TABLE OF CONTENTS
Volume 10, Issue 2 (August 2004)
Inside this month |
Research Update |
Commentary |
Perspective |
Meeting Report |
Reviews |
Original Articles |
Method |
Short Communication |
Erratum
Editorial
Musings for Young Scientists
Inder M. Verma
Mol Ther 10: 201; doi:10.1016/j.ymthe.2004.07.008
Inside this month
Top of pageResearch Update
Top of pageCommentary
Clinical Gene Therapy: Lessons from the Ether Dome
Theodore Friedmann
Mol Ther 10: 205-206; doi:10.1016/j.ymthe.2004.07.009
Perspective
Opening the Floodgates: Clinically Applicable Hydrodynamic Delivery of Plasmid DNA to Skeletal Muscle
Dominic J. Wells
Mol Ther 10: 207-208; doi:10.1016/j.ymthe.2004.07.010
Meeting Report
The Seventh Annual Meeting of the American Society of Gene Theraphy
Robert M. Frederickson
Mol Ther 10: 209-210; doi:10.1016/j.ymthe.2004.07.011
Reviews
Cytokines: Value-Added Products in Hematopoietic Stem Cell Gene Therapy
Steven P. Zielske and Stephen E. Braun
Mol Ther 10: 211-219; doi:10.1016/j.ymthe.2004.05.025
Trends in Enzyme Therapy for Phenylketonuria
Woomi Kim, Heidi Erlandsen, Sankar Surendran, Raymond C. Stevens, Alejandra Gamez, Kimberlee Michols-Matalon, Stephen K. Tyring and Reuben Matalon
Mol Ther 10: 220-224; doi:10.1016/j.ymthe.2004.05.001
Original Articles
Uncertain Benefit: Investigators' Views and Communications in Early Phase Gene Transfer Trials
Gail E. Henderson, Arlene M. Davis, Nancy M.P. King, Michele M. Easter, Catherine R. Zimmer, Barbra Bluestone Rothschild, Benjamin S. Wilfond, Daniel K. Nelson and Larry R. Churchill
Mol Ther 10: 225-231; doi:10.1016/j.ymthe.2004.05.013
Targeted Exon Skipping in Transgenic hDMD Mice: A Model for Direct Preclinical Screening of Human-Specific Antisense Oligonucleotides
Mattie Bremmer-Bout, Annemieke Aartsma-Rus, Emile J. de Meijer, Wendy E. Kaman, Anneke A. M. Janson, Rolf H. A. M. Vossen, Gert-Jan B. van Ommen, Johan T. den Dunnen and Judith C. T. van Deutekom
Mol Ther 10: 232-240; doi:10.1016/j.ymthe.2004.05.031
Nitric Oxide Is a Regulator of Hematopoietic Stem Cell Activity
Tatyana Michurina, Peter Krasnov, Alejandro Balazs, Naoki Nakaya, Tamara Vasilieva, Boris Kuzin, Nikolay Khrushchov, Richard C. Mulligan and Grigori Enikolopov
Mol Ther 10: 241-248; doi:10.1016/j.ymthe.2004.05.030
Self-Inactivating Lentiviral Vectors Resist Proviral Methylation but Do Not Confer Position-Independent Expression in Hematopoietic Stem Cells
Azim Mohamedali, Francois Moreau-Gaudry, Emmanuel Richard, Ping Xia, Jan Nolta and Punam Malik
Mol Ther 10: 249-259; doi:10.1016/j.ymthe.2004.05.002
Integration and Long-Term Expression in Xenografted Human Glioblastoma Cells Using a Plasmid-Based Transposon System
John R. Ohlfest, Paul D. Lobitz, Scott G. Perkinson and David A. Largaespada
Mol Ther 10: 260-268; doi:10.1016/j.ymthe.2004.05.005
Long-term Transgene Expression from Plasmid DNA Gene Therapy Vectors Is Negatively Affected by CpG Dinucleotides
Bradley L. Hodges, Kristin M. Taylor, Macy F. Joseph, Sarah A. Bourgeois and Ronald K. Scheule
Mol Ther 10: 269-278; doi:10.1016/j.ymthe.2004.04.018
HLA-A*0201-restricted Cytolytic Responses to the rtTA Transactivator Dominant and Cryptic Epitopes Compromise Transgene Expression Induced by the Tetracycline on System
F. Ginhoux, S. Turbant, D.A. Gross, J. Poupiot, T. Marais, Y. Lone, F. A. Lemonnier, H. Firat, N. Perez, O. Danos and J. Davoust
