TABLE OF CONTENTS

Volume 13, Issue 1 (January 2006)

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Editorial

New AAV Serotypes May Broaden the Therapeutic Pipeline to Human Gene Therapy

Terence R. Flotte

Mol Ther 13: 1-2; doi:10.1016/j.ymthe.2005.11.004

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Inside This Month

Inside This Month

Mol Ther 13: 3; doi:10.1016/j.ymthe.2005.11.006

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Research Update

Research Update

Mol Ther 13: 4; doi:10.1016/j.ymthe.2005.11.005

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Review Articles

Generation, Culture, and Differentiation of Human Embryonic Stem Cells for Therapeutic Applications

Shin Yong Moon, Yong Bin Park, Dae-Sung Kim, Sun Kyung Oh and Dong-Wook Kim

Mol Ther 13: 5-14; doi:10.1016/j.ymthe.2005.09.008

The Role of LMO2 in Development and in T Cell Leukemia After Chromosomal Translocation or Retroviral Insertion

Chang-Hoon Nam and Terence H. Rabbitts

Mol Ther 13: 15-25; doi:10.1016/j.ymthe.2005.09.010

Allogeneic Hematopoietic Cell Transplantation Following Nonmyeloablative Conditioning as Treatment for Hematologic Malignancies and Inherited Blood Disorders

Frédéric Baron and Rainer Storb

Mol Ther 13: 26-41; doi:10.1016/j.ymthe.2005.09.011

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Original Articles

Bone Marrow Transplantation Combined with Gene Therapy to Induce Antigen-specific Tolerance and Ameliorate EAE

Biying Xu, Peter Haviernik, Lawrence A. Wolfraim, Kevin D. Bunting and David W. Scott

Mol Ther 13: 42-48; doi:10.1016/j.ymthe.2005.09.002

In Vivo Genetic Selection of Renal Proximal Tubules

Patrice K. Held, Muhsen Al-Dhalimy, Holger Willenbring, Yassmine Akkari, Shuguang Jiang, Yumi Torimaru, Susan Olson, William H. Fleming, Milton Finegold and Markus Grompe

Mol Ther 13: 49-58; doi:10.1016/j.ymthe.2005.09.004

Epigenetic Regulation of Lentiviral Transgene Vectors in a Large Animal Model

Andreas Hofmann, Barbara Kessler, Sonja Ewerling, Andrea Kabermann, Gottfried Brem, Eckhard Wolf and Alexander Pfeifer

Mol Ther 13: 59-66; doi:10.1016/j.ymthe.2005.07.685

High Levels of Persistent Expression of alpha1-Antitrypsin Mediated by the Nonhuman Primate Serotype rh.10 Adeno-associated Virus Despite Preexisting Immunity to Common Human Adeno-associated Viruses

Bishnu P. De, Adriana Heguy, Neil R. Hackett, Barbara Ferris, Philip L. Leopold, John Lee, Lorraine Pierre, Guangping Gao, James M. Wilson and Ronald G. Crystal

Mol Ther 13: 67-76; doi:10.1016/j.ymthe.2005.09.003

Biology of AAV Serotype Vectors in Liver-Directed Gene Transfer to Nonhuman Primates

Guangping Gao, You Lu, Roberto Calcedo, Rebecca L. Grant, Peter Bell, Lili Wang, Joanita Figueredo, Martin Lock and James M. Wilson

Mol Ther 13: 77-87; doi:10.1016/j.ymthe.2005.08.017

The Inhibitory Effects of Anticoagulation on in Vivo Gene Transfer by Adeno-associated Viral or Adenoviral Vectors

Joerg Schuettrumpf, Jianxiang Zou, Yi Zhang, Alexander Schlachterman, Yi-Lin Liu, Shyrie Edmonson, Weidong Xiao and Valder R. Arruda

Mol Ther 13: 88-97; doi:10.1016/j.ymthe.2005.08.004

Lipid Emulsions Potently Increase Transgene Expression in Hepatocytes after Adenoviral Transfer

Jan Snoeys, Geertrui Mertens, Joke Lievens, Theo van Berkel, Désiré Collen, Erik A. L. Biessen and Bart De Geest

Mol Ther 13: 98-107; doi:10.1016/j.ymthe.2005.06.477

Rapid Kupffer Cell Death after Intravenous Injection of Adenovirus Vectors

Elanchezhiyan Manickan, Jeffrey S. Smith, Jie Tian, Thomas L. Eggerman, Jay N. Lozier, Jacqueline Muller and Andrew P. Byrnes

Mol Ther 13: 108-117; doi:10.1016/j.ymthe.2005.08.007

Adenovirus-Mediated Gene Transfer and Lipoprotein-Mediated Protein Delivery of Plasma PAF-AH Ameliorates Proteinuria in Rat Model of Glomerulosclerosis

Naoyuki Iso-O, Hiroshi Noto, Masumi Hara, Masako Togo, Ken Karasawa, Noriko Ohashi, Eisei Noiri, Yoshiaki Hashimoto, Takashi Kadowaki, Satoshi Kimura, Tsuyoshi Watanabe and Kazuhisa Tsukamoto

