Retroviral Vectors: A Safety Concern

Eric Piver, Christine Collin, No|[eacute]|mie Renault, Thierry Bru and Jean-Christophe Pages

Mol Ther 13: S183-S183; doi:10.1016/j.ymthe.2006.08.542

474. Deletion of All Membranous Genes of Recombinant Sendai Virus Results in the Dramatic Reduction of Toxicity for Pulmonary Gene Transfer in Neonatal Mice

Sakura Tanaka, Yoshikazu Yonemitsu, Mamoru Hasegawa, Tomoaki Taguchi and Katsuo Sueishi

Mol Ther 13: S184-S184; doi:10.1016/j.ymthe.2006.08.543

475. SeV-Mediated Gene Transfer after Three Re-Administrations in Mice and Sheep

Uta Griesenbach, Gerry McLachlan, Lucinda Somerton, David Collie, Makoto Inoue, Takashi Hironaka, Seng Cheng, Ronald Scheule, Toshiyuki Owaki, Alison Baker, Peter Tennant, Mamoru Hasegawa and Eric W.F.W. Alton

Mol Ther 13: S184-S184; doi:10.1016/j.ymthe.2006.08.544

476. In Vivo Repopulation of Syngenic Hematopoietic Cells Expressing GFP Transfected by Recombinant Sendai Virus |[ndash]| Toward Development of 'Cytoplasmic Gene Therapy' for Hematopoietic Disorders

Kumi Yoshida, Yoshikazu Yonemitsu, Mamoru Haswgawa and Katsuo Sueishi

Mol Ther 13: S185-S185; doi:10.1016/j.ymthe.2006.08.545

477. Replication Deficiency: The Safety Record of a New Sendai Virus Vector Generation

Sascha Bossow, Sabine Schlecht, Marian Wiegand and Wolfgang J. Neubert

Mol Ther 13: S185-S185; doi:10.1016/j.ymthe.2006.08.546

478. Novel Gene Delivery System of Sendai Virus Vector-Transduced Human Peripheral Monocytes

Tomoko Tanaka, Kashiya Takasugi, Ryo Kurita, Takafumi Nakamura, Makoto Inoue, Mamoru Hasegawa, Fumiko Ono, Keiji Terao, Yasuhiro Yoshikawa and Kenzaburo Tani

Mol Ther 13: S185-S186; doi:10.1016/j.ymthe.2006.08.547

479. Development and Characterization of a New Noncytopathic Vector Derived from Semliki Forest Virus

Erkuden Casales, Juan R. Rodriguez-Madoz, Nerea Razquin, Yolanda Cuevas, Jesus Prieto and Cristian Smerdou

Mol Ther 13: S186-S186; doi:10.1016/j.ymthe.2006.08.548

480. Gene Transfer to Gut K Cells for Physiologic Insulin Replacement in Diabetes

Eric C. Hsu, Scott Pownall, Timothy J. Kieffer, Yvonne Luu, Simon Leong, Paul D. Robbins, Xiao Xiao and Anthony T. Cheung

Mol Ther 13: S186-S186; doi:10.1016/j.ymthe.2006.08.549

481. EPIDEMIOLOGY of Seneca Valley Virus (SVV-001), a Novel Oncolytic Picornavirus for the Systemic Treatment of Patients with Solid Cancers with Neuroendocrine Features

Laura M. Hales, Brian H. Jones, Ann-Jeanette Vasko, Nick J. Knowles, Seshidar R. Police and Paul L. Hallenbeck

Mol Ther 13: S187-S187; doi:10.1016/j.ymthe.2006.08.550

482. T Cells as Carriers for Systemic Measles Virotherapy of Multiple Myeloma

Hooi T. Ong, Kosei Hasegawa, Mary Harvey, Allan Dietz, Stephen J. Russell and Kah-Whye Peng

Mol Ther 13: S187-S187; doi:10.1016/j.ymthe.2006.08.551

483. Phenotypic Correction of Von Willebrand Disease Type 3 Blood-Derived Endothelial Cells with Lentiviral Vectors Expressing Von Willebrand Factor

Simon F. DeMeyer, Karen Van hoorelbeke, Marinee K. Chuah, Inge Pareyn, Veerle Gilijns, Robert P. Hebbel, D|[eacute]|sir|[eacute]| Collen and Thierry Vandendriessche

Mol Ther 13: S187-S187; doi:10.1016/j.ymthe.2006.08.552

484. Murine Liver as a Model for AAV Replication, Recombination and Evolution

Xun Sun, You Lu, Gaung-Ping Gao, Michael T. Korn, Julio SanMiguel, Martin W. Lock and James M. Wilson

Mol Ther 13: S187-S188; doi:10.1016/j.ymthe.2006.08.554

485. Long-Term In Vivo Engraftment & Transgene Expression from CD34+ Human Hematopoietic Stem Cells Transduced with Pseudotyped rAAV

Sarah Hardy, Margaret Heerwagen, Lane Bilbrey, Kamehameha K. Wong and Saswati Chatterjee

Mol Ther 13: S188-S188; doi:10.1016/j.ymthe.2006.08.555

486. Efficient and Selective Gene Transfer Directed to Muscle by Tropism-Modified Adeno-Associated Virus Vector

Chi-Yi Yu, Bing Wang, Zhong Wang, Zhongren Cao, Juan Li and Xiao Xiao

Mol Ther 13: S188-S189; doi:10.1016/j.ymthe.2006.08.556

487. Liver-Targeted Gene Therapy in Glycogen Storage Disease Type Ia (GSD-Ia) Requires Widespread, Regulated Glucose-6-phosphatase

Dwight D. Koeberl, Lopamudra Banerjee, Andrew Bird, Baodong Sun and Y.T. Chen

Mol Ther 13: S189-S189; doi:10.1016/j.ymthe.2006.08.557

488. Adeno-Associated Viral Serotype 2/1 Is a Highly Efficient Vector for In Utero Gene Transfer to Hair Cell Precursors

Jeffrey C. Bedrosian, Michael Anne Gratton, John V. Brigande, Waixing Tang and Jean Bennett

Mol Ther 13: S189-S189; doi:10.1016/j.ymthe.2006.08.558

489. Treatment for Hemophilia B Using Self-Complimentary AAV8 Vectors

Micheal L. Hebert, Dirk Grimm, Theresa A. Storm and Mark A. Kay

Mol Ther 13: S189-S190; doi:10.1016/j.ymthe.2006.08.559

490. Successful Readministration of AAV8 Following Administration of Nondepleting CD4 Antibody at the Time of Vector Administration

Jenny H. McIntosh, Melanie Cochrane, Arnold Prizzey, Herman Waldmann, Andrew M. Davidoff and Amit C. Nathwani

Mol Ther 13: S190-S190; doi:10.1016/j.ymthe.2006.08.560

491. Mosaic AAV Vectors Display Novel Properties for Neuronal Transduction

Stanley G. LeRoy, Laryssa A. Comer, Fabricio F. Costa, Marike L.D. Broekman and Miguel Sena-Esteves

Mol Ther 13: S190-S190; doi:10.1016/j.ymthe.2006.08.561

492. Biodistribution and Integration Assessment of AAV1 gag-PR-RT(|[Delta]|RNaseH) after Intramuscular Administration in Rabbits

Bruce C. Schnepp, Michael C. Soult, Tara Allen, Pervin Anklesaria, Philip R. Johnson and Keith Munson

Mol Ther 13: S190-S191; doi:10.1016/j.ymthe.2006.08.562

493. High Efficiency Gene Targeting to Mammalian Joint Tissue Using Self- Complementary Adeno-Associated Viral Vector Serotypes

Laurie R. Goodrich, Vivian W. Choi, Beth C. DudaCarbone, C. Wayne McIlwraith and Richard J. Samulski

Mol Ther 13: S191-S191; doi:10.1016/j.ymthe.2006.08.563

494. Optimizing the Mannitol-Facilitated CNS Entry of Peripherally-Delivered AAV2 Vector

Haiyan Fu, Julianne DiRosario and Douglas M. McCarty

Mol Ther 13: S191-S191; doi:10.1016/j.ymthe.2006.08.564

495. Transfer of LEDGF to the Mouse Retina Via Systemic AAV Vector Administration

Lyudmyla G. Glushakova, Marina Gorbatuyk, Yuanging Lu, Sihong Song, Min Zheng, Toshimichi Shinohara and William W. Hauswirth

Mol Ther 13: S192-S192; doi:10.1016/j.ymthe.2006.08.565

496. AAV-Mediated, Somatic Gene Transfer to RPE Cells in Order To Study the Pathogenesis of Macular Degeneration: Proteomic and Genomic Analysis

Garrett C. Du Bois, Petya D. Radoeva and Jean Bennett

Mol Ther 13: S192-S192; doi:10.1016/j.ymthe.2006.08.566

497. Central CART Gene Delivery by Recombinant AAV Vector Decreases Lean Body Mass in Diet-Induced Obese Male Rats

Keyun Qing and Yanyun Chen

Mol Ther 13: S192-S193; doi:10.1016/j.ymthe.2006.08.567

498. AAV |[Delta]|264CFTR Enhances Maturation of |[Delta]|F508CFTR and wt CFTR Expression

Liudmila Cebotaru, Terence R. Flotte and William B. Guggino

Mol Ther 13: S193-S193; doi:10.1016/j.ymthe.2006.08.568

499. Improving the Stability of Ad-AAV Hybrid Vectors

Haim Burstein, Richard Peluso, Ziv Sandalon, Kurt Lustig and Tony Stepan

Mol Ther 13: S193-S193; doi:10.1016/j.ymthe.2006.08.569

500. Tetanus Toxin Heavy Chain-Streptoavidin Fusion Protein for Targeted Motor Neuron Gene Delivery through Metabolically Biotinylated AAV

Qingshan Teng, Jeffrey S. Bartlett, Thais Federici, Jun Yang and Nicholas M. Boulis

Mol Ther 13: S193-S193; doi:10.1016/j.ymthe.2006.08.570

501. RheoSwitch|[reg]| Therapeutic System-Inducible Recombinant AAV Vectors for Tightly Regulated Transgene Expression

Dawn Karzenowski, Zhijian J. Chen, David W. Potter and Malla Padidam

Mol Ther 13: S194-S194; doi:10.1016/j.ymthe.2006.08.571

502. Advances in the Application of Combinatorial Technology for the Optimization of Adeno-Associated Virus (AAV) Vectors

Luca Perabo, Jan Endell, Stephan Maersch, Michael Hallek and Hildegard Buening

Mol Ther 13: S194-S194; doi:10.1016/j.ymthe.2006.08.572

503. A Novel Herpes Simplex Virus Helper Based Production of Adeno-Associated Virus Vectors for Treatment of Retinal Angiogenesis

Guo-jie Ye, Chris Drogemuller, Darby Thomas, Marina Scotti, Wen Kang, David Knop, Sanford Boye, Peter Pechan, James Peterson, William Hauswirth, Abraham Scaria and Samuel Wadsworth

Mol Ther 13: S194-S194; doi:10.1016/j.ymthe.2006.08.573

504. Neuronal Affinity of a C7C Loop Peptide Identified through Phage Display

Thais Federici, James K. Liu, Qingshan Teng, Mary Garrity-Moses, Jun Yang and Nicholas M. Boulis

Mol Ther 13: S195-S195; doi:10.1016/j.ymthe.2006.08.574

505. Advances in Large-Scale Production of Recombinant Adeno-Associated Vectors

Alejandro Negrete, Masashi Urabe Urabe and Robert M. Kotin

Mol Ther 13: S195-S195; doi:10.1016/j.ymthe.2006.08.575

506. Production of Recombinant Adeno-Associated Virus Type 1 Vector Using a Herpes Simplex Virus Based System

Wen Kang, Chris Drogemuller, Marina M. Scotti and Guo-jie Ye

Mol Ther 13: S195-S195; doi:10.1016/j.ymthe.2006.08.576

507. Engineering a Novel AAV Variant for Purification Via Immobilized Metal Affinity Chromatography

James T. Koerber, Jae-Hyung Jang Jang, Julie Yu, Ravindra Kane and David V. Schaffer

Mol Ther 13: S196-S196; doi:10.1016/j.ymthe.2006.08.577

508. Development of Optimized AAV2 Vector Biosynthesis and Purification Processes To Support High Capacity Production of Clinical Vectors of High Purity and Potency

Bernd Hauck, Jitin Bajaj, Sonali Joyce, Guang Qu, Olga A. Zelenaia, Katherine A. High and J. Fraser Wright

Mol Ther 13: S196-S196; doi:10.1016/j.ymthe.2006.08.578

509. Adeno-Associated Vector Mediated Delivery of Anti-HIV Genes

Mayur C. Tamhane and Ramesh Akkina

Mol Ther 13: S196-S196; doi:10.1016/j.ymthe.2006.08.579

510. Detection and Quantification of rcAAV in rAAV Stocks by Real-Time qPCR

Traci L. Mayfield, Irina Korytov, Joyce D. Francis, David R. Knop and Richard O. Snyder

Mol Ther 13: S196-S197; doi:10.1016/j.ymthe.2006.08.580

511. An Enzyme Linked Immunosorbent Assay for the Detection of Herpes Simplex Virus Type 1 Proteins in a Novel rAAV Production and Purification Process

Guo-jie Ye and Tammy Mandell

Mol Ther 13: S197-S197; doi:10.1016/j.ymthe.2006.08.581

512. Characterization of Adsorption of Adeno-Associated Virus to Commonly Used Catheter Materials: AAV2 vs. AAV1/2

Daisy P. Cross and Marty Morris

Mol Ther 13: S197-S197; doi:10.1016/j.ymthe.2006.08.582

513. A Simple Method To Ensure Titer Conservation of AAV2 Vector Preparations Delivered with Stainless Steel Needles

Elias T. Ketchum, Kevin Kwok, Anthony Ramirez, Junshan Hao, Brian Kruegel, Dominick Vacante, Raymond Bartus and Mehdi Gasmi

Mol Ther 13: S197-S198; doi:10.1016/j.ymthe.2006.08.583

514. mRNA Transfection Results in Efficient Overexpression of Transgenes in Leukemic Cell Lines and Hematopoietic Stem Cells

Martin F. Ryser, Marcus Gentsch, Fernando Ugarte, Harry L. Malech and Sebastian Brenner

Mol Ther 13: S198-S198; doi:10.1016/j.ymthe.2006.08.585

515. Sequence Requirements for Alveolar Epithelial Cell-Specific Plasmid Nuclear Import

James V. DeGiulio and David A. Dean

Mol Ther 13: S198-S198; doi:10.1016/j.ymthe.2006.08.586

516. Development of a Minicircle Vector Free of Plasmid Bacterial DNA Sequences and Capable of |[oslash]|C31-Mediated Site-Specific Integration

Zhi-Ying Chen, Cheng-Yi He, Anja Ehrhardt, Hui Xu and Mark A. Kay

Mol Ther 13: S198-S199; doi:10.1016/j.ymthe.2006.08.587

517. Lipopolythioureas: Non Cationic System for Gene Delivery

Jeanne Leblond, Nathalie Mignet, Maria-Vittoria Spanedda, Daniel Scherman and Jean Herscovici

Mol Ther 13: S199-S199; doi:10.1016/j.ymthe.2006.08.588

518. Mechanism of Difference in the Transcription Activity of Nucleus-Delivered Transgene Introduced by Adenovirus and Lipoplex

Hidetaka Akita, Susumu Hama, Hiroyuki Mizuguchi and Hideyoshi Harashima

Mol Ther 13: S199-S199; doi:10.1016/j.ymthe.2006.08.589

519. Development of S/MAR Plasmid Vectors for Persistent Expression and Maintenance, In Vivo

Orestis Argyros, Suet-Ping Wong, Andrew A. Miller and Richard Harbottle

Mol Ther 13: S199-S200; doi:10.1016/j.ymthe.2006.08.590

520. ProTIS, a Method for Prediction of Insertion-Site Preferences into Chromosomes of Vectors Used for Gene Therapy

Aron M. Geurts, Christopher S. Hackett, Jason B. Bell, Tracy L. Bergemann, Lara S. Collier, Corey M. Carlson, David A. Largaespada and Perry B. Hackett

Mol Ther 13: S200-S200; doi:10.1016/j.ymthe.2006.08.591

521. Gene Transfer of an Anti-CCR5 siRNA by Sleeping Beauty (SB) Transposon System

Mayur C. Tamhane and Ramesh Akkina

Mol Ther 13: S200-S200; doi:10.1016/j.ymthe.2006.08.592

522. Neural Retina Limits Delivery Non Viral Vectors to Retinal Pigment Epithelium

Liesbeth Peeters, Niek Sanders, Koen Boussery, Johan Van de Voorde, Joseph Demeester and Stefaan De Smedt

Mol Ther 13: S200-S201; doi:10.1016/j.ymthe.2006.08.593

523. Deoxyribonuclease I and Endonuclease G Are Host Defense Enzymes Responsible for Inactivation of Foreign DNA in Kidney Tubular Epithelial Cells

Timea Buzder, Xiaoyan Yin, Xiaoying Wang, Gaspar Banfalvi and Alexei G. Basnakian

Mol Ther 13: S201-S201; doi:10.1016/j.ymthe.2006.08.594

524. Analysis of Unique Proteins Bound to Sequentially Injected DOTAP:DNA Vectors

Christine C. Conwell and Leaf Huang

Mol Ther 13: S201-S201; doi:10.1016/j.ymthe.2006.08.595

525. Mutants of phiC31 Integrase with Increased Efficiency and Specificity

Annahita Keravala, Solomon Lee, Eric C. Olivares, Bhaskar Thyagarajan, Alfonso Farruggio, Vanessa E. Gabrovsky and Michele P. Calos

Mol Ther 13: S201-S202; doi:10.1016/j.ymthe.2006.08.596

526. Induction of Apoptosis in Melanoma Cell Lines by the Noxa Gene

Mohamed Hassan, Amine Alaoui, Alireza Mirmohammadsadegh, Alessandra Marini, Sandeep Nambiar and Ulrich R. Hengge

Mol Ther 13: S202-S202; doi:10.1016/j.ymthe.2006.08.597

527. Pharmaceutical Plasmid Manufacturing: Development of Economical and Innovative Process Solutions

Joachim Schorr, Markus Mueller, Juergen Hubbuch and Andreas Frerix

Mol Ther 13: S202-S202; doi:10.1016/j.ymthe.2006.08.598

528. Significant Silencing Effect of a Multifunctional Envelope-Type Nano Device Encapsulating Antisense Oligodeoxynucleotide and Double-Stranded siRNA

Kentaro Kogure, Yoshio Nakamura, Ikramy A. Khalil, Shiroh Futaki and Hideyoshi Harashima

Mol Ther 13: S202-S203; doi:10.1016/j.ymthe.2006.08.599

529. Development of Novel Systemic Gene Delivery System for Cancer Therapy with Tumor-Specifically Cleavable PEG-Lipid

Hiroto Hatakeyama, Hidetaka Akita, Kentaro Kogure, Motoi Oishi, Yukio Nagasaki, Hideo Kobayashi, Hiroshi Kikuchi and Hideyoshi Harashima

Mol Ther 13: S203-S203; doi:10.1016/j.ymthe.2006.08.600

530. The Effects DNA Molecular Weights and Conformations on Cell Uptake and the Binding Interaction with Cationic Polymers Used for Non-Viral Gene Delivery

Charlie Y.-M. Hsu, Cezary Kucharski and Hasan Uludag

Mol Ther 13: S203-S204; doi:10.1016/j.ymthe.2006.08.601

531. Complexes of DNA-Cationic Liposomes with Baculovirus GP64 Envelope Fusion Protein Vesicles Demonstrate Enhanced Transfection Efficiency

Ghiabe H. Guibinga, Shaochun Song, Jeanne Loring and Theodore Friedmann

Mol Ther 13: S204-S204; doi:10.1016/j.ymthe.2006.08.602

532. An Inducible Fed-Batch Fermentation Process for Scale-Up and Production of DNA Vaccines and Gene Medicines

Aaron E. Carnes, James A. Williams and Clague P. Hodgson

Mol Ther 13: S204-S204; doi:10.1016/j.ymthe.2006.08.603

533. Recombinant (KHG)6-FGF2 Biopolymer for Targeted Gene Transfer

Arash Hatefi and Hamid Ghandehari

Mol Ther 13: S204-S205; doi:10.1016/j.ymthe.2006.08.604

534. Silk-Elastinlike Polymers for Matrix-Mediated Adenoviral Gene Delivery

Arash Hatefi and Hamid Ghandehari

Mol Ther 13: S205-S205; doi:10.1016/j.ymthe.2006.08.605

535. Physicochemical and Transfection Properties of Cationic Hydroxyethylcellulose/DNA Nanoparticles

Farzaneh Fayazpour, Bart Lucas, Carmen Alvarez-Lorenzo, Niek Sanders, Joseph Demeester and Stefaan De Smedt

Mol Ther 13: S206-S206; doi:10.1016/j.ymthe.2006.08.606

536. Charge Switchable Helper Lipids for Gene Delivery

Mark W. Grinstaff, Carla A. Hernandez Prata, Yougen Li, Dan Luo and Tom J. MacIntosh

Mol Ther 13: S206-S206; doi:10.1016/j.ymthe.2006.08.607

537. Charge-Reversal Lipids for Gene Transfection

Mark W. Grinstaff, Carla A. Hernandez Prata, Steven R. Meyers, Philippe Barthelemy, Yougen Li, Dan Luo, Tom J. McIntosh and Stephen J. Lee

Mol Ther 13: S206-S207; doi:10.1016/j.ymthe.2006.08.608

538. DNAvaletTM Transfection Reagent

Carla Prata

Mol Ther 13: S207-S207; doi:10.1016/j.ymthe.2006.08.609

539. Unraveling the Mechanisms Underlying Silencing/Activation of Episomal Vectors In Vivo

Efren Riu, Zhi-Ying Chen and Mark A. Kay

Mol Ther 13: S207-S207; doi:10.1016/j.ymthe.2006.08.610

540. Genetic Intervention towards Improving the Long Term Outcome of CABG Using a Lipid Peptide DNA Vector System

Scott A. Irvine, Faiza Afzal, Qing H. Meng, Jimmy Ho, Andrew Wu, Jean R. McEwan and Stephen L. Hart

Mol Ther 13: S207-S208; doi:10.1016/j.ymthe.2006.08.611

541. Species-Specific Characteristics in Muscle Resistance and Their Impact on In Vivo Electroporation

Amir S. Khan, Patricia A. Brown, Melissa A. Pope and Ruxandra Draghia-Akli

Mol Ther 13: S208-S208; doi:10.1016/j.ymthe.2006.08.613

542. Development and Characterization of Ultrasound Responsive Microbubbles for Gene Delivery

Ine Lentacker, Stefaan C. De Smedt, Joseph Demeester and Niek N. Sanders

Mol Ther 13: S208-S209; doi:10.1016/j.ymthe.2006.08.614

543. Monitoring Transgene Expression by Radio-Peptide Positron Emission Tomography

Amiq Gazdhar, Murat Bilici, Erick Ayuni, Thomas Krause, Michal Hofmann and Raplh A. Schmid

Mol Ther 13: S209-S209; doi:10.1016/j.ymthe.2006.08.615

544. PLGA Nanoparticles for DNA Vaccination |[ndash]| Waiving Complexity and Increasing Efficiency

Jacob Gvili and Marcelle Machluf

Mol Ther 13: S209-S209; doi:10.1016/j.ymthe.2006.08.616

545. Comparison between Different Tissues for Efficient and Safe DNA Electrotransfer In Vivo

Franck M. Andre and Lluis M. Mir

Mol Ther 13: S210-S210; doi:10.1016/j.ymthe.2006.08.617

546. Targeted Non-Viral Gene Delivery Using Microbubbles and Focused Ultrasound

Ahad Rahim, Sarah L. Taylor, Nigel L. Bush, Gail R. ter Haar, Jeff C. Bamber and Colin D. Porter

Mol Ther 13: S210-S210; doi:10.1016/j.ymthe.2006.08.618

547. Magnetically Driven Non-Viral Gene Delivery Efficiently Transfects Cultured Smooth Muscle Cells and Inhibits Their Growth Via Adiponectin Transgene Expression

Boris Polyak, Michael Chorny, Ivan Alferiev, Kenneth Walsh, Gary Friedman and Robert J. Levy

Mol Ther 13: S211-S211; doi:10.1016/j.ymthe.2006.08.619

548. Cellular Defense Response in Transduced and Transfected Human Tumor and Primary Cell Lines

Riikka Pellinen, Outi Rautsi, Saara Lehmusvaara, Sillanp|[auml]||[auml]| Maarit, Hakkarainen Tanja, V|[auml]|h|[auml]|kangas Elisa, Yl|[auml]|-herttuala Seppo, Hinkkanen Ari, Julkunen Ilkka and Wahlfors Jarmo

Mol Ther 13: S211-S211; doi:10.1016/j.ymthe.2006.08.620

549. Ultrasound with Microbubbles Enhances Gene Expression of Plasmid DNA Delivered through Portal Vein Injection

Zhenping Shen, Andrew A. Brayman, Liping Chen and Carol H. Miao

Mol Ther 13: S212-S212; doi:10.1016/j.ymthe.2006.08.621

550. Delivery of Oligodeoxynucleotides into Human Saphenous Veins and the Adjunct Effect of Ultrasound and Microbubbles

Tetsuya Kodama, Peng H. Tan, Andrew J.T. George and Martin J.K. Blomley

Mol Ther 13: S212-S212; doi:10.1016/j.ymthe.2006.08.622

551. The Use of Electroporation To Transfer Plasmids to the Lung Results in Reduced TLR9 Signaling and Inflammation

Rui Zhou, James E. Norton, Ning Zhang and David A. Dean

Mol Ther 13: S212-S213; doi:10.1016/j.ymthe.2006.08.623

552. Collateral Circulation under Cerebral Ischemia by Hypoxia Inducible Factor Naked DNA in Rat Indirect-Bypass Model

Mitsuhiro Anan, Tatsuya Abe, Takeshi Matsuda, Ryo Inoue, Keisuke Ishii, Minoru Fujiki and Hidenori Kobayashi

Mol Ther 13: S213-S213; doi:10.1016/j.ymthe.2006.08.624

553. Development of Echo-Contrast Gas Entrapping Liposome as Gene and siRNA Delivery Tool

Yoichi Negishi, Tetsuya Fukuyama, Yoko Endo, Ryo Suzuki, Kumiko Tanaka, Kaori Sawamura, Tomoko Takizawa, Kazuo Maruyama and Yukihiko Aramaki

Mol Ther 13: S213-S213; doi:10.1016/j.ymthe.2006.08.625

554. Improved Efficiency of Gene Expression Using the Stiletto|[trade]| Endocardial Direct Injection Catheter

Samuel J. Epstein, Wendy Naimark, Maria Palasis, Kian K. Poh, Tengiz Tkebuchava, Corinne Luedemann and Douglas Losordo

Mol Ther 13: S213-S214; doi:10.1016/j.ymthe.2006.08.626

555. Large-Scale, Flow-Based Electroporation To Deliver Engineered Zinc Finger Protein Nucleases That Mediate High-Efficiency Disruption of the Human CCR5 Gene

Michael C. Holmes, Linda Liu, Elena Perez, Linhong Li, Rama Shivakumar, Cornell Allen, Olga Liu, Jeffrey C. Miller, Fyodor D. Urnov, Kenneth Kim, Edward J. Rebar, Dale Ando, Philip D. Gregory, James Riley, Madhusudan Peshwa and Carl June

Mol Ther 13: S214-S214; doi:10.1016/j.ymthe.2006.08.627

556. Proteasome Inhibitors Increase Cationic-Lipid Mediated Gene Transfer in A549 Cells In Vitro

Uta Griesenbach, Maresa Brake, Aaron Gardner and Eric W.F.W. Alton

Mol Ther 13: S214-S214; doi:10.1016/j.ymthe.2006.08.628

557. A Study of AAV2/1/SERCA2a Delivered Via the V-Focus Cardiac Delivery System in an Ovine Pacing Model of Heart Failure

Melissa J. Byrne, David Kaye and John M. Power

Mol Ther 13: S214-S215; doi:10.1016/j.ymthe.2006.08.629

558. High Efficiency Transfection of Primary Cells for Basic Research and Gene Therapy

Hans-Guenter Bruenker

Mol Ther 13: S215-S215; doi:10.1016/j.ymthe.2006.08.630

559. A Pseudo-Exon Derived from an Intronic Insertion is Responsible for Duchenne-Like Muscular Dystrophy in the Welsh Corgi Dog

Bruce F. Smith and Joseph N. Kornegay

Mol Ther 13: S215-S215; doi:10.1016/j.ymthe.2006.08.632

560. GNE Gene Replacement in Hereditary Inclusion Body Myopathy

Phillip B. Maples, Daniel Darvish, Gregory Nemunaitis, Esther Chang, Julie Ogden and John Nemunaitis

