<?xml version="1.0" encoding="UTF-8"?>
<sbml xmlns="http://www.sbml.org/sbml/level2" level="2" version="1">
  <model name="LeloupNeurospora2loop">
    <listOfCompartments>
      <compartment id="default" name="default" size="1"/>
    </listOfCompartments>
    <listOfSpecies>
      <species id="FC" name="FC" compartment="default" initialConcentration="2.46246334204771"/>
      <species id="FCp" name="FCp" compartment="default" initialConcentration="2.7123114824279"/>
      <species id="FN" name="FN" compartment="default" initialConcentration="1.84400040515923"/>
      <species id="FNp" name="FNp" compartment="default" initialConcentration="2.74224951500791"/>
      <species id="MF" name="MF" compartment="default" initialConcentration="0.725579308537909"/>
    </listOfSpecies>
    <listOfParameters>
      <parameter id="vs" name="vs" value="1.2236333742524"/>
      <parameter id="ki" name="ki" value="5.04543346939346"/>
      <parameter id="n" name="n" value="6.3958"/>
      <parameter id="vm" name="vm" value="0.885376326739544"/>
      <parameter id="km" name="km" value="0.0846004096489894"/>
      <parameter id="ks" name="ks" value="0.313846476998244"/>
      <parameter id="vd" name="vd" value="0.161111487362275"/>
      <parameter id="k1n" name="k1n" value="0.222636680929471"/>
      <parameter id="k2n" name="k2n" value="0.331484503209686"/>
      <parameter id="ksp" name="ksp" value="0.294840169149965"/>
      <parameter id="vdp" name="vdp" value="0.139750313979272"/>
      <parameter id="k1np" name="k1np" value="0.272306464006464"/>
      <parameter id="k2np" name="k2np" value="0.295420749525813"/>
      <parameter id="amp" name="amp" value="0"/>
      <parameter id="dawn" name="dawn" value="6"/>
      <parameter id="dusk" name="dusk" value="18"/>
      <parameter id="d/dt(time)" name="d/dt(time)" value="1"/>
      <parameter id="time" name="time" value="0"/>
    </listOfParameters>
    <listOfReactions>
      <reaction id="MFtrn" name="MFtrn" reversible="false">
        <listOfProducts>
          <speciesReference species="MF"/>
        </listOfProducts>
        <listOfModifiers>
          <modifierSpeciesReference species="FN"/>
          <modifierSpeciesReference species="FNp"/>
        </listOfModifiers>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <divide/>
              <apply>
                <times/>
                <apply>
                  <plus/>
                  <ci> vs </ci>
                  <apply>
                    <times/>
                    <ci> amp </ci>
                    <apply>
                      <divide/>
                      <apply>
                        <times/>
                        <apply>
                          <plus/>
                          <cn type="integer"> 1 </cn>
                          <apply>
                            <tanh/>
                            <apply>
                              <times/>
                              <cn type="integer"> 2 </cn>
                              <apply>
                                <minus/>
                                <apply>
                                  <minus/>
                                  <ci> time </ci>
                                  <apply>
                                    <times/>
                                    <cn type="integer"> 24 </cn>
                                    <apply>
                                      <floor/>
                                      <apply>
                                        <divide/>
                                        <ci> time </ci>
                                        <cn type="integer"> 24 </cn>
                                      </apply>
                                    </apply>
                                  </apply>
                                </apply>
                                <ci> dawn </ci>
                              </apply>
                            </apply>
                          </apply>
                        </apply>
                        <apply>
                          <minus/>
                          <cn type="integer"> 1 </cn>
                          <apply>
                            <tanh/>
                            <apply>
                              <times/>
                              <cn type="integer"> 2 </cn>
                              <apply>
                                <minus/>
                                <apply>
                                  <minus/>
                                  <ci> time </ci>
                                  <apply>
                                    <times/>
                                    <cn type="integer"> 24 </cn>
                                    <apply>
                                      <floor/>
                                      <apply>
                                        <divide/>
                                        <ci> time </ci>
                                        <cn type="integer"> 24 </cn>
                                      </apply>
                                    </apply>
                                  </apply>
                                </apply>
                                <ci> dusk </ci>
                              </apply>
                            </apply>
                          </apply>
                        </apply>
                      </apply>
                      <cn type="integer"> 4 </cn>
                    </apply>
                  </apply>
                </apply>
                <apply>
                  <power/>
                  <ci> ki </ci>
                  <ci> n </ci>
                </apply>
              </apply>
              <apply>
                <plus/>
                <apply>
                  <power/>
                  <ci> ki </ci>
                  <ci> n </ci>
                </apply>
                <apply>
                  <power/>
                  <apply>
                    <plus/>
                    <ci> FN </ci>
                    <ci> FNp </ci>
                  </apply>
                  <ci> n </ci>
                </apply>
              </apply>
            </apply>
          </math>
        </kineticLaw>
      </reaction>
      <reaction id="MFdeg" name="MFdeg" reversible="false">
        <listOfReactants>
          <speciesReference species="MF"/>
        </listOfReactants>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <divide/>
              <apply>
                <times/>
                <ci> vm </ci>
                <ci> MF </ci>
              </apply>
              <apply>
                <plus/>
                <ci> km </ci>
                <ci> MF </ci>
              </apply>
            </apply>
          </math>
        </kineticLaw>
      </reaction>
      <reaction id="FCtrl" name="FCtrl" reversible="false">
        <listOfProducts>
          <speciesReference species="FC"/>
        </listOfProducts>
        <listOfModifiers>
          <modifierSpeciesReference species="MF"/>
        </listOfModifiers>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> ks </ci>
              <ci> MF </ci>
            </apply>
          </math>
        </kineticLaw>
      </reaction>
      <reaction id="FCdeg" name="FCdeg" reversible="false">
        <listOfReactants>
          <speciesReference species="FC"/>
        </listOfReactants>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> vd </ci>
              <ci> FC </ci>
            </apply>
          </math>
        </kineticLaw>
      </reaction>
      <reaction id="FCtrs" name="FCtrs">
        <listOfReactants>
          <speciesReference species="FC"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="FN"/>
        </listOfProducts>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <minus/>
              <apply>
                <times/>
                <ci> k1n </ci>
                <ci> FC </ci>
              </apply>
              <apply>
                <times/>
                <ci> k2n </ci>
                <ci> FN </ci>
              </apply>
            </apply>
          </math>
        </kineticLaw>
      </reaction>
      <reaction id="FCptrl" name="FCptrl" reversible="false">
        <listOfProducts>
          <speciesReference species="FCp"/>
        </listOfProducts>
        <listOfModifiers>
          <modifierSpeciesReference species="MF"/>
        </listOfModifiers>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> ksp </ci>
              <ci> MF </ci>
            </apply>
          </math>
        </kineticLaw>
      </reaction>
      <reaction id="FCpdeg" name="FCpdeg" reversible="false">
        <listOfReactants>
          <speciesReference species="FCp"/>
        </listOfReactants>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> vdp </ci>
              <ci> FCp </ci>
            </apply>
          </math>
        </kineticLaw>
      </reaction>
      <reaction id="FCptrs" name="FCptrs">
        <listOfReactants>
          <speciesReference species="FCp"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="FNp"/>
        </listOfProducts>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <minus/>
              <apply>
                <times/>
                <ci> k1np </ci>
                <ci> FCp </ci>
              </apply>
              <apply>
                <times/>
                <ci> k2np </ci>
                <ci> FNp </ci>
              </apply>
            </apply>
          </math>
        </kineticLaw>
      </reaction>
    </listOfReactions>
  </model>
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