FIGURE 2 

The effects of the magnitude of extrinsic fluctuations (the coefficient of variation) and their duration (the autocorrelation time ) on measurements of the extrinsic noise (A, B), mean protein numbers (C, D), and the intrinsic noise (E, F) for the gene expression of Figure 1A. We simulate fluctuations in either k₀ (orange circles), k₁ (green squares), v₀ (blue triangles), d₀ (red triangles), v₁ (black crosses), or d₁ (purple diamonds). When the coefficient of variation of the extrinsic variable changes, is 10³ s (A, C, E). When varies, the coefficient of variation is 1 (B, D, F). Each simulation data point is calculated from 10⁸ s of simulation. The dashed lines are analytical solutions using the unified colored noise approximation (applied to d₁; C, D) or Langevin theory (applied to v₀; A, B, E, F).