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Mathematical modeling of pathogenicity of Cryptococcus neoformans

Jacqueline Garcia, John Shea, Fernando Alvarez-Vasquez, Asfia Qureshi, Chiara Luberto, Eberhard O Voit & Maurizio Del Poeta

doi:10.1038/msb.2008.17

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Figure 1

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Table 1

Identification of ceramide species at 48 h of growth

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Table 2

Loss of Isc1 sensitizes Cn to the Pma1 inhibitor ebselena

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Table 3

Comparison between model predictions and experimental data for acidic pH at 48 h of growth

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Table 4

Experimental measurements of phytoceramides C18 and C26 in Cn WT, GAL7:IPC1, and Deltaisc1 mutant strains during in vitro growth at neutral and acidic pH

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Table 5

Experimental measurement of KM and Vmax of Pma1 in Cn WT, Deltaisc1, Deltaisc1-reconstituted (Deltaisc1-Rec), and GAL7:IPC1 strains in cell membranes extracted from cells grown at pH 4.0

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