TABLE OF CONTENTS
Volume 11, Issue 4 (April 2005)
Editorial
Genetic theraphy for cancer: hurdles remain
David Kirn
Mol Ther 11: 493; doi:10.1016/j.ymthe.2005.02.008
Inside this month
Top of pageResearch Update
Top of pageReview
Genetically based therapeutics for cancer: similarities and contrasts with traditional drug discovery and development
Terry W. Hermiston and D.H. Kirn
Mol Ther 11: 496-507; doi:10.1016/j.ymthe.2004.12.004
Original Articles
Reversal of different drug-resistant phenotypes by an autocatalytic multitarget multiribozyme directed against the transcripts of the ABC transporters MDR1/P-gp, MRP2, and BCRP
Petra Kowalski, Pawel Surowiak and Hermann Lage
Mol Ther 11: 508-522; doi:10.1016/j.ymthe.2004.11.016
Delivery of MDR1 Small Interfering RNA by Self-Complementary Recombinant Adeno-Associated Virus Vector
Dong Xu, Doug McCarty, Alda Fernandes, Michael Fisher, R.J. Samulski and R.L. Juliano
Mol Ther 11: 523-530; doi:10.1016/j.ymthe.2004.12.019
Effective gene–virotherapy for complete eradication of tumor mediated by the combination of hTRAIL (TNFSF10) and plasminogen k5
Xin-Yuan Liu, Song-Bo Qiu, Wei-Gou Zou, Zi-Fei Pei, Jin-Fa Gu, Chun-Xia Luo, Hong-Mei Ruan, Yu Chen, Yi-Peng Qi and Cheng Qian
Mol Ther 11: 531-541; doi:10.1016/j.ymthe.2004.12.003
Depsipeptide (FR901228) Enhances the Cytotoxic Activity of TRAIL by Redistributing TRAIL Receptor to Membrane Lipid Rafts
Rebecca L. VanOosten, Jill M. Moore, Aaron T. Ludwig and Thomas S. Griffith
Mol Ther 11: 542-552; doi:10.1016/j.ymthe.2004.12.008
Suppression of tumor growth by oncolytic adenovirus-mediated delivery of an antiangiogenic gene, Soluble Flt-1
Zilai Zhang, Weiguo Zou, Jinhui Wang, Jinfa Gu, Yunkun Dang, Binghua Li, Lili Zhao, Cheng Qian, Qijun Qian and Xinyuan Liu
Mol Ther 11: 553-562; doi:10.1016/j.ymthe.2004.12.015
Viral and nonviral factors causing nonspecific replication of tumor- and tissue-specific promoter-dependent oncolytic adenoviruses
Almudena Hurtado Picó, Xiaomin Wang, Isaac Sipo, Ulrike Siemetzki, Jürgen Eberle, Wolfgang Poller and Henry Fechner
Mol Ther 11: 563-577; doi:10.1016/j.ymthe.2004.10.021
Eradication of epstein–barr virus episome and associated inhibition of infected tumor cell growth by adenovirus vector-mediated transduction of dominant-negative EBNA1
Md. Nasimuzzaman, Masayuki Kuroda, Sumitaka Dohno, Takenobu Yamamoto, Keiji Iwatsuki, Shigenobu Matsuzaki, Rashel Mohammad, Wakako Kumita, Hiroyuki Mizuguchi, Takao Hayakawa, Hiroyuki Nakamura, Takahiro Taguchi, Hiroshi Wakiguchi and Shosuke Imai
Mol Ther 11: 578-590; doi:10.1016/j.ymthe.2004.12.017
eGFP reporter genes silence LCR
-globin transgene expression via CpG dinucleotides
Bruno Dalle, Joel E. Rubin, Ozan Alkan, Tanya Sukonnik, Peter Pasceri, Shuyuan Yao, Rob Pawliuk, Philippe Leboulch and James Ellis
Mol Ther 11: 591-599; doi:10.1016/j.ymthe.2004.11.012
Proteasome Inhibition Enhances AAV-Mediated Transgene Expression in Human Synoviocytes in Vitro and in Vivo
Kristi Jennings, Takako Miyamae, Russell Traister, Anthony Marinov, Shigeki Katakura, Dawn Sowders, Bruce Trapnell, James M. Wilson, Guangping Gao and Raphael Hirsch
Mol Ther 11: 600-607; doi:10.1016/j.ymthe.2004.10.020
Attenuation of pain-related behavior in a rat model of trigeminal neuropathic pain by viral-driven enkephalin overproduction in trigeminal ganglion neurons
Alice Meunier, Alban Latrémolière, Annie Mauborgne, Sylvie Bourgoin, Valérie Kayser, François Cesselin, Michel Hamon and Michel Pohl
Mol Ther 11: 608-616; doi:10.1016/j.ymthe.2004.12.011
Herpes Simplex Virus Targeting to the EGF Receptor by a gD-Specific Soluble Bridging Molecule
Kenji Nakano, Ryutaro Asano, Kouhei Tsumoto, Heechung Kwon, William F. Goins, Izumi Kumagai, Justus B. Cohen and Joseph C. Glorioso
Mol Ther 11: 617-626; doi:10.1016/j.ymthe.2004.12.012
Development of cellular models for ribosomal protein S19 (RPS19)-deficient diamond–blackfan anemia using inducible expression of siRNA against RPS19
Koichi Miyake, Johan Flygare, Thomas Kiefer, Taiju Utsugisawa, Johan Richter, Zhi Ma, Maciej Wiznerowicz, Didier Trono and Stefan Karlsson
Mol Ther 11: 627-637; doi:10.1016/j.ymthe.2004.12.001
Short Communications
RNA interference mediated in human primary cells via recombinant baculoviral vectors
Linda J. Nicholson, Marie Philippe, Alan J. Paine, Derek A. Mann and Colin T. Dolphin
Mol Ther 11: 638-644; doi:10.1016/j.ymthe.2004.12.010
Baculovirus GP64-pseudotyped HIV-based lentivirus vectors are stabilized against complement inactivation by codisplay of decay accelerating factor (DAF) or of a GP64–DAF fusion protein
Ghiabe H. Guibinga and Theodore Friedmann
Mol Ther 11: 645-651; doi:10.1016/j.ymthe.2004.12.002
