TABLE OF CONTENTS
Volume 11, Issue 1 (January 2005)
Editorial
A New Year and a Renewed Mission
David A Williams
Mol Ther 11: 1; doi:10.1016/j.ymthe.2004.11.010
Inside this month
Top of pageResearch Update
Top of pageReviews
mda-7/IL-24: Exploiting Cancer's Achilles' Heel
Irina V. Lebedeva, Moira Sauane, Rahul V. Gopalkrishnan, Devanand Sarkar, Zhao-zhong Su, Pankaj Gupta, John Nemunaitis, Casey Cunningham, Adly Yacoub, Paul Dent and Paul B. Fisher
Mol Ther 11: 4-18; doi:10.1016/j.ymthe.2004.08.012
Adenovirus Protein IX: A New Look at an Old Protein
Robin J. Parks
Mol Ther 11: 19-25; doi:10.1016/j.ymthe.2004.09.018
Original Articles
Kupffer Cells and Not Liver Sinusoidal Endothelial Cells Prevent Lentiviral Transduction of Hepatocytes
Niek P. van Til, David M. Markusic, Roos van der Rijt, Cindy Kunne, Johan K. Hiralall, Heleen Vreeling, Wilma M. Frederiks, Ronald P.J. Oude-Elferink and Jurgen Seppen
Mol Ther 11: 26-34; doi:10.1016/j.ymthe.2004.09.012
Liver-directed neonatal gene therapy prevents cardiac, bone, ear, and eye disease in mucopolysaccharidosis I mice
Yuli Liu, Lingfei Xu, Anne K. Hennig, Attila Kovacs, Annabel Fu, Sarah Chung, David Lee, Bin Wang, Ramin S. Herati, Judith Mosinger Ogilvie, Shi-Rong Cai and Katherine Parker Ponder
Mol Ther 11: 35-47; doi:10.1016/j.ymthe.2004.08.027
Replacing acid 
-glucosidase in Pompe disease: recombinant and transgenic enzymes are equipotent, but neither completely clears glycogen from type II muscle fibers
Nina Raben, Tokiko Fukuda, Abigail L. Gilbert, Deborah de Jong, Beth L. Thurberg, Robert J. Mattaliano, Peter Meikle, John J. Hopwood, Kunio Nagashima, Kanneboyina Nagaraju and Paul H. Plotz
Mol Ther 11: 48-56; doi:10.1016/j.ymthe.2004.09.017
Efficacy of an Adeno-associated Virus 8-Pseudotyped Vector in Glycogen Storage Disease Type II
Baodong Sun, Haoyue Zhang, Luis M. Franco, Sarah P. Young, Ayn Schneider, Andrew Bird, Andrea Amalfitano, Y.-T. Chen and Dwight D. Koeberl
Mol Ther 11: 57-65; doi:10.1016/j.ymthe.2004.10.004
Evaluation of polyethylene glycol modification of first-generation and helper-dependent adenoviral vectors to reduce innate immune responses
Hoyin Mok, Donna J. Palmer, Philip Ng and Michael A. Barry
Mol Ther 11: 66-79; doi:10.1016/j.ymthe.2004.09.015
Hsp70 Gene Transfer by Adeno-associated Virus Inhibits MPTP-Induced Nigrostriatal Degeneration in the Mouse Model of Parkinson Disease
Zhizhong Dong, David P. Wolfer, Hans-Peter Lipp and Hansruedi Büeler
Mol Ther 11: 80-88; doi:10.1016/j.ymthe.2004.09.007
Lentiviral-Mediated Delivery of Bcl-2 or GDNF Protects against Excitotoxicity in the Rat Hippocampus
Liang-Fong Wong, G. Scott Ralph, Lucy E. Walmsley, Alison S. Bienemann, Stephen Parham, Susan M. Kingsman, James B. Uney and Nicholas D. Mazarakis
Mol Ther 11: 89-95; doi:10.1016/j.ymthe.2004.08.026
