TABLE OF CONTENTS
Volume 12, Issue 5 (November 2005)
Editorial
Nucleic Acid Medicines Move Towards the Clinic
Robert M. Frederickson
Mol Ther 12: 775-776; doi:10.1016/j.ymthe.2005.10.002
Inside This Month
Top of pageOriginal Articles
Combinatorial Antiangiogenic Gene Therapy by Nonviral Gene Transfer Using the Sleeping Beauty Transposon Causes Tumor Regression and Improves Survival in Mice Bearing Intracranial Human Glioblastoma
John R. Ohlfest, Zachary L. Demorest, Yasuhiko Motooka, Isabelita Vengco, Seunguk Oh, Eleanor Chen, Frank A. Scappaticci, Rachel J. Saplis, Stephen C. Ekker, Walter C. Low, Andrew B. Freese and David A. Largaespada
Mol Ther 12: 778-788; doi:10.1016/j.ymthe.2005.07.689
HSV Oncolytic Therapy Upregulates Interferon-Inducible Chemokines and Recruits Immune Effector Cells in Ovarian Cancer
Fabian Benencia, Maria C. Courrèges, José R. Conejo-García, Alisha Mohamed-Hadley, Lin Zhang, Ronald J. Buckanovich, Richard Carroll, Nigel Fraser and George Coukos
Mol Ther 12: 789-802; doi:10.1016/j.ymthe.2005.03.026
Herpes Simplex Virus 1 Amplicon Vector-Mediated siRNA Targeting Epidermal Growth Factor Receptor Inhibits Growth of Human Glioma Cells in Vivo
Okay Saydam, Daniel L. Glauser, Irma Heid, Gulen Turkeri, Monika Hilbe, Andreas H. Jacobs, Mathias Ackermann and Cornel Fraefel
Mol Ther 12: 803-812; doi:10.1016/j.ymthe.2005.07.534
Identification of Amino Acids of Sindbis Virus E2 Protein Involved in Targeting Tumor Metastases in Vivo
Alicia Hurtado, Jen-Chieh Tseng, Christopher Boivin, Brandi Levin, Herman Yee, Christine Pampeno and Daniel Meruelo
Mol Ther 12: 813-823; doi:10.1016/j.ymthe.2005.06.476
Specific Regression of Human Cancer Cells by Ribozyme-Mediated Targeted Replacement of Tumor-Specific Transcript
Byung-Su Kwon, Heung-Su Jung, Min-Sun Song, Kyung Sook Cho, Sung-Chun Kim, Kuchan Kimm, Jin Sook Jeong, In-Hoo Kim and Seong-Wook Lee
Mol Ther 12: 824-834; doi:10.1016/j.ymthe.2005.06.096
A Preclinical Large Animal Model of Adenovirus-Mediated Expression of the Sodium–Iodide Symporter for Radioiodide Imaging and Therapy of Locally Recurrent Prostate Cancer
Roisin M. Dwyer, Stephen M. Schatz, Elizabeth R. Bergert, Rae M. Myers, Mary E. Harvey, Kelly L. Classic, Michael C. Blanco, Craig S. Frisk, Ronald J. Marler, Brian J. Davis, Michael K. O'Connor, Stephen J. Russell and John C. Morris
Mol Ther 12: 835-841; doi:10.1016/j.ymthe.2005.05.013
Single-Shot, Multicycle Suicide Gene Therapy by Replication-Competent Retrovirus Vectors Achieves Long-Term Survival Benefit in Experimental Glioma
Chien-Kuo Tai, Wei Jun Wang, Thomas C. Chen and Noriyuki Kasahara
Mol Ther 12: 842-851; doi:10.1016/j.ymthe.2005.03.017
Therapeutic Lentivirus-Mediated Neonatal in Vivo Gene Therapy in Hyperbilirubinemic Gunn Rats
Tuan Huy Nguyen, Marta Bellodi-Privato, Dominique Aubert, Virginie Pichard, Anne Myara, Didier Trono and Nicolas Ferry
Mol Ther 12: 852-859; doi:10.1016/j.ymthe.2005.06.482
Long-term Correction of Hyperbilirubinemia in the Gunn Rat by Repeated Intravenous Delivery of Naked Plasmid DNA into Muscle
Zhen Jia and István Dankó
Mol Ther 12: 860-866; doi:10.1016/j.ymthe.2005.04.023
Efficient Hepatic Delivery and Expression from a Recombinant Adeno-associated Virus 8 Pseudotyped 
1-Antitrypsin Vector
Thomas J. Conlon, Travis Cossette, Kirsten Erger, Young-Kook Choi, Tracy Clarke, Marda Scott-Jorgensen, Sihong Song, Martha Campbell-Thompson, James Crawford and Terence R. Flotte
Mol Ther 12: 867-875; doi:10.1016/j.ymthe.2005.05.016
Evasion of Immune Responses to Introduced Human Acid -Glucosidase by Liver-Restricted Expression in Glycogen Storage Disease Type II
Luis M. Franco, Baodong Sun, Xiaoyi Yang, Andrew Bird, Haoyue Zhang, Ayn Schneider, Talmage Brown, Sarah P. Young, Timothy M. Clay, Andrea Amalfitano, Y.T. Chen and Dwight D. Koeberl