Mol Ther 10: 279-289; doi:10.1016/j.ymthe.2004.05.012
Therapeutic HER2/Neu DNA Vaccine Inhibits Mouse Tumor Naturally Overexpressing Endogenous Neu
Chi-Chen Lin, Ching-Wen Chou, Ai-Li Shiau, Cheng-Fen Tu, Tai-Ming Ko, Yi-Ling Chen, Bei-Chang Yang, Mi-Hua Tao and Ming-Derg Lai
Mol Ther 10: 290-301; doi:10.1016/j.ymthe.2004.05.015
Recombinant AAV Viral Vectors Pseudotyped with Viral Capsids from Serotypes 1, 2, and 5 Display Differential Efficiency and Cell Tropism after Delivery to Different Regions of the Central Nervous System
Corinna Burger, Oleg S. Gorbatyuk, Margaret J. Velardo, Carmen S. Peden, Philip Williams, Sergei Zolotukhin, Paul J. Reier, Ronald J. Mandel and Nicholas Muzyczka
Mol Ther 10: 302-317; doi:10.1016/j.ymthe.2004.05.024
Intradermal Injection of Lentiviral Vectors Corrects Regenerated Human Dystrophic Epidermolysis Bullosa Skin Tissue in Vivo
David T. Woodley, Douglas R. Keene, Tom Atha, Yi Huang, Ramin Ram, Noriyuki Kasahara and Mei Chen
Mol Ther 10: 318-326; doi:10.1016/j.ymthe.2004.05.016
Enhanced Repair of the Anterior Cruciate Ligament by in Situ Gene Transfer: Evaluation in an in Vitro Model
Arnulf Pascher, Andre F. Steinert, Glyn D. Palmer, Oliver Betz, Jean-Noel Gouze, Elvire Gouze, Carmencita Pilapil, Stephen C. Ghivizzani, Christopher H. Evans and Martha Meaney Murray
Mol Ther 10: 327-336; doi:10.1016/j.ymthe.2004.03.012
Adenoviral-mediated Expression of Porphobilinogen Deaminase in Liver Restores the Metabolic Defect in a Mouse Model of Acute Intermittent Porphyria
Annika Johansson, Grzegorz Nowak, Christer Möller, Pontus Blomberg and Pauline Harper
Mol Ther 10: 337-343; doi:10.1016/j.ymthe.2004.05.018
Effect of Adenovirus Serotype 5 Fiber and Penton Modifications on in vivo Tropism in Rats
Campbell G. Nicol, Delyth Graham, William H. Miller, Stephen J. White, Theodore A. G. Smith, Stuart A. Nicklin, Susan C. Stevenson and Andrew H. Baker
Mol Ther 10: 344-354; doi:10.1016/j.ymthe.2004.05.020
A Novel TARP-Promoter-Based Adenovirus against Hormone-Dependent and Hormone-Refractory Prostate Cancer
Wing-Shing Cheng, Robert Kraaij, Berith Nilsson, Laura van der Weel, Corrina M. A. de Ridder, Thomas H. Tötterman and Magnus Essand
Mol Ther 10: 355-364; doi:10.1016/j.ymthe.2004.05.022
Ribozyme-Mediated Induction of Apoptosis in Human Cancer Cells by Targeted Repair of Mutant p53 RNA
Kyung-Sook Shin, Bruce A. Sullenger and Seong-Wook Lee
Mol Ther 10: 365-372; doi:10.1016/j.ymthe.2004.05.007
Macropinocytosis of Polyplexes and Recycling of Plasmid via the Clathrin-Dependent Pathway Impair the Transfection Efficiency of Human Hepatocarcinoma Cells
Christine Gonçalves, Eric Mennesson, Renate Fuchs, Jean-Pierre Gorvel, Patrick Midoux and Chantal Pichon
Mol Ther 10: 373-385; doi:10.1016/j.ymthe.2004.05.023
Method
A Facile Nonviral Method for Delivering Genes and siRNAs to Skeletal Muscle of Mammalian Limbs
James E. Hagstrom, Julia Hegge, Guofeng Zhang, Mark Noble, Vladimir Budker, David L. Lewis, Hans Herweijer and Jon A. Wolff
Mol Ther 10: 386-398; doi:10.1016/j.ymthe.2004.05.004
Short Communication
Parvalbumin Gene Delivery Improves Diastolic Function in the Aged Myocardium in Vivo
Daniel E. Michele, Michael L. Szatkowski, Faris P. Albayya and Joseph M. Metzger
Mol Ther 10: 399-403; doi:10.1016/j.ymthe.2004.05.011
