FIGURE 2 

The textbook pathway of RB has been expanded by integrating data from the literature. The E2F transcription factors (represented here by single proteins in the nuclear compartment) are connected by activation and inhibition arrows to their gene targets. (A) Map of target genes of E2F transcription factors. Each E2F associates with different cofactors to activate or inhibit the transcription of many genes; pointed arrows mean activation and flat arrows mean inhibitions (B) Map of protein–protein interaction network. Each icon on the diagram represents distinct chemical species. See Kitano and co-workers' description of CellDesigner's standard notation (Kitano et al, 2005) for a detailed meaning of shapes. When the information is available (from Atlas Oncology web-page: http://www.atlasgeneticsoncology.org/), tumour suppressor genes and the corresponding proteins are coloured in blue and oncogenes in red, the other proteins are in green. To read and navigate through the map, visit our webpage: http://bioinfo-out.curie.fr/projects/rbpathway/. The map is clickable and allows easy access to all included information (such as literature references or standard protein ids) and hyperlinked to other databases.