Mol Ther 13: S215-S216; doi:10.1016/j.ymthe.2006.08.633

Top

Abstracts

561. Novel Tissue-Specific Regulatory Cassettes Direct High-Level Transgene Expression in Skeletal and Cardiac Muscle

Maja Z. Salva, Charis L. Himeda, Phillip Tai, Eiko Nishiuchi, Eric E. Finn, James M. Allen, Paul Gregorevic, Michael J. Blankinship, Leonard A. Meuse, Jeffrey S. Chamberlain and Stephen D. Hauschka

Mol Ther 13: S216-S216; doi:10.1016/j.ymthe.2006.08.634

562. Ex Vivo Gene Therapy for Duchenne Muscular Dystrophy: Lentiviral Vectors, Exon Skipping and PhiC31 Integrase Approaches

Simon P. Quenneville, Pierre Chapdelaine, Joel Rousseau and Jacques P. Tremblay

Mol Ther 13: S216-S216; doi:10.1016/j.ymthe.2006.08.635

563. Correction of Glycogen Storage Disease Type II by Systemic Delivery of an AAV2/8 Vector Containing a Muscle-Specific Promoter

Baodong Sun, Ping Li, Brown Talmage, Bird Andrew, Zhen Yan and Dwight D. Koeberl

Mol Ther 13: S217-S217; doi:10.1016/j.ymthe.2006.08.636

564. Correction of Hyposialylation in Hereditary Inclusion Body Myopathy, by Ex-Vivo Therapy

Zo|[eacute]| Coulombe, Dominic Gagn|[eacute]| and Jacques P. Tremblay

Mol Ther 13: S217-S217; doi:10.1016/j.ymthe.2006.08.637

565. Acceleration of Fracture Healing with Adenovirally Transduced Human BMP-2 and -6 Genes in Horse Metatarsal Osteotomy and Ostectomy Models

Akikazu Ishihara, Alicia L. Bertone, Alan L. Litsky, John S. Mattoon and Stephen E. Weisbrode

Mol Ther 13: S217-S218; doi:10.1016/j.ymthe.2006.08.638

566. Delaying the Onset of Diabetes in the NOD Mouse Using Exosomes Derived from Dendritic Cells Transfected with Adenoviral Vectors

Melanie A. Ruffner, Seon Hee Kim, Nicole R. Bianco, William J. Shufesky, Nick Giannoukakis, Adrian E. Morelli and Paul D. Robbins

Mol Ther 13: S218-S218; doi:10.1016/j.ymthe.2006.08.639

567. Adeno-Associated Virus Vector 8 (AAV8) Provides Efficient Gene Delivery to Skeletal Muscles In Utero by Systemic Adminstration

Bhanu Munil Koppanati, Juan Li, Bing Wang, Xiao Xiao and Paula Ruth Clemens

Mol Ther 13: S218-S218; doi:10.1016/j.ymthe.2006.08.640

568. Ex Vivo Mesenchymal Stem Cell Therapy with rAAV2 Encoding BMP-2 Enhances Bone Regeneration in Ovariectomized Mouse Model

Sanjay Kumar, Tim R. Nagy and Selvarangan Ponnazhagan

Mol Ther 13: S219-S219; doi:10.1016/j.ymthe.2006.08.641

569. Gene Therapy of Uterine Leiomyoma: Adenovirus-Mediated Herpes Simplex Virus Thymidine Kinase/Ganciclovir Treatment Inhibits Growth of Human and Rat Leiomyoma Cells In Vitro and in a Nude Mouse Model

Salama A. Salama, Marwa W. Kamel, Gregory M. Christman, Hui Q. Wang and Ayman A. Al-Hendy

Mol Ther 13: S219-S219; doi:10.1016/j.ymthe.2006.08.642

570. Ectopic Expression of Adenoviral Smad7 Significantly Reduces Hypertrophic Scarring in Rabbit Ears by Abrogating TGF|[beta]|1 Signalling

Juergen Kopp, Harun Seyhan, Katrin Messingschlager, Vanessa Pe|[ntilde]|a de Bender and Raymund E. Horch

Mol Ther 13: S219-S220; doi:10.1016/j.ymthe.2006.08.643

571. Increasing BMP Responsiveness in Human Mesenchymal Stem Cells In-Vitro by Delivery of the Osteoinductive LMP-1 Gene

Manjula Viggeswarapu, Maggie Bargouti, Mesfin Teklemariam, Chantrice Rogers, Liping Zhu, Nancy Baker, Louisa F. Titus and Scott D. Boden

Mol Ther 13: S220-S220; doi:10.1016/j.ymthe.2006.08.644

572. rAd-p21 To Reduce Excessive Dermal Scarring: Efficacy, Expression, and Tensile Strength in Animal Models

David W. Kang, Dan-Ling Gu, L. David Looper, Barry J. Sugarman, Erlinda M. Quijano and Monica L. Zepeda

Mol Ther 13: S220-S220; doi:10.1016/j.ymthe.2006.08.645

573. Enhanced Level of Gene Correction Mediated by Oligonucleotides Containing CpG Modification in the mdx Mouse Model for Duchenne Muscular Dystrophy

Carmen Bertoni, Arjun Rustagi and Thomas A. Rando

Mol Ther 13: S221-S221; doi:10.1016/j.ymthe.2006.08.646

574. Models of Cancer Cachexia: Treatment with Inhibition of NF-kB

Jad R. Maamary, Zhilong Jiang and Paula R. Clemens

Mol Ther 13: S221-S221; doi:10.1016/j.ymthe.2006.08.647

575. Correction of Ventilation in Glycogen Storage Disease Type II Mice after Gel-Mediated Delivery of Adeno-Associated Virus Serotype 1 Vectors

Cathryn Mah, Lara R. DeRuisseau, Christina A. Pacak, Melissa A. Lewis, David D. Fuller and Barry J. Byrne

Mol Ther 13: S221-S222; doi:10.1016/j.ymthe.2006.08.648

576. Hypoxic Adipocytes Support Early Heterotopic Bone Formation

Elizabeth A. Olmsted-Davis, Francis H. Gannon, Zbigniew Gugala, John A. Hipp, Christine Foultier-Dilling, Michael H. Heggeness and Alan R. Davis

Mol Ther 13: S222-S222; doi:10.1016/j.ymthe.2006.08.649

577. Inducible Regulation of Runx2-Stimulated Osteogenesis

Charles A. Gersbach, Joseph M. Le Doux, Robert E. Guldberg and Andres J. Garcia

Mol Ther 13: S222-S223; doi:10.1016/j.ymthe.2006.08.650

578. Suppression of Inflammation Following Intramuscular Administration of Pseudotyped AAV-TNFR:Fc Vectors in a Rat Model of Arthritis

Haim Burstein, Kurt Lustig and Ziv Sandalon

Mol Ther 13: S223-S223; doi:10.1016/j.ymthe.2006.08.651

579. Non-Invasive Measurement of Maximal Strength in the Normal and Dystrophic Dog Quadriceps Using Magnetic Stimulation of the Femoral Nerve

Frederick J. Balzer, Martin K. Childers, Janet R. Bogan, Daniel J. Bogan, Joe N. Kornegay and Hansell H. Stedman

Mol Ther 13: S223-S223; doi:10.1016/j.ymthe.2006.08.652

580. Gene Therapy of Chronic Hepatitis B Infection Using a High-Capacity Adenovirus Expressing Interleukin 12 under the Control of a Liver Specific Mifepristone-Inducible Promoter

Julien S. Crettaz, Pedro Berraondo, Laura Ochoa, Astrid Paneda, Itziar Otano, Cristina Olague, Africa Vales, Stefan Kochanek, Jesus Prieto and Gloria Gonzalez-Aseguinolaza

Mol Ther 13: S224-S224; doi:10.1016/j.ymthe.2006.08.654

581. IL-23 Is Required for B-Cell Memory after CD40 Ligand-Modified Dendritic Cell Vaccination

Mingquan Zheng, Jolia A. Bindas, Rekha Rapaka and Jay K. Kolls

Mol Ther 13: S224-S224; doi:10.1016/j.ymthe.2006.08.655

582. CNS Gene Delivery Targeting CCR3 Protects Brain Microglia from HIV-1

Lokesh Agrawal and David S. Strayer

Mol Ther 13: S224-S225; doi:10.1016/j.ymthe.2006.08.656

583. Evaluation of a pDNA-Based Anthrax Vaccine and Immune Correlates of Protection in Mice and Non-Human Primates

Peggy Lalor, Vanessa Whitlow, C. Richard Lyons, Julie Lovechik, Mark R. Perry, Jane Morrow, Peter Hobart, Holly Horton, Larry Smith, David Kaslow and Alain Rolland

Mol Ther 13: S225-S225; doi:10.1016/j.ymthe.2006.08.657

584. Enhanced Inhibition of HIV Using Combinatorial Genetic Therapy Against HIV-1 Integrase Delivered by SV40 Vectors

Elena I. Marusich and David S. Strayer

Mol Ther 13: S225-S225; doi:10.1016/j.ymthe.2006.08.658

585. Improved Efficacy of DNA Vaccines for HIV and Smallpox Using Constant-Current Electroporation

Lauren Hirao, Amir S. Khan, Ruxandra Draghia-Akli and David B. Weiner

Mol Ther 13: S226-S226; doi:10.1016/j.ymthe.2006.08.659

586. Anti-HIV-1 Neutralizing Antibody Gene Delivery to Rhesus Macaques and Rodents: A Novel Vaccination Approach

K. Reed Clark, Jianchao Zhang, David C. Montefiori and Philip R. Johnson5

Mol Ther 13: S226-S226; doi:10.1016/j.ymthe.2006.08.660

587. HIV-1 Glycoprotein gp120 Induces Apoptosis in the Caudate-Putamen In Vivo: Implications for Gene Transfer of Anti-Oxidant Enzymes Using SV40 Vectors

Jean-Pierre Louboutin, Lokesh Agrawal, Beverly A.S. Reyes, Elisabeth J. van Bockstaele and David S. Strayer

Mol Ther 13: S226-S227; doi:10.1016/j.ymthe.2006.08.661

588. Hepatic HB-EGF (Heparin-Binding EGF-Like Growth Factor) Gene Therapy for Fulminant Hepatic Failure in Mice: More Potent Protective and Mitogenic Effects for Hepatocytes Than HGF (Hepatocyte Growth Factor)

Ken-ichiro Kosai, Ngin Cin Khai and Tomoyuki Takahashi

Mol Ther 13: S227-S227; doi:10.1016/j.ymthe.2006.08.662

589. Repeated Recombinant Adenovirus (rAd) Administration To Generate Mucosal Antibodies (Abs) vs Botulinum Toxin A (BoNT/A)

Marlene S. Strayer, Andrew B. Maksymowych, Carmen N. Nichols, Steven Elek, Jean-Pierre Louboutin, Lance L. Simpson and David S. Strayer

Mol Ther 13: S227-S228; doi:10.1016/j.ymthe.2006.08.663

590. Recombinant Adenovirus Vaccines Against Anthrax

Michael J. McConnell and Michael J. Imperiale

Mol Ther 13: S228-S228; doi:10.1016/j.ymthe.2006.08.664

591. Development of Anti-JC Virus |[ldquo]|Designer T Cells|[rdquo]| for Progressive Multifocal Leukoencephalopathy (PML) Immunotherapy

Wen Yang, Esther Beaudoin, Renaud A. Du Pasquier, Igor J. Koralnik and Richard P. Junghans

Mol Ther 13: S228-S229; doi:10.1016/j.ymthe.2006.08.665

592. Effective Transduction of Nondividing PBL, Monocytes and Monocyte-Derived Macrophages with SV40-Derived Vectors Protects from HIV-1 Challenge

Elena I. Marusich and David S. Strayer

Mol Ther 13: S229-S229; doi:10.1016/j.ymthe.2006.08.666

593. Combination Anti-HIV-1 Gene Therapy Simultaneously Targeting CCR5 and Rev Protein Using SV40-Derived Vectors Inhibits Replication of HIV

Alena A. Chekmasova and David S. Strayer

Mol Ther 13: S229-S229; doi:10.1016/j.ymthe.2006.08.667

594. Protection Against In Vivo Tumor Growth after Electroporation-Enhanced DNA Vaccination with the Hepatitis C Virus Non-Structural 3/4A

Rune Kjeken, Gustaf Ahlen, Jonas Soderholm, Torunn Tjelle, Iacob Mathiesen and Matti Sallberg

Mol Ther 13: S229-S230; doi:10.1016/j.ymthe.2006.08.668

595. Nasal Delivery of Adenovirus Expressing the Ebola Glycoprotein Protects Mice Against Ebola Virus in the Presence of Preexisting Immunity to the Vaccine Carrier

Maria Croyle, Heinz Feldmann, Steven Jones, James M. Wilson and Gary P. Kobinger

Mol Ther 13: S230-S230; doi:10.1016/j.ymthe.2006.08.669

596. A Novel Replication Incompetent Human Subgroup D Adenoviral Vector Based on Type 49: Manufacture on PER.C6|[reg]|, Cell Tropism and Immunogenicity

Angelique Lemckert, Jos Grimbergen, Anna Thorner, Ronald Vogels, Paul Quax, Jaap Goudsmit, Dan Barouch and Menzo Havenga

Mol Ther 13: S230-S230; doi:10.1016/j.ymthe.2006.08.670

597. DNA Vaccines: Induction of Humoral and Cellular Responses Via Skin or Muscle Immunization Enhanced by Electroporation

Lei Zhang, Georg Widera, Susan Bleecher and Dietmar Rabussay

Mol Ther 13: S231-S231; doi:10.1016/j.ymthe.2006.08.671

598. Effective Humoral and Cellular Smallpox-Immune Responses Using a Combination of Plasmids Delivered by Intramuscular Injection Followed by Constant-Current Electroporation in Rabbits

Amir S. Khan, Lauren Hirao, David B. Weiner and Ruxandra Draghia-Akli

Mol Ther 13: S231-S231; doi:10.1016/j.ymthe.2006.08.672

599. Neuron Loss Mediated by HIV-1 gp120 In Vivo: Neuroprotection Using SV40 Gene Transfer of Antioxidant Enzymes

Jean-Pierre Louboutin, Lokesh Agrawal, Beverly A.S. Reyes, Elisabeth J. van Bockstaele and David S. Strayer

Mol Ther 13: S232-S232; doi:10.1016/j.ymthe.2006.08.673

600. Transduced Cells with Lentiviral Vector Expressing gp41-Derived c-Peptide Are Protected from HIV-1 Infection

Kwang-soo Ahn, Seok Kee Chang, Dokeun Kim, Won Shin and Yeowon Sohn

Mol Ther 13: S232-S232; doi:10.1016/j.ymthe.2006.08.674

601. Potential of Gene Transfer for HIV/AIDS Therapy: Overwhelming and Repeated HIV Challenge Selects for Transduced Lymphocytes Capable of Long-Term Survival and Enduring Resistance to HIV

Elena I. Marusich and David S. Strayer

Mol Ther 13: S232-S233; doi:10.1016/j.ymthe.2006.08.675

602. Effectiveness of Gene Delivery Targeting HIV-1 Integrase in Inhibiting HIV Integration: Lack of HIV-1 Genomes in T-Lymphocytes during Repeated Challenges with HIV-1

Elena I. Marusich, Christine B. Mitchell and David S. Strayer

Mol Ther 13: S233-S233; doi:10.1016/j.ymthe.2006.08.676

603. Withdrawn

Mol Ther 13: S233-S233; doi:10.1016/j.ymthe.2006.08.677

604. Comparative Analysis of Different Methods for Quantitative Evaluation of Neutralizing Antibody to Ebola Virus in a Biosafety Level 2 or 4 Environment

Hideki Ebihara, Xiangguo Qiu, Steven Theriault, Matthew Klassen, Ute Stroeher, Jim Strong, Steven Jones, James M. Wilson, Heinz Feldmann and Gary Kobinger

Mol Ther 13: S233-S234; doi:10.1016/j.ymthe.2006.08.678

605. Long-Term Protection Afforded by a Single Administration of an Ad-Based Anti-Y. pestis Vaccine Against a Lethal Respiratory Challenge with Y. pestis

Maria J. Chiuchiolo, Anja Krause, Ronald G. Crystal and Julie L. Boyer

Mol Ther 13: S234-S234; doi:10.1016/j.ymthe.2006.08.679

606. Identification of a 45-aa Domain of the F12-Vif Mutant Possessing Anti-HIV Activity

Simona Porcellini, Rossella Lupo, Giuliana Vallanti, Maurizio Federico, Fulvio Mavilio and Chiara Bovolenta

Mol Ther 13: S234-S234; doi:10.1016/j.ymthe.2006.08.680

607. Novel Adeno-Associated Viruses as Vaccine Carriers for HIV-1: Evaluation in Non-Human Primates

Roberto Calcedo, Yan Zhi, Joanita M. Figueredo, Judith I. Franco, Julie C. Johnston, Rebecca L. Grant and James M. Wilson

Mol Ther 13: S234-S235; doi:10.1016/j.ymthe.2006.08.681

608. Dose Escalation of Recombinant Adenovirus-Based Influenza Virus Vaccine Encoding the Full Length Hemagglutinin (HA) of the A/Vietnam/1203/2004 (H5N1) To Immunize Na|[iuml]|ve and Ad-Immune Mice

Julia Steitz, Wentao Gao, Edward Nwanegbo, Ruben O. Donis, Jacqueline M. Katz and Andrea Gambotto

Mol Ther 13: S235-S235; doi:10.1016/j.ymthe.2006.08.682

609. Acute-Phase Toxicity Following Systemic Administration of Non-Human Primate Derived Adenoviral Vectors to Mice

Suryanarayan Somanthan, Zhe Zhang, Guang-Ping Gao, Martin W. Lock, Peter L. Bell, Soumitra Roy, Arbansjit K. Sandhi and James M. Wilson

Mol Ther 13: S235-S235; doi:10.1016/j.ymthe.2006.08.683

610. The Effect of In Vitro Antiviral Therapy on Lentiviral Transduction

Priscilla Yam, Paola Marcovecchio, Shirley Li, Jiing-Kuan Yee and John A. Zaia

Mol Ther 13: S235-S236; doi:10.1016/j.ymthe.2006.08.684

611. Induction of Persistent Passive Immunity Against Anthrax Toxin by an Adeno-Associated Virus Type rh10 Vector Expressing Anti-Protective Antigen Antibody

Bishnu P. De, Neil R. Hackett, Jian Ping Qiu, Julie L. Boyer, James M. Wilson and Ronald G. Crystal

Mol Ther 13: S236-S236; doi:10.1016/j.ymthe.2006.08.685

612. Withdrawn

Mol Ther 13: S236-S236; doi:10.1016/j.ymthe.2006.08.687

613. Challenging an Old Drug in a New Context: Low-Dose Cyclophosphamide in Immunogenetherapy of Cancer

Sebastian Tuve, Shaoheng Ni and Andre Lieber

Mol Ther 13: S236-S237; doi:10.1016/j.ymthe.2006.08.688

614. The Role of the Activated MAPK Pathway through the Oncogenic BRAFV600E-Mutation in the Immune Escaping Mechanism of Melanoma

Hidetoshi Sumimoto and Yutaka Kawakami

Mol Ther 13: S237-S237; doi:10.1016/j.ymthe.2006.08.689

615. Anti-Tumor Activities of IL-12 and IL-23 Are Mediated by Similar, yet Divergent, Effector Mechanisms

JaNean C. Ceidro, Euan Lockhart, Seon-Hee Kim and Paul D. Robbins

Mol Ther 13: S237-S237; doi:10.1016/j.ymthe.2006.08.690

616. Enhancement of Antitumor Activity of Interferons by RNAi-Mediated Silencing of SOCS Genes in Tumor Cells

Yuki Takahashi, Haruka Kaneda, Makiya Nishikawa and Yoshinobu Takakura

Mol Ther 13: S237-S238; doi:10.1016/j.ymthe.2006.08.691

617. Tumor Lysates Prepared from Cells Infected with a Fusogenic Oncolytic HSV Stimulates Potent Antitumor Immunity Against Primary and Metastatic Murine Mammary Carcinoma

Xinping Fu, Lihua Tao and Xiaoliu Zhang

Mol Ther 13: S238-S238; doi:10.1016/j.ymthe.2006.08.692

618. Hydrodynamic Limb Vein-Delivered Xenogeneic Plasmid DNA Cancer Vaccine Effectively Induces Antitumor Protection

Zane C. Neal, Mary Kay Bates and Hans Herweijer

Mol Ther 13: S238-S238; doi:10.1016/j.ymthe.2006.08.693

619. Tumor-Derived Chemokine MCP-1/CCL2 Is Sufficient for Mediating Tumor Tropism of Adoptively Transferred T-Cells

Christine E. Brown, Reena Vishwanath, Brenda Aguilar, WenChung Chang and Michael C. Jensen

Mol Ther 13: S239-S239; doi:10.1016/j.ymthe.2006.08.694

620. Liposome-Based Therapeutic Vaccine for Cervical Cancer

Weihsu Claire Chen and Leaf Huang

Mol Ther 13: S239-S239; doi:10.1016/j.ymthe.2006.08.695

621. Immunological Memory in a Syngeneic Model of Recurrent and Multifocal Glioblastoma

Gwendalyn D. King, James F. Curtin, Chunyan Liu, Catherine Bresee, Sarah B. Honig, Jeffery M. Zirger, Nico VanRooijen, Antoni Ribas, Robert Pechnick, Pedro R. Lowenstein and Maria G. Castro

Mol Ther 13: S239-S239; doi:10.1016/j.ymthe.2006.08.696

622. Effective Prevention of Spontaneous Lung Metastasis of AT6.3 Prostate Cancer by Intravenous Administration of Dendritic Cells Activated by Non-Transmissible Sendai Virus

Tomonori Kato, Yasuji Ueda, Yasuo Yoneyama, Akinao Matsunaga, Megumi Akizawa, Akira Komiya, Hiroyoshi Suzuki, Makoto Inoue, Mamoru Hasegawa, Tomohiko Ichikawa and Yoshikazu Yonemitsu

Mol Ther 13: S240-S240; doi:10.1016/j.ymthe.2006.08.697

623. Polymer Microparticles Delivering a Idiotype/Chemokine Fusion DNA Vaccine Generate Protective Immunity in a Mice Model of B Cell Lymphoma

Sudhir P. Kasturi, Bilal Ghosn, Kassandra S. Thomson, Hong Qin, Larry Kwak and Krishnendu Roy

Mol Ther 13: S240-S240; doi:10.1016/j.ymthe.2006.08.698

624. Conditionally Replicative Adenovirus Vector Overexpressing the ADP (E3-11.6K) Protein and Armed with Human Interferon Alpha

Elena V. Shashkova, Jacqueline F. Spencer, William S.M. Wold and Konstantin Doronin

Mol Ther 13: S240-S241; doi:10.1016/j.ymthe.2006.08.699

625. Viral Shedding after Intratumoral Injection of Adenoviral Vectors to Patients with Cancer

Gloria Gonz|[aacute]|lez-Aseguinolaza, Maria Ruiz, Cristina Olag|[uuml]|e, Jesus Prieto, Juan Ruiz and Bruno Sangro

Mol Ther 13: S241-S241; doi:10.1016/j.ymthe.2006.08.700

626. Inactivated Sendai Virus Particle (HVJ-E) Solely Induces Specific Anti-Tumor Immune Response and Eradicates Murine Carcinoma

Masayuki Kurooka and Yasufumi Kaneda

Mol Ther 13: S241-S241; doi:10.1016/j.ymthe.2006.08.701

627. Calcium Phopspate Precipitation of Adenovirus Enhances Gene Delivery into Human Dendritic Cells

Michael P. Seiler, Stephen M. Gottschalk, Vincenzo Cerullo, Christian Clarke, Cliona M. Rooney and Brendan Lee

Mol Ther 13: S242-S242; doi:10.1016/j.ymthe.2006.08.702

628. Cancer Immunotherapy Against Murine Squamous Cell Carcinoma with Dendritic Cells Activated by Sendai Virus

Akinao Matsunaga, Yasuji Ueda, Yasuo Yoneyama, Yasunori Akutsu, Hideaki Shimada, Tomonori Kato, Shinji Okano, Satoko Shibata, Mamoru Hasegawa, Yoshikazu Yonemitsu, Katsuo Sueishi and Takenori Ochiai

Mol Ther 13: S242-S242; doi:10.1016/j.ymthe.2006.08.703

629. Development and Characterization of Immunotherapy Using SeV/dF-Activated Dendritic Cells Against Squamous Cell Carcinoma

Yasuo Yoneyama, Yasuji Ueda, Akinao Matsunaga, Yasunori Akutsu, Hideaki Shimada, Tomonori Kato, Shinji Okano, Satoko Shibata, Mamoru Hasegawa, Yoshikazu Yonemitsu, Katsuo Sueishi and Takenori Ochiai

Mol Ther 13: S242-S243; doi:10.1016/j.ymthe.2006.08.704

630. A Phase 2 Randomized Study of GM-CSF Gene-Modified Autologous Tumor Cell Immunotherapy (CG8123) with and without Low- Dose Cyclophosphamide in Advanced Stage Non- Small Cell Lung Cancer (NSCLC)

John Nemunaitis, J. Schiller, Helen Ross, David Jablons, H. Harper, D. Sterman, K. Kelly, D. Carbone, A. Lin, D. Maslyar10 and Kristen Hege10

Mol Ther 13: S243-S243; doi:10.1016/j.ymthe.2006.08.705

631. Phase 1/2 Trial of Autologous Tumor Mixed with an Allogeneic GVAX|[reg]| Immunotherapy in Advanced Stage Non-Small Cell Lung Cancer

John Nemunaitis, Thierry Jahan, Helen Ross, Daniel Sterman, Donald Richards, Bernie Fox, David Jablons, Junko Aimi, Andy Lin and Kristen Hege

Mol Ther 13: S243-S243; doi:10.1016/j.ymthe.2006.08.706

632. Sustained Function and Enhanced Replicative Capacity of Anti-Tumor CD4+ Effectors by Enforced Co-Stimulation

Lufen Chang and Michael Jensen

Mol Ther 13: S243-S244; doi:10.1016/j.ymthe.2006.08.707

633. Improved Antitumoral Efficacy of Semliki Forest Virus Vectors Expressing IL-12 in Orthotopic Hepatocellular Carcinoma Models

Juan R. Rodriguez, Min Guan, Erkuden Casales, Jesus Prieto, Cheng Qian and Cristian Smerdou

Mol Ther 13: S244-S244; doi:10.1016/j.ymthe.2006.08.708

634. Engineered Herpes Simplex Virus Expressing IL-12 for the Treatment of Experimental Brain Tumors

Shinya Miyamoto, Yasushi Ino, Hiroshi Fukuhara and Tomoki Todo

Mol Ther 13: S244-S244; doi:10.1016/j.ymthe.2006.08.709

635. Systemic Oncolytic and Immunologic Therapy for Cancer with JX-594, a Targeted Poxvirus Expressing GM-CSF

David H. Kirn, Stephen Thorne, J.K. Kim, J.Y. Oh, B.H. Park, D.E. Lee, J.S. Kim, J.E. Je and Tae-Ho Hwang

Mol Ther 13: S244-S245; doi:10.1016/j.ymthe.2006.08.710

636. Antitumoral Activity Mediated by a Lipid- Based Gene Delivery System Containing Therapeutic Genes

Henrique Faneca, Ant|[oacute]|nio Cabrita, S|[eacute]|rgio Sim|[otilde]|es and Maria Pedroso de Lima

Mol Ther 13: S245-S245; doi:10.1016/j.ymthe.2006.08.711

637. Specific Oncolytic Adenovirus Driven by Human A33 Promoter Region for Colorectal Cancer Therapy

Eduardo G. Cafferata, Daniela R. Maccio, Maria V. Lopez, Diego L. Viale and Osvaldo L. Podhajcer

Mol Ther 13: S245-S245; doi:10.1016/j.ymthe.2006.08.713

638. The Optimal Placement and Orientation of the Bipartite Two-Step Transcription Amplification (TSTA) Expression System in Adenoviral Vectors for Prostate Cancer Gene Therapy

Marxa L. Figueiredo, Makoto Sato, May N. Chen, Russell Powell, Michael Carey, Sam Gambhir and Lily Wu

Mol Ther 13: S245-S246; doi:10.1016/j.ymthe.2006.08.714

639. In Vivo Imaging of Lymph Node Metastasis with Telomerase-Specific Replication-Competent Adenovirus Containing Green Fluorescent Protein Gene

Toru Kojima, Hiroyuki Kishimoto, Yuichi Watanabe, Shunsuke Kagawa, Fuminori Teraishi, Masayoshi Hioki, Yoshihiro Ikeda, Ryo Sakai, Yasuo Urata, Noriaki Tanaka and Toshiyoshi Fujiwara

Mol Ther 13: S246-S246; doi:10.1016/j.ymthe.2006.08.715

640. Oncolytic Transcriptionally Retargeted Adenovirus Expressing Nitroreductase in Combination with Antiangiogenic Drug RAD001

