Supplementary information

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Chemical combination effects predict connectivity in biological systems

Joseph Lehár, Grant R Zimmermann, Andrew S Krueger, Raymond A Molnar, Jebediah T Ledell, Adrian M Heilbut, Glenn F Short, III, Leanne C Giusti, Garry P Nolan, Omar A Magid, Margaret S Lee, Alexis A Borisy, Brent R Stockwell & Curtis T Keith

doi:10.1038/msb4100116

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Supplementary figures

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XPPAUT ODE file specifying the reaction network shown in Fig. 3

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Drugs used in the HCT116 tumour cell proliferation screen Sup_5

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Response surfaces and shape model fits for the pathway simulations

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Monte Carlo simulation results for the multiply-inhibited branched pathway

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Combination response data and shape fitting results for the C. glabrata proliferation experiment

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Combination scores from the HCT116 tumour cell proliferation screen

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Statistical results for the HCT116 tumour cell proliferation screen

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S. cerrevisiae drug sensitivity and genetic interaction data relevant to the C. glabrata experiment

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