FIGURE 3 

Schematic of stimulus-specific NF-B responses. Both TNF and LPS activate NF-B through IKK, yet the NF-B responses to each are different. In response to a 45-min pulse of TNF, NF-B activity rises quickly then terminates after approximately 60 min (bottom right). In contrast, in response to a 45-min pulse of LPS, NF-B activity rises slowly over 2 h (bottom left). The NF-B response correlates with the IKK activity profile, which is highly peaked in response to TNF (upper right) but sustained in response to LPS (upper left). This illustrates how IKK helps to mediate stimulus-specific NF-B responses.