Alexander N. Lukashev, Krizstian G. Homicsko, Cristophe Fuerer and Richard Iggo

Mol Ther 13: S246-S246; doi:10.1016/j.ymthe.2006.08.716

641. Retargeting Adenoviruses to Surface Expressed Antigens on Oral Mucosa

Hester J.T. van Zeeburg, Aafke Huizenga, N. Korokhov, Victor W. van Beusechem and Ruud H. Brakenhoff

Mol Ther 13: S247-S247; doi:10.1016/j.ymthe.2006.08.717

642. Toxicological Findings with Oncolytic Adenovirus Vector VRX-007, Wild-Type Ad5, and a Replication-Defective Adenovirus Vector in Syrian Hamsters and C57BL/6 Mice

Karoly Toth, Jacqueline F. Spencer, Drew L. Lichtenstein, Ann E. Tollefson, Debabrata Patra, Jennifer M. Meyer, Elena Shashkova, Mohan Kuppuswamy, Konstantin Doronin, Debanjan Dhar, Maria A. Thomas, Louis A. Zumstein and William S.M. Wold

Mol Ther 13: S247-S247; doi:10.1016/j.ymthe.2006.08.718

643. Human Matrix Metalloproteinase-8 Gene Delivery Enhances the Oncolytic Activity of a Replicating Adenovirus

Jin Cheng, Harald Sauthoff, Yao Qi Huang, David I. Kutler, Sheila Heitner, William N. Rom and John G. Hay

Mol Ther 13: S248-S248; doi:10.1016/j.ymthe.2006.08.719

644. A Dual-Action Armed Replicating Adenovirus for the Treatment of Bone Metastases of Breast Cancer

James J. Cody and Joanne T. Douglas

Mol Ther 13: S248-S248; doi:10.1016/j.ymthe.2006.08.720

645. Combination of Oncolytic Adenovirotherapy and Bax Gene Therapy Does Not Augments Antitumor Efficacy

Masayoshi Hioki, Shunsuke Kagawa, Toshiya Fujiwara, Yoshihiro Ikeda, Toru Kojima, Ryo Sakai, Futoshi Uno, Fuminori Teraishi, Yoshiko Shirakiya, Yuichi Watanabe, Yuuri Hashimoto and Yasuo Urata

Mol Ther 13: S248-S249; doi:10.1016/j.ymthe.2006.08.721

646. Utilization of Human Mesenchymal Stem Cells for Delivery of Targeted Oncolytic Adenoviruses into Orthotopic Lung Tumors

Tanja Hakkarainen, Merja S|[auml]|rkioja, Petri Lehenkari, Susanna Miettinen, Timo Ylikomi, Anna Kanerva and Akseli Hemminki

Mol Ther 13: S249-S249; doi:10.1016/j.ymthe.2006.08.722

647. Evaluation of Dose, Scheduling, Combination with Chemotherapy and Specificity of Ad5/3 Fiber-Chimeric Oncolytic Adenoviruses for Treatment of Ovarian Cancer

Mari Raki, Lotta Kangasniemi, Anna Kanerva, Gerd Bauerschmitz, Helena Isoniemi, Krister Hockerstedt and Akseli Hemminki

Mol Ther 13: S249-S249; doi:10.1016/j.ymthe.2006.08.723

648. Transductionally Modified Oncolytic Adenoviruses for Treatment of Advanced Pancreatic Cancer

Tommi Pisto, Lotta Kangasniemi, Tanja Hakkarainen, Tuula Kiviluoto, Kilian Guse, Anna Kanerva and Akseli Hemminki

Mol Ther 13: S250-S250; doi:10.1016/j.ymthe.2006.08.724

649. Increased Therapeutic Efficacy of the Prostate-Specific Oncolytic Adenovirus Ad[I/PPT-E1A] by Introduction of the Entire E3 Region or the Adenovirus Death Protein

Angelika Danielsson, Helena Dzojic, Berith Nilsson, Wing-Shing Cheng and Magnus Essand

Mol Ther 13: S250-S250; doi:10.1016/j.ymthe.2006.08.725

650. AU-rich 3' UTR Elements for Increasing the Specificity of Promoter Regulated Adenoviral Gene Therapy

Merja Sarkioja, Minna Eriksson, Ristimaki Ari, Kanerva Anna, Hakkarainen Tanja and Hemminki Akseli

Mol Ther 13: S250-S250; doi:10.1016/j.ymthe.2006.08.726

651. VRX-007, an Oncolytic Adenovirus Vector, Replicates in Syrian Hamsters but Not Mice: Comparison of Biodistribution Studies Performed in the Syrian Hamster and Mouse

Drew L. Lichtenstein, Karoly Toth, Jaqueline F. Spencer, Jenifer Meyer, Baoling Ying, Ann E. Tollefson, Debabrata Patra, Elena Shashkova, Mohan Kuppuswamy, Konstantin Doronin, Debanjan Dhar, Louis A. Zumstein and William S.M. Wold

Mol Ther 13: S251-S251; doi:10.1016/j.ymthe.2006.08.727

652. In Vivo Evaluation of an Oncolytic Adenovirus Regulated by Hypoxia

Sergia Bortolanza, Jesus Prieto, Pilar Alzuguren, Elvira Carro and Ruben Hernandez-Alcoceba

Mol Ther 13: S251-S251; doi:10.1016/j.ymthe.2006.08.728

653. The Controlled Transgene Expression in Oncolytic Adenoviral Vectors with Major Late Promoter for Therapy of Cancer

Wei Jiang, Rong Cai, Guanghua Yang, Kai Chen, Yu Chen, Xinyuan Liu and Cheng Qian

Mol Ther 13: S251-S251; doi:10.1016/j.ymthe.2006.08.729

654. Targeting Adenoviral Vectors for Use in Breast Cancer Gene Therapy

Alan D. DeSilva, Leonard I. Wiebe, Chang-Xin Shi, Mabrouk M. Elgadi, Gianluca Bossi and Mary M. Hitt

Mol Ther 13: S252-S252; doi:10.1016/j.ymthe.2006.08.730

655. Development of a Human Carboxylesterase That Can Efficiently Metabolize CPT-11

Monika Wierdl, Randy M. Wadkins, Matthew R. Redinbo, Lyudmila Tsurkan and Philip M. Potter

Mol Ther 13: S252-S252; doi:10.1016/j.ymthe.2006.08.731

656. Combined Oncolysis and Anti-Angiogenesis Gene Therapy Using a Herpes Simplex Virus Expressing Endostatin in a Murine Lung Cancer Model

Michael Lanuti, Jonathan M. Goodwin and Kenneth K. Tanabe

Mol Ther 13: S252-S253; doi:10.1016/j.ymthe.2006.08.732

657. Combination Therapy with Cyclophosphamide and the Oncolytic Herpes Virus Mutant rRp450, Expressing a Cyclophosphamide Prodrug, Is Clinically Safe by Intratumoral, Intravenous, and Intracerebral Administration in an HSV-1 Susceptible Mouse Model

Mark A. Currier, Yonatan Y. Mahller, Greg Stroup, Hirokazu Kambara, E.A. Chiocca and Timothy P. Cripe

Mol Ther 13: S253-S253; doi:10.1016/j.ymthe.2006.08.733

658. Oncolytic Herpes Virus Mutants Are Efficacious Against Malignant Peripheral Nerve Sheath Tumor Xenografts

Yonatan Y. Mahller, Mark A. Currier, Margaret H. Collins, Nancy Ratner and Timothy P. Cripe

Mol Ther 13: S253-S254; doi:10.1016/j.ymthe.2006.08.734

659. Application of HSVtk Suicide Gene to X- SCID Gene Therapy: Ganciclovir Treatment Selectively Elmiinates Gene Corrected Cells In Vitro and In Vivo

Toru Uchiyama, Yoshinori Ishikawa, Naoto Ishii, Masafumi Onodera, Miki Sato, Yoji Sasahara, Nobuyuki Tanaka, Kazuo Sugamura, Satoru Kumaki and Shigeru Tsuchiya

Mol Ther 13: S254-S254; doi:10.1016/j.ymthe.2006.08.736

Top

Abstracts

660. The Effect of the B2 Mutation on Hematopoietic Reconstitution in the French X-SCID Gene Therapy Trial

John T. Gray, Salima Hacein-Bey-Abina, Marina Cavazzana-Calvo and Alain Fischer

Mol Ther 13: S254-S255; doi:10.1016/j.ymthe.2006.08.737

661. Ex Vivo Pre-Selection of Transgenic Mouse Cells Expressing Green Fluorescent Protein-Methylguanine Methyltransferase P144K Fusion Protein Increases Marking Following Transplant into Wild Type Mice

Uimook Choi, Lanise Cardwell and Harry L. Malech

Mol Ther 13: S255-S255; doi:10.1016/j.ymthe.2006.08.738

662. Retroviral Insertion Site Analysis Following Therapeutic Gene Transfer of CD18 in a Canine Model of Leukocyte Adhesion Deficiency

Mehreen Hai, Thomas R. Bauer Jr., Laura M. Tuschong, Yuchen Gu, Robert A. Sokolic and Dennis D. Hickstein

Mol Ther 13: S255-S255; doi:10.1016/j.ymthe.2006.08.739

663. Gene Modified Human Mesenchymal Stem Cells Expressing Osteoprotegerin Reverse Osteoclast Activation in a Xenogeneic Murine Model of Multiple Myeloma

Neil Rabin, Chara Kyriakou, Arnold Pizzey, Clive Buckle, Matthew Prideaux, Peter Croucher, Amit Nathwani and Kwee Yong

Mol Ther 13: S256-S256; doi:10.1016/j.ymthe.2006.08.740

664. WHIM Syndrome Type Myelokathexis In Vivo in the NOD/SCID Mouse Model Following Transplant of Healthy Human Stem Cells Transduced with C-Terminus Truncated CXCR4

Toshinao Kawai, Uimook Choi, Lanise Cardwell, Suk See Deravin, Nora Naumann, Narda L. Whiting-Theobald, Gilda F. Linton, Sebastian Brenner, Philip M. Murphy and Harry L. Malech

Mol Ther 13: S256-S256; doi:10.1016/j.ymthe.2006.08.741

665. Novel Gammaretroviral Vectors for Gene Therapy of SCID-X1

Susannah I. Bailey, Steven J. Howe, Axel Schambach, Christine Kinnon, Christopher Baum and Adrian J. Thrasher

Mol Ther 13: S256-S257; doi:10.1016/j.ymthe.2006.08.742

666. Conversion of |[beta]|A- to |[beta]|S-Globin by Small Fragment Homologous Replacement (SFHR) in Hematopoietic Stem/Progenitor Cells (HSPCs)

Alireza Abdolmohammadi, Rosalie Maurisse, Babak Bedayat, David De Semir, Judy Wai-Men Cheung and Dieter C. Gruenert

Mol Ther 13: S257-S257; doi:10.1016/j.ymthe.2006.08.743

667. Gene Therapy for Beta Thalassemia: Preclinical Studies on Human Cells

Emanuela A. Roselli, Rossano Cesari, Annarita Miccio, Francesca Tiboni, Paola Corbella, Claudia Rossi, Erika Biral, Sarah Marktel, Michael Antoniou, Marco Andreani, Guido Lucarelli and Giuliana Ferrari

Mol Ther 13: S257-S257; doi:10.1016/j.ymthe.2006.08.744

668. Progress toward a Non-Viral Gene Therapy Protocol for the Treatment of Anemia

Magdolna G. Sebesty|[eacute]|n, Julia O. Hegge, Mark A. Noble, David L. Lewis, Hans Herweijer and Jon A. Wolff

Mol Ther 13: S257-S258; doi:10.1016/j.ymthe.2006.08.745

669. Drug Selection of Hematopoietic Cells by Regulated MGMT Activity

Barbara Verbeek, Thomas D. Southgate, Michael D. Milsom, Amanda J. Watson, Lorna B. Woolford, Geoff P. Margison and Leslie J. Fairbairn

Mol Ther 13: S258-S258; doi:10.1016/j.ymthe.2006.08.746

670. Combined Strategy of Minimal Myeloablation and Optimal BMT Regimen To Cure Murine |[beta]|-Thalassemia

Hady Felfly and Marie Trudel

Mol Ther 13: S258-S259; doi:10.1016/j.ymthe.2006.08.747

671. SIV-Derived Lentiviral Vectors Pseudotyped with Modified RD114 Envelope and Containing Mutant MGMT Efficiently Transduce Human CD34+ PBSCs and Allow Selection

Nora Naumann, Uimook Choi, Suk See De Ravin, Morvarid Moayeri, Larry Lantz, Lanise Cardwell-Miller and Harry L. Malech

Mol Ther 13: S259-S259; doi:10.1016/j.ymthe.2006.08.748

672. Lentiviral Vectors Targeting WASp Expression to Hematopoietic Cells, Efficiently Transduce CD34+ Cells and Correct Functions of Lymphocytes and Dendritic Cells from Wiskott-Aldrich Syndrome Patients

Sabine Charrier, Loic Dupre, Samantha Scaramuzza, Laurence Jeanson, Mike Blundell, Olivier Danos, Federica Cattaneo, Alessandro Aiuti, Adrian Thrasher, Maria-Grazia Roncarolo and Anne Galy

Mol Ther 13: S259-S259; doi:10.1016/j.ymthe.2006.08.749

673. Threshold of Normal Stem Cells for Successful Correction of Murine |[beta]|-Thalassemia

Hady Felfly and Marie Trudel

Mol Ther 13: S259-S260; doi:10.1016/j.ymthe.2006.08.750

674. Administration of rAAV2 and rAAV5 to the Parotid Gland of Non-Human Primates

A. Voutetakis, C. Zheng, J.A. Chiorini, M. Schmidt, S. Afione, M. Metzger, C. Dunbar, R.E. Donahue and B.J. Baum

Mol Ther 13: S260-S260; doi:10.1016/j.ymthe.2006.08.751

675. Correction of Anemia in Uremic Rats by Intramuscular Injection of Lentivirus Carrying an Erythropoietin Gene

Taekeun Oh, Guihong Quan, Haeyoung Kim, Frank Park and Seungtaik Kim

Mol Ther 13: S260-S261; doi:10.1016/j.ymthe.2006.08.752

676. AAV-Rep 78 Mediated Rescue and Integration of a 27kb Transgene Cassette

Hongjie Wang and Andre Lieber

Mol Ther 13: S261-S261; doi:10.1016/j.ymthe.2006.08.753

677. Generation and Application of an Efficient Chronic Myelogenous Leukemia (CML)-Targeted Recombinant Adeno-Associated Virus (rAAV) Vector: New Therapeutic Options?

Marlon R. Veldwijk, Marius Stiefelhagen, Juergen A. Kleinschmidt, Anna Jauch, Stephanie Laufs, Frederik Wenz, W. Jens Zeller and Stefan Fruehauf

Mol Ther 13: S261-S261; doi:10.1016/j.ymthe.2006.08.754

678. Production of a Novel Recombinant AAV Vector Containing beta-Globin Gene and Essential Segments of LCR and Transfer of the Construct into the CD133+, Mesenchymal Stem Cell and Unrestricted Somatic Stem Cell (USSCs)

Pedram Kharaziha, Mehdi Forouzandeh, Mohammad J. Rasaee, Masood Soleimani, Jafar Kyani and Mahboobeh Mohseni

Mol Ther 13: S262-S262; doi:10.1016/j.ymthe.2006.08.755

679. Gene Transfer to Hematopoietic Stem/Progenitor Cells Using SV40-Derived Vectors

Alena A. Chekmasova, Mahender Singh and David S. Strayer

Mol Ther 13: S262-S262; doi:10.1016/j.ymthe.2006.08.756

680. Non-Viral Transposon Mediated Gene Transfer of Human Factor VIII to Hemophilia A Mice

Litao Xie, Yubin Kang, Stephen Yant, Mark Kay and Paul McCray

Mol Ther 13: S262-S262; doi:10.1016/j.ymthe.2006.08.757

681. Inadvertent Transduction of Recipient Tissues after Transplantation of Ex Vivo Lentivirally Transduced Hematopoietic Cells

Yung-Wei Pan and Peter Kurre

Mol Ther 13: S263-S263; doi:10.1016/j.ymthe.2006.08.758

682. Collection and Genetic Correction of Fanconi Complement Type A Hematopoietic Stem Cells: Results of Two Pilot Studies

P.F. Kelly, B. Balcik, K. Bohn, R. Mueller, T. Schuesler, L. Reeves, T. Leemhuis, R. Harris, S.M. Davies, F.O. Smith, C. von Kalle and D.A. Williams

Mol Ther 13: S263-S263; doi:10.1016/j.ymthe.2006.08.759

683. Bronchoscope-Guided, Targeted Lobar Aersolization of HDAd into the Lungs of Nonhuman Primate Results in Exceedingly High Pulmonary Transduction Uniformally throughout the Entire Lung with Negligible Toxicity

Peter Hiatt, Nicola Brunetti-Pierri, Ruth McConnell, Donna Palmer, Julie Katkin, David Dimmock, Yu Zuo, Milton Finegold, Arthur Beaudet and Philip Ng

Mol Ther 13: S264-S264; doi:10.1016/j.ymthe.2006.08.761

684. Improved Performance of AAV6 in Airways In Vivo

Maria Limberis, Luk H. Vandenberghe, Julie C. Johnston, Di Wu, Deirdre McMenamin, Regina L. Munden and James M. Wilson

Mol Ther 13: S264-S265; doi:10.1016/j.ymthe.2006.08.762

685. Single-Dose Lentivirus Gene Transfer In Vivo Maintains Airway Gene Expression for over Six Months

Alice G. Stocker, Don S. Anson and David W. Parsons

Mol Ther 13: S265-S265; doi:10.1016/j.ymthe.2006.08.763

686. Exploring Different Formulations as a Strategy To Enhance Adenoviral Gene Delivery to the Lung

Rahul Kushwah, Benjamin H. Lee and Jim Hu

Mol Ther 13: S265-S265; doi:10.1016/j.ymthe.2006.08.764

687. In a Model of Irradiation Retreatment of the Murine Lung, Gene Therapy with Manganese Superoxide Dismutase-Plasmid Liposome (MnSOD-PL) Increases Lung Tolerance

Joel S. Greenberger, Yunyun Niu and Michael W. Epperly

Mol Ther 13: S266-S266; doi:10.1016/j.ymthe.2006.08.765

688. The Effects of Cyclic Stretch on Microtubule Stability and Exogenous Gene Expression in the Alveolar Epithelium

Christopher Geiger and David A. Dean

Mol Ther 13: S266-S266; doi:10.1016/j.ymthe.2006.08.766

689. Restriction Profiles of Primate TRIM5|[alpha]| on FIV

Douglas E. Dylla, Melissa A. Hickey, Theodora Hatziioannou, Paul D. Bieniasz and Paul B. McCray Jr.

Mol Ther 13: S266-S267; doi:10.1016/j.ymthe.2006.08.767

690. Gene Delivery Targeting CCR3 Using SV40-Derived Vectors: A Novel Therapeutic Approach for Allergic Diseases

Lokesh Agrawal and David S. Strayer

Mol Ther 13: S267-S267; doi:10.1016/j.ymthe.2006.08.768

691. Efficient Downregulation of ENaC Activity by Synthetic siRNAs

Christa M. Schmidt, Stephanie Huth, Olga Mykhaylyk, Christian Plank, Carsten Rudolph and Joseph Rosenecker

Mol Ther 13: S267-S267; doi:10.1016/j.ymthe.2006.08.769

692. Aerosol Delivery of Concentrated pDNA/PEI Formulations to the Murine Lung

Lee A. Davies, Stephen C. Hyde and Deborah R. Gill

Mol Ther 13: S267-S268; doi:10.1016/j.ymthe.2006.08.770

693. Airway Pre-Treatment with a Novel Surfactant Compound Improves Standard Enhancement of Lentiviral Gene Transfer In Vivo

Patricia L. Cmielewski, Don S. Anson and David W. Parsons

Mol Ther 13: S268-S268; doi:10.1016/j.ymthe.2006.08.771

694. Involvement of Glycosaminoglycans in VSV-G Pseudotyped Lentiviral Vector Mediated Gene Transfer into Airway Epithelial Cells

Elena Copreni, Lucia Palmieri, Salvatore Carrabino, Stefano Castellani, Luigi Naldini and Massimo Conese

Mol Ther 13: S268-S269; doi:10.1016/j.ymthe.2006.08.772

695. Low-Frequency Ultrasound Increases Non-Viral Lung Gene Transfer

Stefania Xenariou, Hai-Dong Liang, Uta Griesenbach, Jie Zhu, Raymond Farley, Lucinda Somerton, Charanjit Singh, Peter K. Jeffery, Ronald K. Scheule, Seng H. Cheng, Duncan M. Geddes, Martin Blomley and Eric W.F.W. Alton

Mol Ther 13: S269-S269; doi:10.1016/j.ymthe.2006.08.773

696. Development of Lipid/Peptide (Lip/Tide) Vectors for Respiratory Gene Transfer

Stephen L. Hart, Aris Tagalakis, Michele J. Writer, James Devaney, Helen C. Hailes, Alethea B. Tabor, John B. Wong, Steve Bottoms, Robin J. McAnulty, Ron Scheule, Seng Cheng and Adam Jaffe

Mol Ther 13: S269-S270; doi:10.1016/j.ymthe.2006.08.774

697. Molecular Forms of Feline Immunodeficiency Virus Following Gene Transfer to Airway Epithelia

Marisa Banasik, Christopher Moressi, Melissa Hickey, Todd Scheetz and Paul McCray

Mol Ther 13: S270-S270; doi:10.1016/j.ymthe.2006.08.775

698. Towards Non-Invasive Assessment of CF Airway Gene Therapy: High Resolution Propogation-Based Imaging of Airway Surface Liquid Via Synchrotron Light

David W. Parsons, Karen W. Siu, Jeffrey Crosbie, Ivan Williams, Boucher C. Richard, Kentaro Uesugi and Naoto Yagi

Mol Ther 13: S270-S270; doi:10.1016/j.ymthe.2006.08.776

699. Bactofection into Airway Epithelial Cells In Vitro and In Vivo Using a Genetically Modified Escherichia coli

Mia D.B. Larsen, Uta Griesenbach, Sylvie Goussard, Dieter Gruenert, Duncan M. Geddes, Catherine Grillot-Courvalin and Eric W.F.W. Altom

Mol Ther 13: S270-S271; doi:10.1016/j.ymthe.2006.08.777

700. Formulation of Chemically Modified Short Interfering RNA (siRNA) for Local Delivery to the Respiratory Tract

Paul B. McCray, Brent A. Dickinson, Kim C. Hartsough, Anna M. Gomez, Sharon F. Jamison, Tim R. Shadel, Jennifer A. Lockridge, Pam A. Pavco, Wei-min Wang, Tongqian Chen, Chandra Vargeese, David K. Tung, Christine L. Wohlford-Lenane and Ivan M. Richards

Mol Ther 13: S271-S271; doi:10.1016/j.ymthe.2006.08.778

701. Gene Delivery of PEI-DNA Complexes to the Lungs of Mice by Inhalation Is Mouse Strain-Dependent

Aurora Ortiz, Schillinger Ulrike, Dames Petra, Lesina Eugenia, Plank Christian, Rosenecker Joseph and Rudolph Carsten

Mol Ther 13: S271-S271; doi:10.1016/j.ymthe.2006.08.779

702. Use of Perfluorochemical Liquid Suspensions To Facilitate Gene Delivery to the Lung: Distribution of Recombinant Adenovirus- Delivered Transgene Expression

Marlene S. Strayer, Marla R. Wolfson, Daniel J. Malone, Jichuan Wu, Hshi-chi Koo, Thomas H. Shaffer, David S. Strayer, Jonathan M. Davis and Jeffrey A. Kazzaz

Mol Ther 13: S271-S272; doi:10.1016/j.ymthe.2006.08.780

703. Analysis of the Stability and Functionality of siRNA after Nebulization of siRNA Polyplexes

Stephanie Huth, Christa Schmidt, Carsten Rudolph and Joseph Rosenecker

Mol Ther 13: S272-S272; doi:10.1016/j.ymthe.2006.08.782

704. RNA Interference of Stat3 Using Adenovirus Vector Inhibits Pancreatic Cancer Growth In Vitro and In Vivo

Chen Huang, Ju Feng Zhang, Zheng Jun Qiu and Fang Zhang

Mol Ther 13: S272-S272; doi:10.1016/j.ymthe.2006.08.783

705. A Practical Approach to siRNA-Based Treatment Design Using Bioluminescent Imaging and Mathematical Modeling

Derek W. Bartlett and Mark E. Davis

Mol Ther 13: S272-S273; doi:10.1016/j.ymthe.2006.08.784

706. Withdrawn

Mol Ther 13: S273-S273; doi:10.1016/j.ymthe.2006.08.785

707. Real-Time Monitoring of Single-Stranded and Duplex Short Interfering RNA Integrity inside Living Cells

Koen Raemdonck, Katrien Remaut, Bart Lucas, Niek N. Sanders, Jo Demeester and Stefaan C. De Smedt

Mol Ther 13: S273-S273; doi:10.1016/j.ymthe.2006.08.786

708. Gene Targeting with Triplex-Forming Oligonucletides in the Pyrimidine Motif

Jennifer M. Kalish, Melissa P. Knauert, Denise C. Hegan and Peter M. Glazer

Mol Ther 13: S273-S274; doi:10.1016/j.ymthe.2006.08.787

709. Adeno-Associated Virus Delivery of siRNAs Leads to a Reduction in Phospholamban Levels

Lourdes M. Andino, Barry J. Byrne, Hideko Kasahara and Alfred S. Lewin

Mol Ther 13: S274-S274; doi:10.1016/j.ymthe.2006.08.788

710. Comparison of the Activity of siRNAs and shRNAs Against Furin: A Cellular Target for HIV-1 Inhibition

Pavlina Konstantinova, Olivier ter Brake, Rogier Sanders, Bart van Heertum and Ben Berkhout

Mol Ther 13: S274-S274; doi:10.1016/j.ymthe.2006.08.789

711. Allele-Specific Silencing of Mutant Huntingtin for Huntington's Disease Therapy

Alex Mas-Monteys, Scott Q. Harper, Brian L. Gilmore, Patrick D. Staber, Chris Schaffer, Barry Polisky, Chandra Vargeese and Beverly L. Davidson

Mol Ther 13: S274-S275; doi:10.1016/j.ymthe.2006.08.790

712. AAV-Mediated Allele-Specific RNA Interference of a Common Dominant Rhodopsin Mutation Causing Retinitis Pigmentosa

Alessandra Tessitore, Fabiana Parisi, Mariacarmela Allocca, Umberto Di Vicino, Michela A. Denti, Luciano Domenici, Irene Bozzoni and Alberto Auricchio

Mol Ther 13: S275-S275; doi:10.1016/j.ymthe.2006.08.791

713. NFkB Decoy Oligodeoxynucleotides Inhibit Osteoclast Differentiation and Activation In Vitro and Improve Osteoporosis of Ovariectomized and Vitamin C Difficient Rat Models

Hideo Shimizu, Hironori Nakagami, Natsuki Yasumasa, Rie Hanayama, Toshio Ogihara and Ryuichi Morishita

Mol Ther 13: S275-S275; doi:10.1016/j.ymthe.2006.08.792

714. Effect of Adenovirus-Mediated RNA Interference on Endogenous micro-RNA Functionality in a Mouse Model of Multidrug Resistance Protein-2 Gene Silencing

Oscar Aparicio, I|[ntilde]|igo Narvaiza, Maria Vera, Nerea Razquin, Jesus Prieto and Puri Fortes

Mol Ther 13: S275-S276; doi:10.1016/j.ymthe.2006.08.793

715. Targeted Delivery of Antisense Oligonucleotide and siRNA into Lung Cancer Cells

Shyh-Dar Li and Leaf Huang

Mol Ther 13: S276-S276; doi:10.1016/j.ymthe.2006.08.794

716. Differential Effects of Secondary Structure on Antisense Oligonucleotide (AON) and Short Interfering RNA (siRNA) Mediated mRNA Cleavage

Stephen I. Rudnick and Alan M. Gewirtz

Mol Ther 13: S276-S276; doi:10.1016/j.ymthe.2006.08.795

717. VCP Short Hairpin RNA Rescues |[Delta]|F508-CFTR and Suppresses IL8 Levels: Therapeutic Implications in Cystic Fibrosis

Neeraj Vij, Shengyun Fang and Pamela L. Zeitlin

Mol Ther 13: S276-S277; doi:10.1016/j.ymthe.2006.08.796

718. PTD-Fusion Peptide as a Delivery Vehicle for siRNA To Target HIV Reservoirs

Ashok Chauhan, Avindra Nath, Daivd Levy and Suzanne Gartner

Mol Ther 13: S277-S277; doi:10.1016/j.ymthe.2006.08.797

719. Specific Cancer Regression by Trans-Splicing Ribozyme-Mediated Replacement of K-RASV12 Transcript

Ju Hyun Kim, Sung Jin Kim, Sun Young Jang and Seong-Wook Lee

Mol Ther 13: S277-S277; doi:10.1016/j.ymthe.2006.08.798

720. Inhibition of Coxsackievirus B3 (CVB3) Replication by Self-Complementary AAV Vector-Based Expression of shRNAs Directed Against the RNA-Dependent RNA Polymerase of CVB3

