FIGURE 3
FROM:
Ligand-dependent responses of the ErbB signaling network: experimental and modeling analyses
Marc R Birtwistle, Mariko Hatakeyama, Noriko Yumoto, Babatunde A Ogunnaike, Jan B Hoek & Boris N Kholodenko
doi:10.1038/msb4100188
BACK TO ARTICLE
Composition of the multi-domain proteins (A) Grb2 and (B) Gab1. Grb2 has C- and N-terminal SH3 domains that bind to Gab1 and SOS, respectively, and an SH2 domain. GAB1 has a PH domain, a PRD, and several tyrosine phosphorylation sites. SH3 domains bind to proline-rich domains, PH domains bind to phospholipids such as PIP3, while SH2 domains bind to phosphotyrosine. SH3, Src homology 3; SH2, Src homology 2; PH, Pleckstrin homology; PRD, proline-rich domain; pY: phosphotyrosine.