FIGURE 3 

Dependence of period on temperature for the Neurospora model. Circles denote the WT. Left panel: mutant strains obtained through optimisation or suppression of splicing (Diernfellner et al, 2005, 2007). Inverted triangles: strain A; triangles: strain A with divergent FRQ pathways; diamonds: strain B; squares: strain B with divergent FRQ pathways. For the simulations obtained assuming FRQ pathway asymmetry, strain A has an increasing period–temperature profile, while strain B has a decreasing one with the period of strain A greater than that of strain B, as observed experimentally (Diernfellner et al, 2007). Right panel: mutant strains obtained through modification of the l-FRQ AUG or s-FRQ coding region (Liu et al, 1997). Triangles: strain C; squares: strain D. Strain is compensated at lower temperatures with a period greater than that of the wild-type, becoming arrhythmic at the upper end of the range. Strain D is compensated at higher temperatures with a period smaller than that of the WT, becoming arrhythmic at the lower end of the range. This is in agreement with experimental data (Liu et al, 1997).