Isaac Sipo, Xiaomin Wang, Jens Kurreck, Stefan Weger, Heinz Zeichhardt, Wolfgang Poller and Henry Fechner

Mol Ther 13: S277-S278; doi:10.1016/j.ymthe.2006.08.799

721. Antisense Oligonucleotide Therapy for Duchenne Muscular Dystrophy: From Cell Culture to Clinical Trial

Jignya Ashar, Terence Partridge and Qi L. Lu

Mol Ther 13: S278-S278; doi:10.1016/j.ymthe.2006.08.800

722. Silencing of Transforming Growth Factor-|[beta]| Receptor II by RNA Interference Suppresses Extracellular Matrix Production in Rat Hepatic Stellate Cells

Jin Wook Kim, Song-Qing He, Mark A. Zern, John J. Rossi and Jian Wu

Mol Ther 13: S278-S278; doi:10.1016/j.ymthe.2006.08.801

723. In Vivo Expansion of MDS1/EVI1, PRDM16 and SETBP1 Integration Clones in Successful Chronic Granulomatous Disease (CGD) Gene Therapy Trial

Kerstin Schwarzwaelder, Manfred Schmidt, Marion G. Ott, Stefan Stein, Hanno Glimm, Annette Deichmann, Ulrich Siler, Dieter Hoelzer, Reinhard Seger, Manuel Grez and Christof von Kalle

Mol Ther 13: S279-S279; doi:10.1016/j.ymthe.2006.08.803

724. Phase I Study of Replication-Competent Adenovirus-Mediated Suicide Gene Therapy in Combination with Conformal Radiotherapy for the Treatment of Intermediate- to High-Risk Prostate Cancer: Two Year Efficacy Results

Svend O. Freytag, Jae Ho Kim, Hans Stricker2, Jan Pegg, Stephen L. Brown and Mei Lu

Mol Ther 13: S279-S279; doi:10.1016/j.ymthe.2006.08.804

725. Correction of Laminin-5-Deficient Junctional Epidermolysis Bullosa by Transplantation of Genetically Modified Epidermal Stem Cells. A Phase-I Clinical Trial

Fulvio Mavilio, Stefano Ferrari, Francesca Di Nunzio, Giulietta Maruggi, Chiara Bonini, Sergio Capurro, Andrea Conti, Alberto Giannetti, Graziella Pellegrini and Michele De Luca

Mol Ther 13: S280-S280; doi:10.1016/j.ymthe.2006.08.805

726. Clinical Trial of Recombinant Adenovirus-p53 (Gendicine) Combined with Radiotherapy in Nasopharyngeal Carcinoma Patients

Shanwen Zhang, Shaowen Xiao, Yan Sun, Changqing Liu, Xing Su, Dongming Li, Gang Xu, Guangying Zhu and Bo Xu

Mol Ther 13: S280-S280; doi:10.1016/j.ymthe.2006.08.806

727. Improvements in Clinical and Radiographic Outcomes in a Phase I Study of AAV-GAD Gene Therapy for Parkinson's Disease

Michael G. Kaplitt, David Eidelberg, Andrew Feigin, Helen Fitzimmons, Patricia Lawlor, Kristin Strybing, Marie Cox, Chris Tang, Ross Bland and Matthew J. During

Mol Ther 13: S280-S281; doi:10.1016/j.ymthe.2006.08.807

728. Safety and Bioactivity of rAAV2-hAAT in alpha-1 Antitrypsin-Deficient Patients in a Phase I Clinical Trial

Mark L. Brantly, Terry Spencer, Carolyn T. Spencer, Thomas J. Conlon, Sihong Song, Margaret Humphries, Barry J. Byrne, Richard O. Snyder and Terence R. Flotte

Mol Ther 13: S281-S281; doi:10.1016/j.ymthe.2006.08.808

729. Phase I Trial of Intraperitoneal (IP) Administration of a Measles Virus (MV) Strain Expressing the Human Carcinoembryonic Antigen (CEA) in Ovarian Cancer Patients

Evanthia Galanis, Lynn C. Hartmann, William A. Cliby, Paula Zollman, Prema P. Peethambaram, Harry J. Long, Judith S. Kaur, Jeff A. Sloan, Gregory A. Poland, Kah-Whye Peng and Stephen J. Russell

Mol Ther 13: S281-S281; doi:10.1016/j.ymthe.2006.08.809

730. T Cell Responses to AAV Vector Capsid in Normal Donors and Subjects Who Have Undergone Liver-Directed AAV-Mediated Gene Transfer

Marcela V. Maus, Federico Mingozzi, Denise E. Sabatino, Daniel Hui, Margaret V. Ragni and Katherine A. High

Mol Ther 13: S282-S282; doi:10.1016/j.ymthe.2006.08.810

731. Hematopoietic Stem Cell Gene Transfer and Integration Site Analysis in Tumor-Prone Mice Uncovers Low Genotoxicity of Lentiviral Vector Integration

Eugenio Montini, Daniela Cesana, Manfred Schmidt, Francesca Sanvito, Maurilio Ponzoni, Lucia Sergi Sergi, Fabrizio Benedicenti, Cynthia Bartholomae, Clelia Di Serio, Claudio Doglioni, Christof von Kalle and Luigi Naldini

Mol Ther 13: S282-S282; doi:10.1016/j.ymthe.2006.08.812

732. Avian Sarcoma Leukosis Virus Vectors Can Transduce Rhesus Macaque HSCs and Result in a Potentially Safer Integration Profile

Jingqiong Hu, Andrea Ferris, Allen Krause, Robert E. Donahue, Stephen H. Hughes and Cynthia E. Dunbar

Mol Ther 13: S283-S283; doi:10.1016/j.ymthe.2006.08.813

733. Integration Site Distribution and Clonal Selection Related to the Insertion of Lentiviral SIN-Vectors

Cynthia C. Bartholomae, Manfred Schmidt, Rafael J. Yanez-Munoz, Steven J. Howe, Sonja Schmidt, Claudia Prinz, Adrian J. Thrasher and Christof von Kalle

Mol Ther 13: S283-S283; doi:10.1016/j.ymthe.2006.08.814

734. The Influence of Vector Design on Integration Site Selection by gamma-Retroviral and Lentiviral Vectors

Alessandra Recchia, Claudia Cattoglio, Annarita Miccio, Antonella Antonelli, Anna Testa, Giulia Facchini, Daniela Sartori, Giuliana Ferrari and Fulvio Mavilio

Mol Ther 13: S284-S284; doi:10.1016/j.ymthe.2006.08.815

735. VITA, a Method for the Analysis of Lentiviral Integration Patterns

Julie Mantovani, Nathalie Holic, Olivier Danos and Javier Perea

Mol Ther 13: S284-S284; doi:10.1016/j.ymthe.2006.08.816

736. Engineering Enhanced Retroviral and Lentiviral Vectors through the Selection of Peptide Insertion Libraries

Julie H. Yu and David V. Schaffer

Mol Ther 13: S284-S285; doi:10.1016/j.ymthe.2006.08.817

737. Efficient In Vivo Selection and Chemoprotection Following Drug Resistance Gene Therapy in a Nonmyeloablative Allogeneic Transplantation Setting in the Dog

Brian C. Beard, Sabine Gerull, Laura J. Peterson, Tobias Neff and Hans-Peter Kiem

Mol Ther 13: S285-S285; doi:10.1016/j.ymthe.2006.08.818

738. Towards Gene Correction of X-Linked SCID Using Engineered Zinc Finger Nucleases and Integrase Defective Lentiviral Delivery

Angelo Lombardo, Christian Beausejour, Fyodor D. Urnov, Jeffrey C. Miller, Alessandro Aiuti, Philip D. Gregory, Michael C. Holmes and Luigi Naldini

Mol Ther 13: S285-S285; doi:10.1016/j.ymthe.2006.08.819

739. Bioluminescent Virion Shells: A Novel Tool for Visualization of Viral Vectors in Animal Tissue

Aravind Asokan, Jarrod S. Johnson and Richard J. Samulski

Mol Ther 13: S286-S286; doi:10.1016/j.ymthe.2006.08.821

740. A Novel Hybrid System Efficiently Expands AAV Packaging Capacity

Arka Ghosh, Yongping Yue and Dongsheng Duan

Mol Ther 13: S286-S286; doi:10.1016/j.ymthe.2006.08.822

741. Self-Complementary Adeno-Associated Virus Vectors: Packaging Capacity and Purity

Jianqing Wu, Weihong Zhao, Li Zhong, Kenneth H. Warrington. Jr. and Arun Srivastava

Mol Ther 13: S286-S286; doi:10.1016/j.ymthe.2006.08.823

742. Molecular Evolution of Adeno-Associated Viral (AAV) Vectors Via DNA Family Shuffling of Primate and Non-Primate Serotypes

Dirk Grimm, Joyce S. Lee, Theresa A. Storm and Mark A. Kay

Mol Ther 13: S287-S287; doi:10.1016/j.ymthe.2006.08.824

743. Directed Evolution of Adeno-Associated Virus (AAV) by DNA Shuffling Yields Enhanced Gene Delivery Vectors

Wuping Li and Jude Richard Samulski

Mol Ther 13: S287-S287; doi:10.1016/j.ymthe.2006.08.825

744. Novel Vectors for Gene Therapy: Covering the Spectrum of Primate AAV Diversity

Luk H. Vandenberge, Katya Breous, Guang-Ping Gao, Deirdre McMenamin, Regina L. Munden, Tran Nguyen Duc and James M. Wilson

Mol Ther 13: S287-S288; doi:10.1016/j.ymthe.2006.08.826

745. AAV12, Isolated from Vervet Monkey, Has Unique Tropism and Biological as Well as Neutralization Properties

Michael Schmidt, Antonis Voutetakis, Sandra Afione, Changyu Zheng and John A. Chiorini

Mol Ther 13: S288-S288; doi:10.1016/j.ymthe.2006.08.827

746. Localization of Structural Determinants in AAV Capsid for Efficient Liver Transduction by Domain Swapping between AAV-2 and AAV-8

Xuan Shen, Hui Xu, Theresa Storm and Mark A. Kay

Mol Ther 13: S288-S288; doi:10.1016/j.ymthe.2006.08.828

747. Plasmid Electrotransfer of Eye Ciliary Muscle: Principle and Therapeutic Efficacy in an Acute Inflammatory Model

Carole Bloquel, R. Bejjani, Pascal Bigey, Fethi Bedioui, M. Doat, David BenEzra, Francine Behar-Cohen and Daniel Scherman

Mol Ther 13: S289-S289; doi:10.1016/j.ymthe.2006.08.830

748. Requirements for Microtubule-DNA Interactions during Cytoplasmic Trafficking of Plasmids

Erin E. Vaughan and David A. Dean

Mol Ther 13: S289-S289; doi:10.1016/j.ymthe.2006.08.831

749. Effective Plasmid DNA Dose Range and Promoters for Gene Expression in Muscle Following Hydrodynamic Limb Vein Delivery of pDNA into Rodents and Primates

Christine I. Wooddell, Julia O. Hegge, Guofeng Zhang, Patricia Kleinpeter, Magdolna G. Sebesty|[eacute]|n, Mark A. Noble, Loretta V. Pfannes, Hans Herweijer, Serge Braun, Thierry Huss and Jon A. Wolff

Mol Ther 13: S289-S290; doi:10.1016/j.ymthe.2006.08.832

750. Coelectrotransfer to Spinal Cord of Three Plasmids Coding for Pain Killer Gene and Regulatory Factors of the Tetracycline-Inducible System to Achieve Tightly Regulated Expression, Inhibition of Thermal Hyperalgesia, and Mechanical Allodynia

Chung-Ren Lin, Chien-Cheug Liu, Yi-Shen Chen and H-T Huang

Mol Ther 13: S290-S290; doi:10.1016/j.ymthe.2006.08.833

751. Magnetic Microbubbles: New Carriers for Localized Gene and Drug Delivery

Dialekti Vlaskou, Olga Mykhaylyk, Riccardo Giunta, Iva Neshkova, Nicole Hellwig, Florian Kroetz, Christian Bergemann and Christian Plank

Mol Ther 13: S290-S290; doi:10.1016/j.ymthe.2006.08.834

752. Delivery of Non-Microparticle Naked DNA Vaccine Using Supersonic Flow by a Low-Pressure Gene Gun

Chi-Chen Lin, Ying-Chang Wang, Men-Chi Yen and Ming-Derg Lai

Mol Ther 13: S291-S291; doi:10.1016/j.ymthe.2006.08.835

753. Ectopic Bone Formation In Vivo Induced by Sonoporation: Ultrasound-Based Non Viral Gene Delivery System

Dima Sheyn, Gadi Pelled, Yoram Zilberman, Zulma Gazit and Dan Gazit

Mol Ther 13: S291-S291; doi:10.1016/j.ymthe.2006.08.836

754. Volumetry of Mouse Liver during and after Hydrodynamic Injection

Takeshi Suda and Dexi Liu

Mol Ther 13: S292-S292; doi:10.1016/j.ymthe.2006.08.837

755. Phase II Clinical Trial Demonstrates the Safety and Tolerability of Multiple Doses of Autologous CD4+ T Cells Transduced with VRX496, a Lentiviral Vector Delivering Anti-HIV Antisense in Patients Failing 1 or More HAART Treatment

Tessio Rebello, Cathy Afable, Sherri Callahan, Laurent Humeau, Arvind Chopra, Xiaobin Lu and Vladimir Slepushkin

Mol Ther 13: S292-S292; doi:10.1016/j.ymthe.2006.08.839

756. Targeting Viral Entry in Gene Therapy of HIV-Infection

Jan van Lunzen, Tobias Glaunsinger, Felix Hermann, Klaus Kuehlcke, Alexander Alexandrov and Dorothee von Laer

Mol Ther 13: S293-S293; doi:10.1016/j.ymthe.2006.08.840

757. Engineered Expression of Novel TRIM5 Isoforms Inhibits HIV-1 Infection in CD34 Hematopoietic Stem Cell Derived Macrophages

Joseph S. Anderson and Ramesh Akkina

Mol Ther 13: S293-S293; doi:10.1016/j.ymthe.2006.08.841

758. Towards Gene Knock out Therapy for AIDS/HIV: Targeted Disruption of CCR5 Using Engineered Zinc Finger Protein Nucleases (ZFNs)

Elena Perez, Yann Jouvenot, Jeffrey C. Miller, Olga Liu, Jianbin Wang, Dmitry Guschin, Victor Bartsevich, Kenneth Kim, Ya-Li Lee, Edward J. Rebar, Dale Ando, Philip D. Gregory, James Riley, Michael C. Holmes and Carl June

Mol Ther 13: S293-S293; doi:10.1016/j.ymthe.2006.08.842

759. In Search of an Effective Target: In Vivo Approach Using HIV-1 Specific siRNA and Ribozyme Libraries

Hoshang J. Unwalla, Atilla A. Seyhan, Brian H. Johnston and John J. Rossi

Mol Ther 13: S293-S294; doi:10.1016/j.ymthe.2006.08.843

760. Overcoming Rhesus Macaque Endogenous Restriction Factors during HIV-1 Vector Transduction

Christina H. Swan, Udayan Chatterji, Philippe Gallay, Louis J. Picker and Bruce E. Torbett

Mol Ther 13: S294-S294; doi:10.1016/j.ymthe.2006.08.844

761. Genotoxicity Free Intranasal Gene Vaccines for Alzheimer's Disease and AIDS with Remarkable Efficacy in Model Animals; Use of a Cytoplasmic RNA Vector, Sendai Virus Vectors

Makoto Inoue, Hideo Hara, Tetsuro Matano, Yumiko Tokusumi, Yoshikazu Yonemitsu, Natsuko Kurosawa, Takumi Kanaya, Takashi Hironaka, Yoshiyuki Nagai, Takeshi Tabira and Mamoru Hasegawa

Mol Ther 13: S294-S295; doi:10.1016/j.ymthe.2006.08.845

762. Inhibition of HIV-1 Replication by Simian Intrinsic Restriction Factors, TRIM5alpha and APOBEC3G

Ryuta Sakuma, Josh A. Noser and Yasuhiro Ikeda

Mol Ther 13: S295-S295; doi:10.1016/j.ymthe.2006.08.846

763. Multimodality Imaging of Genetically Modified Lymphocytes In Vivo

Konstantin Dobrenkov, Malgorzata Dabrowska, Larissa Shenker, Elena Vider, Gertrude Gunset, Michel Sadelain and Vladimir Ponomarev

Mol Ther 13: S295-S295; doi:10.1016/j.ymthe.2006.08.848

764. Attenuation of Treg Cells by GITR Ligand Led to Synergistic Enhancement of Treatment Efficacy with Immune-Stimulatory Therapies in Mice Bearing Metastatic 4T1 Breast Carcinoma

Li Chen, Tian-gui Huang, Marcia Meseck and Savio L.C. Woo

Mol Ther 13: S295-S296; doi:10.1016/j.ymthe.2006.08.849

765. Suicide Gene Therapy by Central Memory Human T Lymphocytes

Shin Kaneko, Sara Mastaglio, Attilio Bondanza, Maurilio Ponzoni, Luca Aldrighetti, Salvatore Toma, Marina Radrizzani, Simona La Seta, Fabio Ciceri, Claudio Bordignon and Chiara Bonini

Mol Ther 13: S296-S296; doi:10.1016/j.ymthe.2006.08.850

766. Immunotherapy for Her2-Positive Medulloblastoma: Regression of Experimental Tumors by Transfer of Her2-Redirected T Cells In Vivo

Nabil M. Ahmed, Maheshika K. Ratnayake, Barbara Savoldo, Laszlo Perlaky, Gianpietro Dotti, Winfried Wels, Meenakshi B. Bhattacharjee, H. David Shine, Cliona M. Rooney, Helen E. Heslop and Stephen Gottschalk

Mol Ther 13: S296-S296; doi:10.1016/j.ymthe.2006.08.851

767. Genetic Engineering of an Immortal Human CD8+ T Cell Line

Stephanie Jones, Cary Hsu, Richard Morgan and Steven Rosenberg

Mol Ther 13: S297-S297; doi:10.1016/j.ymthe.2006.08.852

768. Redirected T Cells to Selectively Target Mature B Cell Derived Malignancies

Juan Vera, Barbara Savoldo, Stephane Vigouroux, Ettore Biagi, Martin Pule, Claudia Rossig, Malcolm Brenner and Gianpietro Dotti

Mol Ther 13: S297-S297; doi:10.1016/j.ymthe.2006.08.853

769. Genes Encoding Receptors, Signal Transducers and Transcription Regulators are Preferred Targets of Retroviral Vector Integration in T-Lymphocytes In Vitro and In Vivo

Frank A. Giordano, Boris Fehse, Agnes Hotz-Wagenblatt, Sunitha Jonnakuty, Coral Del Val, Jens-Uwe Appelt, Katalin Z. Nagy, Klaus Kuehlcke, Sonja Naundorf, Axel R. Zander, W. Jens Zeller, Stefan Fruehauf and Stephanie Laufs

Mol Ther 13: S297-S298; doi:10.1016/j.ymthe.2006.08.854

770. Selective Elimination of Alloreactive GVHD-Mediating Donor T Cells by Ex Vivo sFasL Treatment

Osnat Bohana-Kashtan, Hyam I. Levitsky and Curt I. Civin

Mol Ther 13: S298-S298; doi:10.1016/j.ymthe.2006.08.855

771. Human mda-7/Interleukin 24 (IL-24) Protein Kills Breast Cancer Cells Via the IL-20 Receptor and is Antagonized by IL-10

Minghong Zheng, Dora Bocangel, Abner Mhashilkar, Rajagopal Ramesh, Kelly K. Hunt, Suhendan Ekmekcioglu, Nancy Poindexter, Elizabeth A. Grimm and Sunil Chada

Mol Ther 13: S298-S298; doi:10.1016/j.ymthe.2006.08.857

772. Inhibition of Ovarian Tumor Growth Following Treatment with an Oncolytic Vaccinia Virus

Xiang Da Dong (Eric), Mark E. O'Malley, Sri Chalikonda1, Zongsheng Guo, Herbert J. Zeh and David L. Bartlett

Mol Ther 13: S298-S299; doi:10.1016/j.ymthe.2006.08.858

773. Chemoprotection of Mouse Marrow Transplant Recipients by Ex Vivo Lentiviral Transduction of Murine tyr22 Dihydrofolate Reductase Conferring Resistance to Methotrexate

Jennifer L. Gori, Kelly Podetz-Pederson, Debra Swanson, Andrea D. Karlin, Nikunj V. Somia and R. Scott McIvor

Mol Ther 13: S299-S299; doi:10.1016/j.ymthe.2006.08.859

774. Evaluation of Adenovirus Vectors Containing Serotype 35 Fibers for Gene Therapy of Cervical Cancer

Ying Liu, Pavel Sova, Robert Strauss, Sebastian Tuve, Janice Morihara, Nancy Kiviat, Papa Toure, Salif Sow and Andre Lieber

Mol Ther 13: S299-S300; doi:10.1016/j.ymthe.2006.08.860

775. Folate Receptor Targeted Virotherapy of Ovarian Cancer Using a Tropism Modified Measles Virus

Kosei Hasegawa, Takafumi Nakamura, Mary Harvey, Yashiro Ikeda, Ann Oberg, Mariangela Figini, Silvana Canevari, Lynn Hartmann and Kah-Whye Peng

Mol Ther 13: S300-S300; doi:10.1016/j.ymthe.2006.08.861

776. Evaluation of an Ad5/35-Based Oncolytic Adenovirus Vector Formulated in Icodextrin Delivery Solution in a Model of Ovarian Cancer

Sudesh Kothari, Shaoheng Ni, Robert Strauss and Andre Lieber

Mol Ther 13: S300-S300; doi:10.1016/j.ymthe.2006.08.862

777. A Novel Pan-Oncolytic Adenovirus Therapeutically Effective in Different Cancer Cell Types

Maria V. Lopez, Diego Viale, Eduardo G. Cafferata, Daniela R. Macio, David Gould, Yuti Chernajovsky and Osvaldo L. Podhajcer

Mol Ther 13: S300-S301; doi:10.1016/j.ymthe.2006.08.863

778. A Novel Genetically Modified Adenovirus Vector Shows Enhanced Infectivity towards Ex Vivo Pancreatic Cancer

Michael van Geer, Piter Bosma, Koert Kuhlmann, Conny Bakker, Dirk Gouma and Ronald Oude Elferink

Mol Ther 13: S301-S301; doi:10.1016/j.ymthe.2006.08.864

779. Genetic Delivery of an Anti-RSV Antibody Protects Against Pulmonary Infection with RSV in Mice

Chani Traube, Adriana Heguy, Bishnu De, Anja Krause, James M. Wilson, Ronald G. Crystal and Stefan Worgall

Mol Ther 13: S301-S302; doi:10.1016/j.ymthe.2006.08.866

780. Inhibition of Respiratory Syncytial Virus Gene Expression and Replication by 27mer Dicer Substrate siRNAs

Anthony J. Fischer, Christine L. Wohlford-Lenane, Scott D. Rose, Steven M. Varga, Mark A. Behlke and Paul B. McCray Jr

Mol Ther 13: S302-S302; doi:10.1016/j.ymthe.2006.08.867

781. Adenoviral Gene Transfer of Angiopoietin-1 Corrects Post-Pneumonectomy Compensatory Lung Growth in the MMP-9-/- Mice Via Mobilization of Endothelial Progenitor Cells

A. Marwan, S. Vaikunth, J. Parvadia, U. Harkness, A. Maldonado, M. Ripberger, B. Kalinowska, D. Alaee, E. Uzvolgyi and T. Crombleholme

Mol Ther 13: S302-S302; doi:10.1016/j.ymthe.2006.08.868

782. Long-Term Expression of EIAV Lentivectors Pseudotyped with Influenza Virus Spike Glycoproteins after Nasal Delivery to Mice

Angela M. Giddings, Manij Patel, Lawrence E. Ostrowski and John C. Olsen

Mol Ther 13: S303-S303; doi:10.1016/j.ymthe.2006.08.869

783. Correction of |[beta]|c-Deficient Pulmonary Alveolar Proteinosis (PAP) by Hematopoietic Stem Cell Gene Transfer in a Murine Model

V. Kleff, U.R. Sorg, C. Bury, B. Opalka, M. Flasshove, U. Dirksen and T. Moritz

Mol Ther 13: S303-S303; doi:10.1016/j.ymthe.2006.08.870

784. Sleeping Beauty-Mediated eNOS Gene Therapy Attenuates Monocrotaline-Induced Pulmonary Hypertension

Li Liu, Hanzhong Liu, Gary Visner and Bradley S. Fletcher

Mol Ther 13: S303-S304; doi:10.1016/j.ymthe.2006.08.871

785. A Novel Adeno Associated Virus Vector That Efficiently Transduces Airway Epithelium In Vivo and Can Be Re-Administered

Maria Limberis, Roberto Calcedo, Julio SanMiguel, Julie C. Johnston, Deirdre McMenamin, Peter L. Bell and James M. Wilson

Mol Ther 13: S304-S304; doi:10.1016/j.ymthe.2006.08.872

786. Development of Zero-CpG Plasmids with Reduced Inflammatory Responses Following Delivery of Lipid/pDNA Complexes to the Mouse Lung

Ian A. Pringle, Syahrilnizam Abdullah, Anna E. Lawton, Anusha Varathalingam, Nelson S. Yew, Seng H. Cheng, Deborah R. Gill and Stephen C. Hyde

Mol Ther 13: S304-S305; doi:10.1016/j.ymthe.2006.08.873

787. Engineered Fok I Heterodimers for Enhanced Zinc Finger Nuclease Specificity

Jeffrey C. Miller, Michael Holmes, Jianbin Wang, Ya-Li Lee, Igor Rupniewski, Adam Waite, Dmitry Guschin, Philip Gregory, Carl O. Pabo and Edward J. Rebar

Mol Ther 13: S305-S305; doi:10.1016/j.ymthe.2006.08.875

788. Engineered Zinc Finger Protein Transcription Factors as a Potential Therapy for Choroidal Neovascularization

Steve Zhang, Shu Kachi, Sean F. Hackett, Michido Kachi, Hideo Akiyama, Naoyasu Umeda, Katsutoshi Yokoi, Pei-qi Liu, Gabor Veres, Philip D. Gregory and Peter A. Campochiaro

Mol Ther 13: S305-S305; doi:10.1016/j.ymthe.2006.08.876

789. Regulated VEGF Expression Modulates Bone Formation Elicited by Muscle Stem Cells Expressing BMP4

Andrew Ho, Arvydas Usas, Hairong Peng, Brian Gearhart and Johnny Huard

Mol Ther 13: S306-S306; doi:10.1016/j.ymthe.2006.08.877

790. Murine Retroviral but Not Human Cellular Promoters Induce In Vivo Erythroid-Specific Promoter Deregulation That Can Be Prevented by Insulators

Elodie Robert, Emmanuel Richard, Cecile Ged, Punam Malik, Hubert De Verneuil and Francois Moreau-Gaudry

Mol Ther 13: S306-S306; doi:10.1016/j.ymthe.2006.08.878

791. Unraveling Disease-Inducible Promoters from Gene Expression Profiling for Therapeutic Application in Arthritis

Jeroen Geurts, Onno J. Arntz, Miranda B. Bennink, Leo A. Joosten, Wim B. van den Berg and Fons A. van de Loo

Mol Ther 13: S306-S307; doi:10.1016/j.ymthe.2006.08.879

792. Post-Integrative Gene Silencing in the Sleeping Beauty Transposition System

Brian S. Garrison, Stephen R. Yant, Jacob G. Mikkelsen and Mark A. Kay

Mol Ther 13: S307-S307; doi:10.1016/j.ymthe.2006.08.880

793. Induction of Molecular Chimerism in NOD Mice Is Resistant to the Occurrence of Type I Diabetes Induced by Blockade of the Programmed Death-1 Pathway

Chaorui Tian, Jessamyn Bagley, Mohammed Javeed I. Ansari, Mohamed Sayegh and John Iacomini

Mol Ther 13: S307-S308; doi:10.1016/j.ymthe.2006.08.881

794. Retroviral-Based Gene Therapy with Cyclo-Oxygenase-2 Promotes Bony Union and Accelerates Fracture Healing in the Rat

Charles H. Rundle, Donna D. Strong, Shin-Tai Chen, Matilda H.-C. Sheng, Jon E. Wergedal, K.-H. William Lau and David J. Baylink

Mol Ther 13: S308-S308; doi:10.1016/j.ymthe.2006.08.882

795. RNA Interference of Influenza Virus Infection

Jianzhu Chen, Qing Ge, James Lu and Eisen N. Herman

Mol Ther 13: S308-S308; doi:10.1016/j.ymthe.2006.08.884

796. Pol II-Driven shRNA as an Effective Hepatitis B Virus Therapeutic

Jeffery C. Giering, Dirk Grimm, Theresa A. Storm, Hui Xu and Mark A. Kay

Mol Ther 13: S308-S309; doi:10.1016/j.ymthe.2006.08.885

797. Long-Term Inhibition of Hepatitis B Virus in Transgenic Mice by Adeno-Associated Virus- Delivered Short Hairpin RNA

Chun-Chi Chen, Tai-Ming Ko, Hsin-I Ma, Hui-Lin Wu, Xiao Xiao and Mi-Hua Tao

Mol Ther 13: S309-S309; doi:10.1016/j.ymthe.2006.08.886

798. Anti-Influenza-Viral Efficacy Attributed to siRNA Formulated as Simple Lipoplex or PEI Polyplexes Is a Result of Their Immunostimulatory Properties

Marjorie Robbins, Ellen Ambegia, Matthew Fedoruk, Lorne Palmer, Kevin McClintock, Adam Judge and Ian MacLachlan

Mol Ther 13: S309-S309; doi:10.1016/j.ymthe.2006.08.887

799. Expressed Long Hairpin RNA Sequences Inhibit HBV Replication In Vivo without Inducing an Interferon Response

Abdullah Ely, Sergio Carmona, Carol Crowther, Steven Mufamadi, Samantha Barichievy, Marc Weinberg and Patrick Arbuthnot

Mol Ther 13: S309-S310; doi:10.1016/j.ymthe.2006.08.888

800. Complete Suppression of CCR5 Expression and Inhibition of HIV-1 Infection by Transfected and Lentiviral Vector Expressed shRNAs

Joseph S. Anderson, Annaleen Vermeulen, Jon Karpilow and Ramesh Akkina

Mol Ther 13: S310-S310; doi:10.1016/j.ymthe.2006.08.889

801. RNA Gene Therapy Targeting Herpes Simplex Virus

Jia Liu, Sonal S. Tuli, David C. Bloom, Gregory S. Schultz, Steve C. Ghivizzani and Alfred S. Lewin

Mol Ther 13: S310-S310; doi:10.1016/j.ymthe.2006.08.890

802. Silencing of HIV-1 with RNA Interference: A Multiple shRNA Approach

Olivier ter Brake and Ben Berkhout

Mol Ther 13: S310-S311; doi:10.1016/j.ymthe.2006.08.891

803. Endogenous microRNA Regulation Suppresses Transgene Expression in Hematopoietic Lineages and Enables Stable Gene Transfer

Brian D. Brown, Mary Anna Venneri, Anna Zingale, Lucia Sergi Sergi and Luigi Naldini

Mol Ther 13: S311-S311; doi:10.1016/j.ymthe.2006.08.1224

804. In Vivo Correction of a Metabolic Liver Disease by AAV8-Mediated Homologous Recombination

Karsten Wursthorn, Terry Storm, Mark A. Kay, Milton Finegold and Markus Grompe

Mol Ther 13: S311-S312; doi:10.1016/j.ymthe.2006.08.1225

805. Fatality in Mice Due to Oversaturation of Cellular Micro/Short Hairpin RNA Pathways

Dirk Grimm, Konrad L. Streetz, Theresa A. Storm, Catherine L. Jopling, Joyce S. Lee and Mark A. Kay

Mol Ther 13: S312-S312; doi:10.1016/j.ymthe.2006.08.1226

806. Immunologic Improvement after Gene Therapy in 3 Preadolescents with X-Linked Severe Combined Immunodeficiency (XSCID)

Javier Chinen, Joie Davis, Suk-See de Ravin, Gilda Linton, Amy Hsu, B. Nora Naumann, Effie Nomicos, Christopher Silvin, Narda Theobald-Whiting, Jean Ulrick, Harry Malech and Jennifer Puck

Mol Ther 13: S312-S312; doi:10.1016/j.ymthe.2006.08.1227

807. NADPH-Dependent Endosomal ROS Is Critical for rAAV Capsid Processing during Infection

Liang N. Zhang, Jennifer Marden, Ziying Yan and John F. Engelhardt

Mol Ther 13: S313-S313; doi:10.1016/j.ymthe.2006.08.1228

808. Optimizing Non-Primate Lentiviral Vectors for Gene Transfer of CFTR to Airway Epithelia

Jessica D. Goreham-Voss, Patrick L. Sinn, Melissa A. Hickey, Ariadna Arias and Paul B. McCray Jr.

