FIGURE 2 

Iterative elimination of models that do not fit experimental data. Initial analysis identified 10 000 models (belonging to 1500 groups) that agree with WT data. (A–D) Four examples of the forces on the four MT populations (asMT—blue; ipMT—green; chrMT—red and ktMT—cyan) in different models. (E) Crosses illustrate projections of the points in the parameter space corresponding to all identified models onto a two-dimensional manifold in the parameter space (explained in the Supplementary information). The models corresponding to (A–D) are marked with red circles. The iterative process of addition of experimental data to the search reduced the number of identified groups of models (F) and the area they occupy in the two-dimensional projection of model space (G) (same projection as that in (E)). The probability density distributions of the parameter values governing the timing of kinesin-14 activity and force for each iteration are shown in (H) with the same color coding as that in (F).