Top 10
The top ten charts the articles that have been downloaded most often, in HTML format, from the Molecular Systems Biology website in recent weeks. The chart does not rank the quality, scientific significance or citation impact of the content. However, it may bring articles to your attention that you might not have otherwise noticed. We hope you enjoy them.
October 2009
Harnessing gene expression to identify the genetic basis of drug resistance
Bo-Juen Chen, Helen C Causton, Denesy Mancenido, Noel L Goddard, Ethan O Perlstein & Dana Pe'er
doi:10.1038/msb.2009.69
Synopsis | Full Text | PDF (1,599K) | Supplementary information
Report
Disease signatures are robust across tissues and experiments
Joel T Dudley, Robert Tibshirani, Tarangini Deshpande & Atul J Butte
doi:10.1038/msb.2009.66
Listening to the noise: random fluctuations reveal gene network parameters
Brian Munsky, Brooke Trinh & Mustafa Khammash
doi:10.1038/msb.2009.75
Global effects of DNA replication and DNA replication origin activity on eukaryotic gene expression
Larsson Omberg, Joel R Meyerson, Kayta Kobayashi, Lucy S Drury, John F X Diffley & Orly Alter
doi:10.1038/msb.2009.70
Article
Genomic analysis reveals a tight link between transcription factor dynamics and regulatory network architecture
Raja Jothi, S Balaji, Arthur Wuster, Joshua A Grochow, Jörg Gsponer, Teresa M Przytycka, L Aravind & M Madan Babu
doi:10.1038/msb.2009.52
Synopsis | Full Text | PDF (2,664K) | Supplementary information
Global analysis of the glycoproteome in Saccharomyces cerevisiae reveals new roles for protein glycosylation in eukaryotes
Li A Kung, Sheng-Ce Tao, Jiang Qian, Michael G Smith, Michael Snyder & Heng Zhu
doi:10.1038/msb.2009.64
Synopsis | Full Text | PDF (2,023K) | Supplementary information
Perspective
Pathway databases and tools for their exploitation: benefits, current limitations and challenges
Anna Bauer-Mehren, Laura I Furlong & Ferran Sanz
doi:10.1038/msb.2009.47
Systems biology and the virtual physiological human
Peter Kohl & Denis Noble
doi:10.1038/msb.2009.51
Viral adaptation to host: a proteome-based analysis of codon usage and amino acid preferences
Iris Bahir, Menachem Fromer, Yosef Prat & Michal Linial
doi:10.1038/msb.2009.71
Synopsis | Full Text | PDF (1,917K) | Supplementary information
Article
Systematic phenome analysis of Escherichia coli multiple-knockout mutants reveals hidden reactions in central carbon metabolism
Kenji Nakahigashi, Yoshihiro Toya, Nobuyoshi Ishii, Tomoyoshi Soga, Miki Hasegawa, Hisami Watanabe, Yuki Takai, Masayuki Honma, Hirotada Mori & Masaru Tomita
doi:10.1038/msb.2009.65
Synopsis | Full Text | PDF (2,878K) | Supplementary information