Mol Ther 13: S313-S313; doi:10.1016/j.ymthe.2006.08.893

809. Suppression of Human Pancreatic Cancer Growth by Lentiviral Vector-Mediated Gene Transfer of Pigment Epithelium Derived Factor (PEDF)

Pranay D. Khare, Nils Loewen and Eric M. Poeschla

Mol Ther 13: S313-S314; doi:10.1016/j.ymthe.2006.08.894

810. Comparison of Anti-HIV Activity from Various Lentiviral Vectors Carrying Anti-HIV shRNA In Vitro

Shirley Li, Haitang Li, Daniela Castanotto, Keith Meinking, Guihua Sun, John A. Zaia and John J. Rossi

Mol Ther 13: S314-S314; doi:10.1016/j.ymthe.2006.08.895

811. Correction of Laminin-5 |[beta]|3 Chain Deficiency in Human Epidermal Stem Cells by Transcriptionally Targeted Lentiviral Vectors

Francesca Di Nunzio, Giulietta Maruggi, Stefano Ferrari, Marcela del Rio, Fernando Larcher, Michele De Luca and Fulvio Mavilio

Mol Ther 13: S314-S315; doi:10.1016/j.ymthe.2006.08.896

812. Cellular Delivery of Gene Therapy Vectors

Jian Qiao, Hongxun Wang, Rosa Maria Diaz, Atique Ahmed, Jill Thompson and Richard Vile

Mol Ther 13: S315-S315; doi:10.1016/j.ymthe.2006.08.897

813. Targeted Delivery of Biotinylated Compounds by Lodavin|[trade]|, LDL-Receptor |[ndash]| Avidin Fusion Protein, Expressing Lentivirus

Hanna P. Lesch, Jere T. Pikkarainen, Thomas Wirth, Minna U. Kaikkonen, Olli H. Laitinen, Kari J. Airenne and Seppo Yla- Herttuala

Mol Ther 13: S315-S315; doi:10.1016/j.ymthe.2006.08.898

814. Biomaterial-Mediated Retroviral Gene Delivery

Charles A. Gersbach, Sean R. Coyer, Joseph M. Le Doux and Andres J. Garcia

Mol Ther 13: S315-S316; doi:10.1016/j.ymthe.2006.08.899

815. 293 FLEX a New Cell Line for Fast, Reproducible and Efficient Production of Retroviral Gene Therapy Vectors

Ana S. Coroadinha, Paula M. Alves and Manuel J.T. Carrondo

Mol Ther 13: S316-S316; doi:10.1016/j.ymthe.2006.08.900

816. Rapid, Consistent and Scalable Production of Viral Vectors in Suspension Cells by Cotransfection of Viral Component Plasmid DNA or RNA

James Brady, Rama Shivakumar, Matthew Malehorn, Stephanie Feller, Cornell Allen, Linhong Li, Nicholas Chopas, Sergey Dzekunov, Madhusudan V. Peshwa and Linda N. Liu

Mol Ther 13: S317-S317; doi:10.1016/j.ymthe.2006.08.901

817. Rapid and Efficient Titration of Retroviral Vectors Using Quantitative Real-Time PCR

Seung Shin Yu, Kazuyuki Dan, Takashi Ueno, Junichi Mineno and Ikunosin Kato

Mol Ther 13: S317-S317; doi:10.1016/j.ymthe.2006.08.902

818. Development of Packaging Cell Lines for the Large-Scale Production of High-Titer Clinical Grade Recombinant Retroviruses

Karim Ghani and Manuel Caruso

Mol Ther 13: S317-S318; doi:10.1016/j.ymthe.2006.08.903

819. EGF Ligands Decrease Retroviral Gene Transfer through Protein Kinase C-delta

Raghvendra Singh and Stelios T. Andreadis

Mol Ther 13: S318-S318; doi:10.1016/j.ymthe.2006.08.904

820. Development of Efficient Self-Inactive Retroviral Vectors

Jaehyung Yoon, Vivian P. Yip, Lillian G. Yun, J.Kelly Ganjei and Youngsuk Yi

Mol Ther 13: S318-S318; doi:10.1016/j.ymthe.2006.08.905

821. Successful Adaptation of the RCAS-TVA Gene Transfer System for Use in a Bovine Mammary Epithelial Cell Culture Model

Peta M. Phillips, Peter C. Wynn and Paul A. Sheehy

Mol Ther 13: S318-S318; doi:10.1016/j.ymthe.2006.08.906

822. Lentiviral Vector Delivery of the RheoSwitch|[reg]| Therapeutic System for Inducible Therapeutic Transgene Expression

Zhijian J. Chen and Malla Padidam

Mol Ther 13: S319-S319; doi:10.1016/j.ymthe.2006.08.907

823. SLC350F2 Transporter Protein Is the Receptor Targeted by a Library-Selected Retroviral Envelope

Anindita Sarangi, Keith Bupp and Monica J. Roth

Mol Ther 13: S319-S319; doi:10.1016/j.ymthe.2006.08.908

824. Control of Splicing Efficiency by the Mouse Histone H2a Element in an MLV-Based Retroviral Vector

Jun-Tae Lee, Seung Shin Yu, V. Narry Kim, Joong-Gon Kim, Youngtae Hong, Sujeong Kim, Karim Lee, Sun Mee Bae, Kyung Mi Koh, Hye Lim Cho and Sunyoung Kim

Mol Ther 13: S319-S319; doi:10.1016/j.ymthe.2006.08.909

825. Primary Canine Marrow Cells Support HIV-1 Vector Mediated Expression of Functional Human Factor VIII

Michail Zaboikin, Srinivas N. Kumar, Tatiana Zaboikina and Friedrich G. Schuening

Mol Ther 13: S319-S320; doi:10.1016/j.ymthe.2006.08.910

826. Transduction of Human Hematopoietic Stem Cells by RD114-TR-Pseudotyped Lentiviral Vectors

Anna A. Stornaiuolo, Francesca F. Di Nunzio, Bianca B. Piovani, Francois F.-L. Cosset and Fulvio F. Mavilio

Mol Ther 13: S320-S320; doi:10.1016/j.ymthe.2006.08.911

827. Oncogenesis Following Delivery of Lentiviral Vectors to Fetal and Neonatal Mice

Michael Themis, Simon N. Waddington, Manfred Schmidt, Christof von Kalle, Yoahe Wang, Faisal Al-Allaf, Lisa Gregory, Megha Nivsarkar, Matthew Themis, Maxine Holder, Suzanne M.K. Buckley, Niraja Dighe, Alaine Ruthe, Ajay Mistry, Brian Bigger, Adrian J. Thrasher and Charles Coutelle

Mol Ther 13: S320-S320; doi:10.1016/j.ymthe.2006.08.912

828. Promoter Strength Versus Transactivation Potential: Creating a Safer Integrating Vector

Erin L. Weber and Paula M. Cannon

Mol Ther 13: S320-S321; doi:10.1016/j.ymthe.2006.08.913

829. Withdrawn

Mol Ther 13: S321-S321; doi:10.1016/j.ymthe.2006.08.914

830. Determination of the Profile and Site Preference of Lentiviral Vector Integration In Vivo

Caroline V. Hacker, Conrad V. Vink, Susan M. Kingsman, Kyriacos A. Mitrophanous and James E. Miskin

Mol Ther 13: S321-S321; doi:10.1016/j.ymthe.2006.08.915

831. Apoptosis Induced by Oncolytic M Protein Mutant Vesicular Stomatitis Virus Is Dependent on PKR, Fas, and Daxx

Daniel F. Gaddy and Douglas S. Lyles

Mol Ther 13: S321-S321; doi:10.1016/j.ymthe.2006.08.916

832. Efficient Readministration of Adenovectors to the Inner Ear

Hinrich Staecker, Mark Praetorius, Chi Hsu and Douglas E. Brough

Mol Ther 13: S321-S322; doi:10.1016/j.ymthe.2006.08.918

833. Combined Manganese Superoxide Dismutase Gene Therapy and 5-FU Chemotherapy for Colorectal Cancer

Yanhong Zhang, Lingfeng He, Songqing He, Jian Wu and Xinyuan Liu

Mol Ther 13: S322-S322; doi:10.1016/j.ymthe.2006.08.919

834. Protective Effect of Bcl-XL Gene Expression on the Radiation-Induced Acute Intestinal Injuries

Kazuaki Uchimoto, Fumikazu Koyama, Kazuo Ohashi, Kenichi Ohtsuki, Hirofumi Hamada, Takeo Nomi, Hisao Fujii, Tomohide Mukogawa and Yoshiyuki Nakajima

Mol Ther 13: S322-S322; doi:10.1016/j.ymthe.2006.08.920

835. Inhibition of Hepatic SPARC (Secreted Protein Acidic and Rich in Cysteine) Expression for the Treatment of Experimental Cirrhosis

Alejandra M. Camino, Federico Prada, Osvaldo Podhajcer, Marcelo O. Silva and Guillermo D. Mazzolini

Mol Ther 13: S322-S323; doi:10.1016/j.ymthe.2006.08.921

836. Changes in Maturation Profiles of Dendritic Cells Transduced with a CD40-Targeted Adenoviral Vector

Disha A. Mody, Alexander V. Pereboev, Don A. Sibley, David T. Curiel and J. Michael Mathis

Mol Ther 13: S323-S323; doi:10.1016/j.ymthe.2006.08.922

837. Colon-Directed Delivery of Viral Vectors Using Virus-Microbead Conjugates for Gene Therapy of Inflammatory Bowel Disease

Alan Jerusalmi, Samuel J. Farlow and Takeshi Sano

Mol Ther 13: S323-S324; doi:10.1016/j.ymthe.2006.08.172

838. 10 Year Follow-Up of 146 Advanced Stage NSCLC Patients Who Received Adenoviral Based Therapy

John Nemunaitis, Been Pappen, Rosemarie Arzaga, Casey Cunningham and Neil Senzer

Mol Ther 13: S324-S324; doi:10.1016/j.ymthe.2006.08.924

839. Long-Term Knockdown of Phospholamban in Cultured Neonatal Rat Cardiomyocytes by a Viral Vector Expressing PLB-shRNAs

Lennart Suckau, Jens Kurreck, Roland Vetter, Stefan Weger, Jos Lamers, Wolfgang Poller and Henry Fechner

Mol Ther 13: S324-S324; doi:10.1016/j.ymthe.2006.08.925

840. Markedly Enhanced Cytolysis by E1B-19kD-Deleted Oncolytic Adenovirus in Combination with Cisplatin

A-Rum Yoon, Young-Sook Lee, Ji-Young Yoo, Hoguen Kim, Jinsun Kim, Joong Bae Ahn, Joo-Hang Kim and Chae-Ok Yun

Mol Ther 13: S324-S325; doi:10.1016/j.ymthe.2006.08.926

841. Anti-Tumor Effect of Tumor Specific Replicating Adenovirus Expressing IL-12 and IL-18

Jing-Hua Huang, Il-Kyu Choi, Sung-Mi Jung, Minjung Kim, Joo-Hyuk Sohn, Chae-Ok Yun and Joo-Hang Kim

Mol Ther 13: S325-S325; doi:10.1016/j.ymthe.2006.08.927

842. Novel Oncolytic Adenoviruses for Cancer Gene Therapy

Devanand Sarkar, Zao-zhong Su and Paul B. Fisher

Mol Ther 13: S325-S325; doi:10.1016/j.ymthe.2006.08.928

843. MicroPET Imaging of HSV-TK Activity To Assess Cancer-Specific Gene Expression Targeted at the Level of Protein Translation Initiation

Don A. Sibley, Shayne Barlow, Ricky DeBenedetti, David T. Curiel and J. Michael Mathis

Mol Ther 13: S325-S326; doi:10.1016/j.ymthe.2006.08.929

844. A Single Vector-Dependent, Doxycycline- Regulatable, Lung Cancer Specific Oncolytic Adenovirus

Isaac Sipo, Almudena Hurtado Pico, Judith Wildner, Lennart Suckau, Sandra Pinkert, Stefan Weger, Wolfgang Poller and Henry Fechner

Mol Ther 13: S326-S326; doi:10.1016/j.ymthe.2006.08.930

845. The Loss Expression of Coxsackie and Adenovirus Receptor Enhances the Feature of Aggressive Bladder Cancer

Kazumasa Matsumoto, Sharokh F. Shariat, Akira Irie, Tetsuo Fujita, Hiroshi Okusa, Takefumi Satoh, Masatsugu Iwamura, Shiro Baba and Seth P. Lerner

Mol Ther 13: S326-S326; doi:10.1016/j.ymthe.2006.08.931

846. Enhanced Antitumor Effect of Oncolytic Adenovirus Expressing Interleukin-12 and B7.1 in an Immuneocompetenet Mouse Model

Ji Young Yoo, Young-Sook Lee, Jaesung Kim, Hyejin Choi, Joo-Hang Kim and Chae-Ok Yun

Mol Ther 13: S326-S326; doi:10.1016/j.ymthe.2006.08.932

847. Combined Oncolytic Adenovirus with Double Suicide Gene in Killing Lung Cancer

Ju Feng Zhang and Chen Huang

Mol Ther 13: S327-S327; doi:10.1016/j.ymthe.2006.08.933

848. Helper Dependent Adenovirus-Epstein- Barr Virus Hybrid Vector for Long Term Persistance in Hepatocytes

Jose S. Gil, Sean D. Gallaher and Arnold J. Berk

Mol Ther 13: S327-S327; doi:10.1016/j.ymthe.2006.08.934

849. E1A- and E1B-Double Mutant Replicating Adenovirus Elicits Enhanced Oncolytic and Anti- Tumor Effects

Jinsun Kim, Jaesung Kim, Joo-Hang Kim, Kyung-Ju Choi, Pyung-Hwan Kim and Chae-Ok Yun

Mol Ther 13: S327-S327; doi:10.1016/j.ymthe.2006.08.935

850. Concurrent Delivery of GM-CSF and B7-1 Using an Oncolytic Adenovirus Elicits Potent Anti- Tumor Effect on the Growth Established B16-F10 Tumor Model

Min-Ju Kim, Kyung-Ju Choi, Yoon-A Kang, Oh-Joon Kwon, Pyung-Hwan Kim, Chae-Ok Yun and Joo-Hang Kim

Mol Ther 13: S327-S328; doi:10.1016/j.ymthe.2006.08.936

851. Molecular Determination of High-Capacity Helper Dependent Adenoviral Vector Genomes In Vitro and In Vivo

Mariana Puntel, James F. Curtin, Jeffrey M. Zirger, A.K.M. Muhammad, Xiong Weidong, Chunyan Liu, Jinwei Hu, Kurt M. Kroeger, Peter Czer, Sandra Sciascia, Pedro R. Lowenstein and Maria G. Castro

Mol Ther 13: S328-S328; doi:10.1016/j.ymthe.2006.08.937

852. Chromatin Study of Adenovirus Vector DNA In Vivo

Dan Cao and Mark A. Kay

Mol Ther 13: S328-S328; doi:10.1016/j.ymthe.2006.08.938

853. Monitoring of Promoter-Controlled Adenoviral Replication with Noninvasive Imaging in Lung Cancer

Julia Davydova, Amy R. Nelson, Tatyana Gavrikova, Long P. Le, Hidetaka A. Ono, David T. Curiel and Masato Yamamoto

Mol Ther 13: S328-S328; doi:10.1016/j.ymthe.2006.08.939

854. Potential of the Oncolytic Adenovirus Delo3 RGD in the Treatment of Malignant Carcinoma Cells

Klaus Mantwill, Per S. Holm and Bernd Gansbacher

Mol Ther 13: S329-S329; doi:10.1016/j.ymthe.2006.08.939

855. B-Specific Lentiviral Vectors Expressing Btk: Tools for a Gene Therapy of X-Linked Agammaglobulinemia

Thomas Moreau, Vincent Barlogis, Christian Chabannon and Cecile Tonnelle

Mol Ther 13: S329-S329; doi:10.1016/j.ymthe.2006.08.941

856. Improvements on Safety and Efficacy of Nonviral Gene Therapy of Factor VII for Hemophilia A with Inhibitors

Steven C. Chen, Daniel Greenberg, Peiqing Ye, Earl W. Davie and Carol H. Miao

Mol Ther 13: S329-S330; doi:10.1016/j.ymthe.2006.08.942

857. Molecular Engineering of Factor VIII for rAAV Delivery

Lingxia Chen, Hui Lu, Juan Li, Haiyan Jiang, Rita Sarkar, Glenn Pierce, Rodney Camira, Valder Arruda, Xiao Xiao and Weidong Xiao

Mol Ther 13: S330-S330; doi:10.1016/j.ymthe.2006.08.943

858. In Vivo Engineering of Hepatic Tissues Expressing Factors VIII and IX as a Potential New Therapy toward Hemophilia

Kazuo Ohashi, Takashi Yokoyama, Hiroyuki Kuge, Masayuki Yamato, Akira Yoshioka and Yoshiyuki Nakajima

Mol Ther 13: S330-S330; doi:10.1016/j.ymthe.2006.08.944

859. Cats Produce a CTL Response That Reduces Expression of Human Factor IX and Human Factor VIII after Neonatal Gene Transfer and Represent an Important Model for Translation into Humans

Lingfei Xu, Manxue Mei, Mark E. Haskins, Patty O'Donnell, Karyn Cullen and Katherine P. Ponder

Mol Ther 13: S331-S331; doi:10.1016/j.ymthe.2006.08.945

860. Sustained Long-Term In Vivo Expression of Human Factor IX from Keratinocytes Transduced with HIV-Based Vectors

Angeles Escarti-Nebot, Fernando Serrano, Marcela del Rio, Fernando Larcher and Antonio Bernad

Mol Ther 13: S331-S331; doi:10.1016/j.ymthe.2006.08.946

861. Recombinant Adeno-Associated Virus Vector Mediated Gene Therapy of Adenosine Deaminase Deficiency in a Mouse Model

Jennifer M. Crawford, Teh-sheng Chan and Lillian L. Chan

Mol Ther 13: S331-S332; doi:10.1016/j.ymthe.2006.08.947

862. Feasibility of Cutaneous Gene Therapy Using a Factor VIII Gene and a Marker Gene in Factor VIII-Deficient Mice by Non-Invasive Electroporation

Lei Zhang, Amy Goldbeck, Hongbo Lu, Edward Nolan, Dietmar Rabussay and Steve Fakharzadeh

Mol Ther 13: S332-S332; doi:10.1016/j.ymthe.2006.08.948

863. Liver Gene Therapy for Hemophilia with phiC31 Integrase

Lauren E. Woodard, Annahita Keravala, Robert T. Hillman, Julien Sage and Michele P. Calos

Mol Ther 13: S332-S332; doi:10.1016/j.ymthe.2006.08.949

864. Characterization of Transgenic Mice Over-Expressing Arylsulfatase A: Implications for Gene Therapy and Sulfatases Activation Mechanisms

Alessia Capotondo, Mary A. Venneri, Maria P. Cosma, Isabella Pallavicini, Andrea Ballabio, Luigi Naldini and Alessandra Biffi

Mol Ther 13: S332-S333; doi:10.1016/j.ymthe.2006.08.950

865. In Vivo Gene Transfer of Prostacyclin Synthase by Using AAV Vector Prevents Monocrotaline-Induced Pulmonary Hypertension and Pulmonary Vasoconstriction in Rats

Takayuki Ito, Takashi Okada, Jun Mimuro, Hiroshi Miyashita, Mutsuko Nonaka-Sarukawa, Hiroaki Mizukami, Akihiro Kume, Masafumi Takahashi, Keiji Yamamoto, Kazuyuki Shimada and Keiya Ozawa

Mol Ther 13: S333-S333; doi:10.1016/j.ymthe.2006.08.953

866. Aortic Disease in Mucopolysaccharidodis I Mice Is Due to Increased Expression of Matrix Metalloproteinase 12 (MMP 12) Can Be Prevented with Neonatal Retroviral Vector-Mediated Gene Therapy

Xiucui Ma, Mindy Tittiger, Russ Knutson, Robert Mecham, Laura Schaller and Katherine Ponder

Mol Ther 13: S333-S334; doi:10.1016/j.ymthe.2006.08.954

867. Spliceosome Mediated RNA Trans-Splicing To Increase Blood Levels of Apolipoprotein A-I and High Density Lipoproteins

Madaiah Puttaraju, Jun Wang, Alan T. Remaley, Bryan H. Brewer Jr., Mariano A. Garcia-Blanco and Gerard J. McGarrity

Mol Ther 13: S334-S334; doi:10.1016/j.ymthe.2006.08.955

868. Novel Strategies To Inhibit Ocular Neovascularization Based on Sonic Hedgehog Pathway Blockade

Gabriella  Cotugno, Enrico M Suace and Alberto Auricchio

Mol Ther 13: S334-S334; doi:10.1016/j.ymthe.2006.08.956

869. Accelerated Re-Endothelilization in eNOS Transduced Iliac Artery Following Gene Delivery from an Adenoviral Eluting Stent

Faisal Sharif, Sean O. Hynes, James Crowley, Kieran Daly and Timothy O'Brien

Mol Ther 13: S334-S335; doi:10.1016/j.ymthe.2006.08.957

870. NOS Isoforms, Intimal Hyperplasia and Endothelial Regeneration after Balloon Injury

Ronan Cooney, Sean O. Hynes, Sharif Faisal and Timothy O'Brien

Mol Ther 13: S335-S335; doi:10.1016/j.ymthe.2006.08.958

871. Surface Modification of Adenovectors with TAT- and Antp-Containing Polymers Protects Them from Neutralizing Antibodies and Increases Expression of Reporter Genes In Vitro and In Vivo

Ilia Fishbein, Ivan S. Alferiev, Richard Gaster, Meizan Lai and Robert J. Levy

Mol Ther 13: S335-S335; doi:10.1016/j.ymthe.2006.08.959

872. Highly Efficient Virus-Mediated Gene Transfer to Human Vein Grafts Via Intraluminal Pressure Delivery

Oliver Y. Bernecker, Robert Stigler, Severin Semsroth, Guenther Laufer and Johannes Bonatti

Mol Ther 13: S335-S336; doi:10.1016/j.ymthe.2006.08.960

873. Development of High Throughput Functional Screening of Cardiovascular Therapeutic Genes Using the HVJ-E Vector

Tomoyuki Nishikawa, Hironori Nakagami, Atsuhi Matsuki, Yukihiro Saito, Ryuichi Morishita, Katsuto Tamai and Yasufumi Kaneda

Mol Ther 13: S336-S336; doi:10.1016/j.ymthe.2006.08.961

874. Prolonged Adenovirus and Adeno-Associated Virus-Mediated Gene Delivery to Rabbit Iliac Arteries Using Gene-Eluting Stents: A Direct Comparison

Faisal Sharif, Sean Hynes, Jill McMahon, James Crowley and Kieran Daly

Mol Ther 13: S336-S336; doi:10.1016/j.ymthe.2006.08.962

875. Development of Human Skin Gene Therapy for Systemic In Vivo Delivery of Atrial Natriuretic Peptide (ANP) To Treat Hypertension

Jean-Philippe Therrien, Christine L. Tock and Jonathan C. Vogel

Mol Ther 13: S337-S337; doi:10.1016/j.ymthe.2006.08.963

876. Development of Novel Angiogenic DNA Medicine Using a Genomic/cDNA Hybrid of Hepatocyte Growth Factor Gene

Woong Hahn, Dong-Sik Kim, Wook-Bum Pyun, Won-Sun Yoo, Sun-young Kim and Jong-Mook Kim

Mol Ther 13: S337-S337; doi:10.1016/j.ymthe.2006.08.964

877. Differential Expression of Indoleamine 2,3-dioxygenase (IDO) by Endothelial Cells and Its Overexpression by Gene Transfer: Implications for Cardiovascular Biology

Peng H. Tan and Andrew J.T. George

Mol Ther 13: S337-S338; doi:10.1016/j.ymthe.2006.08.965

878. Overexpression of Fibromodulin Inhibits Neointima Formation in Cultured Human Saphenous Veins

Parisa Ranjzad, Husein K. Salem and Paul A. Kingston

Mol Ther 13: S338-S338; doi:10.1016/j.ymthe.2006.08.966

879. Effects of Continuous Expression of Activated Protein C (APC) in Novel Murine Thrombosis Models

Christian Furlan Freguia, Joerg Schuettrumpf, Stefano Baila, Jianhua Liu, Ralph Bunte, Rodney M. Camire and Valder R. Arruda

Mol Ther 13: S338-S338; doi:10.1016/j.ymthe.2006.08.967

880. Towards a Gene Therapy Treatment for Peripheral Vascular Disease |[ndash]| High Level of Expression of Angiogenic Genes in Rat Limb Muscle Following Intravenous Delivery of Plasmid DNAs