Mol Ther 13: 118-126; doi:10.1016/j.ymthe.2005.08.011

Fully Deleted Adenovirus Persistently Expressing GAA Accomplishes Long-Term Skeletal Muscle Glycogen Correction in Tolerant and Nontolerant GSD-II Mice

Anne Kiang, Zachary C. Hartman, Shaoxi Liao, Fang Xu, Delila Serra, Donna J. Palmer, Philip Ng and Andrea Amalfitano

Mol Ther 13: 127-134; doi:10.1016/j.ymthe.2005.08.006

Lysosomal Enzyme Delivery by ICAM-1-Targeted Nanocarriers Bypassing Glycosylation- and Clathrin-Dependent Endocytosis

Silvia Muro, Edward H. Schuchman and Vladimir R. Muzykantov

Mol Ther 13: 135-141; doi:10.1016/j.ymthe.2005.07.687

Complete Cure of Persistent Virus Infections by Antiviral siRNAs

Aure Saulnier, Isabelle Pelletier, Karine Labadie and Florence Colbère-Garapin

Mol Ther 13: 142-150; doi:10.1016/j.ymthe.2005.07.697

High-Efficiency Transfection of Primary Human and Mouse T Lymphocytes Using RNA Electroporation

Yangbing Zhao, Zhili Zheng, Cyrille J. Cohen, Luca Gattinoni, Douglas C. Palmer, Nicholas P. Restifo, Steven A. Rosenberg and Richard A. Morgan

Mol Ther 13: 151-159; doi:10.1016/j.ymthe.2005.07.688

Viral-Mediated Temporally Controlled Dopamine Production in a Rat Model of Parkinson Disease

Xiao-gang Li, Takashi Okada, Mika Kodera, Yuko Nara, Naomi Takino, Chieko Muramatsu, Kunihiko Ikeguchi, Fumi Urano, Hiroshi Ichinose, Daniel Metzger, Pierre Chambon, Imaharu Nakano, Keiya Ozawa and Shin-ichi Muramatsu

Mol Ther 13: 160-166; doi:10.1016/j.ymthe.2005.08.009

Dimerizer Regulation of AADC Expression and Behavioral Response in AAV-Transduced 6-OHDA Lesioned Rats

Laura M. Sanftner, Victor M. Rivera, Brian M. Suzuki, Lan Feng, Lori Berk, Shangzhen Zhou, John R. Forsayeth, Tim Clackson and Janet Cunningham

Mol Ther 13: 167-174; doi:10.1016/j.ymthe.2005.06.480

Regulatable Acetylcholine-Producing Fibroblasts Enhance Cognitive Performance

Donald P. Pizzo, Nicole G. Coufal, Mark J. Lortie, Fred H. Gage and Leon J. Thal

Mol Ther 13: 175-182; doi:10.1016/j.ymthe.2005.08.001

Recombinant Vaccinia Virus Expressing Interleukin-2 Invokes Anti-tumor Cellular Immunity in an Orthotopic Murine Model of Head and Neck Squamous Cell Carcinoma

Santanu Dasgupta, Malaya Bhattacharya-Chatterjee, Bert W. O'Malley Jr. and Sunil K. Chatterjee

Mol Ther 13: 183-193; doi:10.1016/j.ymthe.2005.06.481

Enhancement of Immunity by a DNA Melanoma Vaccine against TRP2 with CCL21 as an Adjuvant

Tomoki Yamano, Yasufumi Kaneda, Sharon Huang, Suzanne H. Hiramatsu and Dave S. B. Hoon

Mol Ther 13: 194-202; doi:10.1016/j.ymthe.2005.05.018

Chimeric DNA Vaccine Reverses Morphine-Induced Immunosuppression and Tumorigenesis

Wen-Fang Cheng, Li-Kuei Chen, Chi-An Chen, Ming-Cheng Chang, Po-Ni Hsiao, Yi-Ning Su, Chien-Nan Lee, Huei-Jiuan Jeng, Chang-Yao Hsieh and Wei-Zen Sun

Mol Ther 13: 203-210; doi:10.1016/j.ymthe.2005.06.479

Dermal Wound Healing Is Subject to Redox Control

Sashwati Roy, Savita Khanna, Kishore Nallu, Thomas K. Hunt and Chandan K. Sen

Mol Ther 13: 211-220; doi:10.1016/j.ymthe.2005.07.684

Phase I/II Trial of Intravenous NDV-HUJ Oncolytic Virus in Recurrent Glioblastoma Multiforme

Arnold I. Freeman, Zichria Zakay-Rones, John M. Gomori, Eduard Linetsky, Linda Rasooly, Evgeniya Greenbaum, Shira Rozenman-Yair, Amos Panet, Eugene Libson, Charles S. Irving, Eithan Galun and Tali Siegal

Mol Ther 13: 221-228; doi:10.1016/j.ymthe.2005.08.016

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Short Communication

Rapid Intravascular Injection into Limb Skeletal Muscle: A Damage Assessment Study

Hechmi Toumi, Julia Hegge, Vladimir Subbotin, Mark Noble, Hans Herweijer, Thomas M. Best and James E. Hagstrom

Mol Ther 13: 229-236; doi:10.1016/j.ymthe.2005.07.699

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