FIGURE 3 

Modular organization of the predicted genetic landscape of human diseases. (A) Hierarchical clustering of the concordance scores between 8919 genes and 1126 phenotypes. The color of each cell represents the concordance score of a phenotype (column) and a gene (row), where red/blue indicates high/low concordance score. Phenotype clusters are annotated with enriched disease categories (bottom) and gene clusters are annotated with the most enriched biological process terms of GO (right). The pink circled region indicates a module composed of a gene set of muscle contraction involving in a set of cardiovascular diseases. (B) Zoom-in plot of part of the pink circled region, involving 8 cardiovascular diseases and 26 highly related genes. VT-S: ventricular tachycardia, stress-induced polymorphic [MIM 604772]; VT-I: ventricular tachycardia, idiopathic [MIM 192605]; HB: heart block, non-progressive [MIM 11390]; BS: Brugada syndrome [MIM 601144]; LQT3: long QT syndrome-3 [MIM 603830]; SSS-R: sick sinus syndrome, autosomal recessive [MIM 608567]; SSS-D: sick sinus syndrome, autosomal dominant [MIM 163800]; VF-I: ventricular fibrillation, idiopathic [MIM:603829]. (C) Protein interaction network of the 26 genes (circles) and 2 other genes (diamond) linking GNB4 to the main component.