FIGURE 1 

FROM:

Transient heterogeneity in extracellular protease production by Bacillus subtilis

Jan-Willem Veening, Oleg A Igoshin, Robyn T Eijlander, Reindert Nijland, Leendert W Hamoen & Oscar P Kuipers

doi:10.1038/msb.2008.18

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aprE activation by a logic AND gate. (A) Kinetic scheme showing the reactions used to generate the computational model. Dotted boxes show the DegU system, which includes positive feedback and the bistable sporulation switch. Thin arrows represent basal transcription reactions, whereas thick arrows represent activated levels. For simplicity of the scheme, several reactions are omitted (e.g. SinR binding/dissociation, degradation of mRNA/proteins). (B) Cells require both DegUapproxP AND Spo0AapproxP to activate aprE transcription.

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