FIGURE 1
FROM:
Selection to minimise noise in living systems and its implications for the evolution of gene expression
Ben Lehner
doi:10.1038/msb.2008.11
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Noise is minimised for dosage-sensitive genes. The relationship between gene expression and the proportion of genes that are (A) essential, (B) haploinsufficient, (C) inhibit growth when deleted or (D) inhibit growth when overexpressed. The result when considering all dosage-sensitive genes is shown in (E). The percentage of genes with each phenotype is shown for each of 10 equally sized bins of genes ranked according to an expression-level-adjusted measure of noise (DM). The range of each bin is shown, except for the maximum of the top bin, which extends to 61.0.