TABLE OF CONTENTS
Volume 12, Issue 6 (December 2005)
Editorial
FDA Guidance Document on Monitoring Delayed Adverse Events a Good First Start
David A. Williams
Mol Ther 12: 991-992; doi:10.1016/j.ymthe.2005.10.011
Inside This Month
Top of pageReviews
Contribution of Bone Marrow-Derived Cells to Blood Vessels in Ischemic Tissues and Tumors
Manish Aghi and E. Antonio Chiocca
Mol Ther 12: 994-1005; doi:10.1016/j.ymthe.2005.07.693
Spliceosome-Mediated RNA Trans-Splicing
Yanping Yang and Christopher E. Walsh
Mol Ther 12: 1006-1012; doi:10.1016/j.ymthe.2005.09.006
Original Articles
Correction of SMN2 Pre-mRNA Splicing by Antisense U7 Small Nuclear RNAs
Csilla Madocsai, Sharlene R. Lim, Till Geib, Bianca J. Lam and Klemens J. Hertel
Mol Ther 12: 1013-1022; doi:10.1016/j.ymthe.2005.08.022
Identification of Mouse AAV Capsid-specific CD8+ T Cell Epitopes
Denise E. Sabatino, Federico Mingozzi, Daniel J. Hui, Haifeng Chen, Peter Colosi, Hildegund C. J. Ertl and Katherine A. High
Mol Ther 12: 1023-1033; doi:10.1016/j.ymthe.2005.09.009
Correction of Murine Hemophilia a by Hematopoietic Stem Cell Gene Therapy
Morvarid Moayeri, Teresa S. Hawley and Robert G. Hawley
Mol Ther 12: 1034-1042; doi:10.1016/j.ymthe.2005.09.007
Local Delivery of a Viral Vector Mitigates Neutralization by Antiviral Antibodies and Results in Efficient Transduction of Rabbit Liver
Bradley L. Hodges, Kristin M. Taylor, Qiuming Chu, Samantha E. Scull, Rebecca G. Serriello, Scott C. Anderson, Fei Wang and Ronald K. Scheule
Mol Ther 12: 1043-1051; doi:10.1016/j.ymthe.2005.06.475
Identification of Novel Insertion Sites in the Ad5 Genome That Utilize the Ad Splicing Machinery for Therapeutic Gene Expression
Fang Jin, Peter J. Kretschmer and Terry W. Hermiston
Mol Ther 12: 1052-1063; doi:10.1016/j.ymthe.2005.07.696
In Vitro and in Vivo Enhancement of Ganciclovir-Mediated Bystander Cytotoxicity with Gemcitabine
Paul D. Boucher and Donna S. Shewach
Mol Ther 12: 1064-1071; doi:10.1016/j.ymthe.2005.07.643
Long-Term Restoration of Rod and Cone Vision by Single Dose rAAV-Mediated Gene Transfer to the Retina in a Canine Model of Childhood Blindness
Gregory M. Acland, Gustavo D. Aguirre, Jean Bennett, Tomas S. Aleman, Artur V. Cideciyan, Jeannette Bennicelli, Nadine S. Dejneka, Susan E. Pearce-Kelling, Albert M. Maguire, Krzysztof Palczewski, William W. Hauswirth and Samuel G. Jacobson
Mol Ther 12: 1072-1082; doi:10.1016/j.ymthe.2005.08.008
Oncolytic Adenovirus Expressing a p53 Variant Resistant to Degradation by HPV E6 Protein Exhibits Potent and Selective Replication in Cervical Cancer
Daniëlle A. M. Heideman, Renske D. M. Steenbergen, Jaco van der Torre, Martin Scheffner, Ramon Alemany, Winald R. Gerritsen, Chris J. L. M. Meijer, Peter J. F. Snijders and Victor W. van Beusechem
Mol Ther 12: 1083-1090; doi:10.1016/j.ymthe.2005.06.443
Adenoviral Vectors Expressing Human Endostatin–Angiostatin and Soluble Tie2: Enhanced Suppression of Tumor Growth and Antiangiogenic Effects in a Prostate Tumor Model
Sudhanshu P. Raikwar, Constance J. Temm, Nandita S. Raikwar, Chinghai Kao, Bruce A. Molitoris and Thomas A. Gardner
Mol Ther 12: 1091-1100; doi:10.1016/j.ymthe.2005.07.690
The Role of ICP0-Null HSV-1 and Interferon Signaling Defects in the Effective Treatment of Breast Adenocarcinoma
Jeff L. Hummel, Ekaterina Safroneeva and Karen L. Mossman
Mol Ther 12: 1101-1110; doi:10.1016/j.ymthe.2005.07.533
