TABLE 1 

FROM:

Ligand-dependent responses of the ErbB signaling network: experimental and modeling analyses

Marc R Birtwistle, Mariko Hatakeyama, Noriko Yumoto, Babatunde A Ogunnaike, Jan B Hoek & Boris N Kholodenko

doi:10.1038/msb4100188

Table 1: Description of membrane-localized -states

-State	Description
G	Grb2-containing species in which the Grb2 SH2 domain is bound to tyrosine-phosphorylated receptor dimer (EijP) or to tyrosine-phosphorylated Shc (SP), and both Grb2 SH3 domains are unbound.
S	Shc-containing species in which the Shc SH2 domain is bound to tyrosine-phosphorylated receptor dimer (EijP) or to membrane-localized, tyrosine-phosphorylated GAB1 (AP), and Shc is unphosphorylated.
I	PI-3K-containing species in which PI-3K is bound to tyrosine-phosphorylated receptor dimer (EijP) or to membrane-localized, tyrosine-phosphorylated GAB1 (AP).
R	RasGAP-containing species in which RasGAP is bound to tyrosine-phosphorylated receptor dimer (EijP) or to membrane-localized, tyrosine-phosphorylated GAB1 (AP), but is not phosphorylated.
T	PTP-1B-containing species in which PTP-1B is bound to tyrosine-phosphorylated receptor dimer (EijP) or to membrane-localized, tyrosine-phosphorylated GAB1 (AP).
A	GAB1-containing species in which the GAB1 PH domain is bound to PIP3 or the PRD is bound to Grb2, and GAB1 is unphosphorylated.
O	SOS-containing species that are bound to a membrane-localized N-terminal SH3 domain of Grb2.