FIGURE 2 

Static and dynamic neighborhoods resemble functional modules. (A) Plot of the sub-network formed by hubs. Proteins are colored according to their EV. (B) Plot of hubs' nPCC values against their neighborhood density. Neighborhood density (see Materials and methods) is a measure of how densely the neighbors of a protein are connected to each other, and ranges from 0, for the least dense neighborhood, to 1, for a maximally densely connected neighborhood. Proteins within dense clusters are expected to have high neighborhood densities. Dots (hubs) are colored according to the hub EVs (left panel) and neighborhood EVs (right panel).