FIGURE 6
FROM:
An integrated network approach identifies the isobutanol response network of Escherichia coli
Mark P Brynildsen & James C Liao
doi:10.1038/msb.2009.34
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Isobutanol response network related to quinone malfunction. Isobutanol disrupts quinone/quinol function, which releases inhibition of ArcB and PhoR autophosphorylation. Once phosphorylated, ArcB activates ArcA and PhoR activates PhoB, each of which goes on to control its regulon. Disruption of enzymatic activity of cytochromes, NADH dehydrogenases, and succinate dehydrogenase by quinone malfunction results in a decrease in endogenous O2- leading to a reduction in H2O2 and increase in Fe2+ through a diminished Fenton reaction. Fur then binds free Fe2+ to become active and control its regulon.