Weijun Cheng, Julia O. Hegge, Vladimir Subbotin, Steven Coakley and James E. Hagstrom

Mol Ther 13: S339-S339; doi:10.1016/j.ymthe.2006.08.968

881. Safety, Efficacy and Biodistribution of Recombinant AAV2-RPE65 Vector Delivered by Ocular Subretinal Injection

Samuel G. Jacobson, Gregory M. Acland, Gustavo D. Aguirre, Tomas S. Aleman, Sanford L. Boye, Sharon B. Schwartz, Artur V. Cideciyan, Caroline J. Zeiss, Andras M. Komaromy, Alejandro J. Roman, Elizabeth A.M. Windsor, Alexander Sumaroka, Susan E. Pearce-Kelling, Thomas J. Conlon, Quihong Li, Vincent A. Chiodo, Terence R. Flotte, Albert M. Maguire, Jean Bennett and William W. Hauswirth

Mol Ther 13: S339-S339; doi:10.1016/j.ymthe.2006.08.970

882. Non-Viral Ocular Gene Transfer for Hereditary Retinal Degeneration

Muna I. Naash, Ron M. Ballard, Jeff Skaggs, Zack Nash, Alexander B. Quiambao, Mark J. Cooper and Rafal Farjo

Mol Ther 13: S340-S340; doi:10.1016/j.ymthe.2006.08.971

883. AAV-2 Based Gene Therapy Using Novel Anti-VEGF Molecules for Inhibition of Angiogenesis in the Eye

Abraham Scaria, Peter Pechan, Hillard Rubin, Michael Lukason, Elizabeth Barry, Jeffrey Ardinger, Huawei Qiu, Qiuhong Li, James Peterson, William Hauswirth and Samuel Wadsworth

Mol Ther 13: S340-S340; doi:10.1016/j.ymthe.2006.08.972

884. Anti-Oxidant Gene Delivery to Retinal Epithelial Cells: A Gene Therapy Approach for Macular Degeneration

Lisa McGinley, Gillian Cosgrave, Aoife Duffy, Timothy O'Brien and Padraig M. Strappe

Mol Ther 13: S340-S341; doi:10.1016/j.ymthe.2006.08.973

885. AAV-Mediated Gene Transfer of Constitutively and Pharmacologically-Activated Glial Cell-Derived Neurotrophic Factor Receptor To Inhibit Retinal Degeneration

Mariacarmela Allocca, Umberto Di Vicino, Luciano Domenici, Victor M. Rivera and Alberto Auricchio

Mol Ther 13: S341-S341; doi:10.1016/j.ymthe.2006.08.974

886. AAV-Mediated Somatic Gene Transfer as an Approach To Delineate Pathogenic Mechanisms in an Autosomal Dominant Blindness Disorder Resembling Age-Related Macular Degeneration (AMD)

Nicholas W. Keiser, Arvydas Maminishkis, Jeannette L. Bennicelli, Sheldon S. Miller and Jean Bennett

Mol Ther 13: S341-S341; doi:10.1016/j.ymthe.2006.08.975

887. G Protein-Coupled Receptor Kinase Interacting Protein 1 Slows down the Apoptosis Process of Retinal Ganglion Cells in a Rat Model

Ann-Shung Lieu, Yi Wang, Donna Webb, Gerold R. Hankins, Gergory A. Helm and Jin Zhong Li

Mol Ther 13: S341-S342; doi:10.1016/j.ymthe.2006.08.976

888. Characterization of New Murine Models of Globoid Cell Leukodystrophy: Relevance for Gene Therapy Applications and Studies on Disease Pathogenesis

Ilaria Visigalli, Ubaldo del Carro, Letterio Politi, Angelo Quattrini, Paola Luzi, David Wenger, Luigi Naldini and Alessandra Biffi

Mol Ther 13: S342-S342; doi:10.1016/j.ymthe.2006.08.977

889. Adeno-Associated Virus Gene Therapy of Feline Gangliosidosis

Douglas R. Martin, Begona Cachon-Gonzalez, Miguel Sena-Esteves, Misako Hwang, Atoska S. Gentry, Nancy E. Morrison, Nancy R. Cox, Timothy M. Cox and Henry J. Baker

Mol Ther 13: S342-S342; doi:10.1016/j.ymthe.2006.08.978

890. Improvement of Behavior and Mortality Following CNS Administration of AAVrh.10hCLN2 to CLN2 |[minus]|/|[minus]| Mice, a Model LINCL (Battan Disease) a Fatal Childhood Neurological Disorder (Batten Disease)

Dolan Sondhi, Neil R. Hackett, Daniel A. Peterson, Elizabeth Vassallo, Jamie A. Stratton, Kelly Travis, Timothy P. O'Connor, James M. Wilson and Ronald G. Crystal

Mol Ther 13: S343-S343; doi:10.1016/j.ymthe.2006.08.979

891. Correction of Established Neurologic Disease and Evidences of In Vivo Cross Correction in the Mouse Model of Metachromatic Leukodystrophy

Alessandra Biffi, Alessia Capotondo, Stefania Fasano, Ubaldo del Carro, Sergio Marchesini, Hisaya Azuma, Riccardo Brambilla, Markus Grompe, Claudio Bordignon, Angelo Quattrini and Luigi Naldini

Mol Ther 13: S343-S343; doi:10.1016/j.ymthe.2006.08.980

892. Neural Deficits Contribute to Respiratory Insufficiency in Pompe Disease: A Therapeutic Approach with AAV1

Lara R. DeRuisseau, Cathryn Mah, David D. Fuller and Barry J. Byrne

Mol Ther 13: S344-S344; doi:10.1016/j.ymthe.2006.08.981

893. Second Generation Gene Therapy Vector for Classical Late Infantile Neuronal Ceroid Lipofuscinosis

Mario A. Cabrera-Salazar, Bradley L. Hodges, Nelson S. Yew, Jie Bu, Jonathan A. Fidler, Eric M. Roskelley, Ronald K. Scheule, David E. Sleat, Peter Lobel, Seng H. Cheng and Marco A. Passini

Mol Ther 13: S344-S344; doi:10.1016/j.ymthe.2006.08.982

894. Selective Targeting of GABAergic Neurons Using rAAV: The Potential Role of EAAC1 in Seizure Susceptibility

Melodie L. Weller, Christopher J. Maki, Ida M. Stone and David J. Poulsen

Mol Ther 13: S344-S345; doi:10.1016/j.ymthe.2006.08.983

895. Separate rAAV1 Vectors Co-Infect Striatal Neurons Efficiently

Fredric P. Manfredsson, Aaron C. Rising and Ronald J. Mandel

Mol Ther 13: S345-S345; doi:10.1016/j.ymthe.2006.08.984

896. Long Term Transgene Expression in the Brain Delivered by SV40-Derived Vectors

Jean-Pierre Louboutin, Beverly A.S. Reyes, Lokesh Agrawal, Elisabeth J. van Bockstaele and David S. Strayer

Mol Ther 13: S345-S345; doi:10.1016/j.ymthe.2006.08.985

897. Na,K-ATPase |[beta]|1-Mediated Selective Gene Transfer into Neurons

Keiji Ishii, Kiminori Nakamura, Satoshi Kawaguchi, Rong Li, Sachie Hirai, Naoya Sakuragi, Takuro Wada, Kazunori Kato, Toshihiko Yamashita and Hirofumi Hamada

Mol Ther 13: S346-S346; doi:10.1016/j.ymthe.2006.08.986

898. Intracerebral Exon Skipping Restores Dystrophin Expression in CA1 Pyramidal Neurons of mdx Mice

Elise Peltekian, Karine Ros, Aurelie Goyenvalle, Carole Gruszczynski, Cyrille Vaillend, Serge Laroche, Luis Garcia and Olivier Danos

Mol Ther 13: S346-S346; doi:10.1016/j.ymthe.2006.08.987

899. Utilizing the Vector Transport Properties of AAV-9 as a Method To Get Widespread Distribution of a Therapeutic Gene within the CNS

Cassia N. Cearley and John H. Wolfe

Mol Ther 13: S346-S346; doi:10.1016/j.ymthe.2006.08.988

900. Specific AAV Serotypes Stably Transduce Hippocampal and Cortical Cultures with High Efficiency and Low Toxicity

Nicolas C. Royo, Luk H. Vandenberghe, Julie Johnston, Margaret Maronski, Marc A. Dichter, James M. Wilson and Deborah J. Watson

Mol Ther 13: S347-S347; doi:10.1016/j.ymthe.2006.08.989

901. Targeting of Viral Vectors to Motor Neurons by Botulinum Toxin Binding Domain To Treat ALS

Yang Lu, Robert Adams, Wenji Sun, Iris Lee, Irina Debromilskaya and Daniel B. Drachman

Mol Ther 13: S347-S347; doi:10.1016/j.ymthe.2006.08.990

902. Modulation of Voltage-Gated Potassium Channels in Dorsal Root Ganglion Neurons by an Inducible Adenoviral Vector In Vivo

Chao Ma, Robert H. LaMotte, Jason M. Rosenzweig, Peter L. Gehlbach and David C. Johns

Mol Ther 13: S347-S348; doi:10.1016/j.ymthe.2006.08.991

903. Re-Administration of Recombinant AAV2 and AAV5 in the Brain

Sharon K. Reimsnider, Fredric P. Manfredsson, Corinna Burger, Nicholas Muzczyka and Ronald J. Mandel

Mol Ther 13: S348-S348; doi:10.1016/j.ymthe.2006.08.992

904. The Systemic Human Immune Response to Intraparenchymal Administration of AAV

Scott W.J. McPhee, Chris G. Janson, Chengwen Li, R. Jude Samulski, Angelique S. Camp, Jeremy S. Francis, David Shera, Andrew Freese, Anthony L. Aita, H. Warren Goldman and Paola Leone

Mol Ther 13: S348-S348; doi:10.1016/j.ymthe.2006.08.993

905. The Use of Gene Immunisation To Study the Role of Antibodies to Voltage Gated Potassium Channels in Neuroimmunological Disease

Mary McMenamin, Karen M. McKnight, Matthew J.A. Wood, Bethan Lang, Nikki J. Horwood and Angela C. Vincent

Mol Ther 13: S349-S349; doi:10.1016/j.ymthe.2006.08.994

906. Effective Repetitive Dystrophin Gene Transfer into Skeletal Muscle of Adult mdx Mice Using a Helper-Dependent Adenovirus Vector Expressing the Coxsackievirus and Adenovirus Receptor (CAR) and Dystrophin

Yuji Uchida, Yasushi Maeda, En Kimura and Makoto Uchino

Mol Ther 13: S349-S349; doi:10.1016/j.ymthe.2006.08.996

907. Development of Recombinant Novel Adeno-Associated Viral (rAAV) Vectors Encoding Optimised Microdystrophin cDNAs for Duchenne Muscular Dystrophy (DMD)

Takis Athanasopoulos, Ian Graham, Capucine Trollet, Helen Foster, Norma Perez, Vanessa Hill, Phillippe Moullier and George Dickson

Mol Ther 13: S349-S350; doi:10.1016/j.ymthe.2006.08.997

908. Design and Optimization of U7snRNAs for Skipping of Exon 51 in DMD: Promising Tools for Future Clinical Trials

Aurelie Goyenvalle, Adeline Vulin, Stephanie Lorain, Annemieke Aartsma-Rus, Judith C.T. van Deutekom, Olivier Danos and Luis Garcia

Mol Ther 13: S350-S350; doi:10.1016/j.ymthe.2006.08.998

909. Comparison of Early Stage Healing Responses of Injured Flexor Tendons with Tissue Reactions after Delivery of Adenoviral and Adeno-Associated Viral Vectors to Digital Flexor Tendons

Bei Zhu, Yi Cao, Ke-Qin Xin, Ian C Summerhayes, Xiao Tian Wang, Paul Y. Liu and Jin Bo Tang

Mol Ther 13: S350-S350; doi:10.1016/j.ymthe.2006.08.999

910. Gene Therapy of Glycogenosis Type 2Using SIN-Lentiviral Vectors

Richard Emmanuel, Benhassine Safa, Douillard Gaelle, Batista Lionel and Caillaud Catherine

Mol Ther 13: S350-S351; doi:10.1016/j.ymthe.2006.08.1000

911. C-Terminal Truncated Microdystrophin Recruits Dystrobrevin and Syntrophin to the Dystrophin-Associated Glycoprotein Complex and Reduces Muscular Dystrophy in Symptomatic Utrophin/Dystrophin Double Knock-Out Mice

Yongping Yue, Mingju Liu and Dongsheng Duan

Mol Ther 13: S351-S351; doi:10.1016/j.ymthe.2006.08.1001

912. Accelerated Chondrogenesis in Nanofiber Scaffolds Containing BMP-2 Genetically Engineered Chondrocytes

Robert T. Gorsline, Jin Nam, Prasarn Tangkawattana, John Lannutti and Alicia L. Bertone

Mol Ther 13: S351-S352; doi:10.1016/j.ymthe.2006.08.1002

913. Histone Deacetylase Inhibitors Improve Gene Transfer To Mature Skeletal Muscle

Nancy Larochelle, Jatinderpal R. Deol, Paul Holland, George Karpati and Josephine Nalbantoglu

Mol Ther 13: S352-S352; doi:10.1016/j.ymthe.2006.08.1003

914. Recombinant AAV Gene Delivery of Follistatin for Muscle Enhancement in Models of Muscular Dystrophy

Liza Rizo, Chris Shilling, Amanda Haidet, Priya Umapathi Umapathi, Zarife Sahenk, Jerry R. Mendell and Brian K. Kaspar

Mol Ther 13: S352-S352; doi:10.1016/j.ymthe.2006.08.1004

915. High and Low Affinity Consensus Binding Sequences to Extracellular |[alpha]|7 Integrin X2B Subunit Detected Using Phage Display Biopanning

Daniel P. Reay, Pattarana Sae-chew and Paula R. Clemens

Mol Ther 13: S352-S353; doi:10.1016/j.ymthe.2006.08.1005

916. Genetically Modified Mesenchymal Stem Cells Expressing Transforming Growth Factor-|[beta]|1 Develop a Cartilage Phenotype

Alan J. Nixon, Christina W. Cheng, Lisa Strassheim and Paul D. Robbins

Mol Ther 13: S353-S353; doi:10.1016/j.ymthe.2006.08.1006

917. GM-CSF Gene Transfer to Acute Limb Ischemic Mouse for Limb Recuperation

Mariana Grings, Chester B. Sacramento, Jos|[eacute]| C. Baptista-Silva, Christina M. Takiya, Abram Beutel, Cassia T. Bergamaschi, Ruy R. Campos, Jane Z. Moraes and Sang W. Han

Mol Ther 13: S353-S354; doi:10.1016/j.ymthe.2006.08.1007

918. Rescue of Dystrophin in the GRMD Dog by Multi-Exon Skipping Using Engineered U7 snRNAs

Adeline Vulin, Aurelie Goyenvalle, Ines Barthelemy, France Leturcq, Jean-Claude Kaplan, Olivier Danos, Stephane Blot and Luis Garcia

Mol Ther 13: S354-S354; doi:10.1016/j.ymthe.2006.08.1008

919. Gene Therapy for Duchenne Muscular Dystrophy Using a Gutted Adenovirus Expressing Utrophin

Jatinderpal R. Deol, Renald Gilbert, Gawiyou Danialou, Mylene Bourget, Joon-Shik Moon, Basil J. Petrof, Josephine Nalbantoglu and George Karpati

Mol Ther 13: S354-S355; doi:10.1016/j.ymthe.2006.08.1009

920. Bone Regeneration with Xenogeneic BMP-2 Producing Fibroblasts

Moon Jong Noh, Chae-Lyul Lim, Jong-pil Hyun, Hyeon-youl Lee, Kyoung Baek Choi, Youngsuk Yi and Kwan Hee Lee

Mol Ther 13: S355-S355; doi:10.1016/j.ymthe.2006.08.1010

921. In Vivo Non Viral Gene Delivery of BMP-9 Regenerates Non Union Bone Defect

Nadav Kimelman, Gadi Pelled, Yoram Zilberman, Evellin Zeira, Hagit Yotvat, Eitan Galun, Jinzhong Li, Gregory A. Helm and Dan Gazit

Mol Ther 13: S355-S356; doi:10.1016/j.ymthe.2006.08.1011

922. Improvement of Anti-Tumor Activity by Gene Amplification with a Replicative, Non-Disseminative Adenovirus

Cara J. Lau, Denis Bourbeau, Jairo Jaime, Josephine Nalbantoglu and Bernard Massie

Mol Ther 13: S356-S357; doi:10.1016/j.ymthe.2006.08.1013

923. Combining In Situ Gene Therapy with Radiotherapy and Hormonal Therapy in the Treatment of Stage D1 Prostate Cancer

Tetsuo Fujita, Bin S. Teh, Terry L. Timme, Gustavo Ayala, Wei-Yuan Mai, Takefumi Satoh, Nobuyuki Kusaka, Koji Naruishi, Ken-ichi Tabata, Estuardo Aguilar-Cordova, Thomas Wheeler, E. Brian Butler and Timothy C. Thompson

Mol Ther 13: S356-S357; doi:10.1016/j.ymthe.2006.08.1014

924. D-MAPP Analogue, LCL-204 Sensitizes DU145 Prostate Cancer Cells (PCa) to FasL Gene Therapy through Down-Regulation of Survivin

Ahmed M. El-Zawahry, Xiang Liu, Saeed ElOjeimy, David Holma, Ayman Elmahdy, Nabil K. Bissada, Hashim M. Rashwan, Zdzislaw Szulc, Alicjia Bielwaska, Jasek Bielwaski, Thomas Keane, Yusuf Hannun and James Norris

Mol Ther 13: S357-S357; doi:10.1016/j.ymthe.2006.08.1015

925. Novel Fusion Enzymes of Herpes Simplex Virus Thymidine Kinase Mutants and Guanylate Kinase for Improved Cancer Cell Ablation

Andressa Ardiani, Candice Willmon, Elizabeth Krabbenhoft and Margaret E. Black

Mol Ther 13: S357-S357; doi:10.1016/j.ymthe.2006.08.1016

926. The Combination of P19ARF-HIV Tat Cytotoxic Gene Expression with AAT-1 PDX Increases Cell Killing of Brain Tumor Cells

Wouter J. Driessen and Sean M. Sullivan

Mol Ther 13: S357-S358; doi:10.1016/j.ymthe.2006.08.1017

927. Development of Non-Viral Gene Therapy Targeting Insulin-Like Growth Factor (IGF) System for Treatment of Brain Tumors

Leah R. Villegas, Sean Sullivan and Maria Grant

Mol Ther 13: S358-S358; doi:10.1016/j.ymthe.2006.08.1018

928. Reversal of PPC1 Prostate Cancer Cells Radioresistance by Degradation of Acid Ceramidase Using the Lysosomotropic Drug LCL385

Ayman E.M. Mahdy, Xiang Liu, Saeed N. ELojeimy, Alicja Bielaswka, Yusuf A. Hannun, Thomas E. Keanne, Ahmed M. El-Zawahry and James S. Norris

Mol Ther 13: S358-S359; doi:10.1016/j.ymthe.2006.08.1019

929. Functional Potential of Human T Cells Following Lentiviral Suicide Gene Transduction

Taylor Mackey, Joanne Buddle, Christine Kinnon, Adrian Thrasher, Hubert Gaspar and Waseem Qasim

Mol Ther 13: S359-S359; doi:10.1016/j.ymthe.2006.08.1020

930. Engineering Human Deoxycytidine Kinase for Improved Prodrug Sensitivity for Cancer Gene Therapy

Candice L. Willmon and Margaret E. Black

Mol Ther 13: S359-S359; doi:10.1016/j.ymthe.2006.08.1021

931. Inhibition of VEGF Signaling Pathway and Tumor Metastasis

Yi Lu and Jun Zhang

Mol Ther 13: S359-S360; doi:10.1016/j.ymthe.2006.08.1022

932. Combined Treatment with Tarceva, an EGFR Inhibitor with Ad-mda7 Synergizes To Promote Anti-Tumor Activity Against Human Cancer Cells

Rajagopal Ramesh, Satoshi Inoue and Sunil Chada

Mol Ther 13: S360-S360; doi:10.1016/j.ymthe.2006.08.1023

933. Adenovirus-Mediated Delivery of Secretable Trimeric TRAIL Enhances Apoptosis and Improves Survival Compared with Conventional Chemotherapy for Malignant Gliomas

Moonsup Jeong, In-Ho Kwon, Yong-Sam Kwon, Min-Tae Park, Chae-Young Kim, Sue-Hyung Kang, Kang-Won Song, Yong Ko, Dai-Wu Seol, Paul D. Robbins and Byong-Moon Kim

Mol Ther 13: S360-S360; doi:10.1016/j.ymthe.2006.08.1024

934. Gene Therapy for Colon Cancer by Adeno-Associated Viral Vector-Mediated Transfer of Apolipoprotein(a) Kringles

Kyuhyun Lee, Seong-Tae Yun, Hong-Kyu Lee and Eui-Cheol Jo

Mol Ther 13: S361-S361; doi:10.1016/j.ymthe.2006.08.1025

935. Anti-PI3K/Akt Cell Survival Pathway Gene Therapy Supplemented with Plant Sterol Diet for Prostate Cancer Treatment

Jun Zhang and Yi Lu

Mol Ther 13: S361-S361; doi:10.1016/j.ymthe.2006.08.1026

936. Novel Oncolytic HSV-1 Mutant Expressing ICP 34.5 under the Transcriptional Control of Musashi1 Promoter for the Treatment of Gliomas

Takahito Yazaki, Ryuichi Kanai, Hideyuki Okano and Takeshi Kawase

Mol Ther 13: S361-S361; doi:10.1016/j.ymthe.2006.08.1027

937. Radioprotection of Normal Tissue Cells by Transfer of the Human Superoxide-Dismutase Gene

Marlon R. Veldwijk, Carsten Herskind, Stephanie Laufs, W. Jens Zeller, Stefan Fruehauf and Frederik Wenz

Mol Ther 13: S362-S362; doi:10.1016/j.ymthe.2006.08.1028

938. Ceramide May Have a Role in Sensitizing ACHN Renal Cancer Cells (RCC) to Fas Induced Apoptosis

Ahmed M. El-Zawahry, David Holman, Xiang Liu, Saeed ElOjeimy, Sunil Sudarshan, Nabil K. Bissada, Hashim Rashwan, Zdzislaw Szulc, Alicjia Bielwaska, Thomas Keane, Yusuf Hannun and James Norris

Mol Ther 13: S362-S362; doi:10.1016/j.ymthe.2006.08.1029

939. Adenovirus-Mediated TA-p73|[beta]| Gene Transfer Leads to Chemosensitization of Human Malignant Melanoma

Sebastian Tuve, Tomas Racek, Annett Niemetz, Julia Schultz, Maria S. Soengas and Brigitte M. P|[uuml]|tzer

Mol Ther 13: S362-S362; doi:10.1016/j.ymthe.2006.08.1030

940. Chemotherapeutic Agent DFMO as an Intensifier of Suicide Gene Therapy

Tiina Wahlfors, Tanja Hakkarainen, Juhani J|[auml]|nne, Leena Alhonen and Jarmo Wahlfors

Mol Ther 13: S363-S363; doi:10.1016/j.ymthe.2006.08.1031

941. Manganese Superoxide Dismutase-Plasmid Liposome (MnSOD-PL) Transgenic Effects on Irradiation-Induced Reactive Oxygen Species (ROS) in Normal Tissue Also Destabilize Antioxidant Pools in Orthotopic Oral Cavity Tumors

Michael W. Epperly, Suhua Nie, Anthony J. Kanai and Joel S. Greenberger

Mol Ther 13: S363-S363; doi:10.1016/j.ymthe.2006.08.1032

942. Adenoviral Mediated Re-Expression of Wnt Antagonist Dkk-1 Induces Apoptosis and Suppresses Tumor Growth in Medulloblastoma

Rajeev Vibhakar, Beverly L. Davidson and Anup Madan

Mol Ther 13: S363-S363; doi:10.1016/j.ymthe.2006.08.1033

943. Prognostic Determinants Associated with Efficacy of Adenoviral p53 Gene Therapy in Patients with Recurrent Squamous Cell Carcinoma of the Head and Neck

John Nemunaitis, Carol Bier-Laning, Gary L. Clayman, David Van Echo, L. Guertin, J. Hamm, Robert Dreicer, George H. Yoo, H. Minn, M. Bekradda, W. Sutherland, Kerstin B. Menander, Robert E. Sobol and Jerry Goodwin

Mol Ther 13: S364-S364; doi:10.1016/j.ymthe.2006.08.1034

944. Inhibiting Survivin Expression Enhances Trail-Induced Apoptosis in Human Hepatocellular Carcinoma

Song-Qing He, Ming-Guang Gong, Zhi-Yong Huang, Chang-Hai Li, Wan-Guang Zhang, Jian Wu and Xiao-Ping Chen

Mol Ther 13: S364-S365; doi:10.1016/j.ymthe.2006.08.1035

945. Combination Treatment of Adenovirus Mediated HSV-Thymidine Kinase Suicide Gene Therapy and Docetaxel in Bladder Cancer

Hideyuki Yamashita, Weiguo Jian, April Gillbert and Seth P. Lerner

Mol Ther 13: S365-S365; doi:10.1016/j.ymthe.2006.08.1036

946. Effect of Androgen Receptor Suppression Using Dominant Negative Inhibition on Castration-Resistant Prostate Cancer

Brian J. Zeithaml, Mark Titus, Karin Haack, Adam Cockrell, Angela Ponguta, Elizabeth Wilson, James Mohler and Tal Kafri

Mol Ther 13: S365-S365; doi:10.1016/j.ymthe.2006.08.1037

947. Gene Directed Enzyme/Prodrug Therapy of Human Glioma Xenografts Using Mutant Escherichia coli Cytosine Deaminase

Sergey A. Kaliberov, Valentina Krendelchtchikova, Debbie Della Manna, Jeffrey C. Sellers, Lyudmila N. Kaliberova, Margaret E. Black and Donald J. Buchsbaum

Mol Ther 13: S365-S366; doi:10.1016/j.ymthe.2006.08.1038

948. Rapid Production of Specific Artificial Meganucleases for Gene Correction in Patients with Inherited Disease

Philippe Duchateau, Patrick Chames, Jean-Charles Epinat, Arnould Sylvain, Julie Smith, Agnes Gouble, Christophe Perez, Sylvestre Grizot and Frederic Paques

Mol Ther 13: S366-S366; doi:10.1016/j.ymthe.2006.08.1040

949. Oncolytic Autonomous Parvovirus (rH1-yCD) Targeting with P4/Carcinoembryonic Antigen Chimeric Promoter for Virotherapy of Pancreatic Cancer

Soukaina Rejiba, Marc Aprahamian and Amor Hajri

Mol Ther 13: S366-S366; doi:10.1016/j.ymthe.2006.08.1041

950. |[beta]|hCG Expressing CRAd for Prostate Cancer

Maria Rajecki, Lotta Kangasniemi, Mikko Tenhunen, Anna Kanerva, Renee A. Desmond, Ulf-Hakan Stenman, Martti Y. Ala-Opas and Akseli Hemminki

Mol Ther 13: S366-S367; doi:10.1016/j.ymthe.2006.08.1042

951. A New Vector Based on Baculovirus Was Effective in Inhibiting Glioma Cell Growth in the Rat Brain

Chaoyang Wang and Shu Wang

Mol Ther 13: S367-S367; doi:10.1016/j.ymthe.2006.08.1043

952. Human Mesenchymal Stem Cells Migrate to Colon Cancer Xenografts: Potential Carriers of Cancer Therapeutics

Steven P. Zielske and Theodore S. Lawrence

Mol Ther 13: S367-S367; doi:10.1016/j.ymthe.2006.08.1044

953. Therapeutic Ultrasound Mediated Anti- Angiogenic Gene Delivery Results with Prostate Tumors Inhibition

Maayan Duvshani-Eshet and Marcelle Machluf

Mol Ther 13: S367-S368; doi:10.1016/j.ymthe.2006.08.1045

954. High Intensity Focused Ultrasound (HIFU) Induced Trans-Gene Activation in Solid Tumors

Yunbo Liu, Zhenlin Hu, Xiaochun Lu, Takashi Kon, Chuanyuan Li and Pei Zhong

Mol Ther 13: S368-S368; doi:10.1016/j.ymthe.2006.08.1046

955. Transduction Efficiency Screening for 7 Different AAV Serotypes in 12 Human Cancer Cell Lines and 2 Xenograft Animal Models

Keerang Park, Youn-Ju Kim, Dong Kyu Kim, Young-Hwa Cho, Jong-Koo Kang, Seock-Yeon Hwang, Hee-Jong Kim, Jin-Hyun Lee, Sung-Ha Cho, So-Yong Yi, Sun-Kyoung Kim and Eun-Jung Park

Mol Ther 13: S368-S368; doi:10.1016/j.ymthe.2006.08.1047

956. Imaging of Radiation-Inducible Promoters Using a Naturally Secreted Luciferase from the Marine Copepod Gaussia princeps

