Molecular Therapy

FIGURE 4

FROM:

HSV Oncolytic Therapy Upregulates Interferon-Inducible Chemokines and Recruits Immune Effector Cells in Ovarian Cancer

Fabian Benencia, Maria C. Courrèges, José R. Conejo-García, Alisha Mohamed-Hadley, Lin Zhang, Ronald J. Buckanovich, Richard Carroll, Nigel Fraser and George Coukos

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Figure 4.

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Chemokine and cytokine induction by therapeutic HSV-1716 treatment in a syngeneic model of ovarian carcinoma. (A) ELISA of ascites showed an increase in the levels of IFN-gamma (n = 6), MIG (n = 10), and IP-10 (n = 10) together with a decrease in IL-4 protein (n = 6) 5 days after inoculation of live HSV-1716 (5 times 106 PFU ip) compared to UV-inactivated virus (mock) in the intraperitoneal model of murine ovarian carcinoma. (B) Real-time quantitative RT-PCR analysis of IFN-gamma, IL-4, IP-10, and MIG mRNA expression in solid tumors (n = 5) after intratumoral treatment with HSV-1716 (5 times 106 PFU) or UV-inactivated virus (mock).

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