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Intrapulmonary and intramyocardial gene transfer in rhesus monkeys (Macaca mulatta): Safety and efficiency of HIV-1-derived lentiviral vectors for fetal gene delivery
Alice F. Tarantal, Ruth J. McDonald, Daniel F. Jimenez, C. Chang I. Lee, Cristin E. O'Shea, Alyssa C. Leapley, Rosa H. Won, Charles G. Plopper, Carolyn Lutzko and Donald B. Kohn
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Species comparisons. Lung development is divided into stages based on the events occurring primarily in the gas-exchange area. Four of these stages are prenatal and include the following: embryonic, pseudoglandular, canalicular, and saccular stages. These events occur over different proportions of fetal development in each species, and each species is in a different stage of differentiation at parturition. This figure shows the time period and percent of gestation for the pseudoglandular and canalicular stages for each species represented. In humans with an extended period of gestation, the pseudoglandular stage occurs at 18- 40% and the canalicular stage at 40- 60% gestation. In species with a short gestational time period such as the mouse (19 days), these stages occur over a one day period each, and at 80% and 90% gestation, respectively. d=days. (Adapted from 13).
