FIGURE 1 

Genomic distribution of ER- and MYC-binding sites. The distributions of 1615 ER- (A) and 311 MYC- (B) binding sites in E2-stimulated MCF7 cells relative to known genes. Where multiple genomic probes indicated a transcription factor-bound region, the center of each ER- or MYC-binding region was designated as the bound position. Within annotated genes, binding sites were classified as follows: within 5' untranslated regions (5' UTR), within coding sequences (CDS), within 5'-most intron or the first intron, within other introns, and within 3' untranslated regions (3' UTR). ER or MYC binding in intergenic regions was further classified based on the distance to the nearest annotated gene (010, 1050, and >50 kb).