FIGURE 2 

Pairwise transcription factor-binding motif enrichment at ER- or MYC-bound sites. Possible combinatorial interactions between transcription factors were tested by the enrichment of co-occurrence of transcription factor-binding motifs in ER- (A) or MYC- (B) bound regions identified by ChIP-chip. Logo representations of the position weight matrix or the binding motif for each transcription factor are indicated in Supplementary Figures S1 and S2. Red stars indicate statistically significant enrichment of binding motifs for the single transcription factors (see Supplementary Figure S1 for ER-bound regions and Supplementary Figure S2 for MYC-bound regions). The enrichment of each pair of transcription factors is indicated by the P-value after a Bonferroni multiple testing correction (see color legend).