FIGURE 1 

The regulatory network of histone acetylation in Saccharomyces cerevisiae. The network has been divided into two subnetworks: the one shown here describes the regulation of histone hyperacetylation. The yellow ovals represent the 11 lysines whose acetylation at each promoter has been measured. The TFs that we predict to regulate the acetylation levels of these lysines are shown linked to the lysines. The color of the TFs and the links between TFs and lysines are determined by the linear regression coefficients. Blue indicates correlation with hyperacetylation. White indicates a weak association. The known HAT and HDAC complexes, along with their subunits, are also included in the network. The interactions between HATs, HDACs and TFs are determined from protein–protein interaction data.