Mol Ther 12: 876-884; doi:10.1016/j.ymthe.2005.04.024
Glucagon-like Peptide-1 Plasmid Construction and Delivery for the Treatment of Type 2 Diabetes
Suna Choi, Seungjoon Oh, Minhyung Lee and Sung Wan Kim
Mol Ther 12: 885-891; doi:10.1016/j.ymthe.2005.03.039
Transduction of CpG DNA-Stimulated Primary Human B Cells with Bicistronic Lentivectors
Krisztian Kvell, Tuan H. Nguyen, Patrick Salmon, Frédéric Glauser, Christiane Werner-Favre, Marc Barnet, Pascal Schneider, Didier Trono and Rudolf H. Zubler
Mol Ther 12: 892-899; doi:10.1016/j.ymthe.2005.05.010
Long-Term Inhibition of HIV-1 Infection in Primary Hematopoietic Cells by Lentiviral Vector Delivery of a Triple Combination of Anti-HIV shRNA, Anti-CCR5 Ribozyme, and a Nucleolar-Localizing TAR Decoy
Ming-Jie Li, James Kim, Shirley Li, John Zaia, Jiing-Kuan Yee, Joseph Anderson, Ramesh Akkina and John J. Rossi
Mol Ther 12: 900-909; doi:10.1016/j.ymthe.2005.07.524
HIV-1 Viral Protein-R (VPR) Protects against Lethal Superantigen Challenge While Maintaining Homeostatic T Cell Levels in Vivo
Karuppiah Muthumani, Andrew Y. Choo, Daniel S. Hwang, Nathanael S. Dayes, Michael Chattergoon, Shanmugam Mayilvahanan, Khanh P. Thieu, Peter T. Buckley, Joann Emmanuel, Arumugam Premkumar and David B. Weiner
Mol Ther 12: 910-921; doi:10.1016/j.ymthe.2005.05.009
In Vivo Depletion of CD4+CD25+ Regulatory T Cells Enhances the Antigen-Specific Primary and Memory CTL Response Elicited by Mature mRNA-Electroporated Dendritic Cells
Sonja Van Meirvenne, Melissa Dullaers, Carlo Heirman, Lieven Straetman, Annelies Michiels and Kris Thielemans
Mol Ther 12: 922-932; doi:10.1016/j.ymthe.2005.02.029
A Chimeric T Cell Antigen Receptor that Augments Cytokine Release and Supports Clonal Expansion of Primary Human T Cells
Martin A. Pulè, Karin C. Straathof, Gianpietro Dotti, Helen E. Heslop, Cliona M. Rooney and Malcolm K. Brenner
Mol Ther 12: 933-941; doi:10.1016/j.ymthe.2005.04.016
Administration Route- and Immune Cell Activation-Dependent Tumor Eradication by IL12 electrotransfer
Shulin Li, Lijie Zhang, Marina Torrero, Martin Cannon and Robin Barret
Mol Ther 12: 942-949; doi:10.1016/j.ymthe.2005.03.037
Intratumoral Injection of Dendritic Cells Transduced by an SV40-Based Vector Expressing Interleukin-15 Induces Curative Immunity Mediated by CD8+ T Lymphocytes and NK Cells
Maria Vera, Nerea Razquin, Jesús Prieto, Ignacio Melero, Puri Fortes and Gloria González-Aseguinolaza
Mol Ther 12: 950-959; doi:10.1016/j.ymthe.2005.03.030
Antigen-Specific CD8+ T Lymphocytes Generated from a DNA Vaccine Control Tumors Through the Fas–FasL Pathway
Wen-Fang Cheng, Chien-Nan Lee, Ming-Cheng Chang, Yi-Ning Su, Chi-An Chen and Chang-Yao Hsieh
Mol Ther 12: 960-968; doi:10.1016/j.ymthe.2005.04.020
A Cellular Screening Assay to Test the Ability of PKR to Induce Cell Death in Mammalian Cells
Inbar Friedrich, Menahem Eizenbach, Julia Sajman, Hannah Ben-Bassat and Alexander Levitzki
Mol Ther 12: 969-975; doi:10.1016/j.ymthe.2005.06.442
A Rapid Method for Retrovirus-Mediated Identification of Complementation Groups in Fanconi Anemia Patients
Saurabh Chandra, Orna Levran, Ingrid Jurickova, Chiel Maas, Rick Kapur, Detlev Schindler, Rashida Henry, Kelly Milton, Sat Dev Batish, Jose A. Cancelas, Helmut Hanenberg, Arleen D. Auerbach and David A. Williams
Mol Ther 12: 976-984; doi:10.1016/j.ymthe.2005.04.021
Short Communication
Promoter Dependence of Plasmid–Pluronics Targeted Galactosidase A Expression in Skeletal Muscle of Fabry Mice
Matthieu D. Lavigne, Marita Pohlschmidt, Javier F. Novo, Bernard Higgins, Valery Alakhov, Hanns Lochmuller, Hitoshi Sakuraba, Geoffrey Goldspink, Kay MacDermot and Dariusz C. Górecki
Mol Ther 12: 985-990; doi:10.1016/j.ymthe.2005.02.032
