TABLE OF CONTENTS
Volume 12, Issue 2 (August 2005)
Editorials
The Case for Immunosuppression in Clinical Gene Transfer
Pedro R. Lowenstein
Mol Ther 12: 185-186; doi:10.1016/j.ymthe.2005.06.439
Inside this Month
Top of pageResearch Update
Top of pageReview
Regulatable Gene Expression Systems for Gene Therapy Applications: Progress and Future Challenges
S. Goverdhana, M. Puntel, W. Xiong, J. M. Zirger, C. Barcia, J. F. Curtin, E. B. Soffer, S. Mondkar, G. D. King, J. Hu, S. A. Sciascia, M. Candolfi, D. S. Greengold, P. R. Lowenstein and M. G. Castro
Mol Ther 12: 189-211; doi:10.1016/j.ymthe.2005.03.022
Original Articles
Biological Effects of rAAV-caAlk2 Coating on Structural Allograft healing
Mette Koefoed, Hiromu Ito, Kirill Gromov, David G. Reynolds, Hani A. Awad, Paul T. Rubery, Michael Ulrich-Vinther, Kjeld Soballe, Robert E. Guldberg, Angela S.P. Lin, Regis J. O'Keefe, Xinping Zhang and Edward M. Schwarz
Mol Ther 12: 212-218; doi:10.1016/j.ymthe.2005.02.026
Gene-Induced Chondrogenesis of Primary Mesenchymal Stem Cells in vitro
Glyn D. Palmer, Andre Steinert, Arnulf Pascher, Elvire Gouze, Jean-Noel Gouze, Oliver Betz, Brian Johnstone, Christopher H. Evans and Steven C. Ghivizzani
Mol Ther 12: 219-228; doi:10.1016/j.ymthe.2005.03.024
Improved Tissue Repair in Articular Cartilage Defects in Vivo by rAAV-Mediated Overexpression of Human Fibroblast Growth Factor 2
Magali Cucchiarini, Henning Madry, Chunyan Ma, Tanja Thurn, David Zurakowski, Michael D. Menger, Dieter Kohn, Stephen B. Trippel and Ernest F. Terwilliger
Mol Ther 12: 229-238; doi:10.1016/j.ymthe.2005.03.012
Noggin Improves Bone Healing Elicited by Muscle Stem Cells Expressing Inducible BMP4
Hairong Peng, Arvydas Usas, Dave Hannallah, Anne Olshanski, Gregory M. Cooper and Johnny Huard
Mol Ther 12: 239-246; doi:10.1016/j.ymthe.2005.02.027
Gene Transfer of the Runx2 Transcription Factor Enhances Osteogenic Activity of Bone Marrow Stromal Cells in Vitro and in Vivo
Zhuoran Zhao, Ming Zhao, Guozhi Xiao and Renny T. Franceschi
Mol Ther 12: 247-253; doi:10.1016/j.ymthe.2005.03.009
Characterization of Hemodynamic Events Following Intravascular Infusion of Recombinant Adenovirus Reveals Possible Solutions for Mitigating Cardiovascular Responses
Todd Machemer, Heidrun Engler, Van Tsai, Seoju Lee, Susan Cannon-Carlson, Marcio Voloch, Thomas Schluep, Sundari Ravindran, Gary Vellekamp, Elena Brin, Douglas Cornell, Suganto Sutjipto, Shu Fen Wen, Mark Horn, Nico Van Rooijen, Dan Maneval, Beth Hutchins and Drake LaFace
Mol Ther 12: 254-263; doi:10.1016/j.ymthe.2005.03.007
Transient siRNA-Mediated Attenuation of Liver Expression from an 
-Galactosidase a Plasmid Reduces Subsequent Humoral Immune Responses to the Transgene Product in Mice
Qiuming Chu, Macy Joseph, Malgorzata Przybylska, Nelson S. Yew and Ronald K. Scheule
Mol Ther 12: 264-273; doi:10.1016/j.ymthe.2005.04.007
Ex vivo Transduction of Human Dermal Tissue Structures for Autologous Implantation Production and Delivery of Therapeutic Proteins
Einat Brill-Almon, Baruch Stern, Daniel Afik, Joel Kaye, Noga Langer, Stephen Bellomo, Moni Shavit, Andrew Pearlman, Yitzhak Lippin, Amos Panet and Noam Shani
Mol Ther 12: 274-282; doi:10.1016/j.ymthe.2005.03.023
Long-Term Expression of Erythropoietin from Myoblasts Immobilized in Biocompatible and Neovascularized Microcapsules
G. Orive, M. De Castro, S. Ponce, R. M. Hernández, A. R. Gascón, M. Bosch, J. Alberch and José L. Pedraz
