FIGURE 1 

Interaction pattern of proteins according to their EV. (A) Boxplot of proteins in each of 50 bins with the given EV versus their neighborhood EV. (B) Interaction preference matrix of the yeast network. Each square represents the number of interactions between corresponding bins. Left panel: Interaction preference matrix of the actual network, right panel: Interaction preference matrix of randomized network achieved by randomly shuffling the positions of proteins in the network (right panel). (C) Interaction preference matrix of proteins with different node degrees corresponding to the four quartiles of the node degree distribution. Proteins were binned according to their EVs and node degrees. Each square represents the normalized number of interactions between proteins with given node degree (k) and EV. Normalization of a square (i, j) in the matrix was carried out by calculating the number of interactions between proteins in the bins i and j, and dividing that number with the total number of interactions that proteins in bins i and j have. Color key shows the normalized number of interactions between bins.