Supplementary information

FROM:

Harmonic oscillator model of the insulin and IGF1 receptors' allosteric binding and activation

Vladislav V Kiselyov, Soetkin Versteyhe, Lisbeth Gauguin & Pierre De Meyts

doi:10.1038/msb.2008.78

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General supplementary information

1. General remarks
2. Rule based model of the insulin receptor binding
3. Rule based model of the IGF1 receptor binding
4. Reaction scheme for the insulin/IGF1 receptor binding
5. Modelling receptor recycling
6. Modelling of the competition experiment
7. Modelling of the ligand dependence of the dissociation rate
8. Fitting of the model to the experimental data
9. Supplementary Discussion
10. Supplementary figures

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