Christian E. Badr, Pierre Zalloua, Xandra O. Breakefield and Bakhos A. Tannous

Mol Ther 13: S369-S369; doi:10.1016/j.ymthe.2006.08.1048

957. Effect of Ligand Binding Affinity and Receptor Density in Relation to Biology of Retargeted Viruses

Kosei Hasegawa, Takafumi Nakamura, James D. Marks, Stephen J. Russell and Kah-Whye Peng

Mol Ther 13: S369-S369; doi:10.1016/j.ymthe.2006.08.1049

958. Sleeping Beauty-Mediated Gene Therapy for Colorectal Cancer

Lalitha R. Belur, Tavanna Buske, Brent Sorensen, Kelly Podetz-Peterson, Daniel Saltzman, Perry B. Hackett and R. Scott McIvor

Mol Ther 13: S369-S369; doi:10.1016/j.ymthe.2006.08.1050

959. Tumor Therapy Via Vector-Regulated Expression of Mutant Sodium Channel

Bakhos A. Tannous, Katherine F. Perry, Miguel Sena-Esteves, Jaime Garcias-Anoveros, Andreas Jacobs, David P. Corey, Ralph Weissleder and Xandra O. Breakefield

Mol Ther 13: S370-S370; doi:10.1016/j.ymthe.2006.08.1051

960. Forced Expression of the Heat Shock Protein H11 Causes Growth Arrest and Apoptosis of Melanoma Cells through TAK1 Activation and Inhibits Tumor Growth in Xenograft Models

Baiquan Li, Cynthia C. Smith, Jennifer M. Laing and Laure Aurelian

Mol Ther 13: S370-S370; doi:10.1016/j.ymthe.2006.08.1052

961. Angiopoietin-1 Enhances the Effect of Paclitaxel on Breast Cancer Cell Killing in a Mouse Model

YaoQi Huang, Harald Sauthoff, Jin Cheng, David Kutler, Sheila Heitner, William N. Rom and John G. Hay

Mol Ther 13: S370-S370; doi:10.1016/j.ymthe.2006.08.1053

962. The Ras/Raf-1/MEK/ERK Signaling Pathway Dictates Host Cell Permissiveness to VSV Infection

Josh A. Noser, Ryuta Sakuma, Patrick W.K. Lee and Yasuhiro Ikeda

Mol Ther 13: S371-S371; doi:10.1016/j.ymthe.2006.08.1054

963. MITF as a Potential Molecular Target for Gene Therapy for Human Melanoma; a Synergistic Inhibitory Effect of Inactivation of Both MITF and BRAFV600E on Melanoma Growth

Kenji Kido, Hidetoshi Sumimoto, Sakiyo Asada, Starlyn Okada, Toshiaki Saida and Yutaka Kawakami

Mol Ther 13: S371-S371; doi:10.1016/j.ymthe.2006.08.1055

964. Combinatorial Process for Engineering Specific Meganucleases with Tailored Specificities toward a Natural Target in the XPC Gene

Christophe Perez, Sylvain Arnould, Julie Smith, Sylvestre Grizot, Agnes Gouble, Philippe Duchateau and Frederic Paques

Mol Ther 13: S371-S371; doi:10.1016/j.ymthe.2006.08.1056

965. Lymphatic and Systemic Metastasis of Prostate Cancer Induced by VEGF-C

Jeremy B. Burton, Ebba Brakenhielm, Saul J. Priceman, Nelson Chavarria, Kari Alitalo and Lily Wu

Mol Ther 13: S372-S372; doi:10.1016/j.ymthe.2006.08.1057

966. Withdrawn

Mol Ther 13: S372-S372; doi:10.1016/j.ymthe.2006.08.011

967. Targeted Delivery of Antisense Oligonucleotides to Human T-Leukemia Cells Mediated by Novel Liposomal Formulations: Evaluation of In Vitro and In Vivo Anti-Tumoral Activity

Cristina Fonseca, Liliana Mendon|[ccedil]|a, Jo|[atilde]|o Nuno Moreira, Ant|[oacute]|nio Cabrita, Artur Paiva, Maria Teresa Lopes, Maria C. Pedroso de lima and S|[eacute]|rgio Sim|[otilde]|es

Mol Ther 13: S372-S372; doi:10.1016/j.ymthe.2006.08.1059

968. Next Generation Measles Virus Vectors for Oncolytic Therapy: Targeted, Armed and Stealth

Guy Ungerechts, Christoph Springfeld, Adele Fielding and Roberto Cattaneo

Mol Ther 13: S373-S373; doi:10.1016/j.ymthe.2006.08.1060

969. Bone Marrow Derived Endothelial Progenitor Cells Engineered by Lentiviral Vectors as Therapeutic Antitumoral Strategy

Veronica Fernandez, Milosz Kawa, Guanhua Yang, Jesus Prieto and Cheng Qian

Mol Ther 13: S373-S373; doi:10.1016/j.ymthe.2006.08.1061

970. Transcriptional Activation of krox-1 Induced by Sexual Hormones in Osteosarcoma Cells

Francisco Martinez-F, Fausto A. Jimenez-O, Catalina Machuca-R, Hilda Villegas-C and Kathleen Sakamoto

Mol Ther 13: S373-S374; doi:10.1016/j.ymthe.2006.08.1062

971. Novel Ribozyme-Based Strategy for Cancer Chemoprevention

Suparna Mukhopadhyay, Wolfgang Zacharias and William G. McGregor

Mol Ther 13: S374-S374; doi:10.1016/j.ymthe.2006.08.1063

972. Inhibition of TGF-|[beta]| by RNA Interference To Modulate Breast Cancer Metastasis

Lakisha D. Moore and Selvarangan Pponnazhagan

Mol Ther 13: S374-S374; doi:10.1016/j.ymthe.2006.08.1064

973. SEquence-Enabled Reassembly of |[beta]|-Lactamase (SEER-LAC): A Sensitive Method for the Detection of Double-Stranded DNA

Aik T. Ooi, Cliff I. Stains, Indraneel Ghosh and David J. Segal

Mol Ther 13: S374-S374; doi:10.1016/j.ymthe.2006.08.1065

974. Constitutive Expression of a Mutated Form of CTLA4Ig after Gene Transfer Is Well Tolerated and Prevents Immune Responses Against an Immunogenic Transgene in Nonhuman Primates

Alice Toromanoff, Marcelo Hill, Yan Cherel, Jack-Yves Deschamps, Olivier Gauthier, Bernard Vanhove, Fabienne Rolling, Philippe Moullier, Ignacio Anegon and Caroline Le Guiner

Mol Ther 13: S375-S375; doi:10.1016/j.ymthe.2006.08.1067

975. TLR9 Activation Is Involved in the Immune Response to Helper Dependent Adenoviral Vectors

Vincenzo Cerullo, Michael P. Seiler, Nicola Brunetti-Pierri, Viraje Mane, Christopher Clarcke and Brendan Lee

Mol Ther 13: S375-S375; doi:10.1016/j.ymthe.2006.08.1068

976. TLR and MyD88 Signaling Mediates Innate Immune Responses to Adenoviral Vectors in Mouse

Zhe Zhang, Gaung-Ping Gao, Lee M. Wetzler, Peter L. Bell, Di Wu, Jianping Lin, and James M. Wilson

Mol Ther 13: S375-S376; doi:10.1016/j.ymthe.2006.08.1069

977. Differential Host T Cell Response to the Capsid of AAV2 and 8 in Muscle-Directed Gene Transfer in Murine and Non-Human Primate Models

Lili Wang, Roberto Calcedo, Rebecca Grant, Joanita M. Figueredo and James M. Wilson

Mol Ther 13: S376-S376; doi:10.1016/j.ymthe.2006.08.1070

978. Reduced Immune Response to Adenovirus Vector Formulated with the Anti-Inflammatory Liposome DS/DOPE

Amber Price, Maria Limberis, James M. Wilson and Scott L. Diamond

Mol Ther 13: S376-S376; doi:10.1016/j.ymthe.2006.08.1071

979. Clonal Expansion of a CD8+ T Cell Clone after Retroviral Transduction of Mature T Lymphocytes with the IL-15 Gene

Cary Hsu, Steven A. Rosenberg and Richard A. Morgan

Mol Ther 13: S376-S377; doi:10.1016/j.ymthe.2006.08.1072

980. In Vivo, High Throughput Analysis Expands the Known Anti-Ad Innate Immune Response Profile, and Implicates TLR Pathways in Ad Cellular Immune Response

Zachary Hartman, Anne Kiang and Andrea Amalfitano

Mol Ther 13: S377-S377; doi:10.1016/j.ymthe.2006.08.1073

981. Prevention of Transgene Expression in Antigen Presenting Cells Correlate with Modulated Immune Response after In Vivo Gene Transfer

Andrea Annoni, Brian Brown, Manuela Battaglia, Angelo Lombardo, Luigi Naldini and Maria Grazia Roncarolo

Mol Ther 13: S377-S378; doi:10.1016/j.ymthe.2006.08.1074

982. Adaptive Immune System Down-Regulates Transgene Expression from Adenovirally Infected Neurons in the Brain In Vivo

Jeffrey M. Zirger, Carlos Barcia, Josee Bergeron, Chunyan Lui, Maria G. Castro and Pedro R. Lowenstein

Mol Ther 13: S378-S378; doi:10.1016/j.ymthe.2006.08.1075

983. Repeat Intra-Articular Administration of AAV2 Vectors to Rat Joints

Haim Burstein, Kurt Lustig and Ziv Sandalon

Mol Ther 13: S378-S378; doi:10.1016/j.ymthe.2006.08.1076

984. Liver Restricted Expression of Canine Iduronidase Does Not Prevent a CTL Response in Adult MPS I Mice after Retroviral Vector-Mediated Gene Therapy, but Transient Immunomodulation with CTLA4-Ig Combined with Anti-CD4 or Anti-CD40 Ligand Does

Xiucui Ma, Ramin Herati, Yuli Liu, Anne K. Hennig, Attila Kovacs and Katherine P. Ponder

Mol Ther 13: S378-S379; doi:10.1016/j.ymthe.2006.08.1077

985. Efficient Induction of Tolerance To FIX by Direct Intramuscular Delivery of AAV1

Ellen F. Cohn, Jiacai Zhuo, Meagan Kelly, Jiayin Zhang and Hengjun Chao

Mol Ther 13: S379-S379; doi:10.1016/j.ymthe.2006.08.1078

986. Targeting Transgene Expression to Suprabasal Layers of Epidermis as a Strategy To Evade Immune Responses

Assefa Wondimu, Zhenmei Lu and Soosan Ghazizadeh

Mol Ther 13: S379-S379; doi:10.1016/j.ymthe.2006.08.1079

Top

Abstracts

987. A Cautionary Tale for Immunotherapy Using Genetically Modified Dendritic Cells; Implications for the Future Design of Vaccines

Peng H. Tan and GeorgeJ.T. George

Mol Ther 13: S380-S380; doi:10.1016/j.ymthe.2006.08.1080

988. Repeat Administration of Lentiviral Vector to Mouse Nasal Epithelia

Patrick L. Sinn and Paul B. McCray Jr.

Mol Ther 13: S380-S380; doi:10.1016/j.ymthe.2006.08.1081

989. Induction of Antitumor Immunity by Cell-Penetrating Peptide-Coupled Hsp70 Gene Transfer to Tumor Cells

Takayuki Otsuki, Makiya Nishikawa, Atsushi Ota, Seiji Takemoto and Yoshinobu Takakura

Mol Ther 13: S380-S381; doi:10.1016/j.ymthe.2006.08.1082

990. In Vivo Analysis of Adenovirus Specific Cytotoxic T Lymphocyte Response in CD28, PD-1, Fas Ligand or Perforin Deficient Mice

Jian Chen, Qi Wu, Allan J. Zajac, PingAr Yang, Xin Xu, Hui-Chen Hsu, David T. Curiel and John D. Mountz

Mol Ther 13: S381-S381; doi:10.1016/j.ymthe.2006.08.1083

991. Suppression of Established Collagen Induced Arthritis and Delayed Type Hypersensitivity by Immunosuppressive Dendritic Cell-Derived Exosomes

Seon-Hee Kim, Nicole R. Bianco, William J. Shufesky, Adrian E. Morelli and Paul D. Robbins

Mol Ther 13: S381-S382; doi:10.1016/j.ymthe.2006.08.1084

992. Induction of Immune Tolerance to Transgene Products by Mixed Chimerism with Low Dose Irradiation

Satoru Otsuru, Katsuto Tamai, Takehiko Yamazaki, Takenao Chino, Hideki Yoshikawa and Yasufumi Kaneda

Mol Ther 13: S382-S382; doi:10.1016/j.ymthe.2006.08.1085

993. Optical Bioluminescence and Immunologic Analyses of Lentiviral Vectors Administered In Vivo: Transcriptional Targeting through an MHCII Promoter Yields Persistent Transgene Expression and Lack of CTL Stimulation in Immunocompetent Mice Indicating Tolerance

Takahiro Kimura, Wang Hejing, Richard Koya, Emmanuelle Faure-Kumar, Robert Prins, Begonya Comin-Anduix, Yan Cui, Noriyuki Kasahara and Renata Stripecke

Mol Ther 13: S382-S382; doi:10.1016/j.ymthe.2006.08.1086

994. Effect of Vectors on Human Endothelial Cell Signal Transduction: Implications for Cardiovascular Gene Therapy

Peng H. Tan and George J.T. George

Mol Ther 13: S383-S383; doi:10.1016/j.ymthe.2006.08.1087

995. Effect of Viral Dose on Neutralizing Antibody Response and Transgene Expression after AAV1 Vector Re-Administration in Mice

Harald Petry, Ann Orme, Perry Liu, Maxine Bauzone, Heather Gibson, HuShen Qian, Gabor M. Rubanyi and Richard N. Harkins

Mol Ther 13: S383-S383; doi:10.1016/j.ymthe.2006.08.1088

996. Direct Comparison of Adeno-Associated Virus (AAV) Serotypes for Muscle Expression of Soluble Anti-Angiogenic Proteins

Mayu Isotani, Koichi Miyake, Noriko Miyake, Yukihiko Hirai and Takashi Shimada

Mol Ther 13: S384-S384; doi:10.1016/j.ymthe.2006.08.1089

997. Immune-Mediated Loss of Transgene Expression in Mouse Liver Following Transposon Delivery

Elena L. Aronnovich, Jason B. Bell, Roland Gunther, Brenda Koniar, Aric Frantz, Ilze Matise, R. Scott McIvor, Chester B. Whitley and Perry B. Hackett

Mol Ther 13: S384-S384; doi:10.1016/j.ymthe.2006.08.1090

998. A Comparative Analysis of Transgene-Specific Immune Responses Following In Vivo and Ex Vivo Approaches to Gene Therapy

Zhenmei Lu and Soosan Ghazizadeh

Mol Ther 13: S384-S385; doi:10.1016/j.ymthe.2006.08.1091

999. Mature Effector Immunological Synapses Forming SMAC Mediate Clearance of Virally Infected Astrocytes from the Brain In Vivo

Carlos Barcia, Clare Thomas, James F. Curtin, Gwendalyn D. King, Kolja Wawrowsky, Marianela Candolfi, Wei-Dong Xiong, Liu Chunyan, Kurt Kroeger, Olivier Boyer, Jerzy Kupiec-Weglinski, David Klatzmann, Maria G. Castro and Pedro R. Lowenstein

Mol Ther 13: S385-S385; doi:10.1016/j.ymthe.2006.08.1092

1000. Down-Regulating the Epithelial Glycoprotein-2 Promoter Utilizing Engineered Zinc Finger Protein Transcription Factors

Willemijn M. Gommans, Pamela M.J. McLaughlin, Robbert Cool, Beatrice I. Lindhout, Bert van der Zaal, Hidde J. Haisma and Marianne G. Rots

Mol Ther 13: S385-S385; doi:10.1016/j.ymthe.2006.08.1094

1001. Metabolic Biotinylation of Cell Surface Receptors for In Vivo Imaging

Bakhos A. Tannous, Jan Grimm, Katherine F. Perry, John W. Chen, Weissleder Ralph and Breakefield O. Xandra

Mol Ther 13: S386-S386; doi:10.1016/j.ymthe.2006.08.1095

1002. L1 Cell Adhesion Molecule, a Novel Target of Prostate Cancer Gene Therapy

Kristen Bisanz, Jie Yu, Ira Rajbhandari, Bill Spohn, Mien-Chie Hung, Leland W.K. Chung and Chia-Ling Hsieh

Mol Ther 13: S386-S386; doi:10.1016/j.ymthe.2006.08.1096

1003. Targeted Site-Specific Integration in Human Cells Using Designed Zinc Finger Nucleases

Fyodor D. Urnov, Angelo Lombardo, Jeremy Rock, Erica Moehle, Jeffrey C. Miller, Ya-Li Lee, Philip D. Gregory, Luigi Naldini and Michael C. Holmes

Mol Ther 13: S386-S387; doi:10.1016/j.ymthe.2006.08.1097

1004. c-Jun NH2-Terminal Kinase (JNK)1 and JNK2 Have Distinct Roles in Adenovirus-Mediated Transgene Expression

Fuminori Teraishi, Bingliang Fang, Annin Liu, Futoshi Uno, Shunsuke Kagawa, Toshiyoshi Fujiwara and Noriaki Tanaka

Mol Ther 13: S387-S387; doi:10.1016/j.ymthe.2006.08.1098

1005. Expression of Porcine |[alpha]|(1-3)galactosyltransferase in Non-Human Primate Hematopoietic Progenitors Following Simian Immunodeficiency Virus Mediated Gene Transfer

Lorenzo Benatuil and John Iacomini

Mol Ther 13: S387-S387; doi:10.1016/j.ymthe.2006.08.1099

1006. Effect on Expression of Including Binding Sites for the ELAV-Like Proteins HuD and HuR in Transgene Cassettes

Changyu Zheng and Bruce J. Baum

Mol Ther 13: S387-S388; doi:10.1016/j.ymthe.2006.08.1100

1007. Development of Nuclear Targeting System of Plasmid DNA; Impact of Sugar Display on the Surface of Lipid Envelope

Tomoya Masuda, Hidetaka Akita, Takashi Nishio, Kenichi Niikura, Asako Kudo, Kentaro Kogure, Akitada Iwasa, Kuniharu Ijiro and Hideyoshi Harashima

Mol Ther 13: S388-S388; doi:10.1016/j.ymthe.2006.08.1101

1008. Characterization of Peripheral Regulatory T Cell Phenotype Generated in Molecular Chimeras by Gene Therapy

Jesus R. Paez-Cortez, Chaorui Tian and John Iacomini

Mol Ther 13: S388-S389; doi:10.1016/j.ymthe.2006.08.1102

1009. High Expression of Foxp3 mRNA in Rat Dendritic Cells (DCs) Generated from a Long-Term Culture of Bone Marrow Cells (BMC)

Naoko Fuji (Funeshima), Atsushi Tsuji, Li Xaio-Kang and Hiromitsu Kimura

Mol Ther 13: S389-S389; doi:10.1016/j.ymthe.2006.08.1103

1010. Developing a Potential Pain Therapy Using Engineered Zinc Finger Protein Repressors of the Sodium Channel PN3

Siyuan Tan, Mohammad M. Doroudchi, Xiaohong Zhong, Julie Qiao, Steve Zhang and Philip D. Gregory

Mol Ther 13: S389-S389; doi:10.1016/j.ymthe.2006.08.1104

1011. Growth Factor Receptors as Regulators of Hematopoiesis

Michael A. Weinreich, Ingrid Lintmaer, Linlin Wang, H. Denny Liggitt, Michael A. Harkey and C. Anthony Blau

Mol Ther 13: S389-S389; doi:10.1016/j.ymthe.2006.08.1105

1012. Immortalization of Murine Hematopoietic Stem and Progenitor Cells by AML1-ETO and HoxB4

Michaela Scherr, Gernot Beutel, Karin Battmer, Letizia Venturini, Daniel Schaefer, Arnold Ganser and Matthias Eder

Mol Ther 13: S389-S390; doi:10.1016/j.ymthe.2006.08.1106

1013. Comparison of VP22 Intercellular Spreading in Live Versus Fixed Cells

Ulrich M. Lauer, Marie-Luise Lemken, Wolfgang A. Wybranietz and Michael Bitzer

Mol Ther 13: S390-S390; doi:10.1016/j.ymthe.2006.08.1107

1014. Regulation of Extracellular Matrix Gene Expression in Renal Mesangial Cells by Transcription Factors Sp1 and CREB

Davis W. Cheng and Lalit P. Singh

Mol Ther 13: S390-S390; doi:10.1016/j.ymthe.2006.08.1108

1015. Assessment of Zinc Finger-FOKI Chimeric Endonuclease Activity Using a Single Strand Annealing Assay in Mammalian Cells

Vincent Brondani and David J. Segal

Mol Ther 13: S390-S391; doi:10.1016/j.ymthe.2006.08.1109

1016. Modulation of Transgene Expression: DNA Methylation Is, at Best, Only Partly Responsible

Marlene S. Strayer, Gongyi Ren, Martyn K. White, Dawn Maier and David S. Strayer

Mol Ther 13: S391-S391; doi:10.1016/j.ymthe.2006.08.1110

1017. Genetic Predisposition of the Sensitivity of Prostate Cancer to Radiatherapy

Lilach Agemy, Zelig Eshhar, Itai Kela, Eytan Domany, Avi Orr-Urtreger, Anat Bar-Shira and M. Raphael Pfeffer

Mol Ther 13: S391-S391; doi:10.1016/j.ymthe.2006.08.1111

1018. Stem Cell Gene Therapy: Toward a Universal Platform Relying on Custom Endonuclease-Boosted Gene Targeting, Cybridization, Transient Regenerative/Epigenetic Gene Therapy and Synergistic Combinations

Roger Bertolotti

Mol Ther 13: S392-S392; doi:10.1016/j.ymthe.2006.08.1112

1019. Development of Tissue-Specific RNAi for Gene Therapy

Danny Allen, Paul F. Kenna, Arpad Palfi, Helena McMahon, Sophia Millington-Ward, Mary O'Reilly, Peter Humphries and G. Jane Farrar

Mol Ther 13: S392-S392; doi:10.1016/j.ymthe.2006.08.1114

1020. AAV Delivery of Suppression and Replacement Constructs for Rhodopsin-Linked Autosomal Dominant Retinitis Pigmentosa

Naomi Chadderton, Arpad Palfi, Mary O'Reilly, Sophia Millington-Ward, Marius Ader, Markus Hildinger, Alberto Auricchio, Gearoid Tuohy, Peter Humphries, Paul F. Kenna and G. Jane Farrar

Mol Ther 13: S392-S393; doi:10.1016/j.ymthe.2006.08.1115

1021. Suppression and Replacement Strategies for Rhodopsin-Linked Autosomal Dominant Retinitis Pigmentosa

Arpad Palfi, Mary O'Reilly, Sophia Millington-Ward, Marius Ader, Naomi Chadderton, Gearoid Tuohy, Anna-Sophia Kiang, Niamh McNally, Marian Humphries, Peter Humphries, Paul F. Kenna and G. Jane Farrar

Mol Ther 13: S393-S393; doi:10.1016/j.ymthe.2006.08.1116

1022. Efficient Dystrophin Production in Response to Local and Systemic Administration of Morpholino Antisense Oligonucleotides in the Mdx Mouse

Ian R. Graham, Francesca C. Thorogood, Helen Foster and George Dickson

Mol Ther 13: S393-S393; doi:10.1016/j.ymthe.2006.08.1117

1023. New Generation of shRNA for Targeted Cancer Gene Therapy

Donald D. Rao, David Taube, Padma Kumar, Phil Maples and John Nemunaitis

Mol Ther 13: S393-S394; doi:10.1016/j.ymthe.2006.08.1118

1024. Encapsulation of the NF-kB Decoy Oligonucleotide in Echogenic Liposomes and Its Ultrasound-Triggered Release

Kyle D. Buchanan, ShaoLing Huang, Susan D. Tiukinhoy-Laing, David D. McPherson and Robert C. MacDonald

Mol Ther 13: S394-S394; doi:10.1016/j.ymthe.2006.08.1119

1025. Therapeutic Effect of a Self-Cleaving Hammerhead Ribozyme in a Mouse Model of Osteogenesis Imperfecta

Belinda E. Peace, Christopher J. Frede, Jane B. Florer, Michael W. Kilpatrick, Petros Tsipouras and Richard J. Wenstrup

Mol Ther 13: S394-S394; doi:10.1016/j.ymthe.2006.08.1120

1026. Manipulation of S Phase Progression Can Counteract Cell Cycle Arrest of Corrected Cells during the Oligonucleotide-Directed Gene Repair Reaction

Luciana Ferrara, Julia Engstrom and Eric Kmiec

Mol Ther 13: S395-S395; doi:10.1016/j.ymthe.2006.08.1121

1027. DNase II Knockdown in Human Endothelial Cells Does Not Improve Non-Viral Transfection Efficiency

Gregory A. Barker and Scott L. Diamond

Mol Ther 13: S395-S395; doi:10.1016/j.ymthe.2006.08.1122

1028. Use of Antisense Oligonucleotides To Restore Activity in Mutant p53

Daniel J. Catron, Paloma H. Giangrande and Bruce A. Sullenger

Mol Ther 13: S395-S395; doi:10.1016/j.ymthe.2006.08.1123

1029. Single-Stranded Oligonucleotide Gene Targeting in Mouse Embryonic Stem Cells

Brian R. Murphy, Scott L. Diamond and Eric A. Pierce

Mol Ther 13: S395-S396; doi:10.1016/j.ymthe.2006.08.1124

1030. Pyrazolo[3,4-d]Pyrimidine Guanine Base Substitution in Triplex Forming Oligonucleotides Improves Target Specificity and Chromosomal Mutagenesis

Joanna Y. Chin, Janice A. Lloyd, Faye A. Rogers and Peter M. Glazer

Mol Ther 13: S396-S396; doi:10.1016/j.ymthe.2006.08.1125

1031. Improved Intranuclear Delivery of PNA-Peptide Conjugates Designed for Chromosomal Gene Targeting

Faye A. Rogers and Peter M. Glazer

Mol Ther 13: S396-S396; doi:10.1016/j.ymthe.2006.08.1126

1032. rAAV Mediated Knock-Down of Tyrosine Hydroxylase in the Substantia Nigra Using a pol II Transcribed siRNA

Fredric P. Manfredsson, Ronald J. Mandel, Sergei Zolotukhin and Alfred S. Lewin

Mol Ther 13: S396-S396; doi:10.1016/j.ymthe.2006.08.1127

1033. Tightly Controlled and Reversible Knockdown of Gene Expression Using Lentiviral Vectors Encoding Tetracycline-Dependent Repressors or Transactivators

Krzysztof Pluta, William Diehl, Robert H. Kutner, Xian-Yang Zhang and Jakob Reiser

Mol Ther 13: S396-S397; doi:10.1016/j.ymthe.2006.08.1128

1034. Expression of Short Hairpin RNAs by Liver and Non Liver Specific RNA Pol II Expression Cassettes: What Governs Activity?

