Molecular Therapy

FIGURE 1

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A Cellular Screening Assay to Test the Ability of PKR to Induce Cell Death in Mammalian Cells

Inbar Friedrich, Menahem Eizenbach, Julia Sajman, Hannah Ben-Bassat and Alexander Levitzki

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Figure 1.

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Schematic presentation of wt PKR, GyrB-PKR, and their activation. (A) Wt PKR consists of two dsRNA-binding motifs (dsRBM) and a kinase domain. dsRNA binding induces dimerization of two PKR molecules and subsequent activation. (B) In GyrB-PKR the regulatory domain of gyrase B replaces the dsRNA binding domains. GyrB-PKR activation is induced by the drug coumermycin, which binds to two molecules of GyrB.

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