Mesenchymal stem cells that produce neurotrophic factors reduce ischemic damage in the rat middle cerebral artery occlusion model
Kazuhiko Kurozumi, Kiminori Nakamura, Takashi Tamiya, Yutaka Kawano, Keiji Ishii, Masayoshi Kobune, Sachie Hirai, Hiroaki Uchida, Katsunori Sasaki, Yoshinori Ito, Kazunori Kato, Osamu Honmou, Kiyohiro Houkin, Isao Date and Hirofumi Hamada
Mol Ther 11: 96-104; doi:10.1016/j.ymthe.2004.09.020
Pharmacologically Regulated Regeneration of Functional Human Pancreatic Islets
Gary P. Kobinger, Shaoping Deng, Jean-Pierre Louboutin, Marko Vatamaniuk, Victor M. Rivera, Moh-Moh Lian, James F. Markmann, Tim Clackson, Steven E. Raper, Franz Matschinsky and James M. Wilson
Mol Ther 11: 105-111; doi:10.1016/j.ymthe.2004.09.010
Induction of IFN-regulated factors and antitumoral surveillance by transfected placebo plasmid DNA
Shulin Li, Miles Wilkinson, Xueqing Xia, Michael David, Lihong Xu, Amy Purkel-Sutton and Anjana Bhardwaj
Mol Ther 11: 112-119; doi:10.1016/j.ymthe.2004.09.008
IL-2/B7.1 (CD80) Fusagene Transduction of AML Blasts by a Self-Inactivating Lentiviral Vector Stimulates T Cell Responses in Vitro: a Strategy to Generate Whole Cell Vaccines for AML
Lucas Chan, Nicola Hardwick, Dave Darling, Joanna Galea-Lauri, Joop Gäken, Steve Devereux, Mike Kemeny, Ghulam Mufti and Farzin Farzaneh
Mol Ther 11: 120-131; doi:10.1016/j.ymthe.2004.09.006
Genetically engineered dopamine 
-hydroxylase gene promoters with better PHOX2-binding sites drive significantly enhanced transgene expression in a noradrenergic cell-specific manner
Dong-Youn Hwang, Michelle M. Hwang, Han-Soo Kim and Kwang-Soo Kim
Mol Ther 11: 132-141; doi:10.1016/j.ymthe.2004.08.017
Development of Ecdysone-Regulated Lentiviral Vectors
Francesco Galimi, Enrique Saez, Jason Gall, Nien Hoong, Gerald Cho, Ronald M. Evans and Inder M. Verma
Mol Ther 11: 142-148; doi:10.1016/j.ymthe.2004.08.021
Trial Articles
Clinical and local biological effects of an intratumoral injection of mda-7 (IL24; INGN 241) in patients with advanced carcinoma: a phase I study
C. Casey Cunningham, Sunil Chada, James A. Merritt, Alex Tong, Neil Senzer, Yuan Zhang, Abner Mhashilkar, Karen Parker, Sasha Vukelja, Don Richards, Jill Hood, Keith Coffee and John Nemunaitis
Mol Ther 11: 149-159; doi:10.1016/j.ymthe.2004.09.019
Intratumoral Injection of INGN 241, a Nonreplicating Adenovector Expressing the Melanoma-Differentiation Associated Gene-7 (mda-7/IL24): Biologic Outcome in Advanced Cancer Patients
Alex W. Tong, John Nemunaitis, Dan Su, Yuan Zhang, Casey Cunningham, Neil Senzer, George Netto, Dawn Rich, Abner Mhashilkar, Karen Parker, Keith Coffee, Rajagopal Ramesh, Suhendan Ekmekcioglu, Elizabeth A. Grimm, Jill van Wart Hood, James Merritt and Sunil Chada
Mol Ther 11: 160-172; doi:10.1016/j.ymthe.2004.09.021
