FIGURE 1
FROM:
Translational switch for long-term maintenance of synaptic plasticity
Naveed Aslam, Yoshi Kubota, David Wells & Harel Z Shouval
doi:10.1038/msb.2009.38
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The proposed model of the local
CaMKII synthesis through the
CaMKII–CPEB1 molecular loop. Here, the
CaMKII molecule can be in inactive, active or active and phosphorylated state, whereas CPEB1 can be in unphosphorylated or phosphorylated state. The
CaMKII molecule in each of the three states has a finite turnover time. A new
CaMKII molecule is produced by CPEB1-dependent polyadenylation of
CaMKII mRNA, which is represented by translation stage (T).
