Molecular Therapy

FIGURE 2

FROM:

A Cellular Screening Assay to Test the Ability of PKR to Induce Cell Death in Mammalian Cells

Inbar Friedrich, Menahem Eizenbach, Julia Sajman, Hannah Ben-Bassat and Alexander Levitzki

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Figure 2.

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GyrB-PKR activation leads to U87MG-wtEGFR cell death. U87MG-wtEGFR cells were seeded in 96-well plates, infected with adenoviruses encoding (A) GyrB-PKR or (B) GFP, and treated as described under Materials and Methods. The graphs depict cell growth as determined by methylene blue assay. Infection with GyrB-PKR-encoding viruses followed by coumermycin treatment caused the death of U87MG-wtEGFR cells.

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