Mol Ther 12: 283-289; doi:10.1016/j.ymthe.2005.04.002
Novel Gene Switches for Targeted and Timed Expression of Proteins of Interest
Nuria Vilaboa, Mary Fenna, John Munson, Stephen M. Roberts and Richard Voellmy
Mol Ther 12: 290-298; doi:10.1016/j.ymthe.2005.03.029
No Evidence for Tumorigenesis of AAV Vectors in a Large-Scale Study in Mice
Peter Bell, Lili Wang, Corinna Lebherz, Douglas B. Flieder, Mark S. Bove, Di Wu, Guang Ping Gao, James M. Wilson and Nelson A. Wivel
Mol Ther 12: 299-306; doi:10.1016/j.ymthe.2005.03.020
Long-Term Neuroprotection Achieved with Latency-Associated Promoter-Driven Herpes Simplex Virus Gene Transfer to the Peripheral Nervous System
Munmun Chattopadhyay, Darren Wolfe, Marina Mata, Shaohua Huang, Joseph C. Glorioso and David J. Fink
Mol Ther 12: 307-313; doi:10.1016/j.ymthe.2005.04.009
Gene Transfer to Dorsal Root Ganglia by Intrathecal Injection: Effects on Regeneration of Peripheral Nerves
Xu Wang, Chaoyang Wang, Jieming Zeng, Xiaoyun Xu, Peter Y. K. Hwang, Woon-Chee Yee, Yee-Kong Ng and Shu Wang
Mol Ther 12: 314-320; doi:10.1016/j.ymthe.2005.03.032
Targeting Endothelial Cells with Adenovirus Expressing Nitric Oxide Synthase Prevents Elevation of Blood Pressure in Stroke-prone Spontaneously Hypertensive Rats
William H. Miller, M. Julia Brosnan, Delyth Graham, Campbell G. Nicol, Ian Morecroft, Keith M. Channon, Sergei M. Danilov, Paul N. Reynolds, Andrew H. Baker and Anna F. Dominiczak
Mol Ther 12: 321-327; doi:10.1016/j.ymthe.2005.02.025
Adenoviral-mediated Delivery of Early Growth Response Factor-1 Gene Increases Tissue Perfusion in a Murine Model of Hindlimb Ischemia
Young-Sam Lee, Hyung-Suk Jang, Jeong-Min Kim, Jung-Sun Lee, Jae-Young Lee, Koung Li Kim, In-Soon Shin, Wonhee Suh, Jin-Ho Choi, Eun-Seok Jeon, Jonghoe Byun and Duk-Kyung Kim
Mol Ther 12: 328-336; doi:10.1016/j.ymthe.2005.03.027
Low Therapeutic Threshold for Hepatocyte Replacement in Murine Phenylketonuria
Kelly Hamman, Heather Clark, Eugenio Montini, Muhsen Al-Dhalimy, Markus Grompe, Milton Finegold and Cary O. Harding
Mol Ther 12: 337-344; doi:10.1016/j.ymthe.2005.03.025
Defining the Pathway for Tat-mediated Delivery of 
-Glucuronidase in Cultured Cells and MPS VII Mice
Koji O. Orii, Jeffrey H. Grubb, Carole Vogler, Beth Levy, Yun Tan, Kamelia Markova, Beverly L. Davidson, Q. Mao, Tadao Orii, Naomi Kondo and William S. Sly
Mol Ther 12: 345-352; doi:10.1016/j.ymthe.2005.02.031
Induction of Donor-Specific Tolerance in Sublethally Irradiated Recipients by Gene Therapy
Daron Forman, Chaorui Tian and John Iacomini
Mol Ther 12: 353-359; doi:10.1016/j.ymthe.2005.03.035
Viral IL-10-Mediated Immune Regulation in Pancreatic Islet Transplantation
Jeffrey D. Carter, Justin D. Ellett, Meng Chen, Kellie M. Smith, Lawrence B. Fialkow, Marcia J. McDuffie, Kenneth S. Tung, Jerry L. Nadler and Zandong Yang
Mol Ther 12: 360-368; doi:10.1016/j.ymthe.2005.02.030
Short Communication
Local Administration of an Adeno-associated Viral Vector Expressing IL-10 Reduces Monocyte Infiltration and Subsequent Photoreceptor Damage during Experimental Autoimmune Uveitis
Cathryn A. Broderick, Alexander J. Smith, Kam S. Balaggan, Anastasios Georgarias, Prateek K. Buch, Peter C. Trittibach, Susie E. Barker, Gian-Marco Sarra, Adrian J. Thrasher, Andrew D. Dick and Robin R. Ali
Mol Ther 12: 369-373; doi:10.1016/j.ymthe.2005.03.018