Stable Levels of Long-Term Transgene Expression Driven by the Latency-Associated Transcript Promoter in a Herpes Simplex Virus Type 1 Vector
B. K. Berges, J. H. Wolfe and N. W. Fraser
Mol Ther 12: 1111-1119; doi:10.1016/j.ymthe.2005.06.478
S100A1 Gene Therapy Preserves in Vivo Cardiac Function after Myocardial Infarction
Sven T. Pleger, Andrew Remppis, Beatrix Heidt, Mirko Völkers, J. Kurt Chuprun, Matthew Kuhn, Rui-Hai Zhou, Erhe Gao, Gabor Szabo, Dieter Weichenhan, Oliver J. Müller, Andrea D. Eckhart, Hugo A. Katus, Walter J. Koch and Patrick Most
Mol Ther 12: 1120-1129; doi:10.1016/j.ymthe.2005.08.002
Differential Myocardial Infarct Repair with Muscle Stem Cells Compared to Myoblasts
Hideki Oshima, Thomas R. Payne, Kenneth L. Urish, Tetsuro Sakai, Yiqun Ling, Burhan Gharaibeh, Kimimasa Tobita, Bradley B. Keller, James H. Cummins and Johnny Huard
Mol Ther 12: 1130-1141; doi:10.1016/j.ymthe.2005.07.686
Image-Guided Cardiac Cell Delivery Using High-Resolution Small-Animal Ultrasound
Martin Rodriguez-Porcel, Olivier Gheysens, Ian Y. Chen, Joseph C. Wu and Sanjiv Sam Gambhir
Mol Ther 12: 1142-1147; doi:10.1016/j.ymthe.2005.07.532
Hyperactive Transposase Mutants of the Sleeping Beauty Transposon
James Baus, Li Liu, Arnold D. Heggestad, Sonia Sanz and Bradley S. Fletcher
Mol Ther 12: 1148-1156; doi:10.1016/j.ymthe.2005.06.484
Inhibition of Simian/Human Immunodeficiency Virus Replication in CD4+ T Cells Derived from Lentiviral-Transduced CD34+ Hematopoietic Cells
Stephen E. Braun, Fay Eng Wong, Michelle Connole, Gang Qiu, Lorrin Lee, Jackie Gillis, Xiaobin Lu, Laurent Humeau, Vladimir Slepushkin, Gwendolyn K. Binder, Boro Dropulic and R. Paul Johnson
Mol Ther 12: 1157-1167; doi:10.1016/j.ymthe.2005.07.698
New Multifunctional Molecular Conjugate Vector for Targeting, Imaging, and Therapy of Tumors
Elisabeth Garanger, Didier Boturyn, Zhaohui Jin, Pascal Dumy, Marie-Christine Favrot and Jean-Luc Coll
Mol Ther 12: 1168-1175; doi:10.1016/j.ymthe.2005.06.095
Nonviral Jet-Injection Gene Transfer for Efficient in Vivo Cytosine Deaminase Suicide Gene Therapy of Colon Carcinoma
Wolfgang Walther, Ulrike Stein, Iduna Fichtner, Dennis Kobelt, Jutta Aumann, Franziska Arlt and Peter M. Schlag
Mol Ther 12: 1176-1184; doi:10.1016/j.ymthe.2005.07.700
Cell Death Induced by the Herpes Simplex Virus-1 Thymidine Kinase Delivered by Human Immunodeficiency Virus-1-Based Virus-like Particles
Silvia Peretti, Ilaria Schiavoni, Katherina Pugliese and Maurizio Federico
Mol Ther 12: 1185-1196; doi:10.1016/j.ymthe.2005.06.474
Multigene/Multisubtype HIV-1 Vaccine Induces Potent Cellular and Humoral Immune Responses by Needle-Free Intradermal Delivery
Andreas Bråve, Karl Ljungberg, Andreas Boberg, Erik Rollman, Maria Isaguliants, Björn Lundgren, Pontus Blomberg, Jorma Hinkula and Britta Wahren
Mol Ther 12: 1197-1205; doi:10.1016/j.ymthe.2005.06.473
Stable Transduction of Primary Human Monocytes by Simian Lentiviral Vector PBj
Michael D. Mühlebach, Nina Wolfrum, Silke Schüle, Ulrich Tschulena, Ralf Sanzenbacher, Egbert Flory, Klaus Cichutek and Matthias Schweizer
Mol Ther 12: 1206-1216; doi:10.1016/j.ymthe.2005.06.483
Successful Production of Pseudotyped rAAV Vectors Using a Modified Baculovirus Expression System
Erik Kohlbrenner, George Aslanidi, Kevin Nash, Stanislav Shklyaev, Martha Campbell-Thompson, Barry J. Byrne, Richard O. Snyder, Nicholas Muzyczka, Kenneth H. Warrington Jr. and Sergei Zolotukhin
Mol Ther 12: 1217-1225; doi:10.1016/j.ymthe.2005.08.018