David A. Suhy, Alexander A. Kolykhalov, Linda B. Couto, Luz-Maria Garcia, Annette R. Schroeder, Amy E. Parker, Gabriel Haniff, Mark A. Kay and Peter W. Roelvink

Mol Ther 13: S397-S397; doi:10.1016/j.ymthe.2006.08.1129

1035. Short G-Rich Oligonucleotides as a Therapeutic for Huntingtonss Disease

Michael Skogen, Jennifer Roth, Hetal Parekh-Olmedo and Eric Kmiec

Mol Ther 13: S397-S397; doi:10.1016/j.ymthe.2006.08.1130

1036. Overcoming Suppression of Oligonucleotide-Directed Targeted Gene Repair in Mammalian Cells

Katie Maguire, Timothy Schwartz and Eric Kmiec

Mol Ther 13: S397-S397; doi:10.1016/j.ymthe.2006.08.1131

1037. Formulating and Testing of Targeted siRNA for Applications In Vivo

Marie McAnuff, Garrett Rettig, Ji-seon Kim, Dijie Liu, Changpo Chen, Molly Martin and Kevin Rice

Mol Ther 13: S397-S398; doi:10.1016/j.ymthe.2006.08.1132

1038. Therapy of Cancer by Inhibition of XIAP with RNAi Mediated by Tumor Specific Replicating Adenovirus

Qiuwei Pan, Rong Cai, Kai Chen, Xubin Wei, Yu Chen, Xinyuan Liu and Cheng Qian

Mol Ther 13: S398-S398; doi:10.1016/j.ymthe.2006.08.1133

1039. Targeted Catabolic Gene Knockdown Using RNA Interference in Chondrocytes Abrogates the IL-1|[beta]| Response for Arthritis Control

Alan Nixon and Lisa Strassheim

Mol Ther 13: S398-S398; doi:10.1016/j.ymthe.2006.08.1134

1040. Towards Gene Correction Therapy for Wiskott-Aldrich Syndrome Using Designed Zinc Finger Endonucleases

Brian R. Davis, Nicole L. Prokopishyn, Jonathan Rosenberg, Michael DiCola, Jennifer Brosius, R. Michael Blaese, Richard A. Metz, Lei Zhang, Danny Xia, Jeffrey C. Miller, Kenneth Kim, Fyodor D. Urnov, Philip D. Gregory and Michael C. Holmes

Mol Ther 13: S398-S399; doi:10.1016/j.ymthe.2006.08.1136

1041. Ex Vivo Soluble Fas Ligand Treatment of Donor Cells to Selectively Reduce Murine Acute Graft Versus Host Disease

Robert W. Georgantas, Osnat Bohana-Kashtan and Curt I. Civin

Mol Ther 13: S399-S399; doi:10.1016/j.ymthe.2006.08.1137

1042. Tracking and Gene Expression Profile of Bone Marrow Mesenchymal Stem Cells Injected into Pig Myocardium by Magnetic Resonance Imaging and Laser-Capture Microdissection

Elie R. Chemaly, Irina Pomerantseva, Ryuichi Yoneyama, Djamel Lebeche, Davide Gianni, Kozo Hoshino, Yoshiaki Kawase, Federica del Monte and Roger J. Hajjar

Mol Ther 13: S399-S400; doi:10.1016/j.ymthe.2006.08.1138

1043. Intravenous (I.V.) Administration of Manganese Superoxide Dismutase-Plasmid Liposome (MnSOD-PL) Complex Protects Mice from Whole Body Irradiation

Michael W. Epperly, Yunyun Niu and Joel S. Greenberger

Mol Ther 13: S400-S400; doi:10.1016/j.ymthe.2006.08.1139

1044. Mesenchymal Stem Cell-Mediated Gene Delivery of Bone Morphogenetic Protein-2 in Alginate in an Articular Fracture Model

Terri A. Zachos, Steven E. Weisbrode and Alicia L. Bertone

Mol Ther 13: S400-S400; doi:10.1016/j.ymthe.2006.08.1140

1045. Targeted Elimination of the Brain Tumor Initiating Cell Population with Adoptively Transferred T Cells

Christine E. Brown, Renate Starr, Dorota Korta, Brenda Aguilar and Michael C. Jensen

Mol Ther 13: S401-S401; doi:10.1016/j.ymthe.2006.08.1141

1046. Derivation of Functionally Normal Macrophages from Human Embryonic Stem (hES) Cells for HIV-1 Gene Therapy

Joseph S. Anderson, Sriram Bandi, Dan S. Kaufman and Ramesh Akkina

Mol Ther 13: S401-S401; doi:10.1016/j.ymthe.2006.08.1142

1047. Neural Progenator Cells Can Be Genetically-Modified by a Novel Double-Stranded Adeno-Associated Viral (AAV) Vectors

Chi-Hsieh Wang, Ga-Chen Yin, Xiao Xiao, Hsin-I. Ma and Yung-Hsiao Chiang

Mol Ther 13: S401-S401; doi:10.1016/j.ymthe.2006.08.1143

1048. Gene-Enhanced Mesenchymal Stem Cells for the Treatment of Tendinitis

Alan J. Nixon and Jennifer L. Haupt

Mol Ther 13: S402-S402; doi:10.1016/j.ymthe.2006.08.1144

1049. Regenerative Cell Therapy for White Matter Disorders

Ana Olariu, Jeremy Francis, Scott McPhee, Eiji Kobayashi and Paola Leone

Mol Ther 13: S402-S402; doi:10.1016/j.ymthe.2006.08.1145

1050. Mouse Embryonic Endothelial Progenitor Cells Home to Atherosclerotic Lesions after Intravenous Delivery

Ba-bie Teng, Eva Zsigmond and Kathyjo Jackson

Mol Ther 13: S402-S403; doi:10.1016/j.ymthe.2006.08.1146

1051. BMP2 Induced Chondrogenesis: Can Monocytic Progenitors Differentiate into Chondrocytes?

Alan R. Davis, Jessica Shafer, Francis H. Gannon, Christine Fouletier-Dilling, Zawaunyka Lazard, Zbigniew Gugala, Michael H. Heggeness and Elizabeth A. Olmsted-Davis

Mol Ther 13: S403-S403; doi:10.1016/j.ymthe.2006.08.1147

1052. In Vivo Repopulation Ability of Genetically Corrected Bone Marrow Cells from Fanconi Anemia Patients

Odile Cohen-Haguenauer, Bruno Peault, C|[eacute]|cile Bauche, Marie-Th|[eacute]|r|[egrave]|se Daniel, Ibrahim Casal, Vincent Levy, Jean Dausset, Michel Boiron, Christian Auclair, Eliane Gluckman and Michel Marty

Mol Ther 13: S403-S403; doi:10.1016/j.ymthe.2006.08.1148

1053. Functional Restoration of a Genetic Defect in Multipotent Germline Stem Cells by Human Artificial Chromosome Containing a Genomic Insert

Yasuhiro Kazuki, Hidetoshi Hoshiya, Yoshiteru Kai, Satoshi Abe, Masato Takiguchi, Mitsuhiko Osaki, Mito Kanatsu- Shinohara, Naoyo Kajitani, Yasuaki Shirayoshi, Masaharu Hiratuka, Astuo Ogura, Takashi Shinohara and Mitsuo Oshimura

Mol Ther 13: S403-S404; doi:10.1016/j.ymthe.2006.08.1149

1054. Hematopoietic and Non-Hematopoietic Engraftment after Bone Marrow Transplantation in Newborn Mice

Emanuela M. Bruscia, Joanna E. Price, Elizabeth Ziegler and Diane S. Krause

Mol Ther 13: S404-S404; doi:10.1016/j.ymthe.2006.08.1150

1055. High Levels of Human Factor IX Expression in Hemophilia B Mice after Adult Stem Cell-Based Gene Therapy Combined with Non-Myeloablative Conditioning

Alex H. Chang, Leszek Lisowski and Michel Sadelain

Mol Ther 13: S404-S404; doi:10.1016/j.ymthe.2006.08.1151

1056. Failure of an Insulator Element To Prevent Retroviral Insertional Activation of Oncogenes and Lymphomagenesis

Koyel Mitra and Jack Lenz

Mol Ther 13: S405-S405; doi:10.1016/j.ymthe.2006.08.1153

1057. The cHS4 Chromatin Insulator Blocks Epigenetic Interactions between Integrated Vectors and the Surrounding Genome

Changlong Li and David W. Emery

Mol Ther 13: S405-S405; doi:10.1016/j.ymthe.2006.08.1154

1058. Suppression of Clonal Dominance in Cultured Human Lymphoid Cells by Addition of the 5|[prime]|cHS4 Insulator to a Lentiviral Vector

Marguerite V. Evans-Galea, Matthew M. Wielgosz, Hideki Hanawa and Arthur W. Nienhuis

Mol Ther 13: S405-S406; doi:10.1016/j.ymthe.2006.08.1155

1059. The Influence of a Chromatin Insulator on Interactions between Globin Regulatory Elements and Cellular Promoters in Erythroid Cells

Byoung Y. Ryu, Derek A. Persons and Arthur W. Nienhuis

Mol Ther 13: S406-S406; doi:10.1016/j.ymthe.2006.08.1156

1060. The MSCV-U3 Internal Promoter Strongly Activates Surrounding Cellular Promoter in Combination with Self-Inactivating (SIN)-MSCV Vector Backbone

Hideki Hanawa and Takashi Shimada

Mol Ther 13: S406-S407; doi:10.1016/j.ymthe.2006.08.1157

1061. Upstream Polyadenylation Enhancers in the U3 Region of Self-Inactivating Retroviral and Lentiviral Vectors Improve Titer and Gene Expression, and Prevent Transcriptional Read-Through

Axel Schambach, Melanie Galla and Baum Christopher

Mol Ther 13: S407-S407; doi:10.1016/j.ymthe.2006.08.1158

1062. Intracerebellar Injection of AAV-IGF-1 Improves Motor Function and Extends Survival in a Mouse Model of Amyotrophic Lateral Sclerosis

James C. Dodge, Marco A. Passini, Jennifer Clarke, Liza Grissett, Soo Hyun Kim, Rita Wen, Tatyana V. Taksir, Denise A. Griffiths, Seng H. Cheng, Brian K. Kaspar and Lamya S. Shihabuddin

Mol Ther 13: S407-S407; doi:10.1016/j.ymthe.2006.08.1160

1063. Optimizing Intron Splicing Signal Overcomes the mRNA Accumulation Barrier in Trans-Splicing AAV Vectors

Yi Lai and Dongsheng Duan

Mol Ther 13: S407-S408; doi:10.1016/j.ymthe.2006.08.1161

1064. Haute Couture Vectors: Solving Clinical Problems with Custom Designed AAV Vectors

Dawn E. Bowles, Chengwen Li, Paul E. Monahan, Joseph E. Rabinowitz, Mavis McKenna and Jude Samulski

Mol Ther 13: S408-S408; doi:10.1016/j.ymthe.2006.08.1162

1065. AAV2 Vector-Delivered Myostatin Propeptide Improves Muscle Healing after Injury

Jinhong Zhu, Yong Li, Chunping Qiao, Xiao Xiao and Johnny Huard

Mol Ther 13: S408-S409; doi:10.1016/j.ymthe.2006.08.1163

1066. A Novel Class of Miniature Stabilized Double-Stranded AAV (msdsAAV) Vectors for the In Vivo Expression of Short Hairpin RNAs

Dirk Grimm, Joyce S. Lee, Konrad L. Streetz, Theresa A. Storm and Mark A. Kay

Mol Ther 13: S409-S409; doi:10.1016/j.ymthe.2006.08.1164

1067. Amelioration of Arthritis after Local Delivery of an Adeno-Associated Virus Type 6 Expressing a TNF-Blocking Agent under a Disease-Inducible Promoter

Maroun Khoury, Jan Adriaansen, Pascale Louis-Plence, Dani|[egrave]|le Noel, Pascal Bigey, C. de Cortie, David Gould, Margriet Vervoordeldonk, Daniel Scherman, Paul-Peter Tak, Christian Jorgensen and Florence Apparailly

Mol Ther 13: S409-S409; doi:10.1016/j.ymthe.2006.08.1165

1068. Plasmid DNA Sequences Present in Conventional HSV Amplicon Vectors Cause and Rapid Transgene Silencing by Inactive Chromatin Formation

Masataka Suzuki, Kazue Kasai and Yoshinaga Saeki

Mol Ther 13: S410-S410; doi:10.1016/j.ymthe.2006.08.1167

1069. The HSV-2 Vector |[Delta]|RR Prevents Excitotoxicity-Induced Neuronal Cell Loss through Activation of Survival Pathways and Glial Cell Modulation

Jennifer M. Laing, Michael D. Gober and Laure Aurelian

Mol Ther 13: S410-S410; doi:10.1016/j.ymthe.2006.08.1168

1070. Infectious Delivery and Prolonged Expression of a 135 kb Human Friedreich's Ataxia Genomic DNA Locus in Human and Mouse Neuronal Cells

Silvia Gomez-Sebastian, Alfredo Gimenez-Cassina, Javier Diaz-Nido, Filip Lim and Richard Wade-Martins

Mol Ther 13: S410-S411; doi:10.1016/j.ymthe.2006.08.1169

1071. Development and Characterization of HSV-1 Vector-Expressed Dominant Negative PKC epsilon for Pain Therapy

Rahul Srinivasan, Adrian Sculptoreanu, Darren Wolfe, James Wechuck, Simon Watkins, William C. de Groat and Joseph C. Glorioso

Mol Ther 13: S411-S411; doi:10.1016/j.ymthe.2006.08.1170

1072. Delivery of Oncolytic Herpes Simplex Virus to Infiltrative Brain Tumor Sites Via Neuronal Stem Cells

Tyler T. Voss, Kevin R. Bobbitt, Chaya Brodie, Evan Synder and Cathie G. Miller

Mol Ther 13: S411-S411; doi:10.1016/j.ymthe.2006.08.1171

1073. Cell Tropism of JC-Virus Derived Viral-Like Particles In Vitro and In Vivo

Perry Liu, Linda Cashion, Hu Sheng Qian, Oliver Ast, Andrzej Citkowicz, Susan Harvey, Branka Mitrovic, Mary Rose Masikat, Brent Larsen, Richard N. Harkins, Gabor M. Rubanyi and Harald Petry

Mol Ther 13: S411-S412; doi:10.1016/j.ymthe.2006.08.1172

1074. Interaction of LPD Nanoparticles with Dendritic Cells

Lisa M. Shollenberger and Leaf Huang

Mol Ther 13: S412-S412; doi:10.1016/j.ymthe.2006.08.1174

1075. Cellular Localization and Cell Cycle Dynamics of |[phiv]|C31 Integrase in Mammalian Cells

Robert T. Hillman, Lauren E. Woodard and Michele P. Calos

Mol Ther 13: S412-S412; doi:10.1016/j.ymthe.2006.08.1175

1076. Mechanism of Naked DNA Clearance after Intravenous Injection

Feng Liu, Lisa M. Shollenberger, Christine C. Conwell, Xing Yuan and Leaf Huang

Mol Ther 13: S412-S413; doi:10.1016/j.ymthe.2006.08.1176

1077. Sequences from the Human Type 1|[alpha]|2 Procollagen Promoter Mediate Osteoblast-Specific Plasmid Nuclear Import

David A. Dean, Cindy Stivers, Tom A. Linkhart and Donna D. Strong

Mol Ther 13: S413-S413; doi:10.1016/j.ymthe.2006.08.1177

1078. Silencing of Transgene Expression Following Plasmid Based Delivery to Murine Skeletal Muscle Is Dose Dependent

Alan R. Brooks, Faye Wu, Perry Liu, Hu Sheng Qian, Peiyin Wang, Heather Gibson, Katalin Kauser, Rick N. Harkins and Gabor M. Rubanyi

Mol Ther 13: S413-S413; doi:10.1016/j.ymthe.2006.08.1178

1079. Effect of WPRE on Transgene Expression Using Different Promoters in the Context of Hydrodynamically Delivered Plasmid Vectors

Astrid Pa|[ntilde]|eda, Lucia Vanrell, Ruben Hernande-Alcoceba, Rafael Enriquez de Salamanca, Jesus Prieto, Gloria Gonzalez-Aseguinolaza and Antonio Fontanellas

Mol Ther 13: S413-S413; doi:10.1016/j.ymthe.2006.08.1179

1080. Receptor-Targeting Smart Vectors for Efficient Gene Transfer to Tumours

Stephanie Grosse, Martin Elbs, John Wong, Alethea Tabor, Helen Hailes and Stephen Hart

Mol Ther 13: S414-S414; doi:10.1016/j.ymthe.2006.08.1181

1081. Targeted Nanocapsules for Liver Cell-Type Delivery of Plasmids In Vivo

Betsy T. Kren, Gretchen M. Unger, Mark T. Reding and Clifford J. Steer

Mol Ther 13: S415-S415; doi:10.1016/j.ymthe.2006.08.1182

1082. Delivery of Anti-Oxidative Enzyme Genes Protects Against Ischemia/Reperfusion-Induced Liver Injury in Mice

Song-Qing He, Yan-Hong Zhang, Senthil K. Venugopal, Christopher W. Dicus, Richard V. Perez, Mark A. Zern, Michael H. Nantz and Jian Wu

Mol Ther 13: S415-S415; doi:10.1016/j.ymthe.2006.08.1183

1083. Crosslinked PEI Polyplexes for Light-Triggered DNA Release

Rachel G. Handwerger, Moon-Suk Kim and Scott L. Diamond

Mol Ther 13: S415-S416; doi:10.1016/j.ymthe.2006.08.1184

1084. Converting Non-Infectious Virus-Like Particles into Hybrid Gene Therapy Vectors Using Polyethylenimine

Josh D. Ramsey and Daniel W. Pack

Mol Ther 13: S416-S416; doi:10.1016/j.ymthe.2006.08.1185

1085. In Vivo Imaging of Microencapsulated Gene Therapy

Anna Li, Donna Hou, Feng Shen, Eric P. Seidlitz, Patricia L. Chang and Murray A. Potter

Mol Ther 13: S416-S416; doi:10.1016/j.ymthe.2006.08.1186

1086. T Cell Responses to Canine Factor IX and AAV Capsid Antigens in Hemophilia B Dogs after Intravascular Gene Delivery to Skeletal Muscle

Daniel J. Hui, Federico Mingozzi, Aaron Dillow, Stephanie McCorquodale, Timothy C. Nichols, Valder R. Arruda and Katherine A. High

Mol Ther 13: S417-S417; doi:10.1016/j.ymthe.2006.08.1188

1087. Balloon Occlusion Catheter-Based Delivery of HDAd into the Nonhuman Primate Liver Results in Stable, High Level Transgene Expression with Minimal Toxicity

Nicola Brunetti-Pierri, Gary Stapleton, Donna Palmer, Yu Zuo, Arthur Beaudet, Charles Mullins and Philip Ng

Mol Ther 13: S417-S417; doi:10.1016/j.ymthe.2006.08.1189

1088. Stem Cell Gene Therapy with No Pre-Conditioning for the ADA-Deficiency Patients Leads to Generalized Detoxification and Delayed, but Steady Hematological Reconstitution

Makoto Otsu, Satoru Nakajima, Miyuki Kida, Yoshihiro Maeyama, Nariaki Toita, Norikazu Hatano, Nobuaki Kawamura, Ryouji Kobayashi, Osamu Tatsuzawa, Masafumi Onodera, Fabio Candotti, Pawan Bali, Michael S. Hershfield, Yukio Sakiyama and Tadashi Ariga

Mol Ther 13: S418-S418; doi:10.1016/j.ymthe.2006.08.1190

1089. Neonatal BMT of ADA-Deficient SCID Mice Results in Phenotypic Correction Despite Low Levels of Engraftment and Absence of the Selective T Lymphoid Expansion Seen in |[gamma]|c Gene Knock-Out Mice

Denise A. Carbonaro, Xiangyang Jin, Xiao-Jin Yu, Dianne Skelton and Donald B. Kohn

Mol Ther 13: S418-S418; doi:10.1016/j.ymthe.2006.08.1191

1090. Enzyme Replacement Therapy with Pegylated Adenosine Deaminase (PEG-ADA) Does Not Impede Immune Reconstitution Following Transplantation of Gene-Corrected Bone Marrow Cells in the Murine Model of ADA-SCID

Denise A. Carbonaro, Xiangyang Jin, Karen Pepper and Donald B. Kohn

Mol Ther 13: S419-S419; doi:10.1016/j.ymthe.2006.08.1192

1091. Successful Induction of Immune Tolerance to Canine Factor VIII after Lentiviral-Mediated Gene Therapy in Neonatal Hemophilia A Mice

Hideto Matsui, Masaru Shibata, Brian Brown, Andrea Labelle, Carol Hegadorn, Chandler Andrews, Marinee Chuah, Thierry VandenDriessche, Carol H. Miao, Christine Hough and David Lillicrap

Mol Ther 13: S419-S419; doi:10.1016/j.ymthe.2006.08.1193

1092. Clinical Studies of Intra-Articular Administration of a Recombinant Adeno-Associated Vector Containing a TNF-|[alpha]| Antagonist Gene in Inflammatory Arthritis

Alison Heald, Greg Pate and Pervin Anklesaria

Mol Ther 13: S419-S420; doi:10.1016/j.ymthe.2006.08.1195

1093. Ex Vivo Gene Therapy Approach Using Human Lim Mineralization Protein-3 To Induce Bone Healing in a Rodent Model

Enrico Pola, Wanda Lattanzi, Giandomenico Logroscino, Giovanni Pecorini, Anna Tampieri, Andrea Gambotto, Carlo A. Logroscino and Paul D. Robbins

Mol Ther 13: S420-S420; doi:10.1016/j.ymthe.2006.08.1196

1094. Self-Complementary Vectors Significantly Enhance AAV-Mediated Gene Transfer to Joint Tissues

Jesse Kay, Elvire Gouze, Kenneth Warrington Jr., Irene Zolotukhin, Rachael Watson, Marsha Bush, Jeetpaul Saran, Jean-Noel Gouze, Douglas McCarty, Paul Robbins, Christopher Evans and Steven Ghivizzani

Mol Ther 13: S420-S421; doi:10.1016/j.ymthe.2006.08.1197

1095. Gene-Induced Chondrogenesis of Mesenchymal Stem Cells: A Comparative Analysis of Candidate cDNAs

Jeetpaul Saran, Marsha Bush, Jean-Noel Gouze, Rachael Watson, Jesse Kay, Andre Steinert, Elvire Gouze and Steven Ghivizzani

Mol Ther 13: S421-S421; doi:10.1016/j.ymthe.2006.08.1198

1096. FSTL-1 Is a Novel Pro-Inflammatory Protein

Takako Miyamae, Anthony D. Marinov, David C. Wilson and Raphael Hirsch

Mol Ther 13: S421-S421; doi:10.1016/j.ymthe.2006.08.1199

1097. Retroviral Delivery of the RheoSwitch|[reg]| Therapeutic System for Precisely Regulated Expression of BMP-2 for Bone Regeneration

Anand K. Katakam, J. Kelly Ganjei, Youngsuk Yi, Dug Keun Lee, Moon Jong Noh, Kwan Hee Lee, Dean E. Cress and Prasanna Kumar

Mol Ther 13: S422-S422; doi:10.1016/j.ymthe.2006.08.1200

1098. How Morbilliviruses Antagonize Innate Immunity and Swiftly Inactivate the Adaptive Immune System

Veronika von Messling, Nicholas Svitek and Roberto Cattaneo

Mol Ther 13: S422-S422; doi:10.1016/j.ymthe.2006.08.1202

1099. RNAi-Based Therapy for the Treatment of HCV

Linda B. Couto, Amy E. Parker, Gabriel Haniff, David A. Suhy, Alexander A. Kolykhalov, Peter W. Roelvink, Luz Maria Garcia, Rosanna Schroeder, Mark A. Kay and Sara M. Cunningham

Mol Ther 13: S422-S423; doi:10.1016/j.ymthe.2006.08.1203

1100. Baculovirus Vectors for Malaria Vaccination

Robert Strauss, Andreas Huser, Shaoheng Ni, Salif Sow, Nancy Kiviat, Christian Hofmann and Andre Lieber

Mol Ther 13: S423-S423; doi:10.1016/j.ymthe.2006.08.1204

1101. Rapid and Long-Term Protection Against Anthrax Lethal Toxin

Julie L. Boyer, Kazuhiko Kasuya, Jeffrey Howard, Neil R. Hackett, James M. Wilson and Ronald G. Crystal

Mol Ther 13: S423-S423; doi:10.1016/j.ymthe.2006.08.1205

1102. Genetically Engineered Bifidobacterium animalis Expressing Salmonella flagellin Gene for the Mucosal Immunization in Mouse Model

Toshiro Shirakawa, Tetsuo Takata, Akinobu Gotoh, Yasunobu Kano and Masato Kawabata

Mol Ther 13: S424-S424; doi:10.1016/j.ymthe.2006.08.1206

1103. Augmentation of Immunity Against AAV- Encoded Transgenes by Use of the Genetic Adjuvants C3d3 and CTLA4

Grant J. Logan, Zheng Maolin, Coppel L. Ross, Rowe B. Peter, Wang Lina and Alexander E. Ian

Mol Ther 13: S424-S424; doi:10.1016/j.ymthe.2006.08.1207

1104. Phase II Study of Lucanix|[trade]| a Transforming Growth Factor |[beta]|2 (TGF-|[beta]|2) Antisense Gene Modified Allogeneic Tumor Cell Vaccine in Non Small Cell Lung Cancer (NSCLC)

John Nemunaitis, Robert O. Dillman, Paul O. Schwarzenberger, Neil Senzer, Casey Cunningham, Jodi Cutler, Alex Tong, Padmasini Kumar, Beena Pappen, Cody Hamilton, Edward DeVol, Phillip B. Maples, Lily Liu, Terry Chamberlin, Daniel L. Shawler and Habib Fakhrai

Mol Ther 13: S424-S425; doi:10.1016/j.ymthe.2006.08.1209

1105. A Phase I Clinical Trial of an IL-12 Gene Plasmid Formulated with a Novel Lipopolymeric Gene Delivery System for Intraperitoneal Treatment of Recurrent Ovarian Cancer

Ronald D. Alvarez, Mack N. Barnes, Connie McCombs, Sharmila Makhija, Jason Fewell, Danny H. Lewis and Kursheed Anwer

Mol Ther 13: S425-S425; doi:10.1016/j.ymthe.2006.08.1210

1106. Results of a Phase I Clinical Trial of Adenoviral-Interferon-Beta Gene Therapy for Malignant Mesothelioma and Malignant Pleural Effusions

Daniel H. Sterman, Adriana Recio, Andrew Haas, Michael Machuzak, Colin Gillespie, Jing Sun, Veena Kapoor, Leslie A. Litzky, Robert Vonderheide, Carl June, John C. Kucharczuk, Larry R. Kaiser and Steven M. Albelda

Mol Ther 13: S425-S425; doi:10.1016/j.ymthe.2006.08.1211

1107. Gene Therapy Clinical Trials for Relapsed Leukemia with Infusions of the Suicide-Gene Transduced Donor Lymphocytes in Japan

Masafumi Onodera, Shin Kaneko, Makoto Otsu, Hiroshi Kojima, Ryo Sumazaki, Salvatore Toma, Chiara Bonini, Claudio Bordignon, Hiromitsu Nakauchi and Toshiro Nagasawa

Mol Ther 13: S426-S426; doi:10.1016/j.ymthe.2006.08.1212

1108. High Rate of Anti-Tumor Immune Responses in a Phase 1 Clinical Trial of Adenoviral-Interferon-Beta Gene Transfer for Malignant Mesothelioma (MM) and Malignant Pleural Effusions (MPE)

Steven M. Albelda, Andrew Haas, Collin Gillespie, Andriana Recio, Jing Sun, Veena Kapoor, Jennifer Brown, Parr Michael, Mitchell Ho, Ira Pastan, Robert H. Vonderheide, Richard Carroll, Carl June, Larry R. Kaiser and Daniel H. Sterman

Mol Ther 13: S426-S426; doi:10.1016/j.ymthe.2006.08.1213

1109. Targeting CYP1B1 with a Therapeutic Cancer Vaccine: Results of Preclinical and Clinical Studies

Mary Lynne Hedley

Mol Ther 13: S426-S426; doi:10.1016/j.ymthe.2006.08.1214

1110. Engineering Cell Lines for the Production of Highly Replication Defective HSV-1 Vectors

Kyle G. Grant, David M. Krisky, Mohammed M. Ataai and Joseph C. Glorioso III

Mol Ther 13: S427-S427; doi:10.1016/j.ymthe.2006.08.1216

1111. Removal of Empty Particles from Type 1 Adeno-Associated Virus Vector Stocks by Ion Exchange Chromatography Potentiates Transgene Expression

Masashi Urabe, Ke-Qin Xin, Yoko Obara, Takayo Nakakura, Hiroaki Mizukami, Akihiro Kume, Kenji Okuda and Keiya Ozawa

Mol Ther 13: S427-S427; doi:10.1016/j.ymthe.2006.08.1217

1112. Design and Implementation of VRX496 Phase II Cell Processing for cGMP Production of Multiple Doses of Lentivirally Transduced Autologous HIV Infected CD4+ T Lymphocytes

Laurent Humeau, Reuben Cohen, Tony Encinas, Yelena Skripchenko, Franck Lemiale, Kris Andre, Arvind Chopra, Tessio Rebello and Vladimir Slepushkin

Mol Ther 13: S427-S427; doi:10.1016/j.ymthe.2006.08.1218

1113. Large Scale Ex Vivo Expansion of Human T Cells under GMP Conditions Consistently Yields Fully Functional T Cells In Vivo Proven by Induction of Lethal GvHD in a Mouse Xenotransplant Model

Gerhard Bauer, Jon Walker, Bruno Nervi, Julie Ritchey, Mike Rettig, Jackie Hughes, Bill Eades, Jan Nolta and John DiPersio

Mol Ther 13: S428-S428; doi:10.1016/j.ymthe.2006.08.1219

1114. Bone Regeneration by Osteogenic Gene Delivery without Cell Transplantation Using Supramolecular Nanocarrier

Keiji Itaka, Kayo Masago, Shinsuke Oba, Ung-il Chung and Kazunori Kataoka

Mol Ther 13: S428-S429; doi:10.1016/j.ymthe.2006.08.1220

1115. A Simple Method for the Purification of Lentiviral Vectors Using a Combination of Ultrafiltration and Anion Exchange Chromatography

Rachel M. Koldej and Donald S. Anson

Mol Ther 13: S429-S429; doi:10.1016/j.ymthe.2006.08.1221

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Author Index

Author Index

Mol Ther 13: S430-S446; doi:10.1016/S1525-0016(06)01624-8

Top

Keyword Index

Keyword Index

Mol Ther 13: S447-S467; doi:10.1016/S1525-0016(06)01625-X

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