FIGURE 1
FROM:
A comprehensive modular map of molecular interactions in RB/E2F pathway
Laurence Calzone, Amélie Gelay, Andrei Zinovyev, François Radvanyi & Emmanuel Barillot
doi:10.1038/msb.2008.7
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Textbook view of the RB/E2F pathway. When CycD1/CDK4,6 is activated, it phosphorylates RB, which in turn is inactivated and releases E2F transcription factors leading to cell proliferation.